SUSAN L.GOTTSHALL

C:(651) 274-3063 |

Professional Overview

Sixteen years of drug discovery and preclinical in vivo pharmacology experience and eight years of
laboratory operation experience.
Strengths include: knowledge of small molecule drug discovery, validation of in vivo rodent models, target
validation, training of research staff, facility design and renovation, and animal care and use programs.

Core Qualifications

Preclinical drug discoveryModel validation
Experimental designStatistical analysis
Customer serviceResource allocation

Accomplishments

Algos Preclinical Services - Managed a team of behavioral pharmacologists that generated greater than
$50,000/FTE monthly.
Algos Preclinical Services - Identified a new facility site and oversaw renovation of laboratory and office
space at an average cost less than $70.00/ft2.
Purdue Pharma - Led Interdisciplinary Exploratory Project Team.
Adolor Corporation - Provided in vivo data for four compounds that entered human clinical trials; including
one approved drug.
Author or co-author of 13 peer reviewed journal articles and 29 scientific abstracts.

Education

Masters of Business Administration2017
Southern New Hampshire UniversityManchester, NH

Bachelor of Science:Animal Science
Colorado State UniversityFort Collins,CO

Experience

Resource & Scheduling Coordinator03/2014 toCurrent
CBSET, Inc.Lexington,MA

Schedule resources for in-life study execution
Manage multi-species housing and long term housing
Order and invoice reconciliation
Re-negotiated vendor contract cutting 15% of costs
Provide technical support and training for rodent techniques

Schedule and oversee facility maintenance
Review facility/equipment maintenance contracts

Director of Operations01/2007 to09/2013
Algos Preclinical Services, Inc.Roseville,MN

Project consulting/execution for 100 sponsored research projects delivered results on time and on budget
Developed dashboards to analyze financial and resource performance
Prepared study protocols, amendments, and reports
Analyzed job costs versus budgeted costs and provided recommendations for cost containment
Assessed animal model performance and reliability
Supervised scientists and technical staff
Oversaw the Animal Care and Use Program (IACUC-Chair) and vivarium
Created Standard Operating Procedures
Created templates for protocols, reports, and graphs

Senior Research Associate02/2005 to01/2007
Algos Therapeutics, Inc.Saint Paul,MN

  • Implemented, validated and performed rodent models of behavioral pharmacology: Acute thermal pain (hot
    plate and tail flick), osteoarthritis, bone cancer pain, neuropathic pain (spinal nerve ligation and chronic
    constriction injury), visceral pain (acetic acid induced abdominal constriction, colorectal distention,interstitial cystitis, post-operative ileus), inflammatory pain (Freund's complete adjuvant, carrageenan,
    ultraviolet-B irradiation), chemogenic pain (formalin, capsaicin), incisional pain, rotarod, modified Irwin
    Screen, and gastrointestinal transit
  • Rodent skills; surgery, handling, restraint, blood and tissue collection for bioanalysis, husbandry, and
    euthanasia
  • Compound formulation.
    Dosed rodents via various routes (s.c., p.o., i.p., i.v., and i.d.)
  • Cultured MRMT-1 rat mammary carcinoma cells
    Collected, analyzed, interpreted study data, prepared figures for study reports, poster presentations andmarketing materials
    Prepared study protocols and reports

Scientist09/2002 to11/2004
Purdue Pharma, L.P.Cranbury,NJ

  • Pharmacological profiling of drug development candidates
  • Implemented online records for mouse colony management
  • Bred and phenotyped more than 15 lines of genetically modified mice
  • Implemented, validated and performed rodent models of behavioral pharmacology to assess pain, motorcoordination, behavior, and gastrointestinal effects: Acute thermal pain, osteoarthritis, bone cancer pain,
    incisional pain, neuropathic pain, rotarod, marble burying, Irwin screen, rotarod, and gastrointestinal
    transit

Behavioral endpoints: weight bearing, bone densitometry, and electro von Frey.
Rodent skills: surgery, handling, restraint, drug dosing, tissue collection, and euthanasia.
Use of genetically modified mice for target validation and in vivo mechanism studies.
Analyzed data, prepared figures for presentations, abstracts, posters and manuscripts.
Prepared an exploratory project proposal, screening tree, and target validation studies.

Senior Research Scientist II05/1996 to09/2002
Adolor CorporationExton,PA

Implemented, validated and performed rodent models of behavioral pharmacology to assess pain, motor
coordination, and gastrointestinal effects: inflammatory pain, acute thermal pain, acute cutaneous pain,
neuropathic pain, rotarod assay, gastrointestinal transit.
Behavioral endpoints: Randall-Sellito paw pressure threshold, Hargreave's thermal hyperalgesia, and von
Frey.
Rodent skills; surgery, handling, restraint, blood and tissue collection, husbandry, and euthanasia.
Compound formulation and dosing via various routes.
Prepared in vivo data for IND applications abstracts, and presentations.

Laboratory Manager09/1990 to04/1996
Reproductive/Environmental Physiology Laboratory University of FloridaGainesville,FL

Performed independent research related to immune responses at the maternal-fetal interface in sheep.
Ordered Supplies and maintained grant budgets.
Compliance with EHS, radiation safety
Protein biochemistry techniques: column chromatography (FPLC), gel exclusion, ion-exchange, lectin-
affinity, immuno-affinity, SDS-PAGE, Western blotting, and ELISA.
Tissue culture: collection, isolation and primary culture of murine, ovine and bovine splenocytes,
thymocytes, lymphocytes, in vitro proliferation and cell-mediated cytotoxicity assays, establishment of
primary bovine endometrial and oviductal cell cultures, culture of established human tumor cell lines: K562
erythroleukemia cells, HeLa S3 cervical epithelial cells.
Histology: H&E staining, differential leukocyte staining, immunohistochemistry, tissue preparation for light
and electron microscopy.
Animal handling: cattle and sheep, restraint, estrus detection, breeding, blood collection, estrus
synchronization and superovulation.

Skills

Reproductive Physiology and Behavioral Pharmacology
Software: Microsoft Office, GraphPad Prism, Office Tracker
Statistical analysis: parametric and non-parametric analysis
Training: Transformational Leadership, Strengths Based Professional Development, Six Sigma White Belt,
Time Management

Publications

1. Ilyin, V.I., Pomonis, J.D., Whiteside, G.T., Harrison, J.E., Pearson, M.S., Mark, L., Turchin, P.I.,Gottshall, S.,
Carter, R.B., Nguyen, P., Hogenkamp, D.J., Olanrewaju, S., Benjamin, E., Woodward, R.M. Pharmacology of

2-{4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent
sodium channel blocker for treating pain states. J. Pharmacol. Exp. Ther. 318:1083-93, 2006.

2. Whiteside, G.T.,Gottshall, S.L., Boulet, J.M., Chaffer, S.M., Harrison, J.E., Pearson, M.S., Turchin, P.I., Mark,
L., Garrison, A.E., Valenzano, K.J. A role for cannabinoid receptors, but not endogenous opioids, in the
antinociceptive activity of the CB2-selective agonist, GW405833. Eur. J. Pharmacol. 528:65-72, 2005.

3. Valenzano, K.J., Tafesse, L., Lee, G., Harrison, J.E., Boulet, J.M.,Gottshall, S.L., Mark, L., Pearson, M.S.,
Miller, W., Shan, S., Rabadi, L., Rotshteyn, Y, Chaffer, S.M., Turchin, P.I., Elsemore, D.A., Toth, M., Koetzner, L.,
Whiteside, G.T. Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist
GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. Neuropharmacology
48: 658-72, 2005.

4. Kumar, V., Guo, D., Cassel, J.A., Daubert, J.D., DeHaven, R.N., DeHaven-Hudkins, D.L., Gauntner, E.K.,
Gottshall, S.L., Greiner, S.L., Koblish, M., Little, P.J., Mansson, E., Maycock, A.L. Synthesis and evaluation of
novel peripherally restricted kappa-opioid receptor agonists, Bioorg. Med. Chem. Lett. 15: 1091-5, 2005.

5. Tuthill, P.A., Seida, P.R., Barker, W., Cassel, J.A., Belanger, S., DeHaven, R.N., Koblish, M.,Gottshall, S.L.,
Little, P.J., DeHaven-Hudkins, D.L. and Dolle, R.E. Azepinone as a conformational constraint in the design of
kappa receptor agonists. Bioorg. Med. Chem. Lett. 14: 5693-5697, 2004.

6. Pomonis, J.D., Boulet, J.M.,Gottshall, S.L., Phillips, S., Sellers, R., Bunton, T., and Walker, K. Development
and pharmacological characterization of a rat model of osteoarthritis pain. Pain. 114(3):339-46, 2005.

7. Little, P.J.,Gottshall, S.L.,Koblish, M., Long S., Wiant, D.D., Guo, D. and DeHaven-Hudkins, D. Antagonism
of opioid-induced inhibition of GI transit and secretion by Alvimopan, a novel, peripherally acting opioid
antagonist. J. Pharmacol. Exp. Ther. Submitted. 2004.
8. Whiteside, G.T., Harrison J., Boulet, J., Mark, L., Pearson, M.,Gottshall, S.and Walker K. Pharmacological
characterization of a rat model of incisional pain. Br. J. Phamacol. 141: 85-91, 2004.
9. Kumar V., Marella M.A., Cortes-Burgos L., Chang A.C., Cassel J.A., Daubert J.D., DeHaven R.N., DeHaven-
Hudkins D.L.,Gottshall S.L., Mansson E., and Maycock A.L.: Arylacetamides as peripherally restricted kappa
opioid receptor agonists. Bioorganic & Med. Chem. Letters. 10: 2567-2570, 2000.

10. Liu W.J.,Gottshall S.L.and Hansen P.J.: Increased expression of cell surface markers on endometrial γ/δ
T-cell receptor+ intraepithelial lymphocytes induced by the local presence of the sheep conceptus. Am. J.
Reprod. Immunol. 37: 199-205, 1997.
11. Davidson J.A., Wright J.D., Archbald L.F., Klapstein E.,Gottshall S.L. and Hansen P.J.: Effect of induced
pyometra on luteal lifespan and uterine fluid concentrations of prostaglandins and interferons. Theriogenology.
45: 459-470, 1996.

12. Gottshall S.L. and Hansen P.J.: Enhancement of mitogen-induced lymphocyte proliferation in sheep. J. Vet.
Med. B. 41: 541-548, 1994.
13. Gottshall S.L.and Hansen P.J.: Regulation of leucocyte subpopulations in the sheep endometrium by
progesterone. Immunology. 76: 636-641, 1992.
Abstracts
1. Marker, C.L., Pomonis, J.D.,Gottshall, S.L. Measuring Use-Related Pain in a Rat Model of Osteoarthritis.
IASP 13th World Congress, 2010.
2. Nelson, E.S., Wiant, D.D.,Gottshall, S.L., Marker, C.L. Measuring Mechanical Hyperalgesia in the Chronic
Constriction Injury Model of Neuropathic Pain in the Rat. IASP 13th World Congress, 2010.
3. T.L. Healy, L. Pook,S.L. Gottshall. Characterization of a back incision model of post-surgical pain in the rat
using a diode laser. Soc. Neurosci. Abstr. 40: 2010.
4. Nelson, E.S., Pomonis, J.D.,Gottshall, S.L., Marker, C.L. Measuring Mechanical Hyperalgesia in a Spinal
Nerve Ligation Induced Model of Neuropathic Pain in the Rat. Soc. Neurosci. Abstr. 39: 2009.
5. Sorcic, L.M., Wood, K.,Gottshall, S.L., Marker, C.L. Measuring Mechanical Hyperalgesia in a Complete
Freund's Adjuvant-Induced Model of Inflammatory Pain in the Rat. Soc. Neurosci. Abstr. 39: 2009.
6. T.L. Healy, C. Schaeffer,S.L. Gottshall. Characterization of a model of ultraviolet B irradiation induced pain in
the rat. Soc. Neurosci. Abstr. 39: 2009.
7. Healy, T.L., Marker, C.L.,Gottshall, S.L. Measuring Primary Mechanical Hyperalgesia in a Model of Adjuvant-
Induced Chronic Joint Pain in the Rat. Soc. Neurosci. Abstr. 38: 2008.
8. Marker, C.L., Healy, T.L.,Gottshall, S.L. Measuring Primary Mechanical Hyperalgesia in a Rat Model of
Osteoarthritis. Soc. Neurosci. Abstr. 38: 2008.
9.Gottshall, S.L., Harrison, J., Pearson, M., Turchin, P., Chaffer, S., Whitehead, J., Hachicha, M., Walker, K. and
Pomonis, J.D. Comparison of ajulemic acid and WIN 55,212-2 in models of neuropathic, inflammatory and acute
pain. Soc. Neurosci. Abstr. 34: 2004.
10. Koetzner, L., Mark, L.,Gottshall, S., Turchin, P. and Walker, K. Mouse assays predict therapeutic index of
anxiolytics in humans. Soc. Neurosci. Abstr. 34: 2004.
11. Gottshall S.L., Bartilomo T.A., Cassel J.A., Daubert J.D., DeHaven R.N., Greiner S.L., Koblish M., Kumar V.,
Little P.J. and DeHaven-Hudkins D.L: Antinociception produced by ADL 10-0102, a novel κ opioid receptor
agonist, in models of inflammatory and acute pain. Soc. Neurosci. Abstr. 27: 2001.

12. Murphy D.M., Koblish M., Gauntner E.K., Little P.J.,Gottshall S.L., Garver D.D. and DeHaven-Hudkins D.L.
A screening process for in vivo assessment of blood brain barrier penetration for kappa (κ) opioid receptor
agonists. International Society for the Study of Xenobiotics. 2000.
13. Koblish M., Murphy D.M., Little P.J.,Gottshall S.L., Gauntner E.K., Garver D.D. and Dehaven-Hudkins D.L.
Pharmacokinetic and metabolic differences of kappa (κ) opioid receptor agonists in Wistar and Sprague-Dawley
rats. International Society for the Study of Xenobiotics. 2000.
14. Gauntner E.K., Cassel J.A., Daubert J.D., DeHaven-Hudkins D.L.,Gottshall S.L., Koblish M., Little P.J., and
DeHaven R.N.: N-Desmethylclozapine is a potent κ opioid receptor agonist. Soc. Neurosci. Abstr. 26: 1157,
2000.
15. DeHaven-Hudkins D.L., Gauntner E.K.,Gottshall S.L., Koblish M., Kumar V., Little P.J., Long S.L., and
Murphy D.M.: Peripheral restriction of κ opioid receptor agonists as defined by pharmacokinetic parameters
correlates with behavioral indices of sedation in the rat. Soc. Neurosci. Abstr. 26: 915, 2000.
16. Long, S.L., Cassel J.A., Daubert J.D., DeHaven R.N.,Gottshall S.L., Koblish M., Kumar V., Little P.J., and
DeHaven-Hudkins D.L.: Pharmacological profile of ADL 01-0398, a novel, peripherally restricted κ opioid agonist
in models of nociception and sedation in the rat and mouse. Soc. Neurosci. Abstr. 26: 914, 2000.
17. Gottshall S.L., Cassel J.A., Daubert J.D., DeHaven R.N., Koblish M., Kumar V., Little P.J., Long S.L., and
DeHaven-Hudkins D.L.: ADL 10-0116, a peripherally restricted κ opioid receptor agonist with a long duration of
action. Soc. Neurosci. Abstr., 26: 914, 2000.
18. Little P.J., Long S.L.,Gottshall S.L., Koblish M., Guo D., and Dehaven-Hudkins D.L.: Pharmacological
profile of ADL 8-2698, a peripherally restricted opioid antagonist. Presented at 31st Annual Intl. Narc. Res. Conf.,
2000.
19. Guo D., Kumar V., Maycock A., DeHaven R.N., Daubert J.D., Cassel J.A., Gauntner E.K., Dehaven-Hudkins
D.L.,Gottshall S.L., Greiner S.L., Koblish M., and Little P.J.: Synthesis and evaluation of novel peripheral k
opioid receptor agonists. 219th ACS National Meeting, 2000.
20. Koblish M., Little P.J.,Gottshall S.L., Marella M., Kumar V. and DeHaven-Hudkins D.L.: Profile of ADL
10-0101 in models of central κ opioid agonist activity in the rat and mouse. Soc. Neurosci. Abstr., 25: 1221, 1999.
21. Gottshall S.L., Cassel J.A., Cortes-Burgos L., Daubert J.D., DeHaven R.N., Koblish M., Kumar V., Little P.J.,
Long S.L., Marella M. and DeHaven-Hudkins D.L.: Antinociception produced by ADL 10-0101, a novel peripheral
κ opioid receptor agonist, in models of inflammatory hyperalgesia. Soc. Neurosci. Abstr., 25: 1221, 1999.
22. Little P.,Gottshall S., Gaul F., Zhang W., Maycock A., Kehner G., Cowan A. and DeHaven-Hudkins D.:
Pharmacological activity of the diastereomers of the kappa agonist GR94839. Intl. Narc. Res. Conf. 1999.
23. Little P.J., Koblish M.,Gottshall S.L., Long S. and DeHaven-Hudkins D.L.: Differential effects of peripheral

kappa opiate agonists in the rotarod and diuresis assays. Comm. Prob. Drug Dependence Abstract 1999.
24. DeHaven R.N., Chang A.C., Daubert J.D., Cassel J.A.,Gottshall S.L., DeHaven-Hudkins D.L., Mansson E.
and Yu G.: TRK-820 exhibits both kappa agonist and mu antagonist properties. Soc. Neurosci. Abstr., 24: 889,
1998.
25. Little P.J., Cortes-Burgos L.,Gottshall S.L., Koblish M., Long S. and DeHaven-Hudkins D.L.: Antinociceptive
profiles of kappa opiate agonists. NIDA Research Mono., 179: 231, 1999.
26. Zhang W.Y., Cortes-Burgos L., Daubert J.,Gottshall S. and Maycock A. Modified piperizine derivatives as
peripherally restricted kappa opioid analgesics. 215th American Chemical Society Meeting. 1998.
27. Marella M, Cortes-Burgos L., Daubert J., DeHaven R., DeHaven-Hudkins D.,Gottshall S.and Maycock A.:
Arylacetamides as peripheral kappa agonists. 215th American Chemical Society Meeting, 1998.
28. Gottshall S.L.and DeHaven-Hudkins D.L.: Effects of peripheral administration of κ opioid receptor agonists
in models of inflammatory hyperalgesia. Soc. Neurosci. Abstr. 23: 1018, 1997.
29. Gottshall S.L.and Hansen P.J.: Modulation of lymphocyte populations in ovine endometrium by
progesterone. Biol. Reprod. 46 (suppl. 1), 130, 1992.