Matthew Michael
CURRICULUM VITAE
(November, 2017)
W. Matthew Michael
Contact Information
Molecular & Computational Biology
Department of Biological Sciences
University of Southern California
104B RRI
1050 Childs Way
Los Angeles, CA 90089
Telephone (213) 740-0553
Education
University of California, Berkeley
A.B. in Genetics, 1986
University of Pennsylvania
Ph.D. in Molecular Biology, 1996
Advisor: Professor Gideon Dreyfuss
Postdoctoral Training
1997 - 2000
University of California, San Diego
Advisor: Professor John Newport
Appointments
2010 - Associate Professor
Department of Biological Sciences
Dornsife College of Letters, Arts, and Sciences
University of Southern California
2004 - 2010 Associate Professor
2000 - 2004 Assistant Professor
Department of Molecular and Cellular Biology
Faculty of Arts and Sciences
Harvard University
Honors
1997 Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship
2001 Searle Scholar Award
2002 National Science Foundation CAREER Award
2003 American Cancer Society Research Scholar Award
Publications
1. Drzislav Mismer, W. Matthew Michael, Todd R. Laverty and Gerald M. Rubin. Analysis of the promoter of the Rh2 opsin gene in Drosphila melanogaster. Genetics 120: 173-180. 1988
2. W. Matthew Michael, David D. L. Bowtell, Todd R. Laverty and Gerald M. Rubin. Comparison of the sevenless genes of Drosophila virilis and Drosophila melanogaster. Proceedings of the National Academy of Sciences (USA) 87: 5351-5353. 1990
3. David D. L. Bowtell, Thomas Lila, W. Matthew Michael, David Hackett, and Gerald M. Rubin. Analysis of the enhancer element that controls expression of sevenless in the developing Drosophila eye. Proceedings of the National Academy of Sciences (USA) 88: 6853-6857. 1991
4. Michael J. Matunis, W. Matthew Michael and Gideon Dreyfuss. Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein. Molecular and Cellular Biology 12: 164-171. 1992
5. Andrea Ghetti, Serafín Piñol-Roma, W. Matthew Michael, Carlo Morandi and Gideon Dreyfuss. hnRNP I, the polypyrimidine tract-binding protein: Distinct nuclear Localization and association with hnRNAs. Nucleic Acids Research 20: 3671-3678. 1992
6. Haruhiko Siomi, Michael J. Matunis, W. Matthew Michael and Gideon Dreyfuss. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Research 21: 1193-1198. 1993
7. Zhigang Weng, Sheila M. Thomas, Richard J. Rickles, Jennifer A. Taylor, Andrew W. Brauer, Cynthia Seidel-Dugan, W. Matthew Michael, Gideon Dreyfuss, and Joan S. Brugge. Identification of Src, Fyn, and Lyn SH3-binding proteins: Implications for a function of SH3 domains. Molecular and Cellular Biology 14: 4509-4521. 1994
8. Xose R. Bustelo, K.L. Suen, W. Matthew Michael, Gideon Dreyfuss, and Mariano Barbacid. Association of the Vav protooncogene with poly (rC)-specific RNA-binding proteins. Molecular and Cellular Biology 15: 1324-1332. 1995
9. W. Matthew Michael, Mieyoung Choi, and Gideon Dreyfuss. A nuclear export signal in hnRNP A1: A signal-mediated, temperature-dependent nuclear protein export pathway. Cell 83: 415-422. 1995
10. W. Matthew Michael, Haruhiko Siomi, Mieyoung Choi, Serafín Piñol-Roma, Sara Nakielny, Qing Liu, and Gideon Dreyfuss. Signal sequences which target nuclear import and nuclear export of pre-mRNA binding proteins. Cold Spring Harbor Symposium of Quantitative Biology 60: 663-668. 1995
11. W. Matthew Michael and Gideon Dreyfuss. Distinct domains in ribosomal protein L5 mediate 5S rRNA binding and nucleolar localization. Journal of Biological Chemistry 271: 11571-11574. 1996
12. Utz Fischer, W. Matthew Michael, Reinhard Lührmann, and Gideon Dreyfuss. Signal-mediated nuclear export pathways of proteins and RNAs. Trends In Cell Biology 6: 290-293. 1996
13. Victoria W. Pollard*, W. Matthew Michael*, Sara Nakielny, Mikiko C. Siomi, Fan Wang, and Gideon Dreyfuss. A novel receptor-mediated nuclear protein import pathway. Cell 86: 985-994. 1996 (* denotes equal contribution)
14. Sara Nakielny, Utz Fischer, W. Matthew Michael, and Gideon Dreyfuss. RNA Transport. Annual Review of Neuroscience 20: 269-301. 1997
15. W. Matthew Michael, Paul S. Eder, and Gideon Dreyfuss. The K Nuclear Shuttling Domain: Identification of a novel nuclear import and nuclear export signal in the hnRNP K protein. EMBO Journal 16: 3587-3598. 1997
16. W. Matthew Michael and John Newport. Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1. Science 282: 1886-1889. 1998
17. W. Matthew Michael. Two for the price of one: Nucleocytoplasmic shuttling signals. Trends In Cell Biology 10: 46-50. 2000
18. W. Matthew Michael, Robert Ott, Ellen Fanning, and John Newport. Activation of the DNA replication checkpoint through RNA synthesis by primase. Science 289: 2133-2137. 2000
19. W. Matthew Michael. Cell Cycle: Connecting DNA replication to sporulation in Bacillus. Current Biology 11: R443-R445. 2001
20. Matthew P. Stokes, Ruth A. Van Hatten, Howard Lindsay, and W. Matthew Michael. DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. The Journal of Cell Biology 158: 863-872. 2002
21. Ruth A. Van Hatten, Antonin Tutter, Antonia Holway, Alyssa Khederian, Johannes Walter, and W. Matthew Michael. The Xenopus Mus101 protein is required for recruitment of Cdc45 to origins of DNA replication. The Journal of Cell Biology 159: 541–547. 2002
22. Matthew P. Stokes and W. Matthew Michael. DNA damage-induced replication arrest in Xenopus egg extracts. The Journal of Cell Biology 163: 245-255. 2003
23. Matthew P. Stokes and W. Matthew Michael. A novel replication arrest pathway in response to DNA damage. Cell Cycle 3: 126-127. 2004
24. Antonia H. Holway, Crystal Hung, and W. Matthew Michael. Systematic, RNAi-mediated identification of mus-101 modifier genes in C. elegans. Genetics 169: 1451-1460. 2005
25. Craig A. Leach and W. Matthew Michael. Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts. The Journal of Cell Biology 171: 947-954. 2005
26. Antonia H. Holway, Seung-Hwan Kim, Adriana LaVolpe, and W. Matthew Michael. Checkpoint silencing during the DNA damage response in C. elegans embryos. The Journal of Cell Biology 172: 999-1008. 2006
27. Shan Yan, Howard D. Lindsay, and W. Matthew Michael. Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin-bound Chk1 during checkpoint signaling. The Journal of Cell Biology 173: 181-193. 2006
28. Seung-Hwan Kim, Antonia H. Holway, Suzanne Wolff, Andrew Dillin, and W. Matthew Michael. SMK-1/PPH-4.1 mediated silencing of the CHK-1 response to DNA damage in early C. elegans embryos. The Journal of Cell Biology 179: 41-52. 2007
29. Seung-Hwan Kim and W. Matthew Michael. Regulated proteolysis of DNA polymerase eta during the DNA damage response in C. elegans. Molecular Cell 32: 757-766. 2008
30. Shan Yan and W. Matthew Michael. TopBP1 and DNA polymerase alpha directly recruit the 9-1-1 complex to stalled replication forks. The Journal of Cell Biology 184: 793-804. 2009
31. Shan Yan and W. Matthew Michael. TopBP1 and DNA polymerase alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks: Implications for a replication
restart-based mechanism for ATR checkpoint activation. Cell Cycle 8: 2877-2884. 2009
32. Ashley B. Williams and W. Matthew Michael. Eviction notice: new insights into Rad51 removal from DNA during homologous recombination. Molecular Cell 37: 157-158. 2010
33. Christopher Van, Shan Yan, W. Matthew Michael, Shou Waga, and Karlene A. Cimprich. Continued primer synthesis at a stalled replication fork contributes to checkpoint activation. The Journal of Cell Biology 189: 233-246. 2010
34. Christopher Murphy and W. Matthew Michael. Control of DNA replication by the nucleus/cytoplasm ratio in Xenopus. Journal of Biological Chemistry 288: 29382-29393. 2013
35. Liping Bai, W. Matthew Michael, and Shan Yan. Importin b-dependent nuclear import of TopBP1in ATR-Chk1 checkpoint in Xenopus egg extracts. Cellular Signaling 26: 857-867. 2014
36. Melina Butuci, Ashley B. Williams, Matthew M. Wong, Brendan Kramer, and W. Matthew Michael. Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans. Developmental Cell 34: 85-95. 2015
37. Melina Butuci, Matthew M. Wong, and W. Matthew Michael. Trouble in transitioning: activation of zygotic transcription can lead to DNA breakage and genome instability. Worm 4: e1115946. 2015
38. Julyana Acevedo, Shan Yan, and W. Matthew Michael. Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage. Journal of Biological Chemistry 291: 13124-13131. 2016
39. W. Matthew Michael. The CYB-3 cyclin controls both S-phase and mitosis and is
asymmetrically distributed in the early C. elegans embryo. Development 143: 3119-3127. 2016
40. Holly Stevens, Ashley B. Williams, Williams AB, and W. Matthew Michael. Cell-Type Specific Responses to DNA Replication Stress in Early C. elegans Embryos. PLoS One 11: e0164601. 2016
Funding
R01 GM122887 Michael (PI) 09/08/17-08/31/21
Mechanistic analysis of ATR signaling
The goal of this study is to obtain a biochemical mechanism for ATR kinase signal transduction at sites of DNA damage.
- 5 -