David Ryan Ormond, MD, FAANS / POSITION TITLE
Assistant Professor
Director, Brain Tumor Program
Director, Regenerative Neurobiology Laboratory
Associate Program and Site Director, Neurosurgery Residency Program
Associate Program Director, Neurosurgical Oncology Fellowship
Department ofNeurosurgery
University of ColoradoSchoolof Medicine
12631 E. 17th Avenue, MailStop C307
Academic Office 1, Room5001
Aurora, CO 80045
Tel: 303.724.2305
Fax: 303.724.2300
Email:
EDUCATION/TRAINING
INSTITUTION AND LOCATION / DEGREE / YEAR(s) / FIELD OF STUDY
University of Arkansas, Fayetteville, AR / B.S. / 8/1996-5/2001 / Honors Microbiology, German minor
University of Washington, Seattle, WA / M.D. / 8/2002-6/2006
6/200562006 / Medicine
New York Medical College, Valhalla, NY / N/A / 7/2006-6/2012 / Neurological Surgery
New York Medical College, Valhalla, NY / N/A / 7/2011-6/2012 / Spine Fellowship
Emory University, Atlanta, GA / N/A / 7/2012-6/2013 / Neurosurgical Oncology Fellowship
Rheinische Friedrich Wilhelms Universität, Bonn, Germany / N/A / 7/2013-6/2014 / AANS William P. Van Wagenen Fellowship
PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 7 Biographical Sketch Format Page
Curriculum Vitae: Ormond, David Ryan
A. Positions and Honors.
Positions and Employment
2002 Boise State University, Boise, ID, Graduate Assistant, human anatomy and physiology lab
2006-2007 Westchester Medical Center, Valhalla, NY, Intern, General Surgery
2008-2009 St. Vincent’s Hospital – Manhattan, New York, NY, Chief Resident, Neurosurgery
2006-2012 New York Medical College, New York and Valhalla, NY, Resident, Neurosurgery
2010-2011 Westchester Medical Center, Valhalla, NY, Chief Resident, Neurosurgery
2011-2012 Westchester Medical Center, Valhalla, NY, Neurosurgery Spine Fellowship
2011-2012 New York Medical College, Valhalla, NY, Clinical Instructor
2012-2013 Emory University, Atlanta, GA, Neurosurgical Oncology Fellowship, Senior Associate
2013-2014 2013 AANS William P. Van Wagenen Fellowship at the Institute for Reconstructive Neurobiology, Rheinische Friedrich Wilhelms Universität Bonn
2012-2014 Lincoln Medical and Mental Health Center, New York, NY, Attending Neurosurgeon
2014-Present Assistant Professor, University of Colorado School of Medicine
Honors and Awards
1991 Eagle Scout, Boy Scouts of America
1993 NASA SSIP Regional Winner
1995 Fleet Reserve Association, National Award
1995 National Merit Scholar
1996 Valedictorian, Centennial High School, Meridian, Idaho
1996 State of Idaho Scholarship
1996 Mu Alpha Theta Honor Society, member
1996 National Honor Society, member
1996-2001 Sturgis Fellowship, Fulbright College, University of Arkansas
2000 Golden Key National Honor Society, member
2000 Alpha Epsilon Delta Honor Society, member
2000 Delta Phi Alpha Honor Society, member
2000 The National Dean’s List
2001 Phi Beta Kappa Honor Society, member
2001 Senior Scholar, University of Arkansas
2001 University of Arkansas, B.S., Summa Cum Laude, Honors Microbiology, German minor
2002, 2004 Mary E. Wright Cartier Memorial Fund in Medicine Award
2002, 2003 Eikelberner Endowed Scholarship
2003 John and Mary Wilson Scholarship
2003-2006 Idaho Medical Association Scholarship
2010 New York State Neurosurgical Society Annual Meeting Resident Research Award
2010 Society for Neuroscience Annual Meeting Abstract “Hot Topics” Award
2011 Marquis Who’s Who in America
2011 Anna Samartzis Research Award
2011 New York Society for Neurosurgery Resident Research Night Second Prize
2016 Visiting Professor, New York Medical College, Department of Neurosurgery
2016 Visiting Professor, Muhimbili Orthopedic Institute, Division of Neurosurgery, Dar es Salaam,
Tanzania
2016, 2018 Colorado Humanitarian Surgical Skills Workshop, faculty member
2016 The Leading Physicians of the World
2017 Visiting Professor, Evangelisches Klinikum Bethel Department of Neurosurgery, Bielefeld,
Germany
2017 Albert Nelson Marquis Lifetime Achievement Award
2017 American Board of Neurological Surgeons, board certification
2018 Marquis Who’s Who in the World
Patents
Inventor: D. Ryan Ormond, Edin Nevzati
Country: USA
Title: Balloon brain tissue retractor
Patent Number: pending
Patent Granted Date: pending
Application Number: 62/662,745
Application Date: April 25, 2018
Inventor: D. Ryan Ormond, Jennifer Wagner, Edin Nevzati
Country: USA
Title: Neurosurgical trainer for minimally invasive (endoscopic) brain surgery
Patent Number: pending
Patent Granted Date: pending
Application Number: 62/593,759
Application Date: December 1, 2017
Grants
Sponsor: American Heart Association Career Development Award
Title: The role of mitochondrial transfer and mesenchymal stem cell transplantation in neuronal preservation after cardiac arrest
Principle Investigator: Ormond
Total Project Period: 7/1/2018-6/30/2021
Amount of total support: $231,000
Specific Aims: Aim 1: Study the role of mitochondrial transfer to neurons from MSC after
ischemia, and investigate the metabolic benefit to neurons of MSC transplant in vitro after
ischemia, and the role that mitochondrial transfer plays in neuronal preservation. Aim 2: Study the role Miro1 and TNFAIP2 play in intercellular mitochondrial transfer from MSC to neurons. Additionally, we will study the role of other genes involved in mitochondrial motility and the inflammatory cascade to better understand the role of the neuron in signaling and directing the process of mitochondrial transfer. Aim 3: Study the potential benefit and mechanism of action of mitochondrial transfer to neurons from MSC in animal models of global cerebral ischemia.
Sponsor: National Cancer Institute
Title: Mechanisms underlying pro-metastatic effects of estrogen in the brain niche
Principle Investigator: Cittelly
Role: Collaborator (5% effort)
Total Project Period: 4/1/2018-3/31/2023
Amount of total support: $1,778,530
Specific aims: Aim 1: Determine how E2 upregulates BDNF in the metastatic niche, and whether
BDNF activation of TRKB/EGFR/HER2 is a mechanism of increased brain metastases in response to E2. Aim 2: Determine how E2 regulates microglia activation and polarization at early stages of brain
metastases, and whether this is a mechanism of increased brain metastases in response to E2. Aim 3: Determine whether targeting E2/ER signaling or downstream BDNF/TRKB/EGFR activation reduces brain
metastatic colonization and progression in vivo. This
Sponsor: Medtronic
Title: Cranial Endoscopy and Minimally Invasive Cranial Surgery Course
Principle Investigator: Ormond
Total Project Period: 08/15/2017-9/4/2018
Amount of total support: $4000 + loaner equipment and personnel to support the course
Specific aim: To support a cadaver course for residents on cranial endoscopy and minimally invasive cranial surgery.
Sponsor: Synaptive Medical
Title: MRI Brain Segmentation and its Use in Neurosurgery
Principal Investigator: Ormond
Total Project Period: 07/01/2017-06/30/2018
Amount of annual support: $75,000
Specific aim: To assess the predictive value of segmentation on postoperative clinical examination.
DOD Breast Cancer Research Program Breakthrough Award Level 1 BC141980(Cittelly, PI)
Title: Role of IL13RA2 as a functional biomarker in breast cancer brain metastasis.
Principal Investigator: Cittelly
Role: Co-I (1% effort)
Total Project Period: 09/30/2015 -09/30/2018
Amount of annual support: $350,000 TDC
Specific aim: To decipher the role of Il13RA2 in brain metastatic breast cancer and validate the use of novel brain metastases PDXs for functional studies in brain metastases.
Deutscher Akademischer Austausch Dienst (German Academic Exchange Service) Research Grant
Title: Cell reprogramming: direct neuronal reprogramming of mesenchymal stem cells
Principal Investigator: D. Ryan Ormond
Mentor: Oliver Brüstle
Total Project Period: 10/1/2013-6/30/2014
Amount of annual support: 10,000 €
Specific aims: 1. Develop methods to convert mesenchymal stem cells to neurons in vitro and in vivo. 2. Develop an autologous animal model of neuronal transplant after acute neurologic injury.
American Association of Neurological Surgeons, 2013 William P. Van Wagenen Fellowship
Title: Cell reprogramming: stem cell-based systems for studying nervous system diseases and repair
Principal Investigator: D. Ryan Ormond
Sponsor: Oliver Brüstle
Total Project Period: 7/1/13-6/30/14
Amount of annual support: $146,000
Specific Aims: 1. Transdifferentiate mesenchymal stem cells into functional neurons. 2. Study mechanisms of paracrine effects of neural stem cells.
American Association of Neurological Surgeons, Neurosurgery Research and Education Foundation;
NREF/Medtronic Research Fellowship
Title: Enhanced Recovery After Spinal Cord Injury Utilizing Engineered Stem Cells and Naturally-Occurring Anti-Inflammatory Compounds
Principal Investigator: D. Ryan Ormond
Sponsor: Meena Jhanwar-Uniyal
Total Project Period: 7/1/10-6/30/11
Amount of annual support: $40,000
Specific Aims: 1. To establish that stem cell therapy in conjunction with anti-inflammatory compounds will result in improved recovery from SCI. 2. To determine the molecular markers associated with SCI recovery.
University of Washington School of Medicine, Medical Student Research Training Program
Title: Purification and Properties of PIN, a Putative Protein Target of Organic Solvents in Neurotoxicity
Principal Investigator: D. Ryan Ormond
Sponsor: Martin Pall
Total Project Period: 6/1/03-7/31/03
Amount of annual support: $3200
Specific Aims: 1. Producing chemically pure PIN protein via recombinant DNA techniques, followed by affinity chromatography purification, 2. Testing potential methods to quantify binding affinities of PIN to a fluorescently labeled 13-residue peptide of nNOS.
Other Experience and Professional Membership
2000 Cambridge University, Cambridge, England; International Science Summer School
2002-2010 Idaho Medical Association; student representative to the Board of Trustees, Medical Education
Affairs Committee member, resident member
2006-2012 Committee of Interns and Residents; neurosurgery department representative, hospital delegate
2006-2012 New York State Neurosurgical Society, member
2006-2012 New York Society for Neurosurgery, member
2006-2012 Medical Society of the State of New York, member
2009-2012 American Association for Cancer Research, member
2009-Present Society for Neuroscience, member
2013-Present American Heart Association, member
2002-Present American Medical Association, member, student delegate, alternate delegate, chapter treasurer, chapter president
2006-Present American College of Surgeons, member
2006-Present Congress of Neurological Surgeons, member
2007-Present American Association of Neurological Surgeons, Fellow
2012-Present Ad Hoc Reviewer for Neurosurgery, Operative Neurosurgery, Journal of Neuro-Oncology, Acta Neuropathologica Communications, Biomarker Insights, Journal of Neurology
2014-Present Colorado Neurosurgical Society, member
2014-Present AANS/CNS Section on Tumors, member
2014-Present Member, University of Colorado Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology
2015-Present Member, University of Colorado Cancer Center
2015-Present Member, Research Advisory Forum, University of Colorado Hospital
2015-Present Member, AANS/CNS Joint Guidelines Committee
2016-Present Colorado State Delegate, Member Patient Safety Committee, Southwestern Quadrant Representative to the Reference Committee, Council of State Neurosurgical Societies
2016-Present Senior Convener, Van Wagenen Selection Committee
2015-Present Director of a Faculty and Resident exchange program, and assistance with curriculum development for the residency program, between CU Neurosurgery and Division of Neurosurgery, Muhimbili Orthopedic Institute, Dar es Salaam, Tanzania
B. Publications/Posters/Abstracts/Invited Lectures.
Peer-Reviewed Publications
- Ormond DR, Kahamba J, Lillehei KO, Rutabasibwa N. Overcoming barriers to neurosurgical training in Tanzania: international exchange, curriculum development, and novel methods of resource utilization and subspecialty development. Neurosurgical Focus. Submitted for review.
- Ung TH, Robinson LC, Nevzati E, Harasaki Y, Witt JP, Ormond DR, Finn M. Intraoperative sodium fluorescein for tissue biopsy and resection of spinal cord lesions. Operative Neurosurgery. Submitted for review.
- Contreras-Zarate MJ, Day N, Ormond DR, Borges VF, Tobet S, Gril B, Steeg PS, Cittelly DM. Estradiol induces BDNF/TrkB signaling in triple negative breast cancer to promote brain metastases. Oncogene. Submitted for review.
- Stumpf P, Kabos P, Kavanagh B, Carlson J, Ormond DR, Rabinovitch R, Robin TP, Stuhr K, Contreras Zarate M, Lai S, Diamond J, Liu A, Rusthoven C, Gaspar L, Fisher C. Combination of trastuzumab emtansine (T-DM1) with stereotactic radiosurgery in women with HER2+ brain metastases is associated with elevated rates of clinically significant radionecrosis and upregulation of Aquaporin-4. Journal of Clinical Oncology. Submitted for review.
- Ormond DR, Herson PS, Traystman RJ. Mitochondria in brain ischemia-reperfusion: a potent mediator of neuronal death and survival. Brain Research. In revision.
6. Ormond DR, Cavalcante C, Lucia MS, Kleinschmidt-De Masters MK. Prostatic adenocarcinoma CNS parenchymal and dural metastases: downregulation of ERG, CHD1, MAP3K7 expression. Journal of Neuropathology and Experimental Neurology. In revision.
7. Karsy M, Azab MA, Abou-Al-Shaar H, Guan J, Eli I, Jensen RL, Ormond DR. Clinical Potential of Meningioma Genomic Insights: A Practical Review for Neurosurgeons. Neurosurgical Focus. In press.
8. Cavalcante D, Ormond DR. Risk of Post-Operative Complications after Intracranial Procedures at High Altitude. World Neurosurgery. 2018 May 3. pii: S1878-8750(18)30906-9. doi: 10.1016/j.wneu.2018.04.186. [Epub ahead of print].
9. Ormond DR, Clusmann H, Sassen R, Hoppe C, Helmstaedter C, Schramm J, Grote A. Pediatric temporal lobe epilepsy surgery in Bonn and review of the literature. Neurosurgery. 2018 April 13. doi: 10.1093/neuros/nyy098. [Epub ahead of print].
- Ung TH, Ney DE, Damek D, Rusthoven CG, Youssef AS, Lillehei KO, Ormond DR. The neurologic assessment in neuro-oncology (NANO) scale as a predictive assessment tool for survival in patients with primary glioblastoma. Neurosurgery. 2018 Mar 30. doi: 10.1093/neuros/nyy098. [Epub ahead of print].
11. Aldape K, Amin SB, Ashley DM, Barnholtz-Sloan JS, Bates AJ, Beroukhim R, Bock C, Brat DJ, Claus EB, Costellow JF, de Groot JF, Finocchiaro G, French PJ, Gan HK, Griffith B, Herold-Mende CC, Horbinski C, Iavarone A, Kalkanis SN, Karabatsou K, Kim H, Kouwenhoven MCM, McDonald KL, Miletic H, Nam D-H, Ng HK, Niclou SP, Noushmehr H, Ormond DR, Poisson LM, Reifenberger G, Roncaroli F, Sa JK, Smitt PAES, Smits M, Souza CF, Tabatabai G, Van Meir E, Verhaak RGW, Watts C. Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and theGliomaLongitudinalAnalySiSConsortium. Neuro-Oncology. 2018 Feb. https://doi.org/10.1093/neuonc/noy020. [Epub ahead of print].
12. Harland TA, Freeman JL, Davern M, McCracken DJ, Celano EC, M.D., Lillehei K, Olson JJ, Ormond DR. Progesterone-only Contraception is Associated with a Shorter Progression-Free Survival in Premenopausal Women with WHO Grade I Meningioma. Journal of Neuro-Oncology. 2018 Jan;136(2):327-333. doi: 10.1007/s11060-017-2656-9.
13. Contreras MJ, Ormond DR, Gillen A, Hanna C, Day N, Serkova N, Jacobsen BM, Edgerton S, Thor A, Borges V, Lillehei K, Graner M, Kabos P, Cittelly DM. Development of novel patient derived xenografts from breast cancer brain metastases. Frontiers in Oncology. 2 Nov. 2017. https://doi.org/10.3389/fonc.2017.00252.
- Ormond DR, D'souza S, Thompson JA. Global and Targeted Pathway Impact of Gliomas on White Matter Integrity Based on Lobar Localization. Cureus 2017;9(9): e1660. doi:10.7759/cureus.1660
15. Oushy S, Sillau S, Ney D, Damek D, Youssef AS, Lillehei K, Ormond DR. New Onset Seizure Following Brain Tumor Excision: A Risk Assessment Analysis. Journal of Neurosurgery. 2017 Jul 28:1-6. doi: 10.3171/2017.2.JNS162315. [Epub ahead of print].
16. Vasquez C, Casey M, Folzenlogen Z, Ormond DR, Lillehei KO, Youssef AS. Third Ventricular Cerebrospinal Fluid Cysts of Thalamic Origin: Review of Embryological Origin, Presentation and Management Strategies with a Case Series. World Neurosurgery. World Neurosurg. 2017 Jul;103:210-219.
- Freeman JL, Davern MS, Sillau S, Youssef S, Ormond DR, Lillehei KO. Spheno-Orbital Meningiomas: A 14-Year Surgical Experience and Factors Affecting Recurrence. World Neurosurgery. 2017;99:369-80.
- Ormond DR, Albert L, Das K.