Table 1 Main characteristics of selected studies

First author / Year / Country / Ethnicity / Cancer type / Genotyping method / Hardy-Weinberg equilibrium / Match / Cases / Controls
GG / GC / CC / GG / GC / CC
Duch[17] / 2007 / Brazil / Caucasian / Myeloma / PCR-RFLP / y / y / 28 / 22 / 2 / 35 / 23 / 2
Landi[18] / 2003 / Spain / Caucasian / Colorectal cancer / Taqman / y / y / 133 / 180 / 48 / 145 / 133 / 33
Smith[19] / 2004 / UK / Caucasian / Breast cancer / Taqman / y / y / 57 / 67 / 20 / 79 / 101 / 44
Talar-Wojnarowska[20] / 2009 / Poland / Caucasian / Pancreatic cancer / PCR-RFLP / y / y / 13 / 19 / 9 / 22 / 19 / 9
Howell[21] / 2003 / UK / Caucasian / Melanoma / Taqman / y / y / 48 / 79 / 34 / 79 / 101 / 44
Cordano[22] / 2005 / UK / Caucasian / Lymphoma / Taqman / y / y / 134 / 197 / 77 / 106 / 184 / 59
Snoussi[23] / 2005 / Tunisia / African / Breast cancer / PCR-RFLP / y / n / 199 / 98 / 8 / 150 / 46 / 4
Vasku[24] / 2004 / Czech / Caucasian / Lymphoma / PCR-RFLP / y / y / 19 / 35 / 9 / 36 / 46 / 23
Deans[25] / 2007 / UK / Caucasian / Gastric cancer / Taqman / y / n / 71 / 83 / 43 / 79 / 101 / 44
Berkovic[26] / 2007 / Croatia / Caucasian / GEP-NETs / PCR-RFLP / y / y / 25 / 44 / 11 / 69 / 75 / 18
Mazur[27] / 2005 / Poland / Caucasian / Myeloma / PCR-RFLP / y / n / 11 / 31 / 12 / 16 / 28 / 6
Nearman[28] / 2007 / Germany / Caucasian / Leukaemia / PCR-RFLP / y / y / 32 / 54 / 14 / 50 / 39 / 11
Hefler[29] / 2005 / Germany / Caucasian / Breast cancer / PCR-RFLP / y / n / 78 / 139 / 52 / 91 / 105 / 31
Litovkin[13] / 2007 / Ukraine / Caucasian / Breast cancer / Taqman / y / y / 26 / 39 / 8 / 30 / 39 / 9
Martinez-Escribano[30] / 2002 / Spain / Caucasian / Melanoma / PCR-SSP / y / y / 14 / 26 / 2 / 20 / 26 / 2
Ladd[31] / 2006 / Netherlands / Caucasian / Breast cancer / Taqman / y / n / 55 / 86 / 30 / 1286 / 1733 / 632
Zheng[32] / 2000 / Sweden / Caucasian / Myeloma / PCR-RFLP / y / n / 22 / 36 / 15 / 33 / 69 / 26
Cherel[33] / 2009 / France / Caucasian / Breast cancer / PCR-RFLP / y / n / 102 / 131 / 60 / 29 / 58 / 25
Vasku[34] / 2009 / Czech / Caucasian / Colorectal cancer / PCR-RFLP / y / y / 32 / 46 / 22 / 31 / 47 / 22
Gonullu[35] / 2007 / Turkey / Caucasian / Breast cancer / PCR-SSP / n / n / 15 / 17 / 6 / 14 / 3 / 7
Kamangar[36] / 2006 / Finland / Caucasian / Gastric cancer / Taqman / n / y / 21 / 54 / 27 / 51 / 58 / 43
Seifart[37] / 2005 / Germany / Caucasian / Lung cancer / PCR-RFLP / y / y / 74 / 82 / 26 / 90 / 107 / 46
Zhang[38] / 2004 / Sweden / Caucasian / Basal cell cancer / Pyrosequencing / y / y / 57 / 126 / 58 / 62 / 130 / 68
Ahirwar[39] / 2008 / India / Asian / Bladder cancer / ARMS-PCR / n / y / 86 / 24 / 26 / 130 / 56 / 14
Campa[40] / 2004 / Norway / Caucasian / Lung cancer / Taqman / y / n / 64 / 111 / 68 / 55 / 105 / 47
Slattery[41] / 2007 / US / Caucasian / Colon cancer
rectal cancer / Taqman / n / y / 631 / 696 / 246 / 728 / 897 / 347
Rothman[42] / 2006 / US / Caucasian / Lymphoma / Taqman / y / y / 1097 / 1470 / 499 / 1277 / 1658 / 564
Balasubramanian[43] / 2006 / UK / Caucasian / Breast cancer / Taqman / y / n / 170 / 244 / 83 / 168 / 235 / 87
Ennas[44] / 2008 / Italy / Caucasian / Lymphoma / Taqman / y / y / 17 / 16 / 6 / 64 / 43 / 5
Gunter[45] / 2006 / US / Caucasian / Colorectal cancer / Taqman / y / y / 79 / 90 / 35 / 83 / 81 / 26
Vogel[46] / 2007 / Denmark / Caucasian / Breast cancer / Taqman / y / y / 108 / 167 / 86 / 98 / 177 / 86
Vogel[47] / 2008 / Denmark / Caucasian / Lung cancer / Taqman / y / y / 105 / 202 / 96 / 204 / 361 / 179
Vogel[48] / 2007 / Denmark / Caucasian / Basal cell cancer / Taqman / y / y / 65 / 176 / 63 / 89 / 157 / 69
Wilkening[49] / 2008 / Sweden / Caucasian / Colorectal cancer / Taqman / y / y / 79 / 163 / 61 / 162 / 297 / 121
Lan[50] / 2006 / US / Caucasian / Lymphoma / Taqman / y / y / 211 / 231 / 68 / 241 / 264 / 85
Gatti[51] / 2007 / Brazil / Caucasian / Gastric cancer / PCR-RFLP / y / y / 42 / 13 / 1 / 23 / 27 / 6
Aladzsity[52] / 2009 / Hungary / Caucasian / Myeloma / Taqman / y / n / 37 / 43 / 17 / 36 / 49 / 14
Andrie[53] / 2009 / US / Caucasian / Lymphoma / PCR-RFLP / y / y / 55 / 23 / 3 / 47 / 30 / 4
Kesarwani[54] / 2008 / India / Asian / Prostate cancer / ARMS-PCR / y / y / 102 / 84 / 14 / 103 / 87 / 10
Cozen[63]a / 2006 / US / Caucasian / Myeloma / Taqman / - / y / 85 / 61 / 75 / 50
Slattery[61]a / 2008 / US / Caucasian/AI / Breast cancer / Taqman / - / n / 430 / 741 / 409 / 920
Leibovici[58]b / 2005 / US / Caucasian / Bladder cancer / Taqman / - / y / 334 / 110 / 68 / 375
Skerrett[65]b / 2005 / US / Mixed / Breast cancer / PCR-SSP / - / n / 80 / 8 / 95 / 7
Dossus[66] / 2010 / US/Europe / Mixed / Breast cancer
Prostate cancer / GoldenGate assay and Illumina BeadArray / n / y / 3594 / 3218 / 1125 / 3832 / 3402 / 1274
Falleti[67] / 2009 / Italy / Caucasian / Hepatocellur cancer / PCR-RFLP / y / n / 30 / 35 / 1 / 72 / 63 / 18
Cacev[68] / 2010 / Croatia / Caucasian / Colon cancer / PCR-RFLP / y / y / 64 / 70 / 26 / 68 / 75 / 17
Tsilidis[69] / 2009 / US / Caucasian / Colorectal cancer / Taqman / y / y / 68 / 93 / 39 / 113 / 170 / 71

a For these just presenting the information for genotypes of GG and GC+CC, dominant model is calculated only

bFor these just presenting the information for genotypes of CC and GC+GG, recessive model is calculated only