索书号：Q691/H175(5)(MIT)
Radiobiology for the Radiologist
Contents
Preface to the Edition
Preface
Acknowledgments
milestones in Physics and Biology
Part1： For students of diagnostic radiolog, nuclear medicine, and radiation oncology
1 the physics and Chemistry of Radiation Absorption
2 DNA Strand Breaks and Chromosomal Aberrations
3 Cell Survival Curves
4 Radiosensitivity and Cell Age in the Mitotic Cycle
5 Repair of Radiation Damage and the Dose-Rate Effectiveness
6The Oxygen Effect and Reoxygenation
7 Linear Energy Transfer and Relative Bilological Effectiveness
8 Acute Effects of Total-Body Irradiaton
9 Radioprotectors
10 Radiation Carcinogenesis
11 Hereditary Effects of Radiation
12 Effects of Radiation on the Embryo and Fetus
13 Radiation Cataractogenesis
14 Doses and Risks in Diagnostic Radiology, Interventional Radiology and Cardiology, and Nuclear Medicine
15 Radiation Protection
Part II： For students of radiation oncology
16 Molecular Techniques in Radiobiology
17 Cancer Biology
18 Dose-Response Relationships for Model normal Tissues
19 Clinical Response of Normal Tissues
20 Model Tumor Systems
21 Cell, Tissue, and Tumor Kinetics
22 Time, Dose, and Fractionation in Radiotherapy
23 Predictive Assays
24 Alternative Radiation Modalities
25 Radiosensitizers and Bioreductive Drugs
26 Gene therapy
27 Chemotherapeutic Agents from the Perspective of the Radiation Biologist
28 Hyperthermia
Glossary
Subject Index
Abstracts
This fifth edition has been completely revised and substantially rewritten. The format has been changed so that Part 1, the first 15 chapter, represents both a general introduction to radiation biology and a complete self-contained course in the subject, suitable for residents in diagnostic radiology and nuclear medicine. It follows the format of the Syllabus in Radiation Biology prepared by the Radiological Society of North America in 1999, and its Content reflects the questions appearing in recent years in the written examination for diagnostic radiology residents of the American Board of Radiology.
Part2 consists of More in-depth material designed primarily for residents in radiation oncology. It begins with a chapter on molecular techniques, followed by a chapter on cancer biology, new to this edition.
Times change, fashions are modified, and the relative emphasis of different topics must be revesed. “New” radiation modalities become “alternative” radiation modalities, and this chapter is considerably abbreviated because neutrons and heavy ions have not lived up to their earlier promise, while pions have disappeared altogether. Hypoxic cell radiosensitizers give way to hypoxic cytotoxins, formerly temed bioreductive drugs. Predictive assays are still a tantalizing dream, but may never really come into their own until molecular and genetic assays replace measurements of cellular sensitivity.
A new chapter in this edition describes the basis of gene therapy, an excitingtopic that has enough promise to be worth a mention. A frequent criticism of the third and fourth editions of this book was the absence of a chapter on radiation effects in normal tissues in humans. This absence in the past reflected my own personal ignorance and lack of expertise in the area, as well as the conviction that this was clinical radiation oncology, with no place in a text on radiation Biology. However, since no simple summary of this subject exists, I have yielded to the pressure to include a chapter on normal tissue effects, gleaning basic information from many sources, and seeking advice and counsel from my clinical colleagues.
Most of the other chapters have simply been revised and updated to reflect current thoughts and ideas. For example, we now see hypoxia not simply as a modifier of radiation response, but as an element of the tumor microenvironment driving aggression and malignancy. The cell cycle, too, is no longer an empirical series of events, but is driven by cyclines and cyclin-de-pendent kinases.
This fifth edition is certainly the last. This prediction can be made with some confidence because I feel that the days of the single-authored text are numbered, if not over! A book written entirely by one person has the advantage of continuity of style and depth of coverage. However, it is increasingly difficult for any one person to keep up with a rapidly expanding field, as well as with the introduction of molecular techniques. A series of chapters, each written by the expert in that area, may be somewhat daunting to the new student, but in the end it ensures accuracy and an up-to-date account.