Summer School
Jacobs University Bremen, July 8th - July 14th 2007
Transport across membranes:
Multiple drug resistance, mechanisms and new tools
Sunday, July 8th
17:00 - 17:30 Opening Dean Bernhard Kramer
17:30 - 18:30 Shimon Schuldiner (Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Israel)
When Biochemistry Meets Structural Biology: The Cautionary Tale of EmrE
19:00 - Barbeque
Monday, July 9th
Membrane proteins and disease
09:00 - 09:45 Qijing Zhang (Department of Microbiology and Preventive Medicine, Iowa State University, Ames, USA)
Roles of the multidrug efflux pump CmeABC in Campylobacter pathophysiology
09:45 - 10:30 Jean-Marie Pagès (Faculte de Medecine, Université de la Méditerranée, Marseille, France)
Regulation of Influx and Efflux in enterobacterial pathogens
10:30 - 10:50 Coffee break
10:50 - 11:35 Séamus Fanning (Centre for Food Safety, University College Dublin, Ireland)
Mechanisms of Fluoroquinolone resistance in Salmonella Enteritidis
11:35 - 12:20 Jonathan Cove (Institute of Molecular and Cellular Biology, University of Leeds, UK)
12:20 - 14:00 Lunch break
14:00 - 14:45 Leonard Amaral (Institute of Hygiene and Tropical Medicine of Lisbon, Universidade Nova de Lisboa, Portugal)
Methods for the demonstration, screening and evaluation of distinct efflux pumps and for the screening of MDR strains responsive to inhibitors of efflux pumps
14:45 - 15:30 Laura Piddock (Antimicrobial Agents Research Group, Division of Immunity and Infection, University of Birmingham, UK)
The ABC transporters, PatA and PatB are involved in MDR and reserpine resistance
15:30 - 16:00 Coffee break and Poster session
Antibiotic resistance
16:00 - 16:45 Stefan Schwarz (Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft (FAL), Neustadt-Mariensee)
Efflux-mediated phenicol resistance in staphylococci: identification and transferability of the gene fexA coding for a novel exporter of the Major Facilitator Superfamily
16:45 - 17:30 Herbert P. Schweizer (Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, USA)
Efflux-Mediated Antibiotic Resistance in Burkholderia pseudomallei
17:30 - 18:15 Malcolm Page (Basilea Pharmaceutica AG, Basel, Switzerland)
Multi-drug resistance in Streptococcus pneumoniae - are transporters involved?
18:15 - 20:00 Dinner
20:00 - 21:00 Evening lecture
Paul Tulkens (Cellular and Molecular Pharmacology, Catholic University of Louvain, Bruxelles, Belgium)
Tuesday, July 10th
ABC transporter / Membrane proteins in oncology
09:00 - 09:45 Jose J.G. Marin (Department of Physiology and Pharmacology, School of Pharmacy, University of Salamanca, Spain)
ABC Proteins and Transporters of Organic Anions in Liver Cancer Chemoresistance and Drug Targeting
09:45 - 10:30 Gergely Szakacs (National Medical Center, Institute of Hematology and Immunology, Membrane Research Group, Budapest, Hungary)
Targeting multidrug resistant cancer
10:30 - 10:50 Coffee break
10:50 - 11:35 Hendrik van Veen (Department of Pharmacology, University of Cambridge, UK)
11:35 - 12:20 Xavier Declèves (Faculty of Pharmacy, University Paris, France)
Expression of ABC transporters at the blood-brain barrier and in tumoral glial cells: Role in the chemoresistance of human glioma?
12:20 - 14:00 Lunch break
14:00 - 14:45 Robert Tampé (Johann Wolfgang Goethe-Universität Frankfurt am Main, Institute of Biochemistry, Biocenter, Frankfurt)
Inhibition of transport / Reversal of drug resistance
14:45 - 15:30 Glenn W. Kaatz (John D Dingell Veteran's Affairs Medical Center, Wayne State University, School of Medicine, Detroit, USA)
Inhibition of Secondary Transporters in Staphylococcus aureus
15:30 - 16:00 Coffee break and Poster session
16:00 - 16:45 Winfried Kern (Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg) - to be confirmed
16:45 - 17:30 Beatrice Marquez (Cellular and Molecular Pharmacology, Catholic University of Louvain, Bruxelles, Belgium)
17:30 - 18:00 Student presentation
18:00 - 20:00 Dinner
20:00 - 21:00 Evening lecture
Olga Lomovskaya (Mpex Pharmaceuticals, Inc., San Diego, California, USA)
Wednesday, July 11th
Structure-Function-Relationships / Biophysics
09:00 - 09:45 Eitan Bibi (Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel)
Flexibility in Structure and Function of the Escherichia coli Multidrug Transporter MdfA
09:45 - 10:30 Qinghu Ren (The Institute for Genomic Research, Rockville, USA)
Membrane Transporters across the Three Domains of Life: Annotation, Classification and Comparative Genomics
10:30 - 10:50 Coffee break
10:50 - 11:35 Clemens Glaubitz (Zentrum für Biomolekulare Magnetische Resonanz, Johann-Wolfgang-Goethe-Universität, Frankfurt/Main)
Biophysical and Solid-State NMR Studies on Bacterial Multidrug Efflux Pumps
11:35 - 12:00 Student presentation
12:00 - 14:00 Lunch break
14:00 - 14:45 Anna Seelig (Biophysical Chemistry, Biozentrum, University of Basel,
Switzerland)
The Role of the Lipid Membrane for the Function of the ABC Transporter P-Glycoprotein
14:45 - 15:30 Emad Tajkhorshid (Departments of Biochemistry and Pharmacology, Beckman Institute, University of Illinois, USA)
Computational Nanoscopy of Passive Conduction and Active Transport in Membrane Channels and Transporters
15:30 - 16:00 Coffee break and Poster session
Crystallography / Modelling of transport
16:00 - 16:45 Paolo Ruggerone (Department of Physics, University of Cagliari, Italy)
16:45 - 17:30 Ulrich Kleinekathöfer (Computational Physics and Biophysics Group, School of Engineering and Science, Jacobs University Bremen)
Molecular modeling of ion conduction and substrate translocation through membrane proteins
17:30 - 18:00 Student presentation
18:00 - 20:00 Dinner
20:00 - 21:00 Evening lecture
Klaas M. Pos (Institute of Physiology, University of Zurich, Switzerland)
Antibiotic resistance: The inner workings of the multidrug efflux pump AcrB
Thursday, July 12th
Transporter and resistance
09:00 - 09:45 Pierre Cornelis (Flanders Interuniversity Institute of Biotechnology, Vrije Universiteit Brussel, Sint Genesius Rode, Belgium)
Insights into the type I cytochrome c maturation system (Ccm) in pseudomonads
09:45 - 10:30 Françoise van Bambeke (Cellular and Molecular Pharmacology, Catholic University of Louvain, Bruxelles, Belgium)
10:30 - 10:50 Coffee break
10:50 - 11:35 Jette Kristiansen (Department of Research and Department of Microbiology, University of Southern Denmark, Sønderborg, Denmark)
11:35 - 12:20 Kay Marin (Universität zu Köln, Institut für Biochemie, Köln)
12:20 - 14:00 Lunch break
14:00 - 14:45 Jürg Dreier (Basilea Pharmaceutica AG, Basel, Switzerland)
14:45 - 15:30 Faustino Vidal-Aroca (Basilea Pharmaceutica AG, Basel, Switzerland)
15:30 - 16:00 Coffee break and Poster session
17:00 - Excursion to Bremen
Friday, July 13th
New techniques
09:00 - 09:45 Frank Bernhard (Centre of Biomolecular Magnetic Resonance, Johann Wolfgang Goethe-University of Frankfurt, Frankfurt/Main)
Cell-free expression of functional membrane proteins in preparative scales
09:45 - 10:30 Reiner Peters (CeNTech GmbH, Center for Nanotechnology, Münster)
10:30 - 10:50 Coffee break
10:50 - 11:35 Rikard Blunck (Université de Montréal, GÉPROM, Canada)
Fluorescence Spectroscopy of Proteins in Planar Lipid Bilayer
11:35 - 12:20 Ben Luisi (Department of Biochemistry, University of Cambridge, UK)
Principles of architecture and allostery in the outer membrane component of efflux pumps
12:20 - 14:00 Lunch break
14:00 - 14:45 Thomas Gutsmann (Forschungszentrum Borstel, Laborgruppe Biophysik, Borstel)
14:45 - 15:30 Klaus Fendler (Max-Planck-Institute of Biophysics, Dept. of Biophysical Chemistry, Frankfurt/Main)
Transporters and Ion channels on solid supported membranes: from basic research to drug discovery
15:30 - 16:00 Coffee break and Poster session
Natural Functions / Ecology
16:00 - 16:45 Angela Köhler (Alfred Wegener Institute, Bremerhaven)
Relevance of MDR/MXR transporters in marine organisms in a polluted enviroment
16:45 - 17:15 Matthias Ullrich (Microbiology, School of Engineering and Science, Jacobs University Bremen)
17:15 - 18:00 Helge Weingart (Biophysical Chemistry, School of Engineering and Science, Jacobs University Bremen)
Multidrug efflux systems in the plant-pathogenic bacterium Pseudomonas syringae
18:00 - 18:30 Student presentation
18:30 - 20:00 Dinner
Saturday, July 14th
Channels
09:00 - 09:45 Roland Benz (Biozentrum der Universität Würzburg, Würzburg)
09:45 - 10:30 Mathias Winterhalter (Biophysical Chemistry, School of Engineering and Science, Jacobs University Bremen)
10:30 - 10:50 Coffee break
10:50 - 11:35 Student presentation
11:35 - 12:20 Student presentation
12:20 - 14:00 Lunch break
End