GSTM1 and GSTT1 Null Polymorphisms and Male Infertility Risk: an Updated Meta-Analysis

GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects.

Wei Wu1, 2, 3, *,Jing Lu1, 2, Qiuqin Tang4,Beilei Yuan1, 2, Jing Li1, 2, Di Wu1, 2, Hong Sun 5, Chuncheng Lu1, 2,Yankai Xia1, 2,*, Daozhen Chen3, Jiahao Sha1, Xinru Wang1, 2

Figure S1. Forest plot of the GSTM1 null polymorphism and male infertility risk in ethnicanalysis. Studies are plotted according to the last name of the firstauthor and followed by the publication year in parentheses. Horizontal lines represent 95% CI. Each square represents the OR pointestimate and its size is proportional to the weight of the study. The diamond (andbroken line) represents the overall summary estimate, with confidence interval givenby its width. The unbroken vertical line is at the null value (OR = 1.0). CI, confidenceinterval; OR, odds ratio.

Figure S2. Forest plot of the GSTT1 null polymorphism and male infertility risk in ethnicanalysis. Studies are plotted according to the last name of the firstauthor and followed by the publication year in parentheses. Horizontal lines represent 95% CI. Each square represents the OR pointestimate and its size is proportional to the weight of the study. The diamond (andbroken line) represents the overall summary estimate, with confidence interval givenby its width. The unbroken vertical line is at the null value (OR = 1.0). CI, confidenceinterval; OR, odds ratio.

Figure S3. Forest plot of the GSTT1 null polymorphism and male infertility risk in overall analysis. Studies are plotted according to the last name of the firstauthor and followed by the publication year in parentheses. Horizontal lines represent 95% CI. Each square represents the OR pointestimate and its size is proportional to the weight of the study. The diamond (andbroken line) represents the overall summary estimate, with confidence interval givenby its width. The unbroken vertical line is at the null value (OR = 1.0). CI, confidenceinterval; OR, odds ratio.

Figure S4. Forest plot of the GSTT1 null polymorphism and male infertility risk in subgroup analysis. Studies are plotted according to the last name of the firstauthor and followed by the publication year in parentheses. Horizontal lines represent 95% CI. Each square represents the OR pointestimate and its size is proportional to the weight of the study. The diamond (andbroken line) represents the overall summary estimate, with confidence interval givenby its width. The unbroken vertical line is at the null value (OR = 1.0). CI, confidenceinterval; OR, odds ratio.

Figure S5. Funnel plot for GSTT1analysis to detect publication bias. Each dot represents aseparate study for the indicated association. Location outside the delineated triangle(pseudo 95% confidence intervals) suggests a publication bias.

Figure S6. A predicted effect of the GSTM1null genotype on transcription factor-binding site.The red boxes indicate the significanttranscriptional factor-binding site.

Figure S7. A predicted effect of the GSTT1null genotype on transcription factor-binding site.The red boxes indicate the significanttranscriptional factor-binding site.