May 2015 Pub Med Abstracts on HD Research
May 2015
http://www.ncbi.nlm.nih.gov/pubmed/25736541
Biallelic mutations in huntington disease: A new case with just one affected parent, review of the literature and terminology.
Uhlmann WR, Peñaherrera MS, Robinson WP, Milunsky JM, Nicholson JM, Albin RL.
Am J Med Genet A. 2015 May;167(5):1152-60. doi: 10.1002/ajmg.a.37009. Epub 2015 Mar 3.
PMID: 25736541
http://www.ncbi.nlm.nih.gov/pubmed/25848931
siRNA screen identifies QPCT as a druggable target for Huntington's disease.
Jimenez-Sanchez M, Lam W, Hannus M, Sönnichsen B, Imarisio S, Fleming A, Tarditi A, Menzies F, Ed Dami T, Xu C, Gonzalez-Couto E, Lazzeroni G, Heitz F, Diamanti D, Massai L, Satagopam VP, Marconi G, Caramelli C, Nencini A, Andreini M, Sardone GL, Caradonna NP, Porcari V, Scali C, Schneider R, Pollio G, O'Kane CJ, Caricasole A, Rubinsztein DC.
Nat Chem Biol. 2015 May;11(5):347-54. doi: 10.1038/nchembio.1790. Epub 2015 Apr 6.
PMID: 25848931
Our data reveal a new HD druggable target affecting mutant HTT aggregation and provide proof of principle for a discovery pipeline from druggable genome screen to drug development.
http://www.ncbi.nlm.nih.gov/pubmed/25940443
[Huntington's disease].
Rollnik JD.
Nervenarzt. 2015 May 6. [Epub ahead of print] German.
PMID: 25940443
http://www.ncbi.nlm.nih.gov/pubmed/25942483
Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC.
Elias S, McGuire JR, Yu H, Humbert S.
PLoS Biol. 2015 May 5;13(5):e1002142. doi: 10.1371/journal.pbio.1002142. eCollection 2015 May.
PMID: 25942483
http://www.ncbi.nlm.nih.gov/pubmed/25931812
Free Article
http://www.ncbi.nlm.nih.gov/pubmed/25941077
Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling.
Brustovetsky N.
Mol Neurobiol. 2015 May 5. [Epub ahead of print]
PMID: 25941077
http://www.ncbi.nlm.nih.gov/pubmed/25941073
Rho Kinase Pathway Alterations in the Brain and Leukocytes in Huntington's Disease.
Narayanan KL, Chopra V, Rosas HD, Malarick K, Hersch S.
Mol Neurobiol. 2015 May 5. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/25938884
A SNP in the HTT promoter alters NF-?B binding and is a bidirectional genetic modifier of Huntington disease.
Becanovic K, Nørremølle A, Neal SJ, Kay C, Collins JA, Arenillas D, Lilja T, Gaudenzi G, Manoharan S, Doty CN, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, De Souza RA; REGISTRY Investigators of the European Huntington's Disease Network, Tabrizi SJ, Hermanson O, Langbehn DR, Hayden MR, Wasserman WW, Leavitt BR.
Nat Neurosci. 2015 May 4. doi: 10.1038/nn.4014. [Epub ahead of print]
PMID: 25938884
http://www.ncbi.nlm.nih.gov/pubmed/25778633
Combined lesions of direct and indirect basal ganglia pathways but not changes in dopamine levels explain learning deficits in patients with Huntington's disease.
Schroll H, Beste C, Hamker FH.
Eur J Neurosci. 2015 May;41(9):1227-44. doi: 10.1111/ejn.12868. Epub 2015 Mar 16.
PMID: 25778633
http://www.ncbi.nlm.nih.gov/pubmed/25844897
Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients.
Wild EJ, Boggio R, Langbehn D, Robertson N, Haider S, Miller JR, Zetterberg H, Leavitt BR, Kuhn R, Tabrizi SJ, Macdonald D, Weiss A.
J Clin Invest. 2015 May 1;125(5):1979-86. doi: 10.1172/JCI80743. Epub 2015 Apr 6.
PMID: 25844897
http://www.ncbi.nlm.nih.gov/pubmed/25941090
The Cambridge MRI database for animal models of Huntington disease.
Sawiak SJ, Jennifer Morton A.
Neuroimage. 2015 May 1. pii: S1053-8119(15)00356-0. doi: 10.1016/j.neuroimage.2015.04.056. [Epub ahead of print]
PMID: 25941090
http://www.ncbi.nlm.nih.gov/pubmed/25773959
Complex interplay between the length and composition of the huntingtin-derived peptides modulates the intracellular behavior of the N-terminal fragments of mutant huntingtin.
Milewski M, Gawlinski P, Bak D, Matysiak A, Bal J.
Eur J Cell Biol. 2015 May;94(5):179-89. doi: 10.1016/j.ejcb.2015.02.001. Epub 2015 Feb 20.
PMID: 25773959
http://www.ncbi.nlm.nih.gov/pubmed/25770041
Environmental factors as modulators of neurodegeneration: Insights from gene-environment interactions in Huntington's disease.
Mo C, Hannan AJ, Renoir T.
Neurosci Biobehav Rev. 2015 May;52:178-192. doi: 10.1016/j.neubiorev.2015.03.003. Epub 2015 Mar 10. Review.
PMID: 25770041
http://www.ncbi.nlm.nih.gov/pubmed/25896083
Huntington disease: Cerebrospinal fluid and MRI biomarkers for prodromal HD.
Chase A.
Nat Rev Neurol. 2015 May;11(5):245. doi: 10.1038/nrneurol.2015.63. Epub 2015 Apr 21. No abstract available.
PMID: 25896083