Hashimoto et al.
SupplementaryFigure S1 Extraction of gray matter volumes of the right and left superior frontal gyri.
Colored regions were extracted (pink, right superior frontal gyrus; light-blue, left superior frontal gyrus).
SupplementaryFigure S2 Principal component analysis: Scatter plot of eigenvectors1 and 2.
SupplementaryFigure S3 QQ plot derived from the multiple linear regression analysis of bilateral superior frontal volumes.
SupplementaryFigure S4 Adult human HP1BP3 expression in the superior frontal gyri.
The HP1BP3 has moderate to high gene expression throughout the adult human superior frontal gyri, as visualized in the Allen Institute Human Brain Atlas Explorer 2 software ( An upper view of the brain is shown in two individuals. The colors within the superior frontal gyri indicate the Z-scores of HP1BP3 expression normalized within each subject across brain structures. Heat maps show that the HP1BP3 expression is higher in the superior frontal gyri than in other brain structures, such as the hippocampus, thalamus, and cerebellar cortex. FL, Frontal Lobe; HiP, Hippocampus; OL, Occipital Lobe; PL, Parietal Lobe; TL, Temporal Lobe; Str, Striatum; DT, Dorsal Thalamus; MES, Mesencephalon; CbCx, Cerebellar Cortex; MY, Myelencephalon.
SupplementaryFigure S5 Adult human CAPN14 expression in the superior frontal gyri.
The CAPN14gene also exhibits moderate to high expression throughout the adult human superior frontal gyri, as visualized in the Allen Institute Human Brain Atlas Explorer 2 software ( The colors within the superior frontal gyri indicate the Z-scores of CAPN14 expression normalized within each subject across brain structures. Heat maps show that the CAPN14 expression is higher in the cerebral cortices, including the superior frontal gyri, than in other brain structures, such as the thalamus andstriatum.
Supplementary Table S1 Demographic information of patients with schizophrenia and healthy subjects
Schizophrenia / ControlVariables / (N = 158) / (N = 378) / pvalues (z)
Age (years) / 35.3 ± 11.8 / 36.5 ± 12.7 / 0.50 (-0.67)
Gender (male/female) / 95/63 / 187/191 / 0.024 (5.08)a
Education (years) / 14.1 ± 2.5 / 15.0 ± 2.3 / 0.001 (-3.42)
Estimated premorbid IQ / 100.8 ± 10.5 / 107.6 ± 8.0 / 0.001 (-6.98)
Handedness [rt. / other (lt. or bil.)] / 149/9 / 356/22 / 0.96 (<0.01)a
CPZeq. (mg/day) / 560.6 ± 521.9 / - / -
Age at onset (years) / 24.0 ± 9.1 / - / -
Duration of illness (years) / 11.3 ± 9.3 / - / -
PANSS positive symptoms / 18.9 ± 6.0 / - / -
PANSS negative symptoms / 19.9 ± 6.4 / - / -
PANSS general psychopathology / 42.2 ± 11.6 / - / -
PANSS, Positive and Negative Syndrome Scale; CPZ-eq., chlorpromazine equivalent of total antipsychotics. Means ± SD and p values are shown. Significant p values are shown in bold font and are underlined. Complete demographic information was not obtained for all subjects (estimated premorbid IQ in patients: N = 151, PANSS: N = 156).
aχ2 test
1
Hashimoto et al.
SupplementaryTable S2TOP200 SNPs for the right superior frontal gyrus
Combined subjects / Schizophrenia / ControlsRank / SNP / Chr / Bp / m / M / MAF / N / β / p / N / β / p / N / β / p / Closest gene
1 / rs4654899 / 1 / 21410231 / A / C / 0.33 / 509 / -969.5 / 7.52E-09 / 153 / -1164 / 3.71E-04 / 356 / -935.9 / 1.86E-06 / EIF4G3
2 / rs6702110 / 1 / 21515906 / G / A / 0.32 / 526 / -965.3 / 1.07E-08 / 155 / -1255 / 1.79E-04 / 371 / -902.3 / 4.34E-06 / EIF4G3
3 / rs6700718 / 1 / 21299363 / A / C / 0.33 / 537 / -895.1 / 2.89E-08 / 159 / -1110 / 4.68E-04 / 378 / -847.7 / 6.81E-06 / EIF4G3
4 / rs10218584 / 1 / 21474480 / G / C / 0.33 / 537 / -891.8 / 3.21E-08 / 159 / -1110 / 4.68E-04 / 378 / -842.7 / 7.68E-06 / EIF4G3
5 / rs1354792 / 1 / 21391875 / C / T / 0.33 / 535 / -892.7 / 3.46E-08 / 157 / -1114 / 5.35E-04 / 378 / -847.7 / 6.81E-06 / EIF4G3
6 / rs6703227 / 1 / 21374810 / C / T / 0.33 / 537 / -879.3 / 5.28E-08 / 159 / -1056 / 9.55E-04 / 378 / -847.7 / 6.81E-06 / EIF4G3
7 / rs1609558 / 1 / 21525228 / C / T / 0.30 / 533 / -899.8 / 5.36E-08 / 158 / -1031 / 1.18E-03 / 375 / -870.9 / 7.67E-06 / EIF4G3
8 / rs12402486 / 1 / 21447935 / A / G / 0.34 / 527 / -880.9 / 5.58E-08 / 159 / -1110 / 4.68E-04 / 368 / -830 / 1.20E-05 / EIF4G3
9 / rs2874367 / 1 / 21324491 / A / C / 0.33 / 531 / -874.5 / 7.19E-08 / 157 / -1092 / 6.24E-04 / 374 / -829 / 1.25E-05 / EIF4G3
10 / rs6945071 / 7 / 26122423 / G / A / 0.16 / 537 / -1035 / 8.46E-07 / 159 / -1120 / 3.25E-03 / 378 / -983.2 / 1.02E-04 / NFE2L3
11 / rs1906528 / 4 / 27254628 / T / C / 0.17 / 529 / -966.3 / 1.29E-06 / 156 / -1067 / 3.69E-03 / 373 / -908.3 / 1.38E-04 / FLJ45721
12 / rs10962181 / 9 / 1595160 / G / A / 0.09 / 515 / 1328 / 3.39E-06 / 148 / 1616 / 1.47E-02 / 367 / 1263 / 6.35E-05 / SMARCA2
13 / rs11722885 / 4 / 27250047 / G / T / 0.18 / 528 / -918.4 / 4.18E-06 / 152 / -1036 / 4.40E-03 / 376 / -864.8 / 3.04E-04 / FLJ45721
14 / rs520865 / 5 / 80337457 / A / G / 0.37 / 518 / 770.6 / 4.41E-06 / 155 / 761.4 / 1.63E-02 / 363 / 767.5 / 1.10E-04 / RASGRF2
15 / rs17153217 / 7 / 26128758 / A / C / 0.18 / 532 / -923.6 / 4.50E-06 / 156 / -1134 / 2.15E-03 / 376 / -816.2 / 7.00E-04 / NFE2L3
16 / rs12499371 / 4 / 26511289 / A / G / 0.44 / 536 / 703.9 / 6.51E-06 / 158 / 884.5 / 2.78E-03 / 378 / 618.3 / 7.75E-04 / CCKKR
17 / rs4873403 / 8 / 50974319 / C / A / 0.13 / 517 / 1048 / 6.58E-06 / 154 / 1468 / 3.72E-04 / 363 / 795.4 / 5.11E-03 / SNTG1
18 / rs16914234 / 8 / 50975546 / A / T / 0.13 / 525 / 1028 / 6.62E-06 / 157 / 1412 / 5.25E-04 / 368 / 804 / 3.75E-03 / SNTG1
19 / rs4873420 / 8 / 51114283 / T / A / 0.20 / 524 / 878.5 / 6.74E-06 / 152 / 1313 / 7.70E-04 / 372 / 702.9 / 1.83E-03 / SNTG1
20 / rs3771512 / 2 / 70697720 / A / C / 0.45 / 532 / 740.3 / 6.79E-06 / 159 / 610.5 / 3.89E-02 / 373 / 808.8 / 4.62E-05 / TGFA
21 / rs1109802 / 7 / 26126595 / A / T / 0.10 / 536 / -1169 / 7.50E-06 / 159 / -1027 / 4.00E-02 / 377 / -1217 / 7.06E-05 / MIRN148A
22 / rs10504098 / 8 / 51087221 / G / A / 0.20 / 528 / 876.2 / 8.29E-06 / 159 / 1086 / 3.42E-03 / 369 / 768.1 / 9.38E-04 / SNTG1
23 / rs9298279 / 8 / 51072117 / C / A / 0.20 / 536 / 866 / 9.38E-06 / 159 / 1173 / 1.98E-03 / 377 / 723.4 / 1.55E-03 / SNTG1
24 / rs17758599 / 8 / 50946702 / C / T / 0.20 / 530 / 845.8 / 9.61E-06 / 157 / 1221 / 6.18E-04 / 373 / 653.1 / 4.03E-03 / SNTG1
25 / rs4873408 / 8 / 51056341 / A / G / 0.20 / 535 / 859.5 / 9.64E-06 / 159 / 1173 / 1.98E-03 / 376 / 717.9 / 1.52E-03 / SNTG1
26 / rs4654887 / 1 / 21234923 / T / C / 0.27 / 535 / -775 / 1.04E-05 / 159 / -939.3 / 6.12E-03 / 376 / -758.9 / 2.42E-04 / EIF4G3
27 / rs875309 / 18 / 19795304 / A / G / 0.15 / 529 / 954.3 / 1.07E-05 / 159 / 1339 / 1.20E-03 / 370 / 789.9 / 1.92E-03 / GATA6
28 / rs3852539 / 12 / 28094398 / T / C / 0.29 / 536 / -786.8 / 1.12E-05 / 159 / -830.9 / 8.77E-03 / 377 / -780.5 / 3.45E-04 / PTHLH
29 / rs203953 / 8 / 50975505 / C / T / 0.15 / 527 / 956.1 / 1.13E-05 / 156 / 1373 / 7.25E-04 / 371 / 744 / 4.16E-03 / SNTG1
30 / rs203949 / 8 / 50976537 / A / G / 0.19 / 537 / 858 / 1.27E-05 / 159 / 1230 / 7.38E-04 / 378 / 665.4 / 4.58E-03 / SNTG1
31 / rs6988843 / 8 / 51052035 / A / C / 0.20 / 535 / 846.7 / 1.29E-05 / 158 / 1158 / 2.30E-03 / 377 / 707.6 / 1.75E-03 / SNTG1
32 / rs4574391 / 4 / 27212223 / C / T / 0.25 / 533 / -798.7 / 1.32E-05 / 158 / -424.6 / 2.07E-01 / 375 / -974.1 / 8.51E-06 / STIM2
33 / rs935917 / 1 / 21167102 / T / A / 0.26 / 531 / -779.1 / 1.35E-05 / 157 / -1124 / 1.53E-03 / 374 / -685 / 1.03E-03 / EIF4G3
34 / rs1152998 / 1 / 21124290 / T / C / 0.27 / 537 / -760.2 / 1.46E-05 / 159 / -939.3 / 6.12E-03 / 378 / -735.3 / 3.55E-04 / EIF4G3
35 / rs6704421 / 1 / 21220674 / T / G / 0.28 / 517 / -762.5 / 1.50E-05 / 154 / -948.4 / 5.61E-03 / 363 / -731.8 / 4.32E-04 / EIF4G3
36 / rs2046784 / 4 / 26503983 / G / A / 0.40 / 537 / 682.9 / 1.54E-05 / 159 / 661 / 3.01E-02 / 378 / 688 / 1.95E-04 / CCKAR
37 / rs2130250 / 4 / 26504157 / G / T / 0.40 / 537 / 682.9 / 1.54E-05 / 159 / 661 / 3.01E-02 / 378 / 688 / 1.95E-04 / CCKAR
38 / rs10916900 / 1 / 21239059 / G / C / 0.27 / 537 / -762 / 1.54E-05 / 159 / -942.3 / 6.74E-03 / 378 / -741.3 / 3.25E-04 / EIF4G3
39 / rs9298278 / 8 / 51072013 / A / G / 0.20 / 529 / 842.3 / 1.64E-05 / 157 / 1127 / 3.25E-03 / 372 / 711.8 / 1.79E-03 / SNTG1
40 / rs651085 / 1 / 21097783 / A / G / 0.27 / 536 / -754.9 / 1.76E-05 / 158 / -930.7 / 6.97E-03 / 378 / -731.9 / 3.84E-04 / HP1BP3
41 / rs10517116 / 4 / 27217722 / T / C / 0.16 / 531 / -912.2 / 1.88E-05 / 158 / -857.2 / 2.28E-02 / 373 / -937.6 / 3.07E-04 / STIM2
42 / rs2046701 / 4 / 27211040 / C / A / 0.25 / 532 / -767.1 / 1.93E-05 / 158 / -385.1 / 2.46E-01 / 374 / -949 / 8.73E-06 / STIM2
43 / rs203632 / 8 / 51010744 / A / G / 0.20 / 532 / 819.2 / 1.93E-05 / 159 / 1173 / 1.98E-03 / 373 / 660.4 / 2.96E-03 / SNTG1
44 / rs1021077 / 1 / 21106016 / C / T / 0.27 / 534 / -742.3 / 2.33E-05 / 159 / -939.3 / 6.12E-03 / 375 / -712 / 5.42E-04 / HP1BP3
45 / rs12123092 / 1 / 21067001 / A / G / 0.27 / 524 / -754.2 / 2.42E-05 / 159 / -948.6 / 5.51E-03 / 365 / -722.9 / 6.30E-04 / HP1BP3
46 / rs4654874 / 1 / 21156667 / A / G / 0.27 / 533 / -746 / 2.43E-05 / 157 / -897.5 / 8.69E-03 / 376 / -736.5 / 3.97E-04 / EIF4G3
47 / rs10799665 / 1 / 21152640 / A / G / 0.28 / 524 / -753.5 / 2.61E-05 / 157 / -950.4 / 5.96E-03 / 367 / -717.7 / 6.95E-04 / EIF4G3
48 / rs2385812 / 8 / 51137330 / G / A / 0.20 / 536 / 806.6 / 2.69E-05 / 159 / 1106 / 3.47E-03 / 377 / 672.9 / 2.58E-03 / SNTG1
49 / rs2292343 / 17 / 45455670 / C / G / 0.34 / 524 / -702.1 / 2.87E-05 / 155 / -815.7 / 1.32E-02 / 369 / -642.7 / 1.01E-03 / EFCAB13
50 / rs735877 / 10 / 102104521 / T / C / 0.30 / 533 / -731.1 / 2.87E-05 / 158 / -518.8 / 1.13E-01 / 375 / -815.5 / 8.40E-05 / SCD
51 / rs13260265 / 8 / 51072957 / C / T / 0.19 / 525 / 847.3 / 2.97E-05 / 155 / 1094 / 5.01E-03 / 370 / 722.8 / 2.48E-03 / SNTG1
52 / rs4873409 / 8 / 51072230 / A / G / 0.13 / 537 / 964.2 / 3.16E-05 / 159 / 1323 / 1.22E-03 / 378 / 759.3 / 7.12E-03 / SNTG1
53 / rs10096871 / 8 / 51013729 / A / C / 0.18 / 534 / 828.4 / 3.19E-05 / 157 / 1234 / 1.31E-03 / 377 / 640.7 / 6.06E-03 / SNTG1
54 / rs17709903 / 9 / 1608186 / C / A / 0.10 / 532 / 1114 / 3.30E-05 / 158 / 1685 / 7.28E-03 / 374 / 980.4 / 9.01E-04 / SMARCA2
55 / rs1325020 / 6 / 23716485 / A / G / 0.35 / 537 / -688.3 / 3.39E-05 / 159 / -515 / 1.26E-01 / 378 / -764.7 / 6.09E-05 / NRSN1
56 / rs16899515 / 5 / 26761648 / C / T / 0.07 / 533 / -1337 / 3.41E-05 / 157 / -1247 / 3.20E-02 / 376 / -1357 / 4.96E-04 / CDH9
57 / rs4873135 / 8 / 51127196 / A / G / 0.21 / 536 / 795.1 / 3.49E-05 / 159 / 1101 / 3.47E-03 / 377 / 660.1 / 3.14E-03 / SNTG1
58 / rs17820875 / 16 / 53926790 / G / A / 0.11 / 537 / 1094 / 3.56E-05 / 159 / 1813 / 6.70E-04 / 378 / 816.6 / 7.36E-03 / FTO
59 / rs9864645 / 3 / 81239645 / A / G / 0.14 / 524 / 941 / 3.63E-05 / 158 / 1252 / 4.15E-03 / 366 / 850.4 / 1.48E-03 / LOC728290
60 / rs10962278 / 9 / 1619145 / G / C / 0.11 / 525 / 1112 / 3.72E-05 / 156 / 1204 / 5.45E-02 / 369 / 1104 / 2.09E-04 / SMARCA2
61 / rs10491487 / 5 / 80323368 / G / T / 0.13 / 530 / 963.4 / 3.94E-05 / 159 / 1079 / 2.28E-02 / 371 / 923.1 / 6.05E-04 / RASGRF2
62 / rs10493001 / 1 / 21100916 / G / T / 0.19 / 512 / -820.3 / 4.10E-05 / 149 / -1031 / 1.52E-02 / 363 / -791.1 / 5.03E-04 / HP1BP3
63 / rs3883317 / 17 / 45484111 / A / G / 0.34 / 534 / -671.3 / 4.21E-05 / 158 / -727.1 / 2.74E-02 / 376 / -634.6 / 7.97E-04 / EFCAB13
64 / rs203612 / 8 / 51003269 / G / A / 0.20 / 536 / 790.7 / 4.22E-05 / 159 / 1173 / 1.98E-03 / 377 / 623.7 / 5.49E-03 / SNTG1
65 / rs203932 / 8 / 50988661 / G / A / 0.20 / 537 / 788.8 / 4.31E-05 / 159 / 1173 / 1.98E-03 / 378 / 621.1 / 5.61E-03 / SNTG1
66 / rs769097 / 3 / 132981813 / A / C / 0.46 / 534 / -648 / 4.41E-05 / 158 / -596.5 / 5.40E-02 / 376 / -669.1 / 2.90E-04 / TMEM108
67 / rs2320590 / 1 / 21155195 / C / T / 0.27 / 527 / -727.1 / 4.41E-05 / 157 / -965.1 / 5.15E-03 / 370 / -673.1 / 1.30E-03 / EIF4G3
68 / rs4873431 / 8 / 51132732 / T / C / 0.20 / 536 / 786.2 / 4.49E-05 / 159 / 1070 / 5.03E-03 / 377 / 658 / 3.25E-03 / SNTG1
69 / rs13403709 / 2 / 53131669 / T / C / 0.21 / 537 / 769.3 / 4.61E-05 / 159 / 915.5 / 5.98E-03 / 378 / 683 / 3.03E-03 / MIR4431
70 / rs2237143 / 6 / 15440339 / C / T / 0.24 / 537 / -731.1 / 4.66E-05 / 159 / -920.7 / 5.94E-03 / 378 / -633.4 / 2.98E-03 / JARID2
71 / rs3856173 / 1 / 21114833 / A / G / 0.27 / 523 / -736.5 / 4.67E-05 / 155 / -1018 / 4.43E-03 / 368 / -691.6 / 1.09E-03 / HP1BP3
72 / rs11741853 / 5 / 173730624 / G / A / 0.14 / 537 / -932.4 / 4.91E-05 / 159 / -1102 / 1.73E-02 / 378 / -865.2 / 1.06E-03 / HMP19
73 / rs4873141 / 8 / 51170637 / C / T / 0.18 / 537 / 785.4 / 5.09E-05 / 159 / 1199 / 1.78E-03 / 378 / 610.9 / 6.57E-03 / SNTG1
74 / rs4335431 / 1 / 218557609 / C / T / 0.12 / 534 / 933.2 / 5.15E-05 / 157 / 1082 / 2.32E-02 / 377 / 862.8 / 1.03E-03 / TGFB2
75 / rs12578526 / 12 / 63433435 / C / A / 0.19 / 518 / 803.4 / 5.16E-05 / 150 / 736.4 / 5.34E-02 / 368 / 789.5 / 8.11E-04 / AVPR1A
76 / rs13191089 / 6 / 138786583 / C / G / 0.37 / 520 / 654.4 / 5.30E-05 / 155 / 700.7 / 2.40E-02 / 365 / 624.1 / 1.06E-03 / NHSL1
77 / rs17071302 / 4 / 182337204 / G / C / 0.24 / 537 / 716.4 / 5.78E-05 / 159 / 756.4 / 3.09E-02 / 378 / 698.8 / 7.17E-04 / LINC00290
78 / rs1597426 / 8 / 51176636 / A / G / 0.20 / 517 / 774.8 / 5.94E-05 / 151 / 1071 / 4.47E-03 / 366 / 632.4 / 4.95E-03 / SNTG1
79 / rs4600815 / 3 / 133020968 / T / A / 0.46 / 537 / -633.1 / 5.98E-05 / 159 / -550.4 / 7.25E-02 / 378 / -664.9 / 3.01E-04 / TMEM108
80 / rs6545301 / 2 / 52935725 / G / T / 0.17 / 537 / 862.6 / 6.16E-05 / 159 / 1286 / 6.00E-04 / 378 / 654.4 / 1.34E-02 / MIR4431
81 / rs7599478 / 2 / 230947503 / C / A / 0.35 / 530 / 637.5 / 6.25E-05 / 157 / 665.3 / 2.24E-02 / 373 / 635.5 / 8.67E-04 / SLC16A14
82 / rs1009539 / 12 / 63414655 / T / C / 0.18 / 519 / 799.7 / 6.29E-05 / 155 / 501.6 / 1.89E-01 / 364 / 888.9 / 1.73E-04 / PPM1H
83 / rs1883611 / 6 / 9583920 / G / T / 0.20 / 521 / 819.2 / 6.39E-05 / 156 / 941.5 / 2.67E-02 / 365 / 765.5 / 1.02E-03 / OFCC1
84 / rs209710 / 1 / 22875879 / G / A / 0.27 / 537 / 684.1 / 6.46E-05 / 159 / 561.1 / 7.68E-02 / 378 / 748.9 / 2.46E-04 / EPHA8
85 / rs12662028 / 6 / 138801650 / A / C / 0.35 / 537 / 657.4 / 6.54E-05 / 159 / 836.7 / 9.32E-03 / 378 / 574.5 / 2.77E-03 / NHSL1
86 / rs1450127 / 8 / 51134788 / T / A / 0.21 / 528 / 771.1 / 6.64E-05 / 156 / 969.1 / 1.07E-02 / 372 / 685.3 / 2.29E-03 / SNTG1
87 / rs3734942 / 7 / 138406404 / A / G / 0.21 / 537 / 781.8 / 6.64E-05 / 159 / 212.8 / 5.79E-01 / 378 / 998.6 / 1.13E-05 / ATP6V0A4
88 / rs17441563 / 7 / 138409421 / T / C / 0.21 / 532 / 786.2 / 6.68E-05 / 158 / 251.2 / 5.11E-01 / 374 / 994.8 / 1.48E-05 / ATP6V0A4
89 / rs16878035 / 5 / 59709614 / T / G / 0.11 / 537 / 1025 / 6.79E-05 / 159 / 1548 / 4.38E-03 / 378 / 853.8 / 3.52E-03 / PDE4D
90 / rs16878037 / 5 / 59709752 / T / C / 0.11 / 537 / 1025 / 6.79E-05 / 159 / 1548 / 4.38E-03 / 378 / 853.8 / 3.52E-03 / PDE4D
91 / rs352722 / 15 / 102319742 / T / C / 0.14 / 533 / 944.7 / 6.95E-05 / 156 / 901 / 4.79E-02 / 377 / 931.1 / 8.62E-04 / OR4F6
92 / rs2174440 / 5 / 26766362 / T / C / 0.07 / 535 / -1271 / 7.23E-05 / 159 / -1403 / 1.28E-02 / 376 / -1163 / 2.98E-03 / CDH9
93 / rs2130249 / 4 / 26504912 / C / A / 0.34 / 526 / -648.6 / 7.35E-05 / 158 / -700.8 / 2.58E-02 / 368 / -603 / 1.78E-03 / CCKAR
94 / rs1334078 / 9 / 119800808 / C / T / 0.46 / 515 / 627.4 / 7.57E-05 / 148 / 682 / 3.14E-02 / 367 / 613.2 / 7.93E-04 / ASTN2
95 / rs12545915 / 8 / 51166926 / T / G / 0.20 / 535 / 748.6 / 7.80E-05 / 158 / 1077 / 3.56E-03 / 377 / 601 / 6.47E-03 / SNTG1
96 / rs1218444 / 10 / 14368831 / G / T / 0.12 / 533 / -914.6 / 7.98E-05 / 158 / -1405 / 8.25E-04 / 375 / -670.5 / 1.60E-02 / FRMD4A
97 / rs4864351 / 4 / 131030801 / A / C / 0.34 / 519 / 666 / 8.10E-05 / 156 / 888.2 / 7.51E-03 / 363 / 557 / 4.82E-03 / C4orf33
98 / rs10107397 / 8 / 51205275 / T / C / 0.14 / 535 / 862.5 / 8.19E-05 / 158 / 1194 / 4.58E-03 / 377 / 708.3 / 5.78E-03 / SNTG1
99 / rs16878086 / 5 / 59734600 / A / G / 0.11 / 537 / 1014 / 8.50E-05 / 159 / 1508 / 6.19E-03 / 378 / 853.8 / 3.52E-03 / PDE4D
100 / rs4805539 / 19 / 30768455 / G / A / 0.45 / 531 / 613.7 / 8.68E-05 / 155 / 697.2 / 1.63E-02 / 376 / 596 / 1.36E-03 / ZNF536
101 / rs6932953 / 6 / 19206652 / G / A / 0.22 / 534 / -712.5 / 9.11E-05 / 159 / -908.1 / 1.19E-02 / 375 / -628.8 / 2.85E-03 / TRNAQ22
102 / rs10514925 / 17 / 45444868 / C / G / 0.35 / 534 / -643.3 / 9.42E-05 / 159 / -734.9 / 2.49E-02 / 375 / -592.2 / 1.93E-03 / EFCAB13
103 / rs7305099 / 12 / 975276 / T / G / 0.30 / 532 / -665.8 / 9.61E-05 / 157 / -989.5 / 1.44E-03 / 375 / -535.5 / 8.96E-03 / WNK1
104 / rs6999627 / 8 / 51178175 / C / T / 0.20 / 537 / 737.9 / 9.66E-05 / 159 / 1066 / 3.82E-03 / 378 / 590.7 / 7.47E-03 / SNTG1
105 / rs1276812 / 6 / 23722517 / C / T / 0.35 / 530 / -655.1 / 9.70E-05 / 157 / -470.6 / 1.71E-01 / 373 / -739.5 / 1.22E-04 / NRSN1
106 / rs7172905 / 15 / 102243354 / C / T / 0.15 / 535 / 909 / 1.01E-04 / 159 / 870.4 / 5.49E-02 / 376 / 902.5 / 9.54E-04 / TARSL2
107 / rs1558756 / 16 / 53916508 / A / G / 0.10 / 532 / 1023 / 1.05E-04 / 158 / 1990 / 2.37E-04 / 374 / 675.3 / 2.52E-02 / FTO
108 / rs1218430 / 10 / 14362718 / A / G / 0.11 / 536 / -901.1 / 1.12E-04 / 159 / -1362 / 1.26E-03 / 377 / -669 / 1.70E-02 / FRMD4A
109 / rs352731 / 15 / 102289502 / G / C / 0.13 / 518 / 954.9 / 1.13E-04 / 155 / 881 / 6.22E-02 / 363 / 946.4 / 1.18E-03 / LOC100128108
110 / rs4873402 / 8 / 50937906 / C / T / 0.14 / 531 / 869.1 / 1.13E-04 / 158 / 1179 / 4.43E-03 / 373 / 689.2 / 1.07E-02 / SNTG1
111 / rs3916323 / 5 / 29558211 / T / G / 0.09 / 518 / -1066 / 1.16E-04 / 149 / -1341 / 1.52E-02 / 369 / -940 / 3.28E-03 / CDH6
112 / rs1160795 / 8 / 51215044 / T / C / 0.19 / 525 / 754.3 / 1.17E-04 / 151 / 1161 / 2.53E-03 / 374 / 578.4 / 1.13E-02 / SNTG1
113 / rs1523305 / 2 / 70698856 / C / T / 0.40 / 537 / -611.9 / 1.17E-04 / 159 / -572 / 4.52E-02 / 378 / -638.6 / 8.69E-04 / TGFA
114 / rs1908160 / 15 / 102233260 / G / A / 0.15 / 537 / 887.5 / 1.18E-04 / 159 / 870.4 / 5.49E-02 / 378 / 874.3 / 1.09E-03 / TARSL2
115 / rs7070346 / 10 / 23368845 / A / G / 0.21 / 535 / 756.4 / 1.21E-04 / 158 / 431.3 / 2.58E-01 / 377 / 906.2 / 7.90E-05 / MSRB2
116 / rs1997573 / 8 / 15698639 / C / T / 0.30 / 531 / 706.5 / 1.26E-04 / 157 / 297.1 / 3.99E-01 / 374 / 862.6 / 7.77E-05 / TUSC3
117 / rs207964 / 15 / 92652173 / T / C / 0.05 / 537 / 1399 / 1.27E-04 / 159 / 1174 / 1.24E-01 / 378 / 1458 / 4.33E-04 / SLCO3A1
118 / rs7495447 / 15 / 102233803 / C / T / 0.15 / 535 / 894.3 / 1.29E-04 / 159 / 776 / 8.47E-02 / 376 / 926.4 / 7.04E-04 / TARSL2
119 / rs7730607 / 5 / 173696695 / T / G / 0.11 / 513 / -992.6 / 1.32E-04 / 154 / -1495 / 5.35E-03 / 359 / -810.2 / 6.32E-03 / HMP19
120 / rs2219574 / 8 / 51196413 / T / C / 0.19 / 524 / 750 / 1.35E-04 / 156 / 1075 / 3.64E-03 / 368 / 584 / 1.22E-02 / SNTG1
121 / rs10282933 / 8 / 51155698 / T / C / 0.14 / 533 / 850.1 / 1.37E-04 / 158 / 1195 / 3.55E-03 / 375 / 664.3 / 1.27E-02 / SNTG1
122 / rs12363681 / 11 / 40222380 / C / T / 0.30 / 537 / 649.3 / 1.38E-04 / 159 / 960.4 / 4.39E-03 / 378 / 522.8 / 8.09E-03 / LRRC4C
123 / rs26506 / 5 / 96079402 / T / C / 0.46 / 533 / 610.7 / 1.38E-04 / 158 / 829.6 / 6.92E-03 / 375 / 516.1 / 5.97E-03 / CAST
124 / rs17763435 / 12 / 63416511 / A / G / 0.19 / 533 / 743 / 1.39E-04 / 158 / 467.5 / 2.18E-01 / 375 / 823.5 / 3.33E-04 / PPM1H
125 / rs11099034 / 4 / 131021084 / T / G / 0.34 / 532 / 626.9 / 1.43E-04 / 157 / 952.4 / 3.22E-03 / 375 / 480.5 / 1.25E-02 / C4orf33
126 / rs6822402 / 4 / 31220318 / G / C / 0.21 / 533 / 724.2 / 1.43E-04 / 158 / 403.4 / 2.56E-01 / 375 / 867.5 / 1.26E-04 / PCDH7
127 / rs8094950 / 18 / 74820880 / T / G / 0.18 / 533 / -808.7 / 1.44E-04 / 158 / -1224 / 3.53E-03 / 375 / -661.8 / 7.35E-03 / MBP
128 / rs12476215 / 2 / 53321966 / C / T / 0.08 / 528 / 1048 / 1.52E-04 / 155 / 1252 / 2.19E-02 / 373 / 993.7 / 2.02E-03 / MIR4431
129 / rs1549748 / 2 / 53131229 / G / C / 0.18 / 531 / 753.1 / 1.57E-04 / 156 / 1078 / 2.58E-03 / 375 / 600.8 / 1.24E-02 / MIR4431
130 / rs6456569 / 6 / 23704025 / A / G / 0.36 / 531 / -631.9 / 1.59E-04 / 157 / -441.4 / 1.93E-01 / 374 / -715.2 / 1.97E-04 / NRSN1
131 / rs17353336 / 3 / 132672981 / T / C / 0.32 / 531 / -657 / 1.60E-04 / 158 / -476.5 / 1.67E-01 / 373 / -719.7 / 3.55E-04 / TMEM108
132 / rs712768 / 3 / 7444456 / A / G / 0.41 / 528 / -612.7 / 1.63E-04 / 158 / -660.9 / 2.85E-02 / 370 / -585.6 / 2.42E-03 / GRM7
133 / rs4080260 / 5 / 26744312 / T / G / 0.08 / 535 / -1142 / 1.65E-04 / 159 / -1401 / 9.12E-03 / 376 / -972.6 / 8.43E-03 / CDH9
134 / rs12188430 / 5 / 26753725 / T / C / 0.08 / 532 / -1158 / 1.66E-04 / 157 / -1405 / 9.15E-03 / 375 / -996.5 / 8.12E-03 / CDH9
135 / rs11231294 / 11 / 62755519 / C / T / 0.43 / 537 / 592.8 / 1.67E-04 / 159 / 404 / 1.82E-01 / 378 / 692 / 1.87E-04 / SLC22A6
136 / rs1380792 / 8 / 51183693 / C / T / 0.20 / 529 / 730.1 / 1.70E-04 / 154 / 1077 / 4.18E-03 / 375 / 564 / 1.33E-02 / SNTG1
137 / rs10502520 / 18 / 26801474 / G / A / 0.43 / 536 / -594.6 / 1.71E-04 / 159 / -827.4 / 3.59E-03 / 377 / -470 / 1.40E-02 / CDH2
138 / rs6786115 / 3 / 21821663 / G / A / 0.28 / 532 / 663.2 / 1.71E-04 / 158 / 1022 / 1.61E-03 / 374 / 505.5 / 1.66E-02 / ZNF385D
139 / rs10183352 / 2 / 230992080 / T / C / 0.41 / 530 / 573.5 / 1.73E-04 / 156 / 708.8 / 1.28E-02 / 374 / 537.2 / 3.07E-03 / SP110
140 / rs12550121 / 8 / 64452763 / T / G / 0.40 / 537 / -601.2 / 1.76E-04 / 159 / -655 / 2.53E-02 / 378 / -577 / 2.68E-03 / LOC286184
141 / rs6797720 / 3 / 81230739 / A / G / 0.19 / 536 / 734.9 / 1.78E-04 / 159 / 947.4 / 1.91E-02 / 377 / 682.5 / 2.29E-03 / LOC728290
142 / rs6484249 / 11 / 26781674 / T / C / 0.11 / 512 / 991 / 1.79E-04 / 150 / 1180 / 2.95E-02 / 362 / 924.5 / 2.20E-03 / SLC5A12
143 / rs12051795 / 17 / 45413384 / A / G / 0.23 / 537 / -690.8 / 1.80E-04 / 159 / -907.4 / 7.85E-03 / 378 / -576.7 / 8.71E-03 / EFCAB13
144 / rs9581487 / 13 / 26517809 / G / T / 0.40 / 537 / 628.3 / 1.84E-04 / 159 / 469.2 / 1.67E-01 / 378 / 703 / 2.84E-04 / ATPBA2
145 / rs7958415 / 12 / 27997918 / T / C / 0.39 / 527 / -613.7 / 1.87E-04 / 154 / -569.7 / 7.60E-02 / 373 / -653.8 / 6.43E-04 / KLHDC5
146 / rs6439392 / 3 / 132945022 / C / T / 0.50 / 537 / 589.8 / 1.89E-04 / 159 / 511.3 / 1.02E-01 / 378 / 628.6 / 5.87E-04 / TMEM108
147 / rs473139 / 5 / 80317020 / G / A / 0.38 / 537 / 622.1 / 1.98E-04 / 159 / 797 / 1.59E-02 / 378 / 545.1 / 4.94E-03 / RASGRF2
148 / rs12341921 / 9 / 106255856 / A / G / 0.14 / 536 / -850.2 / 1.98E-04 / 159 / -1791 / 9.24E-06 / 377 / -358.4 / 1.96E-01 / CYLC2
149 / rs17043720 / 2 / 53101066 / G / A / 0.18 / 529 / 755.7 / 2.01E-04 / 157 / 923.1 / 1.72E-02 / 372 / 686.1 / 4.06E-03 / MIR4431
150 / rs10764785 / 10 / 130319747 / A / C / 0.28 / 531 / -673 / 2.09E-04 / 157 / -740.5 / 3.22E-02 / 374 / -635.4 / 2.93E-03 / MKI67
151 / rs17154481 / 7 / 107462330 / A / G / 0.14 / 513 / 852.9 / 2.09E-04 / 153 / 1139 / 9.47E-03 / 360 / 719.5 / 7.71E-03 / SLC26A3
152 / rs9985771 / 4 / 131039227 / A / G / 0.35 / 537 / 605.2 / 2.15E-04 / 159 / 911.5 / 4.87E-03 / 378 / 462.7 / 1.52E-02 / C4orf33
153 / rs6667793 / 1 / 21245835 / A / G / 0.26 / 537 / 676.6 / 2.15E-04 / 159 / 758.4 / 3.42E-02 / 378 / 658.8 / 1.97E-03 / EIF4G3
154 / rs1218436 / 10 / 14365113 / G / A / 0.11 / 537 / -860.5 / 2.17E-04 / 159 / -1362 / 1.26E-03 / 378 / -614 / 2.77E-02 / FRMD4A
155 / rs1604173 / 12 / 100012691 / A / G / 0.06 / 535 / -1209 / 2.18E-04 / 159 / -1718 / 7.23E-03 / 376 / -1020 / 7.38E-03 / ANKS1B
156 / rs17298063 / 3 / 133036810 / G / C / 0.47 / 537 / -582.7 / 2.21E-04 / 159 / -550.4 / 7.25E-02 / 378 / -596.4 / 1.18E-03 / TMEM108
157 / rs6864442 / 5 / 59710033 / G / A / 0.10 / 519 / 1001 / 2.23E-04 / 153 / 1363 / 1.90E-02 / 366 / 888.9 / 3.74E-03 / PDE4D
158 / rs11109244 / 12 / 98233981 / A / G / 0.24 / 515 / 709.1 / 2.23E-04 / 155 / 196.4 / 6.13E-01 / 360 / 898.4 / 4.54E-05 / MIR4495
159 / rs9396584 / 6 / 15389246 / T / C / 0.19 / 529 / -732.2 / 2.24E-04 / 157 / -817.6 / 3.20E-02 / 372 / -704.4 / 2.48E-03 / JARID2
160 / rs10476102 / 5 / 173648583 / A / G / 0.22 / 536 / -666 / 2.25E-04 / 158 / -465.3 / 1.85E-01 / 378 / -751.7 / 3.47E-04 / HMP19
161 / rs6750115 / 2 / 108171153 / A / G / 0.37 / 534 / 600 / 2.25E-04 / 159 / 636.6 / 3.85E-02 / 375 / 575.6 / 2.69E-03 / RGPD4
162 / rs17217144 / 16 / 53790762 / T / C / 0.20 / 531 / -716.6 / 2.26E-04 / 158 / -847.6 / 2.59E-02 / 373 / -702 / 2.01E-03 / FTO
163 / rs1861869 / 16 / 53790181 / G / C / 0.26 / 535 / -659.4 / 2.26E-04 / 159 / -535.4 / 1.26E-01 / 376 / -726.3 / 4.86E-04 / FTO
164 / rs8040836 / 15 / 92600010 / C / G / 0.11 / 537 / 924.1 / 2.29E-04 / 159 / 891 / 7.91E-02 / 378 / 895 / 2.04E-03 / SLCO3A1
165 / rs11763181 / 7 / 27985058 / T / G / 0.15 / 515 / -793.3 / 2.31E-04 / 148 / -1201 / 9.20E-03 / 367 / -647.2 / 7.69E-03 / JAZF1
166 / rs1041051 / 13 / 26523862 / G / A / 0.34 / 517 / 662.2 / 2.31E-04 / 155 / 554.5 / 1.23E-01 / 362 / 735.9 / 4.44E-04 / ATP8A2
167 / rs2936992 / 5 / 173710904 / C / T / 0.15 / 515 / -819.2 / 2.39E-04 / 148 / -1179 / 6.06E-03 / 367 / -676.6 / 9.51E-03 / HMP19
168 / rs7815922 / 8 / 98580680 / C / A / 0.27 / 536 / -643.4 / 2.39E-04 / 159 / -458.1 / 1.67E-01 / 377 / -721 / 4.95E-04 / MTDH
169 / rs6439389 / 3 / 132916612 / A / G / 0.46 / 537 / -576.1 / 2.43E-04 / 159 / -524 / 8.34E-02 / 378 / -598.4 / 1.11E-03 / TMEM108
170 / rs9920203 / 15 / 36229113 / G / A / 0.35 / 530 / 590.5 / 2.43E-04 / 159 / 785.9 / 9.07E-03 / 371 / 498.7 / 8.94E-03 / MIR4510
171 / rs184249 / 13 / 26510069 / G / A / 0.39 / 537 / 607.8 / 2.48E-04 / 159 / 551 / 1.03E-01 / 378 / 646.2 / 7.13E-04 / ATP8A2
172 / rs4529480 / 8 / 51306463 / A / G / 0.22 / 535 / 695.3 / 2.51E-04 / 158 / 1021 / 4.33E-03 / 377 / 532.3 / 1.80E-02 / SNTG1
173 / rs503102 / 5 / 80320026 / G / C / 0.39 / 533 / 615.3 / 2.53E-04 / 159 / 802.4 / 1.53E-02 / 374 / 532.9 / 6.43E-03 / RASGRF2
174 / rs789774 / 15 / 36219977 / A / G / 0.34 / 531 / 590.9 / 2.56E-04 / 158 / 779.7 / 9.00E-03 / 373 / 501.4 / 9.48E-03 / MIR4510
175 / rs11781516 / 8 / 40554742 / C / T / 0.40 / 537 / -584.2 / 2.57E-04 / 159 / -844.2 / 3.88E-03 / 378 / -458 / 1.66E-02 / ZMAT4
176 / rs7094224 / 10 / 23394202 / C / T / 0.21 / 531 / 728.5 / 2.62E-04 / 156 / 452.2 / 2.51E-01 / 375 / 850.1 / 2.36E-04 / MSRB2
177 / rs9691349 / 7 / 111376683 / C / T / 0.10 / 537 / 956.7 / 2.68E-04 / 159 / 1203 / 2.79E-02 / 378 / 885.3 / 3.06E-03 / DOCK4
178 / rs1861868 / 16 / 53790402 / T / C / 0.21 / 537 / -696.8 / 2.69E-04 / 159 / -819.9 / 2.96E-02 / 378 / -680 / 2.26E-03 / FTO
179 / rs1500671 / 12 / 100001352 / C / G / 0.06 / 537 / -1219 / 2.69E-04 / 159 / -1718 / 7.23E-03 / 378 / -1017 / 9.66E-03 / ANKS1B
180 / rs2497821 / 10 / 18369959 / T / A / 0.48 / 537 / 575 / 2.71E-04 / 159 / 570.3 / 7.20E-02 / 378 / 592.5 / 1.12E-03 / SLC39A12
181 / rs10750977 / 11 / 62733609 / T / G / 0.47 / 536 / 572.9 / 2.71E-04 / 159 / 275.3 / 3.48E-01 / 377 / 727 / 1.02E-04 / SLC22A6
182 / rs11922891 / 3 / 133011204 / T / C / 0.47 / 530 / -580.6 / 2.71E-04 / 159 / -550.4 / 7.25E-02 / 371 / -592.4 / 1.50E-03 / TMEM108
183 / rs7296115 / 12 / 14396892 / T / G / 0.49 / 515 / -584.5 / 2.72E-04 / 155 / -1004 / 6.87E-04 / 360 / -401.5 / 3.60E-02 / ATF7IP
184 / rs9849808 / 3 / 81252454 / C / T / 0.13 / 537 / 834.5 / 2.74E-04 / 159 / 1201 / 8.73E-03 / 378 / 727.6 / 6.07E-03 / LOC728290
185 / rs12425655 / 12 / 63434463 / A / G / 0.19 / 533 / 711.3 / 2.76E-04 / 158 / 432.1 / 2.52E-01 / 375 / 791.7 / 6.21E-04 / AVPR1A
186 / rs7218526 / 17 / 77793860 / A / C / 0.18 / 535 / 742.8 / 2.77E-04 / 158 / 851.7 / 2.65E-02 / 377 / 679 / 5.02E-03 / CBX4
187 / rs712786 / 3 / 7486021 / A / G / 0.39 / 537 / -582.3 / 2.78E-04 / 159 / -556.3 / 6.53E-02 / 378 / -590 / 1.83E-03 / GRM7
188 / rs2080947 / 5 / 95192776 / G / C / 0.07 / 532 / -1129 / 2.78E-04 / 157 / -841.3 / 2.50E-01 / 375 / -1226 / 3.16E-04 / C5orf27
189 / rs1893429 / 18 / 26792363 / T / C / 0.44 / 536 / -576 / 2.79E-04 / 159 / -827.4 / 3.59E-03 / 377 / -441.8 / 2.13E-02 / CDH2
190 / rs4617668 / 12 / 29825544 / C / T / 0.49 / 537 / 550.8 / 2.79E-04 / 159 / 448 / 1.08E-01 / 378 / 595.5 / 1.01E-03 / TMTC1
191 / rs2133873 / 12 / 100013168 / A / G / 0.06 / 536 / -1216 / 2.81E-04 / 159 / -1718 / 7.23E-03 / 377 / -1013 / 1.00E-02 / ANKS1B
192 / rs9356889 / 6 / 23773538 / A / C / 0.33 / 537 / 602.6 / 2.81E-04 / 159 / 163.1 / 6.13E-01 / 378 / 776.1 / 5.78E-05 / NRSN1
193 / rs7090905 / 10 / 54831160 / A / G / 0.21 / 537 / 739.9 / 2.82E-04 / 159 / 1293 / 1.08E-03 / 378 / 536.4 / 2.45E-02 / MBL2
194 / rs13412447 / 2 / 52908830 / C / G / 0.20 / 531 / 737.3 / 2.83E-04 / 156 / 1009 / 8.33E-03 / 375 / 639.6 / 7.84E-03 / MIR4431
195 / rs2993329 / 13 / 113563909 / T / C / 0.18 / 537 / 691.5 / 2.84E-04 / 159 / 1070 / 2.13E-03 / 378 / 524.9 / 2.16E-02 / LOC100506063
196 / rs1375942 / 8 / 51266207 / A / G / 0.21 / 530 / 695 / 2.85E-04 / 157 / 1015 / 5.54E-03 / 373 / 541.8 / 1.63E-02 / SNTG1
197 / rs17742420 / 4 / 178438637 / G / A / 0.23 / 537 / -688.1 / 2.88E-04 / 159 / -1188 / 1.09E-03 / 378 / -465.1 / 3.79E-02 / AGA
198 / rs12693506 / 2 / 153760605 / G / A / 0.07 / 520 / 1196 / 2.90E-04 / 155 / 1210 / 4.49E-02 / 365 / 1227 / 1.97E-03 / ARL6IP6
199 / rs17043814 / 2 / 53143562 / G / A / 0.19 / 533 / 715.8 / 2.91E-04 / 156 / 978.7 / 6.62E-03 / 377 / 603.4 / 1.09E-02 / MIR4431
200 / rs7824366 / 8 / 129464632 / T / C / 0.05 / 525 / -1304 / 2.91E-04 / 156 / -2113 / 1.73E-04 / 369 / -689.3 / 1.43E-01 / MIR1208
Chr, chromosome; Bp, nucleotide location; m, minor allele; M, major allele; MAF, minor allele frequency. Genome-wide significant p values are shown as bold font and are underlined.
SupplementaryTable S3TOP200 SNPs for the left superior frontal gyrus
Combined subjects / Schizophrenia / ControlsRank / SNP / Chr / Bp / m / M / MAF / N / β / p / N / β / p / N / β / p / Closest gene
1 / rs4574391 / 4 / 27212223 / C / T / 0.25 / 533 / -880 / 7.63E-07 / 158 / -693 / 4.27E-02 / 375 / -965 / 3.51E-06 / STIM2
2 / rs4654899 / 1 / 21410231 / A / C / 0.33 / 509 / -787 / 1.51E-06 / 153 / -691 / 3.81E-02 / 356 / -863 / 4.22E-06 / EIF4G3
3 / rs2046701 / 4 / 27211040 / C / A / 0.25 / 532 / -826 / 2.22E-06 / 158 / -697 / 3.87E-02 / 374 / -887 / 1.28E-05 / STIM2
4 / rs1609558 / 1 / 21525228 / C / T / 0.3 / 533 / -763 / 2.33E-06 / 158 / -524 / 1.11E-01 / 375 / -885 / 1.67E-06 / EIF4G3
5 / rs6702110 / 1 / 21515906 / G / A / 0.32 / 526 / -769 / 3.37E-06 / 155 / -714 / 3.90E-02 / 371 / -834 / 9.21E-06 / EIF4G3
6 / rs10218584 / 1 / 21474480 / G / C / 0.33 / 537 / -704 / 8.32E-06 / 159 / -566 / 8.48E-02 / 378 / -791 / 1.05E-05 / EIF4G3
7 / rs1354792 / 1 / 21391875 / C / T / 0.33 / 535 / -704 / 8.69E-06 / 157 / -625 / 5.92E-02 / 378 / -776 / 1.59E-05 / EIF4G3
8 / rs2623384 / 3 / 99064220 / G / A / 0.39 / 525 / -724 / 9.15E-06 / 157 / -894 / 6.79E-03 / 368 / -642 / 5.92E-04 / COL8A1
9 / rs2292343 / 17 / 45455670 / C / G / 0.34 / 524 / -721 / 9.74E-06 / 155 / -836 / 1.22E-02 / 369 / -666 / 3.45E-04 / EFCAB13
10 / rs3883317 / 17 / 45484111 / A / G / 0.34 / 534 / -703 / 1.03E-05 / 158 / -743 / 2.70E-02 / 376 / -675 / 1.72E-04 / EFCAB13
11 / rs6700718 / 1 / 21299363 / A / C / 0.33 / 537 / -692 / 1.18E-05 / 159 / -566 / 8.48E-02 / 378 / -776 / 1.59E-05 / EIF4G3
12 / rs1955039 / 8 / 123270717 / A / G / 0.17 / 537 / 888.6 / 1.21E-05 / 159 / 836.8 / 3.40E-02 / 378 / 909.7 / 1.16E-04 / HAS2
13 / rs1461197 / 2 / 166924472 / G / A / 0.21 / 530 / -818 / 1.25E-05 / 157 / -617 / 9.73E-02 / 373 / -906 / 2.62E-05 / SCN1A
14 / rs1368402 / 5 / 145717285 / C / A / 0.22 / 534 / 800.9 / 1.26E-05 / 156 / 763.8 / 4.22E-02 / 378 / 808 / 1.11E-04 / POU4F3
15 / rs12051795 / 17 / 45413384 / A / G / 0.23 / 537 / -781 / 1.33E-05 / 159 / -1054 / 2.38E-03 / 378 / -642 / 2.13E-03 / EFCAB13
16 / rs2874367 / 1 / 21324491 / A / C / 0.33 / 531 / -690 / 1.47E-05 / 157 / -569 / 8.49E-02 / 374 / -775 / 1.91E-05 / EIF4G3
17 / rs6703227 / 1 / 21374810 / C / T / 0.33 / 537 / -683 / 1.57E-05 / 159 / -533 / 1.07E-01 / 378 / -776 / 1.59E-05 / EIF4G3
18 / rs10514925 / 17 / 45444868 / C / G / 0.35 / 534 / -692 / 1.57E-05 / 159 / -724 / 3.04E-02 / 375 / -670 / 2.27E-04 / EFCAB13
19 / rs4410914 / 8 / 123185248 / C / T / 0.15 / 537 / 901.4 / 1.67E-05 / 159 / 686.6 / 8.77E-02 / 378 / 999 / 4.47E-05 / HAS2
20 / rs4628264 / 8 / 123200780 / C / G / 0.15 / 537 / 901.4 / 1.67E-05 / 159 / 686.6 / 8.77E-02 / 378 / 999 / 4.47E-05 / HAS2
21 / rs2700631 / 3 / 99064538 / A / G / 0.39 / 536 / -687 / 1.74E-05 / 159 / -889 / 7.52E-03 / 377 / -602 / 9.06E-04 / COL8A1
22 / rs12402486 / 1 / 21447935 / A / G / 0.34 / 527 / -677 / 1.87E-05 / 159 / -566 / 8.48E-02 / 368 / -760 / 2.27E-05 / EIF4G3
23 / rs7995370 / 13 / 111118948 / T / C / 0.35 / 536 / -694 / 1.91E-05 / 158 / -1100 / 3.88E-04 / 378 / -494 / 9.38E-03 / COL4A2
24 / rs1493130 / 4 / 108782973 / G / A / 0.08 / 523 / -1192 / 1.94E-05 / 155 / -1718 / 2.11E-03 / 368 / -960 / 2.89E-03 / SGMS2
25 / rs769097 / 3 / 132981813 / A / C / 0.46 / 534 / -657 / 1.94E-05 / 158 / -725 / 2.03E-02 / 376 / -633 / 3.11E-04 / TMEM108
26 / rs9319044 / 13 / 85047253 / G / A / 0.34 / 537 / 680.6 / 1.94E-05 / 159 / 946.1 / 2.57E-03 / 378 / 565.4 / 2.16E-03 / LINC00333
27 / rs7994870 / 13 / 85055407 / C / A / 0.34 / 519 / 694.9 / 2.01E-05 / 154 / 710.2 / 2.52E-02 / 365 / 688.2 / 2.77E-04 / LINC00333
28 / rs16851332 / 2 / 166845303 / A / G / 0.36 / 527 / 685.6 / 2.43E-05 / 157 / 776.7 / 1.46E-02 / 370 / 641.5 / 7.08E-04 / SCN1A
29 / rs1325020 / 6 / 23716485 / A / G / 0.35 / 537 / -680 / 2.59E-05 / 159 / -854 / 1.23E-02 / 378 / -626 / 5.95E-04 / NRSN1
30 / rs9991272 / 4 / 74742402 / G / A / 0.5 / 535 / -629 / 2.81E-05 / 157 / -489 / 9.71E-02 / 378 / -709 / 4.70E-05 / CXCL1
31 / rs1883611 / 6 / 9583920 / G / T / 0.2 / 521 / 838.4 / 2.82E-05 / 156 / 870.3 / 4.56E-02 / 365 / 818.3 / 2.35E-04 / OFCC1
32 / rs4871229 / 8 / 123208520 / A / G / 0.15 / 534 / 872.9 / 3.10E-05 / 158 / 625.1 / 1.19E-01 / 376 / 988.3 / 5.67E-05 / HAS2
33 / rs16851382 / 2 / 166913475 / A / G / 0.36 / 526 / 684.5 / 3.18E-05 / 156 / 977.4 / 2.68E-03 / 370 / 558.4 / 3.51E-03 / SCN1A
34 / rs3924859 / 15 / 81666846 / A / T / 0.36 / 516 / -686 / 3.24E-05 / 152 / -819 / 1.32E-02 / 364 / -615 / 1.24E-03 / TMC3
35 / rs1871791 / 3 / 99051153 / C / T / 0.26 / 536 / -746 / 3.29E-05 / 159 / -721 / 4.38E-02 / 377 / -736 / 3.84E-04 / COL8A1
36 / rs6035499 / 20 / 19964274 / A / G / 0.42 / 520 / -670 / 3.33E-05 / 157 / -932 / 3.22E-03 / 363 / -566 / 2.48E-03 / RIN2
37 / rs6545301 / 2 / 52935725 / G / T / 0.17 / 537 / 864.8 / 3.70E-05 / 159 / 1314 / 5.85E-04 / 378 / 635 / 1.18E-02 / MIR4431
38 / rs2128027 / 3 / 99065296 / T / G / 0.36 / 533 / -678 / 3.86E-05 / 159 / -960 / 5.72E-03 / 374 / -569 / 2.17E-03 / COL8A1
39 / rs11210796 / 1 / 43627976 / G / A / 0.25 / 522 / 734.4 / 3.99E-05 / 153 / 812.5 / 3.50E-02 / 369 / 711.4 / 3.64E-04 / EBNA1BP2
40 / rs1481528 / 3 / 99055229 / T / A / 0.22 / 534 / -775 / 4.02E-05 / 157 / -902 / 1.97E-02 / 377 / -717 / 8.50E-04 / COL8A1
41 / rs989025 / 7 / 52581186 / T / C / 0.31 / 537 / 657.8 / 4.09E-05 / 159 / 522.2 / 9.80E-02 / 378 / 729.5 / 8.42E-05 / POM121L12
42 / rs10894626 / 11 / 132815368 / G / A / 0.35 / 521 / -659 / 4.33E-05 / 153 / -444 / 1.82E-01 / 368 / -745 / 4.84E-05 / OPCML
43 / rs12693506 / 2 / 153760605 / G / A / 0.07 / 520 / 1306 / 4.63E-05 / 155 / 960.5 / 1.18E-01 / 365 / 1501 / 6.73E-05 / ARL6IP6
44 / rs16822821 / 2 / 166914465 / T / C / 0.35 / 535 / 660.5 / 4.95E-05 / 158 / 904.7 / 4.59E-03 / 377 / 550.1 / 3.79E-03 / SCN1A
45 / rs989026 / 7 / 52581219 / C / T / 0.31 / 535 / 648.6 / 5.46E-05 / 157 / 478.3 / 1.33E-01 / 378 / 729.5 / 8.42E-05 / POM121L12
46 / rs2999383 / 14 / 51648755 / T / C / 0.19 / 519 / -802 / 5.52E-05 / 152 / -1052 / 1.20E-02 / 367 / -727 / 1.21E-03 / TMCX1
47 / rs2390317 / 2 / 166816537 / C / T / 0.35 / 531 / 663.9 / 5.73E-05 / 158 / 933.3 / 4.18E-03 / 373 / 539.6 / 4.95E-03 / TTC21B
48 / rs10891786 / 11 / 114843409 / T / C / 0.09 / 537 / -1057 / 5.76E-05 / 159 / -1164 / 3.70E-02 / 378 / -1021 / 5.39E-04 / CADM1
49 / rs875309 / 18 / 19795304 / A / G / 0.15 / 529 / 850 / 5.91E-05 / 159 / 1047 / 1.37E-02 / 370 / 762.8 / 1.67E-03 / GATA6
50 / rs4777421 / 15 / 71925074 / T / A / 0.24 / 536 / -735 / 5.94E-05 / 159 / -736 / 5.90E-02 / 377 / -724 / 4.57E-04 / THSD4
51 / rs257365 / 5 / 171101894 / T / C / 0.48 / 536 / 605.2 / 5.98E-05 / 159 / 753.6 / 6.69E-03 / 377 / 515.4 / 4.27E-03 / C5orf50
52 / rs1474396 / 2 / 47313624 / C / A / 0.38 / 536 / 641.6 / 6.21E-05 / 159 / 738.6 / 3.99E-02 / 377 / 597 / 7.43E-04 / C2orf61
53 / rs6858086 / 4 / 74737471 / C / T / 0.49 / 535 / -599 / 6.21E-05 / 159 / -399 / 1.72E-01 / 376 / -714 / 3.98E-05 / CXCL1
54 / rs7333991 / 13 / 111108436 / C / T / 0.36 / 532 / -643 / 6.43E-05 / 158 / -976 / 1.35E-03 / 374 / -489 / 9.82E-03 / COL4A2
55 / rs9835559 / 3 / 99056448 / C / T / 0.4 / 531 / -650 / 6.44E-05 / 157 / -471 / 1.66E-01 / 374 / -703 / 1.34E-04 / COL8A1
56 / rs3097411 / 4 / 74738454 / C / G / 0.49 / 529 / -601 / 6.47E-05 / 158 / -368 / 2.09E-01 / 371 / -726 / 3.19E-05 / CXCL1
57 / rs11952119 / 5 / 145715745 / G / C / 0.23 / 537 / 725.1 / 6.49E-05 / 159 / 508.5 / 1.61E-01 / 378 / 808 / 1.11E-04 / POU4F3
58 / rs9389541 / 6 / 138253479 / C / A / 0.06 / 526 / 1335 / 6.58E-05 / 152 / 1764 / 7.07E-03 / 374 / 1142 / 3.27E-03 / TNFAIP3
59 / rs6872734 / 5 / 145720826 / C / A / 0.23 / 537 / 719.7 / 6.61E-05 / 159 / 380.6 / 2.95E-01 / 378 / 852.4 / 3.72E-05 / POU4F3
60 / rs16882247 / 4 / 29772408 / G / A / 0.06 / 535 / -1298 / 6.71E-05 / 158 / -2052 / 1.72E-03 / 377 / -1036 / 5.49E-03 / MIR4275
61 / rs12218913 / 10 / 19403598 / T / C / 0.37 / 523 / 645.2 / 6.81E-05 / 155 / 582.3 / 5.39E-02 / 368 / 673.3 / 4.71E-04 / LOC101060163
62 / rs10497275 / 2 / 166846730 / G / A / 0.36 / 535 / 634.9 / 6.90E-05 / 158 / 828.3 / 8.60E-03 / 377 / 550.6 / 2.94E-03 / SCN1A
63 / rs16827124 / 2 / 148003475 / C / T / 0.13 / 536 / 924.4 / 6.95E-05 / 158 / 1397 / 1.92E-03 / 378 / 705.7 / 9.22E-03 / ACVR2A
64 / rs33376 / 5 / 171101726 / G / A / 0.47 / 534 / 593.7 / 7.21E-05 / 159 / 604.3 / 2.49E-02 / 375 / 584.7 / 1.23E-03 / C5orf50
65 / rs4240236 / 4 / 36982241 / G / A / 0.1 / 537 / -1002 / 7.50E-05 / 159 / -1512 / 2.71E-03 / 378 / -812 / 5.32E-03 / MIR4801
66 / rs16887804 / 6 / 56207247 / C / T / 0.08 / 533 / 1150 / 7.51E-05 / 158 / 1425 / 1.80E-03 / 375 / 872.7 / 2.41E-02 / COL21A1
67 / rs16827152 / 2 / 148030986 / A / T / 0.12 / 525 / 971.1 / 7.54E-05 / 158 / 1379 / 2.59E-03 / 367 / 763.6 / 8.73E-03 / ACVR2A
68 / rs4870782 / 8 / 123192200 / A / T / 0.07 / 535 / 1180 / 7.77E-05 / 159 / 625.8 / 2.40E-01 / 376 / 1514 / 3.03E-05 / HAS2
69 / rs4600815 / 3 / 133020968 / T / A / 0.46 / 537 / -607 / 7.88E-05 / 159 / -651 / 3.69E-02 / 378 / -589 / 7.92E-04 / TMEM108
70 / rs16923215 / 8 / 59148704 / G / T / 0.12 / 531 / -922 / 7.88E-05 / 157 / -1225 / 1.37E-02 / 374 / -840 / 1.40E-03 / FAM110B
71 / rs6456569 / 6 / 23704025 / A / G / 0.36 / 531 / -642 / 7.90E-05 / 157 / -853 / 1.30E-02 / 374 / -575 / 1.71E-03 / NRSN1
72 / rs9874464 / 3 / 81505488 / G / C / 0.46 / 535 / -589 / 8.35E-05 / 159 / -428 / 1.70E-01 / 376 / -650 / 1.22E-04 / GBE1
73 / rs7642901 / 3 / 132905128 / G / A / 0.45 / 513 / -633 / 8.37E-05 / 152 / -545 / 1.05E-01 / 361 / -679 / 1.89E-04 / TMEM108
74 / rs1276812 / 6 / 23722517 / C / T / 0.35 / 530 / -643 / 8.61E-05 / 157 / -769 / 2.66E-02 / 373 / -610 / 9.46E-04 / NRSN1
75 / rs152367 / 5 / 115189500 / A / G / 0.29 / 523 / 654 / 8.69E-05 / 155 / 328.6 / 3.24E-01 / 368 / 780.5 / 4.61E-05 / AP3S1
76 / rs1900362 / 13 / 85059600 / A / G / 0.31 / 525 / 650.4 / 8.83E-05 / 157 / 903.6 / 6.04E-03 / 368 / 537.8 / 4.88E-03 / LINC00333
77 / rs2235896 / 20 / 19958000 / G / A / 0.4 / 537 / -604 / 8.91E-05 / 159 / -838 / 7.18E-03 / 378 / -518 / 3.31E-03 / RIN2
78 / rs11010245 / 10 / 35924020 / T / C / 0.39 / 535 / 611.6 / 8.99E-05 / 159 / 528.1 / 9.33E-02 / 376 / 650.7 / 2.73E-04 / FZD8
79 / rs672429 / 1 / 43623644 / A / G / 0.24 / 517 / 718.2 / 9.37E-05 / 152 / 754.6 / 5.34E-02 / 365 / 711.3 / 5.75E-04 / FAM183A
80 / rs4862182 / 4 / 184326127 / T / G / 0.49 / 532 / -629 / 9.78E-05 / 157 / -323 / 3.08E-01 / 375 / -768 / 3.80E-05 / CDKN2AIP
81 / rs4140818 / 7 / 52541926 / C / T / 0.22 / 536 / -712 / 9.95E-05 / 159 / -843 / 2.06E-02 / 377 / -657 / 1.79E-03 / POM121L12
82 / rs16934215 / 8 / 69044846 / A / G / 0.16 / 515 / 837.3 / 1.01E-04 / 152 / 1633 / 1.98E-04 / 363 / 569 / 2.06E-02 / PREX2
83 / rs11722885 / 4 / 27250047 / G / T / 0.18 / 528 / -757 / 1.03E-04 / 152 / -1014 / 6.01E-03 / 376 / -634 / 5.78E-03 / STIM2
84 / rs13186331 / 5 / 24577451 / T / C / 0.47 / 523 / 609 / 1.06E-04 / 155 / 888.6 / 3.75E-03 / 368 / 496.6 / 6.42E-03 / CDH10
85 / rs1505880 / 5 / 24579971 / T / C / 0.48 / 518 / 609.8 / 1.06E-04 / 152 / 821.6 / 7.45E-03 / 366 / 513.3 / 4.98E-03 / CDH10
86 / rs4778893 / 15 / 81611253 / A / G / 0.4 / 531 / -597 / 1.07E-04 / 156 / -582 / 5.62E-02 / 375 / -596 / 8.09E-04 / STARD5
87 / rs2766032 / 10 / 129096956 / G / A / 0.34 / 530 / -633 / 1.10E-04 / 158 / -543 / 1.00E-01 / 372 / -680 / 2.81E-04 / DOCK1
88 / rs2292700 / 17 / 45362423 / G / A / 0.21 / 537 / -699 / 1.13E-04 / 159 / -1042 / 2.09E-03 / 378 / -519 / 1.53E-02 / ITGB3
89 / rs8073229 / 17 / 45358844 / T / C / 0.22 / 531 / -700 / 1.14E-04 / 158 / -1048 / 2.08E-03 / 373 / -519 / 1.54E-02 / ITGB3
90 / rs2367291 / 4 / 74730380 / C / A / 0.49 / 535 / 590.7 / 1.20E-04 / 158 / 362.4 / 2.31E-01 / 377 / 709.3 / 6.88E-05 / CXCL1
91 / rs10056950 / 5 / 26762292 / C / T / 0.17 / 511 / -836 / 1.21E-04 / 151 / -1439 / 5.65E-04 / 360 / -602 / 1.77E-02 / CDH9
92 / rs1456168 / 1 / 99738794 / A / T / 0.14 / 536 / -889 / 1.22E-04 / 159 / -930 / 4.13E-02 / 377 / -878 / 1.04E-03 / LPPR4
93 / rs712768 / 3 / 7444456 / A / G / 0.41 / 528 / -608 / 1.23E-04 / 158 / -645 / 3.68E-02 / 370 / -590 / 1.34E-03 / GRM7
94 / rs587771 / 6 / 117105519 / T / G / 0.29 / 531 / 685.5 / 1.24E-04 / 156 / 468.8 / 1.95E-01 / 375 / 803.2 / 8.87E-05 / GPRC6A
95 / rs2366005 / 3 / 191532063 / C / T / 0.4 / 522 / 627 / 1.26E-04 / 153 / 261.6 / 4.40E-01 / 369 / 787.8 / 2.15E-05 / PYDC2
96 / rs7549096 / 1 / 162934489 / C / T / 0.25 / 531 / 650.3 / 1.26E-04 / 157 / 984.8 / 3.18E-03 / 374 / 488.6 / 1.30E-02 / RGS4
97 / rs3793379 / 8 / 69046409 / A / G / 0.16 / 515 / 835.5 / 1.27E-04 / 151 / 1743 / 6.96E-05 / 364 / 504.5 / 4.34E-02 / PREX2
98 / rs11231294 / 11 / 62755519 / C / T / 0.43 / 537 / 587.7 / 1.27E-04 / 159 / 521.7 / 9.05E-02 / 378 / 637.1 / 3.09E-04 / SLC22A6
99 / rs6661035 / 1 / 43673146 / G / C / 0.24 / 516 / 704.6 / 1.29E-04 / 148 / 731 / 5.93E-02 / 368 / 702.5 / 7.35E-04 / WDR65
100 / rs12667471 / 7 / 140076938 / T / C / 0.43 / 529 / -620 / 1.30E-04 / 156 / -860 / 1.01E-02 / 373 / -536 / 3.59E-03 / SLC37A3
101 / rs1505881 / 5 / 24579659 / C / A / 0.48 / 530 / 589.4 / 1.34E-04 / 157 / 807.9 / 6.57E-03 / 373 / 491.6 / 6.33E-03 / CDH10
102 / rs6707348 / 2 / 147999857 / A / C / 0.13 / 537 / 878.1 / 1.37E-04 / 159 / 1329 / 3.27E-03 / 378 / 676.5 / 1.13E-02 / ACVR2A
103 / rs4871230 / 8 / 123208619 / C / G / 0.07 / 537 / 1137 / 1.37E-04 / 159 / 625.8 / 2.40E-01 / 378 / 1446 / 6.74E-05 / HAS2
104 / rs26506 / 5 / 96079402 / T / C / 0.46 / 533 / 597.4 / 1.38E-04 / 158 / 993.5 / 1.44E-03 / 375 / 428.4 / 1.74E-02 / CAST
105 / rs10750977 / 11 / 62733609 / T / G / 0.47 / 536 / 583.8 / 1.39E-04 / 159 / 443.3 / 1.38E-01 / 377 / 667.5 / 1.86E-04 / SLC22A6
106 / rs8077375 / 17 / 45336152 / A / G / 0.21 / 534 / -685 / 1.39E-04 / 157 / -983 / 3.60E-03 / 377 / -529 / 1.29E-02 / ITGB3
107 / rs12405071 / 1 / 24620801 / G / A / 0.43 / 525 / 592.8 / 1.41E-04 / 155 / 364.9 / 2.36E-01 / 370 / 682.9 / 1.45E-04 / GRHL3
108 / rs4659372 / 1 / 26657685 / T / C / 0.41 / 536 / -573 / 1.41E-04 / 159 / -853 / 4.29E-03 / 377 / -443 / 1.08E-02 / AIM1L
109 / rs11260666 / 1 / 5699634 / A / G / 0.05 / 536 / -1367 / 1.42E-04 / 159 / -1007 / 1.18E-01 / 377 / -1594 / 2.64E-04 / MIR4417
110 / rs4672498 / 2 / 62523878 / A / G / 0.26 / 533 / -684 / 1.44E-04 / 159 / -536 / 1.14E-01 / 374 / -752 / 4.25E-04 / B3GNT2
111 / rs4667849 / 2 / 166723057 / T / C / 0.38 / 528 / 613.7 / 1.44E-04 / 155 / 854 / 1.02E-02 / 373 / 515.4 / 5.17E-03 / LOC100506124
112 / rs1468475 / 19 / 18679155 / C / T / 0.36 / 513 / 629.4 / 1.46E-04 / 150 / 694.2 / 3.47E-02 / 363 / 583.7 / 2.34E-03 / KXD1
113 / rs10827519 / 10 / 35912391 / A / G / 0.38 / 528 / 595.7 / 1.47E-04 / 155 / 368.3 / 2.64E-01 / 373 / 692.4 / 8.89E-05 / GJD4
114 / rs3795684 / 1 / 26632781 / T / C / 0.42 / 537 / -578 / 1.47E-04 / 159 / -812 / 6.07E-03 / 378 / -463 / 9.00E-03 / UBXN11
115 / rs16878035 / 5 / 59709614 / T / G / 0.11 / 537 / 950.8 / 1.49E-04 / 159 / 1230 / 2.72E-02 / 378 / 852.3 / 2.22E-03 / PDE4D
116 / rs16878037 / 5 / 59709752 / T / C / 0.11 / 537 / 950.8 / 1.49E-04 / 159 / 1230 / 2.72E-02 / 378 / 852.3 / 2.22E-03 / PDE4D
117 / rs16827118 / 2 / 147992567 / C / G / 0.13 / 526 / 878.8 / 1.50E-04 / 152 / 1408 / 2.19E-03 / 374 / 647.1 / 1.57E-02 / ACVR2A
118 / rs1319548 / 6 / 19551886 / T / C / 0.31 / 537 / 641.1 / 1.53E-04 / 159 / 628.6 / 4.82E-02 / 378 / 644.9 / 1.27E-03 / LOC100506885
119 / rs513009 / 1 / 43663376 / A / G / 0.24 / 536 / 685.8 / 1.53E-04 / 159 / 746.6 / 5.40E-02 / 377 / 671.6 / 9.26E-04 / WDR65
120 / rs6909109 / 6 / 143569095 / C / T / 0.07 / 529 / 1075 / 1.58E-04 / 158 / 1439 / 1.34E-02 / 371 / 907.4 / 5.17E-03 / AIG1
121 / rs7541333 / 1 / 26622889 / A / G / 0.41 / 537 / -573 / 1.58E-04 / 159 / -804 / 6.31E-03 / 378 / -459 / 9.35E-03 / UBXN11
122 / rs7872176 / 9 / 87730894 / T / C / 0.28 / 528 / -674 / 1.63E-04 / 156 / -819 / 2.53E-02 / 372 / -629 / 1.98E-03 / NTRK2
123 / rs963872 / 5 / 2857542 / A / G / 0.2 / 537 / -723 / 1.63E-04 / 159 / -1433 / 3.21E-04 / 378 / -487 / 2.52E-02 / C5orf38
124 / rs2005169 / 4 / 29766633 / A / T / 0.06 / 535 / -1251 / 1.64E-04 / 159 / -2178 / 6.85E-04 / 376 / -884 / 2.25E-02 / MIR4275
125 / rs4808137 / 19 / 18688847 / A / C / 0.34 / 537 / 604.4 / 1.66E-04 / 159 / 691.4 / 3.20E-02 / 378 / 547 / 3.12E-03 / UBA52
126 / rs6439392 / 3 / 132945022 / C / T / 0.5 / 537 / 579.3 / 1.67E-04 / 159 / 617.2 / 5.24E-02 / 378 / 572.7 / 1.02E-03 / TMEM108
127 / rs4896628 / 6 / 143557699 / C / T / 0.07 / 520 / 1175 / 1.70E-04 / 155 / 1648 / 1.19E-02 / 365 / 965.4 / 6.30E-03 / AIG1
128 / rs1865077 / 19 / 50140092 / G / A / 0.16 / 537 / 811.2 / 1.70E-04 / 159 / 914 / 4.20E-02 / 378 / 800.4 / 1.06E-03 / RRAS
129 / rs10017249 / 4 / 60716825 / C / T / 0.28 / 526 / -632 / 1.70E-04 / 156 / -1059 / 2.61E-03 / 370 / -476 / 1.29E-02 / LPHN3
130 / rs7765167 / 6 / 115694836 / G / A / 0.31 / 524 / -628 / 1.71E-04 / 155 / -867 / 8.73E-03 / 369 / -541 / 5.22E-03 / FRK
131 / rs10517116 / 4 / 27217722 / T / C / 0.16 / 531 / -778 / 1.72E-04 / 158 / -809 / 3.40E-02 / 373 / -758 / 2.15E-03 / STIM2
132 / rs149313 / 5 / 96070205 / C / T / 0.46 / 536 / 586.8 / 1.72E-04 / 158 / 944.2 / 1.80E-03 / 378 / 421.3 / 2.05E-02 / CAST
133 / rs2050475 / 1 / 26565665 / A / G / 0.41 / 536 / -570 / 1.73E-04 / 159 / -897 / 2.65E-03 / 377 / -418 / 1.73E-02 / CEP85
134 / rs12059455 / 1 / 99747869 / C / T / 0.13 / 534 / -909 / 1.74E-04 / 158 / -1081 / 2.31E-02 / 376 / -838 / 2.78E-03 / LPPR4
135 / rs887862 / 16 / 6763793 / C / A / 0.42 / 537 / 573.4 / 1.75E-04 / 159 / 592.9 / 5.36E-02 / 378 / 579.4 / 1.03E-03 / RBFOX
136 / rs16882245 / 4 / 29770254 / G / A / 0.07 / 531 / -1157 / 1.78E-04 / 158 / -1940 / 1.31E-03 / 373 / -870 / 1.53E-02 / MIR4275
137 / rs16941855 / 17 / 45381111 / A / G / 0.19 / 537 / -694 / 1.78E-04 / 159 / -964 / 4.66E-03 / 378 / -533 / 1.63E-02 / ITGB3
138 / rs2372905 / 3 / 81504592 / G / C / 0.46 / 522 / -584 / 1.79E-04 / 157 / -333 / 3.03E-01 / 365 / -678 / 1.19E-04 / GBE1
139 / rs2886927 / 4 / 74730231 / A / T / 0.49 / 537 / 575.1 / 1.79E-04 / 159 / 307.6 / 3.10E-01 / 378 / 715 / 5.65E-05 / CXCL1
140 / rs3117598 / 4 / 74731278 / T / G / 0.49 / 537 / 575.1 / 1.79E-04 / 159 / 307.6 / 3.10E-01 / 378 / 715 / 5.65E-05 / CXCL1
141 / rs10894627 / 11 / 132819663 / C / A / 0.39 / 528 / -590 / 1.80E-04 / 155 / -555 / 8.53E-02 / 373 / -619 / 5.67E-04 / OPCML
142 / rs6945071 / 7 / 26122423 / G / A / 0.16 / 537 / -770 / 1.81E-04 / 159 / -863 / 2.71E-02 / 378 / -717 / 3.07E-03 / LOC100996355
143 / rs6129800 / 20 / 39914030 / G / A / 0.25 / 511 / -680 / 1.87E-04 / 151 / -787 / 3.60E-02 / 360 / -647 / 1.75E-03 / ZHX3
144 / rs16955995 / 15 / 71950896 / C / T / 0.22 / 529 / -706 / 1.88E-04 / 158 / -925 / 1.49E-02 / 371 / -602 / 5.89E-03 / THSD4
145 / rs17153217 / 7 / 26128758 / A / C / 0.18 / 532 / -733 / 1.93E-04 / 156 / -957 / 1.09E-02 / 376 / -620 / 7.17E-03 / LOC100996355
146 / rs10902724 / 1 / 26576032 / G / A / 0.41 / 537 / -564 / 1.93E-04 / 159 / -897 / 2.65E-03 / 378 / -411 / 1.89E-02 / CEP85
147 / rs6598947 / 1 / 26560051 / G / C / 0.41 / 532 / -573 / 1.95E-04 / 159 / -864 / 4.11E-03 / 373 / -435 / 1.47E-02 / CEP85
148 / rs1522664 / 2 / 148055505 / C / T / 0.12 / 515 / 915.5 / 1.95E-04 / 155 / 1287 / 6.68E-03 / 360 / 745.1 / 9.47E-03 / ACVR2A
149 / rs6534760 / 4 / 130961465 / A / T / 0.35 / 517 / 611.1 / 1.96E-04 / 154 / 1044 / 1.47E-03 / 363 / 424.7 / 2.45E-02 / C4orf33
150 / rs1547641 / 6 / 23725221 / T / A / 0.5 / 517 / 592.1 / 1.97E-04 / 151 / 699 / 2.85E-02 / 366 / 562.2 / 2.17E-03 / NRSN1
151 / rs17071573 / 8 / 4676578 / C / G / 0.28 / 536 / 635.1 / 1.97E-04 / 158 / 532.7 / 1.20E-01 / 378 / 673.1 / 5.78E-04 / CSMD1
152 / rs12449510 / 17 / 54565703 / A / G / 0.08 / 508 / -1030 / 1.98E-04 / 156 / -1249 / 1.33E-02 / 352 / -888 / 7.63E-03 / ANKFN1
153 / rs509817 / 4 / 74762329 / C / T / 0.45 / 530 / 522.5 / 1.98E-04 / 155 / 446.6 / 1.12E-01 / 375 / 559.8 / 5.27E-04 / CXCL1
154 / rs13028369 / 2 / 212360399 / T / C / 0.35 / 513 / -592 / 2.01E-04 / 152 / -290 / 3.67E-01 / 361 / -710 / 1.04E-04 / ERBB4
155 / rs1381105 / 2 / 166925171 / T / G / 0.27 / 535 / -636 / 2.01E-04 / 158 / -653 / 6.16E-02 / 377 / -631 / 1.22E-03 / SCN1A
156 / rs16878086 / 5 / 59734600 / A / G / 0.11 / 537 / 935.2 / 2.02E-04 / 159 / 1164 / 3.93E-02 / 378 / 852.3 / 2.22E-03 / PDE4D
157 / rs6046510 / 20 / 19965090 / G / A / 0.41 / 530 / -591 / 2.02E-04 / 159 / -932 / 2.55E-03 / 371 / -456 / 1.38E-02 / RIN2
158 / rs3793381 / 8 / 69046742 / A / G / 0.16 / 528 / 789.6 / 2.02E-04 / 157 / 1749 / 3.54E-05 / 371 / 434.9 / 7.51E-02 / PREX2
159 / rs16851381 / 2 / 166913439 / G / A / 0.35 / 512 / 626.5 / 2.02E-04 / 155 / 970.1 / 2.33E-03 / 357 / 459.7 / 2.10E-02 / SCN1A
160 / rs2865886 / 16 / 12873900 / G / C / 0.3 / 520 / -640 / 2.03E-04 / 152 / -923 / 1.31E-02 / 368 / -570 / 3.01E-03 / CPPED1
161 / rs16840213 / 3 / 133022067 / T / G / 0.46 / 533 / -572 / 2.04E-04 / 157 / -665 / 3.20E-02 / 376 / -533 / 2.48E-03 / TMEM108
162 / rs3111694 / 4 / 74731359 / A / G / 0.49 / 534 / 570.3 / 2.07E-04 / 158 / 307.5 / 3.11E-01 / 376 / 708.6 / 6.76E-05 / CXCL1
163 / rs17298063 / 3 / 133036810 / G / C / 0.47 / 537 / -570 / 2.09E-04 / 159 / -651 / 3.69E-02 / 378 / -539 / 2.13E-03 / TMEM108
164 / rs2453412 / 1 / 43675467 / G / A / 0.24 / 536 / 675.2 / 2.10E-04 / 159 / 746.6 / 5.40E-02 / 377 / 658.2 / 1.28E-03 / WDR65
165 / rs11922891 / 3 / 133011204 / T / C / 0.47 / 530 / -577 / 2.15E-04 / 159 / -651 / 3.69E-02 / 371 / -547 / 2.24E-03 / TMEM108
166 / rs16827187 / 2 / 148087726 / T / C / 0.13 / 534 / 870.1 / 2.17E-04 / 159 / 1306 / 4.78E-03 / 375 / 678.7 / 1.28E-02 / ACVR2A
167 / rs12262842 / 10 / 121278072 / G / A / 0.06 / 537 / -1167 / 2.19E-04 / 159 / -1277 / 5.49E-02 / 378 / -1117 / 1.69E-03 / RGS10
168 / rs11665047 / 18 / 57468556 / A / C / 0.21 / 528 / 744.5 / 2.19E-04 / 157 / 680.4 / 8.06E-02 / 371 / 768 / 1.07E-03 / PMAIP1
169 / rs1906528 / 4 / 27254628 / T / C / 0.17 / 529 / -724 / 2.21E-04 / 156 / -916 / 1.50E-02 / 373 / -623 / 6.51E-03 / STIM2
170 / rs1109802 / 7 / 26126595 / A / T / 0.1 / 536 / -942 / 2.28E-04 / 159 / -690 / 1.78E-01 / 377 / -1040 / 3.90E-04 / LOC100996355
171 / rs6439925 / 3 / 140171892 / T / G / 0.4 / 536 / 571.8 / 2.29E-04 / 159 / 578.4 / 7.68E-02 / 377 / 567.7 / 1.15E-03 / CLSTN2
172 / rs4533103 / 12 / 128730071 / C / T / 0.33 / 535 / -598 / 2.30E-04 / 159 / -709 / 2.42E-02 / 376 / -581 / 2.23E-03 / MIR4419B
173 / rs13216134 / 6 / 152328484 / G / A / 0.29 / 534 / 607.7 / 2.31E-04 / 158 / 783 / 1.67E-02 / 376 / 520 / 6.43E-03 / ESR1
174 / rs2497821 / 10 / 18369959 / T / A / 0.48 / 537 / 566.2 / 2.32E-04 / 159 / 654.8 / 4.26E-02 / 378 / 546.2 / 1.63E-03 / SLC39A12
175 / rs1940441 / 18 / 395016 / C / G / 0.42 / 535 / -563 / 2.33E-04 / 159 / -1126 / 1.61E-04 / 376 / -324 / 6.86E-02 / COLEC12
176 / rs209710 / 1 / 22875879 / G / A / 0.27 / 537 / 614.2 / 2.35E-04 / 159 / 748 / 2.03E-02 / 378 / 561.7 / 4.03E-03 / EPHA8
177 / rs12669654 / 7 / 140066411 / G / T / 0.48 / 533 / -581 / 2.37E-04 / 159 / -871 / 5.59E-03 / 374 / -473 / 9.45E-03 / SLC37A3
178 / rs11758475 / 6 / 23700819 / C / T / 0.47 / 510 / -586 / 2.37E-04 / 152 / -811 / 1.34E-02 / 358 / -503 / 5.47E-03 / NRSN1
179 / rs12526936 / 6 / 23721032 / A / G / 0.49 / 537 / 565 / 2.37E-04 / 159 / 737.6 / 1.70E-02 / 378 / 493.9 / 5.14E-03 / NRSN1
180 / rs16955948 / 15 / 71943410 / G / A / 0.22 / 536 / -703 / 2.38E-04 / 158 / -984 / 1.17E-02 / 378 / -576 / 8.93E-03 / THSD4
181 / rs12478776 / 2 / 166653387 / A / C / 0.42 / 536 / 564.7 / 2.40E-04 / 159 / 784.5 / 1.16E-02 / 377 / 459.5 / 9.39E-03 / GALNT3
182 / rs536199 / 9 / 87710847 / G / A / 0.44 / 510 / 569.8 / 2.41E-04 / 150 / 703.5 / 2.96E-02 / 360 / 531.6 / 2.53E-03 / NTRK2
183 / rs1450053 / 3 / 132884215 / A / G / 0.49 / 522 / -580 / 2.42E-04 / 153 / -712 / 2.69E-02 / 369 / -541 / 2.73E-03 / TMEM108
184 / rs11247936 / 1 / 26698884 / T / C / 0.43 / 537 / -553 / 2.42E-04 / 159 / -854 / 3.54E-03 / 378 / -415 / 1.78E-02 / ZNF683
185 / rs12096930 / 1 / 99737222 / T / G / 0.14 / 529 / -851 / 2.43E-04 / 156 / -976 / 3.30E-02 / 373 / -800 / 2.83E-03 / LPPR4
186 / rs305837 / 4 / 39822769 / G / C / 0.47 / 522 / 602.8 / 2.44E-04 / 152 / 802.6 / 2.24E-02 / 370 / 546.8 / 2.95E-03 / PDS5A
187 / rs2020035 / 2 / 166934585 / T / C / 0.4 / 535 / 590.5 / 2.45E-04 / 159 / 738.8 / 2.23E-02 / 376 / 519.5 / 5.09E-03 / SCN1A
188 / rs11871031 / 17 / 45416538 / A / T / 0.17 / 536 / -692 / 2.45E-04 / 158 / -871 / 1.37E-02 / 378 / -591 / 8.33E-03 / EFCAB13
189 / rs16954865 / 17 / 52764600 / T / G / 0.08 / 515 / 1074 / 2.45E-04 / 152 / 1124 / 4.83E-02 / 363 / 1115 / 1.10E-03 / TOM1L1
190 / rs6505599 / 18 / 10806867 / T / C / 0.06 / 537 / 1134 / 2.49E-04 / 159 / 1467 / 1.21E-02 / 378 / 952.6 / 9.32E-03 / PIEZO2
191 / rs13403709 / 2 / 53131669 / T / C / 0.21 / 537 / 674.7 / 2.49E-04 / 159 / 705.5 / 3.89E-02 / 378 / 648.4 / 3.15E-03 / MIR4431
192 / rs1522930 / 3 / 189798109 / G / A / 0.27 / 537 / -623 / 2.51E-04 / 159 / -673 / 5.68E-02 / 378 / -601 / 1.78E-03 / LEPREL1
193 / rs2094945 / 6 / 167640534 / A / G / 0.2 / 517 / 686.3 / 2.51E-04 / 153 / 173.5 / 6.11E-01 / 364 / 1015 / 6.63E-06 / TCP10L2
194 / rs13383811 / 2 / 186217685 / A / G / 0.36 / 522 / 577.3 / 2.55E-04 / 155 / 699.9 / 2.93E-02 / 367 / 518.1 / 4.04E-03 / LOC100506923
195 / rs6676630 / 1 / 26539056 / C / T / 0.42 / 522 / -574 / 2.56E-04 / 158 / -829 / 6.70E-03 / 364 / -448 / 1.40E-02 / CATSPER4
196 / rs1824549 / 2 / 166924971 / T / G / 0.25 / 533 / -643 / 2.56E-04 / 158 / -522 / 1.40E-01 / 375 / -688 / 6.43E-04 / SCN1A
197 / rs12079255 / 1 / 26700631 / A / G / 0.43 / 537 / -552 / 2.56E-04 / 159 / -854 / 3.54E-03 / 378 / -413 / 1.86E-02 / ZNF683
198 / rs6864442 / 5 / 59710033 / G / A / 0.1 / 519 / 969 / 2.57E-04 / 153 / 1175 / 4.80E-02 / 366 / 902 / 2.10E-03 / PDE4D
199 / rs7618973 / 3 / 81619588 / G / A / 0.46 / 537 / -546 / 2.57E-04 / 159 / -376 / 2.25E-01 / 378 / -606 / 3.38E-04 / GBE1
200 / rs16827169 / 2 / 148043085 / C / G / 0.13 / 536 / 861.4 / 2.58E-04 / 159 / 1306 / 4.78E-03 / 377 / 666.7 / 1.48E-02 / ACVR2A
Supplementary Table S4Cis- and trans-acting effects of the rs3767248 polymorphism on gene expressions in Epstein-Barr virus-transformed lymphoblastoid cell lines
Related Gene / CHR / Probe ID / EFFECT / H2 / LOD / pvalueHP1BP3 / 1p36.12 / 1554251_at / 0.354 / 6.09 / 4.34 / 7.80E-06
CAPN14 / 2p23.1 / 1557321_a_at / 0.342 / 5.69 / 4.43 / 6.30E-06
CHR; Chromosome, H2; Heritability, LOD; Lod score.
The mRNA by SNP Browser 1.0.1 ( was consulted regarding the effects of the rs3767248 SNP on gene expression. The SNP was correlated with the genes listed in the above table (LOD score >3.0). EFFECT indicates the influence of the A-allele at the rs3767248 polymorphism on the expression of each gene using a regression model with gender as a covariate.
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