Standard Operating Procedures
Laboratory Specific
Chemical: O,O,O′,O′-tetraethyl dithiopyrophosphate (SULFOTEPP)
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Laboratory Safety Manual and Chemical Hygiene Plan.
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Department:______Date when SOP was written:______
Date when SOP was approved by the lab supervisor: ______
Principal Investigator:______
Internal Laboratory Safety Coordinator/Lab Manager:______
Laboratory Phone:______Office Phone:______
Emergency Contact:______
(Name and Phone Number)
Location(s) covered by this SOP:______
(Building/Room Number)
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Type of SOP: Process Hazardous Chemical Hazardous Class
Purpose
SULFOTEPP is used as an insecticide. It is often used in greenhouses to control aphids, spider mites, thrips and whiteflies populations. SULFOTEPP is characteristic with a garlic type odor and is either a pale yellow or colorless liquid.
Synonyms of SULFOTEPP include diethoxyphosphinothioyloxy-diethoxy-sulfanylidene-λ5-phosphane; O,O,O',O'-Tetraethyldithiopyro phosphate;thiotep ; Thiotepp(r) ; Thiodiphosphoric acid tetraethyl ester ; Tetraethyldithio pyrophosphate ; Sulfotep ; TEDP; Bis-o,o-diethylphosphorothionic anhydride.
Physical & Chemical Properties/Definition of Chemical Group
CAS#: 3689-24-5
Class: Highly Toxic!!! Environmental Hazard!!!
Molecular formula: C8H20O5P2S2
Boiling Point: 136-139 deg C
Melting Point: NA
Potential Hazards/Toxicity
EMERGENCY OVERVIEW:
Danger! Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases (such carbon oxides and oxides of phosphorous). Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. Contact of SULFOTEPP with strong oxidizers may cause fires and explosions.
Potential Health Effects
Eye: May cause irritation, redness, pain and pupillary constriction.
Skin: Skin contact with the material may produce severely toxic effects; systemic effects may result following absorption and these may be fatal. Dermal LD50 for rabbit is 20mg/kg.
Ingestion: Severely toxic effects may result from the accidental ingestion of the material. Effects associated with their use include increased heart rate, decreased saliva production and other secretions and reduction in bowel movements. Ingestion LD50 for rats is 5mg/kg.
Inhalation: Highly toxic by inhalation. Inhalation of dusts, or fume, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress. Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled. Highly toxic gases & vapors of unburned material & phosphoric acid are formed in fires. LC50 for rats is 38 mg/m3.
Target Organs: Central Nervous System, heart, blood and eyes.
Personal Protective Equipment (PPE)
Eyes: Face shield and safety glasses to minimize the possibility of liquid of vapor eye contact. Employees should be provided with and required to use splash-proof safety goggles where there is any possibility of SULFOTEPP contacting the eyes.
Skin: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Complete suit protecting against chemicals depending on the concentration and amount of the dangerous chemical substance at the workplace.
Clothing: Employees should be provided with and required to use impervious clothing, gloves, face shields (eight-inch minimum), and other appropriate protective clothing necessary to prevent any possibility of skin contact with SULFOTEPP.
Respirators: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Engineering Controls
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only in a chemical fume hood. Make sure to wear splash goggles, a lab coat, gloves and a respirator. When necessary wear complete suit for protection. Prevent exposure to the environment. SULFOTEPP will attack some forms of plastics, rubber, and coatings.
First Aid Procedures
Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Do not use an ointment. Seek medical attention.
Skin: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: Call the poison control center at 1-800-222-1222. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation: POISON chemical! If inhaled, get medical aid immediately. Remove victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician: Treat symptomatically and supportively.
Special Handling and Storage Requirements
Handling: Wear protective splash goggles, respirator, gloves and lab attire at all times while handling this chemical. Use only in a fume hood. This chemical is known to be strong oxidizing agent. It is stable under recommended storage conditions.
Storage: This chemical should be stored in moisture-proof container in a cool well-ventilated area. Empty drums should be decontaminated; never re-use containers. Keep in a well-ventilated room. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Spill and Accident Procedure
Chemical Spill Dial 911 and x59797
Spill – Vacuum or sweep up material and place into a suitable disposal container. Reduce airborne dust and prevent scattering by moistening with water. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Remove all sources of ignition. Use a spark-proof tool. If the material is dry, explosives experts may be necessary to dispose of the spill. Provide ventilation.
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 911 (or 310-825-1491 from cell phone) and EH&S at x59797 for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. Seek medical attention. Notify supervisor and EH&S at x59797 immediately.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. Seek medical attention. Notify supervisor and EH&S at x59797 immediately.
Medical Emergency Dial 911 or x52111
Life Threatening Emergency, After Hours, Weekends And Holidays – Dial 911 (or 310-825-1491 from cell phone) or contact the Ronald Reagan UCLA Medical Center (emergency room) directly at x52111 (located at 757 Westwood Plaza, enter from Gayley Avenue). Note: All serious injuries must be reported to EH&S at x59797 within 8 hours.
Non-Life Threatening Emergency– Go to the Occupational Health Facility (OHF), x56771, CHS room 67-120 (This is on the 6th floor, 7th corridor, room 120. Enter through the School of Dentistry on Tiverton Drive and proceed to the “O” elevator to the 6th floor.)Hours: M - F, 7:30 a.m. to 4:30 p.m. At all other times report to Ronald Regan UCLA Medical Center (emergency room) at x52111. Note: All serious injuries must be reported to EH&S at x59797 within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure)– Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 231 from a campus phone, enter 93333 when prompted and then enter your extension. Hours: M – F, 8:00 a.m. to 4:00 p.m. At all other times report to Ronald Regan UCLA Medical Center (emergency room) at x52111. Note: All needle stick/puncture exposures must be reported to EH&S at x59797 within 8 hours.
Decontamination/Waste Disposal Procedure
Waste disposal procedures
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.
Material Safety Data Sheet (MSDS) Location
(State the location of MSDS)
Hardcopy or electronic copy must be available.
Online MSDS can be accessed at http://msds.ehs.ucla.edu.
Protocol/Procedure
(Add specific description of procedure.)
Note: Any deviation from this SOP requires written approval from PI.
Documentation of Training (signature of all users is required)
I have read and understand the content of this SOP:
Name Signature Date
1