J.J. Kwiek Page 6 of 6
Jesse J. Kwiek
J.J. Kwiek Page 6 of 6
Home: 898 Oxford Street
Worthington, OH 43085
T: (614) 203-5122
Work: 1008 BRT, The Ohio State University
460 West 12th Avenue
Columbus, OH 43210
T: (614) 292-3256
J.J. Kwiek Page 6 of 6
Education
1995 B.S., Biochemistry University of Rochester, Rochester, NY
2003 Ph.D., Pharmacology University of Virginia, Charlottesville, VA
Advisor: T.A.J. Haystead
2002-07 Post-Doctoral Fellowship Department of Epidemiology
University of North Carolina at Chapel Hill
Chapel Hill, NC
Sponsor: S.R. Meshnick
Academic appointments
2007-present Assistant Professor Division of Infectious Diseases
Department of Internal Medicine
College of Medicine
The Ohio State University, Columbus, OH
2007-present Assistant Professor Department of Microbiology
College of Biological Sciences,
The Ohio State University, Columbus, OH
ADMINISTRATIVE appointments
2007-present Member Center for Microbial Interface Biology
The Ohio State University, Columbus, OH
2007-present Member Center for Retrovirus Research
The Ohio State University, Columbus, OH
2007-present Member Public Health Preparedness for Infectious Diseases
The Ohio State University, Columbus, OH
2007- present Graduate Faculty Department of Veterinary Biosciences
College of Veterinary Medicine
The Ohio State University, Columbus, OH
2007- present Graduate Faculty The Integrated Biomedical Graduate Program
School of Biomedical Sciences (IBGP)
The Ohio State University, Columbus, OH
2008-present Member Comprehensive Cancer Center/Viral Oncogenesis
The Ohio State University, Columbus, OH
2009- present Training Grant Faculty Microbial Interface Biology
NIH/NIGMS T32 Training Grant
The Ohio State University, Columbus, OH
Research Experience
1993-95 Lab Technician Cancer Center
University of Rochester, Rochester, NY
Supervisor: Dr. P.C. Keng
1996-97 Research Technician Department of Microbiology
University of Virginia, Charlottesville, VA
Supervisor: Dr. M.J. Weber
2000 Visiting Graduate Student Department of Biochemistry
LaTrobe University, Melbourne, Australia.
Sponsor: Dr. M. Foley
2000-02 Visiting Graduate Student Department of Pharmacology
Duke University, Durham, NC
Advisor: Dr. T.A.J. Haystead
2003; 2005 Visiting Scientist Wellcome Trust Research Labs Blantyre, Malawi
Professional Activities
2008-present ad hoc reviewer American Journal of Tropical Medicine and Hygiene; Retrovirology; AIDS Research and Human Retroviruses.
2009-present Grant reviewer AMA Foundation Seed Grant Program
Teaching Experience
1995-96 High School Teacher Biology and Physical Science Instructor (622 students).
The United States Peace Corps
Kalaluma Distance Education Center
Malawi Ministry of Education, Malawi, Africa
2006-07 Co-Instructor Epidemiology 756
School of Public Health
The University of North Carolina at Chapel Hill
Chapel Hill, NC
2008-present Instructor OSU Microbiology 522: Immunology
2008-present Co-Instructor OSU IBGP 740: Selected Topics in Microbial Pathogenesis
2008-present Co-Instructor OSU Undergraduate Biomedical Sciences 581: HIV module
2008, 2010, Co-Instructor OSU MVIMG 841, Retrovirology Module
2008-present Co-Instructor OSU Epidemiology 815, Infectious Disease Epidemiology
2008-present Co-Instructor OSU Microbiology 724: Microbial Pathogenesis
2009 Co-Instructor OSU Medical Students, Year I: Host Defense Block
Postdoctoral Fellows, Research Scientists and Medical Students Supervised
David Beckstead, Medical Student, OSU. Recipient of RTPCR Fellowship. 2008-present.
Jose Bazan, D.O., Infectious Disease Fellow, OSU, 2008-present
Samuel Handelman, Ph.D., MBI Fellow, OSU, 2010-present (co-mentor)
Thesis Advisor
Surender Kumar, Ph.D. Graduate Student, Department of Veterinary Medicine, OSU. 2007-present. Recipient of OSU PHPID graduate fellowship, 2010.
Jessy Mates, Ph.D. Graduate Student, Department of Microbiology, OSU. 2009-present.
Ph.D. and Masters Advisory Committees
Wanja Mwanji, Master’s Candidate, Department of Epidemiology, OSU. Degree awarded in 2008.
Cara Rice, Ph.D. Candidate, Department of Epidemiology, OSU.
Malaika Wilson, Ph.D. Candidate, Department of Epidemiology, OSU.
Kevin Foy, Ph.D. Candidate, Department of Microbiology, OSU.
Geoffrey Gonzalez, Ph.D. Candidate, Department of Microbiology, OSU.
Joanna Marshall, Ph.D. Candidate, IBGP, OSU.
Dawn Walker, Ph.D. Candidate, IBGP, OSU.
Undergraduate Honors Thesis Committee Member
Craig Davis. Honors Thesis in Microbiology, OSU. Degree Awarded in 2008. (Medical Student, OSU).
Undergraduate Research Advisor
Katie Kemme, OSU. 2008-2010
Jacklyn Bakalarski. Honor’s Student in the Biomedical Science Program, OSU. 2009
Megan Reifenberg. Honor’s Student in Microbiology, OSU. 2010-present.
Yu (Emily) Chen. University Honor’s Program; Undergraduate Research Scholarship Award, OSU. 2010-present.
Past areas of research interest
· Using proteomics to decipher signal transduction/phosphorylation pathways
· Pharmacology of antimalarial drugs
· Epidemiology of antimalarial drug resistance
· Placental microtransfusions as a mechanism of intrapartum HIV-1 mother-to-child transmission
current research projects
· HIV-1 interaction with the placenta during in utero HIV-1 mother-to-child transmission
· Pediatric HIV-testing in the developing world
· Targeting host proteins that interfere with HIV-1 replication
Current Research Funding
· UL1RR025755 “Using Laser Capture Microdissection to Query HIV-1 Genomic Diversity in Discrete Regions of Formalin-Fixed Placental Biopsies.” Ohio State University Center for Clinical & Translational Science Novel Clinical and Translational Methodologies Program Pilot grant. Role: PI. 5/1/2010-11/1/2010.
· 5U19AI067854-06. “Is in utero HIV-1 infection mediated by specific envelope phenotypes?” NIH/DUKE Center for HIV/AIDS Vaccine Immunology. Role: PI. 7/1/2010-6/30/2011.
· 1R01AI084110-01 “A Method to Stop HIV Replication: Inhibition of Human Purine Utilizing Proteins.” Role: PI. 7/1/2010-6/30/2014.
PENDING RESEARCH FUNDING
· 1R01HD064342-01 “Molecular mechanisms of in utero HIV-1 mother-to-child transmission.” (PI: Kwiek).
COMPLETED RESEARCH FUNDING
· 4R00HD056586-02 “Viral and Placental Determinants of HIV-1 Subtype C Mother-to-Child Transmission.” NIH/NICHD. 9/1/07- 9/1/09. Role: PI. No Cost Extension until 9/1/2010.
· OSU Public Health Preparedness for Infectious Diseases. “Do Placental Viral Sequestration and Changes in Toll-Like Receptor Expression Promote HIV-1 Mother-to-Child Transmission in Malawi?” 11/19/07-11/19/09
· OSU Office of International Affairs. Travel Award. (January 2008)
· OSU Comprehensive Cancer Center Viral Oncogenesis Program. (July 2008)
· 1K99HD056586-01 “Viral and Placental Determinants of HIV-1 Subtype C Mother-to-Child Transmission.” NIH/NICHD. (2007)
· T32 AI07151-26. Postdoctoral Fellowship, “Infectious Disease Pathogenesis Research Training Grant.” UNC-Chapel Hill (2003-2005).
· T32 GM005077. Predoctoral Fellowship, “Pharmacology Training Grant.” University of Virginia, (1998-2000).
ADMINISTRATIVE SERVICE/COMMITTEES
· Graduate Faculty Representative, OSU Graduate School
· Lai Wei Ph.D. Dissertation, OSU Department of Statistics (2008)
· Lorenzo Serrao Ph.D. Dissertation, OSU Center for Automobile Research (2009)
· Alexander Poster, OSU Department of History (2010).
· Faculty Search Committee: OSU PHPID/VBS search, resulted in hiring of Dr. Li Wu (2008-9)
· Research Day Judge: OSU/OSUMC (2008, 2010); OSU/CMIB (2008, 2010); OSU Comprehensive Cancer Center (2008)
· Retreat Planning Committee: OSU/CMIB (2009, 2010)
· Admissions Committee: OSU MD/PhD Program (2009-present)
· Graduate Admissions Committee: OSU Department of Microbiology (2009-present)
· Awards Committee: OSU/CMIB, (2009-present)
Peer-Reviewed Publications
1. Gioeli D., Ficarro S.B., Kwiek J.J. , Aaronson, D., Hancock, M., Catling, A.D., White, F.M., Christian, R.E., Settlage, R.E., Shabanowitz, J., Hunt, D.F., Weber, M.J. Androgen Receptor Phosphorylation. Regulation and Identification of the Phosphorylation Sites. J Biol Chem 2002, 277:29304-29314.
2. Graves P.R., Kwiek J.J. (co-first author), Fadden P., Ray, R., Hardeman, K., Coley, A. M., Foley, M., Haystead, T. A. Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome. Molecular Pharmacology 2002, 62:1364-1372.
Commentary on above article: Petri, W.A. Jr. “Can a Proteomics Strategy Be Used to Identify the Anti- malarial Activity of Chloroquine?” Trends Pharmacol Sci 2003, 24 (5):210-212.
3. Kwiek J.J., Haystead, T.A., Rudolf, J. The Kinetic Mechanism of Quinone-Oxidoreductase 2 and its Inhibition by the Anti-Malarial Quinolines. Biochemistry 2004, 43 (15): 4538-4547.
4. Abrams, E.T., Milner, D.A. Jr., Kwiek, J.J., Mwapasa, V., Kamwendo, D.D., Zeng, D., Tadesse, E., Lema, V.M., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R. Risk Factors and Mechanisms of Preterm Delivery in Malawi. American Journal of Reproductive Immunology 2004, 52 (2): 174-83.
5. Ngrenngarmlert, W., Kwiek, J.J. (co-first author), Kamwendo, D.D., Ritola, K., Swanstrom, R., Wongsrichanalai, C., Ittarat, W., Miller, R.S., and Meshnick, S.R. Measuring Allelic Heterogeneity in Plasmodium falciparum by Heteroduplex Tracking Assay. American Journal of Tropical Medicine and Hygiene 2005, 72: 694-701.
6. Yeramian, P., Meshnick, S.R., Krudsood, S., Chalermrut, K., Silachamroon, U., Allen, J., Brun, R., Kwiek, J.J., Tidwell, R. Looareesuwan, S. Efficacy of DB289 in Thai Patients with Plasmodium vivax and Acute Uncomplicated Plasmodium falciparum Infections. Journal of Infectious Disease 2005, 192 (2):319-22.
7. Abrams, E.,T., Kwiek, J.J., Mwapasa,V., Kamwendo, D.D., Tadesse, E., Lema, V.M., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R. Malaria During Pregnancy and Fetal Hematological Status in Blantyre, Malawi. Malaria Journal 2005, 4 (1):39.
8. Kwiek J.J., Mwapasa V., Milner, D., Alker, A., Miller, W., Ou, C.Y., Tadesse, E., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R. Maternal-fetal Microtransfusions and HIV-1 Mother-to-Child Transmission in Malawi. PLoS-Medicine 2006, 3(1):e10.
9. Malhotra, I., Mungai, P., Muchiri, E., Kwiek, J.J., Meshnick, S.R., King, C.L. Congenital P. falciparum Malaria Acquired Antenatally in Kenya. Journal of Infectious Diseases 2006, 194(2): 176-83.
10. Mwapasa, V., Rogerson, S.J., Kwiek, J.J., Molyneux, M.E., Kamwendo, D.D., Tadesse, E., Chaluluka, E., Wilson, P.E., Meshnick, S.R. Is Maternal Syphilis Infection a Risk Factor for HIV Mother-to-Child Transmission? AIDS 2006, 20:1869-77.
11. Kwiek, J.J., Alker, A.P., Kalilani, L., Wenink, E.C., Chaponda, M., E., Meshnick, S. R. Estimating True Antimalarial Efficacy by Heteroduplex Tracking Assay in Patients with Complex Plasmodium falciparum Infections. Antimicrobial Agents and Chemotherapy 2007, 51(2):521-7.
12. Juliano, J., Kwiek, J.J., Mwapasa, V., Meshnick, S.R. Development of a Multiple-Site Specific Heteroduplex Tracking Assay that can Detect Low Prevalence pfcrt K76T Mutations. Emerging Infectious Diseases 2007, 13(6):872-7
13. Kalilani L., Mofolo I., Chaponda M., Rogerson S.J., Alker A.P., Kwiek, J.J., Meshnick, S.R. A Randomized Controlled Pilot Trial of Azithromycin or Artesunate Added to Sulfadoxine-Pyrimethamine as Treatment for Malaria in Pregnant Women. PLoS ONE 2007 2(11): e1166 doi:10.1371/journal.pone.0001166
14. Kwiek, J.J., Russell, E.S., Dang, K.K., Burch, C.L., Meshnick, S. R, Mwapasa, V., Swanstrom, R. The Molecular Epidemiology of HIV-1 Envelope Diversity During HIV-1 Subtype C Vertical Transmission in Malawian Mother-Infant Pairs. AIDS 2008, 22:863-71.
15. Kwiek, J.J., Arney, L.A., Pederson, B., Hararwa, V., Mwapasa, V., and Meshnick, S.R. Detection of Placental Microtransfusions during HIV-1 Mother-to-Child Transmission. Journal of Infectious Diseases 2008, 197(10):1378-81.
16. Kwiek, J.J., Mwapasa, V., Mule, A.S., Misiri, H., Alker, A.P., Molyneux, M.E., Rogerson, S.J., Meshnick, S.R. HIV and Syphilis Infections Among Pregnant Women in Blantyre, Malawi. Malawi Medical Journal, 2008, 3: 80-85.
17. Gay, C.L., Mwapasa, V., Murdoch, D.M., Kwiek, J.J., Fiscus, S.A., Meshnick, S.R., Cohen, M.S. “Acute HIV Infection among Pregnant Women in Malawi.” Diagnostic Microbiology and Infectious Disease, 2010, 66(4):356-60.
18. Mwapasa, V., Cachafeiro, A., Makhuta, Y., Beckstead, D.J., Pennell, M.L., Chilima, B., Mwagomba, B., Fiscus, S.A., Kwiek, J.J. “Using a Simplified Human Immunodeficiency Virus Type I p24 Antigen Assay to Diagnose Pediatric HIV-Infections in Malawi.” Accepted, Journal of Clinical Virology, 2010.
Manuscripts in preparation
1. Russell ES, Kwiek J.J., Keys J, Barton K, Mwapasa V, Meshnick S, and Swanstrom R. “HIV-1 Subtype C env Sequence Diversity and Early Evolution in in utero and intrapartum Mother-to-Child Transmission” submitted.
2. Kumar, S., Ramirez, N., Mwapasa, V.M., Rogerson, S.J., Meshnick S.R., Kwiek, J.J. “In utero HIV Mother-to-child transmission is associated a placental Th1/Th2 cytokine imbalance.” in preparation.
3. Kumar, S., Mwapasa, V.M., Rogerson, S.J., Meshnick S.R., Kwiek, J.J. “A Comparison of HIV-1 subtype C gp120 genotypes isolated from matched placenta and plasma samples” in preparation.
4. Knight, D.A., Mwapasa, V.M., Rogerson, S.J., Meshnick S.R., Kwiek, J.J. “Laser Capture Microdissection of HIV-1 from Placental Biopsies.” in preparation.
Invited Presentations
· Kenyon College, Department of Biology, Gambier, OH March 2010.
· The Research Institute at Nationwide Children’s Hospital, Center for Vaccines and Immunity, Columbus OH. March 2010.
· University of Virginia, Department of Infectious Diseases, March 2007.
· UNC-Chapel Hill, Division of Infectious Diseases, March 2007.
· Ohio State University, Center for Microbial Interface Biology, February 2007.
· Case Western Reserve University, Department of Global Health, January 2007.
Oral Presentations
· “HIV/AIDS in Malawi.” The Center for African Studies, The Ohio State University, January 2008.
· “HIV-1 Envelope Diversity During HIV-1 Subtype C Vertical Transmission in Malawian Mother-Infant Pairs.” Malawi College of Medicine Research Dissemination Day, Blantyre, Malawi, November 2007.
· “HIV-1 Mother-to-Child Transmission in Malawi.” The Burnet Institute, Melbourne, Australia, July 2007.
· “P.falciparum Complexity of Infection: New Tools and Strategies.” Walter and Eliza Hall Institute, Melbourne, Australia, July 2007.
· “Pediatric Malaria.” Children’s Right’s Week Seminar, UNC-Chapel Hill, January 2007.
· “Use of the Quantitative MSP-1 Heteroduplex Tracking Assay to Distinguish Plasmodium falciparum Reinfection from Failure.” American Society for Tropical Medicine Conference, Atlanta, GA., November 2006.
· “HIV-1 Envelope Diversity During HIV-1 Transmission in Malawian Mother-Infant Pairs.” 13th International HIV Dynamics & Evolution Conference, Woods Hole, MA, April 2006.
· “Use of a Heteroduplex Tracking Assay to Detect Multiple P.falciparum Infections in Pregnant Malawians.” American Society for Tropical Medicine Conference, Washington, D.C., December 2005.
· “Peace Corps, Malawi, and Malaria.” UNC-Chapel Hill, October 2005.
· “My Peace Corps Experience.” Chapel Hill Kiwanis Club, August 2005.
· “Correlates of HIV-1 Mother-to-Child Transmission.” American Society for Tropical Medicine Conference, Miami, FL, November 2004.
· “Risk Factors for HIV Mother-to-Child Transmission in Malawi.” Infectious Disease Training Grant Symposium, UNC-Chapel Hill, NC, April 2004.
· “Characterization of New Anti-malarial Drug Targets.” Duke University Department of Pharmacology and Cancer Biology, Departmental Retreat, Wilmington, NC, October 2001.
ABSTRACTS
1. Surender Kumar, Samuel Handelman, Victor Mwapasa, Daniel Janies, Jesse Kwiek. (June 2010) Perturbations in HIV-1 quasispecies dynamics during in utero mother to child transmission. DARPA Prophecy Teaming Day, Boston, MA. Oral and Poster Presentation.
2. Handelman SK, Kumar SB, Mwapasa V, Janies D, Rogerson SJ, Meshnick SR, Kwiek JJ. (June 15-17, 2010) Possible role for a placental HIV-1 compartment in uterine mother to child transmission. 5th Annual Ohio Collaborative Conference on Bioinformatics, Columbus, OH. Abst # 94. Oral Presentation.
3. Handelman SK, Kumar SB, Mwapasa V, Janies D, Rogerson SJ, Meshnick SR, Kwiek JJ. (April 25-28, 2010) Possible role for a placental HIV-1 compartment in uterine mother to child transmission. 17th International HIV Dynamics & Evolution, Monterrey, CA. Oral Presentation.