INCOMPARTIBILITIES UN MEDICINAL FORMS
1. Pharmacist got prescription for compounding mixtura with Codeini phosphatum and Natrii hydrocarbonas. Choose the process of their reaction:
A *Sedimentation of alkaloids
B Eutectic mix
C Immiscibility of ingredients
D Hydrolysis of cardiac glycosides
E Adsorbtion of medicinal matters
2. Pharmacist got prescription for compounding powders with Acidum ascorbinicum and Natrii hydrocarbonas. Choose the process of their reaction:
A *Dampening
B Acidification
C Adsorbtion
D Sedimentation
E Bundle
3. Pharmacist found incompartibility in the prescription:
Rp.: Sol. Collargoli 1 % - 10 ml
Sol. Adrenalini hydrochloridi 0,1 \% - 1 ml
M.D.S. Nose drops.
Choose the process of their reaction
A * Acidification
B Neutralization
C Sedimentation
D Hydrolysis
E Adsorbtion
4. Pharmacist got prescription:
Recipe:Extracti Belladonnae 0,015
Papaverini hydrochloridi 0,05
Carbonis activati 0,2
M. f. pulvis
D. t. d. №10
Signa: 1 powder 2 t. p. d.
Choose the reason of incompartibility:
A * Adsorbtion of medicinal matters
B Coagulation of colloidal system
C Oxidation-reduction reaction
D Acid-base interaction
E Eutectic mix
5. Pharmacist got prescription for compounding Decoctum foliorum Uvae ursi (foxberry) and Hexamethylentetraminum. Pharmacist put the stamp “Invalid prescription”. Choose the reason of incompartibility:
A * Sedimentation
B Eutectic mix
C Acidification
D Inwettability
E Insolubility
6. Pharmacist found incompartibility in the prescription with Kalii permanganas and Hydrogenii peroxydi. Choose the type of chemic reaction:
A * Oxidation-reduction
B Neutralization
C Ezchange
D Sedimentation
E Displacement
7. Pharmacist needs to compound the medicinal form: Rp.: Mentholi 0,1Glycerini 10,0M.D.S. Nose drops. Choose the reason of incompartibility:
A * Insolubility
BBundle
CAdsorbtion
D Eutectic mix
E Coagulation
8. Pharmacist got prescription for compounding Decoctum foliorum Uvae ursi (foxberry) and Extractum Belladonnae. Choose the reason of incompartibility:
A * Sedimentation
B Hydrolysis
C Oxidation-reduction reaction
D Gassing
E Coagulation
9. Pharmacist got prescription for compounding mixtura with Natrii bromidum and Validolum. Choose the reason of incompartibility:
A * Immiscibility of ingredients
B Sedimentation
C Coagulation
D Oxidation-reduction reaction
E Adsorbtion
10. Pharmacist found incompartibility in the prescription:
Rp.: Mentholi 0,1 Natrii hydrocarbonatis Natrii tetraboratis ana 1,5 Aquae purificatae 100 ml M.D.S. 1 table spoon 2 t.p.d. What technological methods shoud be used to compound this medicinal form?
A * Adding stabilizator
B Fractional dissolution
C Solvent exchange
D Exchange of one component
E Exchange of the medicinal form
11. Pharmacist refused to compound medicinal form because of incompartibility of prescribed Collargolum and Dimedrolum. Choose the reason of incompartibility:
A * Coagulation
B Immiscibility
C Adsorbtion
D Bundle
E Eutectic mix
12. At compounding complex powders with Phenylii salicylas and Camphora liquid is formed. Choose the reason of incompartibility:
A * Eutectic mix
B Adsorbtion
C Allocation of crystallization water
D Hygroscopicity of the components
E Gassing
13. t compounding ointment with Oleum Ricini and Vaselinum pharmacist couldn’t get homogeneous system. Choose the reason of incompartibility:
A * Immiscibility of the components
B Limited solubility
C Allocation of crystallization water
D Coagulation
E Adsorbtion
14. Doctor prescribed Infusum Digitalis with Acidum hydrochloricum. Choose the reason of incompartibility:
A * Hydrolysis (without visible changes)
B Sedimentation
C Gassing
D Discoloration
E Change in odor
15. Pharmacist found incompartibility in prescription for compounding powders with Acidum ascorbinicum and Hexamethylentetraminum. Choose the process of their reaction:
A * Dampening
B Eutectic mix
C Immiscibility
D Adsorbtion
E Allocation of crystallization water
16. Pharmacist found physical incompartibility because of coagulation. Choose the medicines that have this process as a result of their interaction:
A * Dimedrolum and Collargolum
B Dimedrolum and Novocainum
C Dimedrolum and Natrii chloridum
D Dimedrolum and Diazolinum
E Dimedrolum and Glucosa
17. Pharmacist found physical incompartibility in prescription. Choose the medicines that form eutectic mix at their interaction:
A * Camphora and Mentholum
B Glucosa and Phenylii salicylas
C Streptocidum and Antipyrinum
D Acidum ascorbinicum and Natrii hydrocarbonas
E Bismuthi subnitras and Magnesii oxydum
18. Pharmacy got the prescription for compounding ear drops:
Rp.: CamphoraeMentholi ana 1,0Olei Vaselini 25,0Misce. Da. Signa. Ear drops. What difficulties would pharmacist have at compounding?
A * Eutectic mix
B Insolubility
C Coagulation
D Discoloration
E Adsorbtion
19. Pharmacist found incompartibility in prescription. Choose the medicines that form eutectic mix at their interaction:
A Chlorali hydras + Camphora
B Antipyrinum + Analginum
C Calcii chloridum + Natrii chloridum
D Ephedrini hydrochloridum + Glucosa
E Natrii hydrocarbonas + Hexamethylentetraminum
20. Pharmacy got the prescription for compounding mixtura. Choose the medicines that are incompartible:
A Papaverini hydrochloridum + Euphyllinum
B Novocainum + Dimedrolum
C Natrii bromidum + Natrii chloridum
D Codeini phosphas + Extractum herbae Thermopsidis
EPhenobarbitalum + Glucosa
NON-STERILE LIQUID MEDICINAL FORMS
1. What mass of Furacillini does pharmacist needs to weigh out for compounding of 500 ml of solution of Furacillini /1:5000/:
A *0,1 g
B 0,02 g
C 0,04 g
D 0,05 g
E0,5 g.
2. What volume of standard (officinal) solution of Aluminii subacetatis does pharmacist need to measure for compounding of 100 ml 10% solution of Liquoris Burovi:
A *10 ml
B 25 ml
C 12,5 ml
D 30 ml
E 50 ml.
3. Pharmacist compounded 100 ml 20% solution of Formalin. Choose necessary volume of officinal solution of Formaldegidum:
A *20 ml
B 60 ml
C 10 ml
D 80 ml
E 40 ml.
4. What amount of Perhydrolum is necessary to be used for compounding of 100 ml of 3% solution of Hydrogenii peroxidum:
A *10,0 g
B 20,0 g
C 0,3 g
D 30,0 g
E3,0 g
5. Solubility of High molecular medicines corresponds with their origin. Choose unlimitedly swelling medicinal matter:
A *Pepsin
BStarch
CGelatin
DPectin
EMethylcellulose.
6. Solution of limitedly swelling High molecular medicine was compounded in the pharmacy. What solution was labelled with the label “Heat up before use”:
A *Gelatin
B Tripsin
CPepsin
DMethylcellulose
EPancreatin
7. Pharmacist needs to compound oil emulsion with Menthol. Choose correct way of adding medicinal matter:
A *To solve in oil
BTo disperse with adding of emulsion
CTo solve in water intended for dilution of primary emulsion
DTo solve in ready emulsion with heating up
ETo add to ready primary emulsion.
8. It is necessary to compound emulsion for patient. Choose the oil that should be taken:
A *Peach oil
BCastor oil
CVaseline oil
DMint oil
ETea tree oil
9. Pharmacist compounds heterogeneous medicinal form. Choose medicinal matter that should be added by the suspension type:
A *Phenylii salicylas
BCamfor
CNatrii coffein-benzoas
DNatrii bromidum
EMentholum.
10. Decoction of Uvae ursi leaf is needed to be compounded. Choose correct proportion of medicinal plant material and extractant when there are no instructions in the prescription:
A *1:10
B 1:20
C 1:30
D 1:5
E 1:400.
11. Pharmacist compounded infusion of Thermopsis herb. When there are no instructions in the prescription it is compounded in proportion:
A *1:400
B 1:30
C 1:20
D 1:10
E 1:5.
12. What volume of water should be taken for compounding of 100ml of water extraction from Mint leaf (CWA = 2,4 ml/g)?
A *124 ml
B 110 ml
C 118 ml
D 121 ml
E 126 ml.
13. Pharmacist compounded water extraction by the method of cold infusion. Choose the plant matherial:
A *Radices Altheae.
BCortex Frangulae
CFolia Menthae
DFolia Uvae ursi
EHerba Thermopsidis
14. Pharmacist compounded solution of Aethacridini lactas. Choose correct technology:
A *Dissolving in hot water
BDissolving in freshly distilled water
C Dissolving in cold water
DGrinding in the mortar with water
EDissolving in the solution of Kalii iodidi
15. Pharmacy reseived the prescription:
Rp.: Spiritus aethylici 20 ml
Resorcini 0,2
M.D.S. For skin rubbing
Choose correct technology:
A *Medicinal matter is weighed out in the vial for handling, then alcohol is measured.
BAlcohol is measured to the glass, then medicinal matter is weighed out.
CAlcohol is measured to the vial for handling, then Acidum bоricum is weighed out.
DMedicinal matter is weighed out to the glass then solvent is measured.
EMedicinal matter is grinded in the mortar, then solvent is added.
16. Pharmacist compounded solution by the prescription: Rp.: Sol. Formalini 30 %100 ml D.S. For shoes disinfection. Choose correct proportion of water and officinal (standard pharmacopoeia) solution:
A *70 ml and 30 ml
B 30 ml and 100 ml
C 20 ml and 80 ml
D 60 ml and 40 ml
E 67 ml and 33 ml
17. Pharmacist compounded suspension by the condensation method. Choose medicinal matters that form sediment:
A *Calcium chloride and Sodium hydrocarbonate
BCaffeine-sodium benzoate and Zinc oxide
CSodium bromide and Camphor
DPotassium bromide and Sodium benzoate
EMagnesia sulfate and Potassium iodide
18. Pharmacist compounded oil emulsion with Zinci oxydum. Chhose correct way of adding of medicinal matter:
A *Adding by the type of suspension into ready-made emulsion
BDissolution in oil
CGrinding with the water for diluting primary emulsion
DDissolving in the water for compounding of primary emulsion
EDissolving in the ready emulsion
19. Pharmacist compounded Oak bark (cortex Quercus) decoction. Choose the proportion of medicinal plant material and extractant:
A *1:10
B 1:400
C 1:30
D 1:20
E 1:5
20. . Pharmacist compounded infusion of Adonis herb. What is the feature of extraction technology?
A *Extraction is made in the neutral medium (neutral pH)
BExtraction is made in the weakly alkaline medium
CExtraction is made in the alkaline medium
DExtraction is made in the weakly acidic medium
EExtraction is made in the acidic medium
21. Pharmacy received the prescription for compounding of the infusion of Saponaria. What is the feature of saponines extraction?:
A * Extraction is made in the alkaline medium
BExtraction is made in the strongly acidic medium
CExtraction is made in the neutral medium
DMedium does not affect on extraction
EExtraction is made in the weakly acidic medium
22. Pharmacy received the prescription for compounding of the alcohol solution.
Rp.: Acidi salicylici 0,3
Spiritus aethylici 30 ml
Misce. Da. Signa. To wipe feet
What concentration of alcohol should be used?
A *70%
B 33%
C 95%
D 60%
E 80%
23. Pharmacist compounds100 g of oil emulsion. What amounts of oil end emulsifier (gelatos) should be used?
A *10,0 and 5,0
B 10,0 and 15,0
C 7,5 and 10,0
D 10,0 and 7,5
E 1,5 and 0,75
24. Pharmacist compounded suspension with Bismuthi subnitras. What method did he use?:
A *Method of dispersing with stearing-up technique
BMethod of physical condensation.
CMethod of chemical condensation.
DMethod of solvent change.
E Continental method.
25. Pharmacist compounds 100,0of oil emulsion. What amount of oil is needed if there are no doctor’s instructions?
A *10,0.
B 20,0
C 30,0
D 15,0
E 50,0
26. Solution of Potassium permanganate is needed to be compounded for patient. What solvent should be used in this case?
A * Fresh distilled purified water
BWater for injections
CAlcohol
DDemineralized water
EMint water
27. Pharmacist compounded mixture with 2.0 Sodium benzoate. What volume of 10% concentrated solution of Sodium benzoate did he use?
A * 20 ml.
B 2 ml.
C 8 ml.
D 10 ml.
E 12 ml.
28. For faster compounding of mixtures concentrated solutions are used. Calculate the volume of 5% Sodium hydrocarbonate solution needed for compounding of mixture with 2.0 g of medicinal matter.
A * 40 ml.
B 30 ml.
C 20 ml.
D 10 ml.
E 2, 5 ml.
29. Medicine is prescribed for patient by the prescription:
Rp.: Асіdi hydrochlorici 2%-100 ml
Da.Signa. 1 table spoon 3 times per day before meals.
What volume of Acidi hydrochlorici diluti (1:10) is necessary to measure for compounding of this medicine?
A *20 ml.
B 25 ml.
C 40 ml.
D 10 ml.
E 5 ml.
30. Medicine is prescribed for patient by the prescription:
Rp.: Sol. Асіdi borici spirituosae 3%-50 ml
Da.Signa. For gargling.
What concentration of alcohol should be used for this medicine compounding?
A * 70%
B 95 %
C 90 %
D 60 %
E 40 %
31. When suspension is compounded medicinal matter is grinded with small amount of liquid. Choose correct amount of liquid by the Deryagin’s rule for grinding 10 g of Zinci oxydum
A * 5 ml.
B 10 ml.
C 2 ml.
D 1 ml.
E 0,5 ml.
32. Stability of suspensions increases when substances that increase density of disperse environment are added. Choose the substance which has such properties.
A * Sugar syrup.
BPurified water.
CAlcohol.
DDimethylsulfoxidum.
ETriaethanolminum.
33. Doctor prescribed 300 g of cod-liver oil emulsion. What amount of cod-liver oil does pharmacist need to weigh-out for compounding this emulsion?
A * 30,0 g.
B60,0 g.
C15,0 g.
D3,0 g.
E 0,3 g
34. Pharmacist has compounded medicinal form by the prescription: Rp: Sol. Acidi acetici 3%-100ml D.S. For rubbing down. Choose correct amounts of officinal (standard pharmacopoeia) solution and water:
A *10 ml and 90 ml
B 3 ml and 100 ml
C 3 ml and 97 ml
D 15 ml and 85 ml
E 10 ml and 100 ml
35. Pharmacist has compounded infusion of Althea roots (Radices Altheae). What proportion of medicinal plant matherial and extractant has he used?
A *1:20
B 1:10
C 1:30
D 1:100
E 1:400
36. Water extractions of medical plant matherial (MPM) are compounded in the pharmacy. Choose the group of medicinal matters that are extracted in tightly closed infunder and collated after complete cooling?
A * essential oils
Balkaloids
Ccardiac glycosides
D tannins
E saponins
37. Pharmacist compounded infusion of Valerian rhizomes with roots (Rhizoma cum radicibus Valerianae). Choose correct proportion of medicinal plant material and extractant for compounding:
A * 1:30
B 1:400
C 1:10
D 1:20
E 1:40
38. Pharmacist compounded suspension with2 g of Streptocide. What amount of 5% solution of Methylcelulose is necessary to be used for suspension stabilisation?
A * 2,0
B 0,5
C 1,0
D 5,0
E 0,2
39. Pharmacist compounded 150.0 g of emulsion. What amount of oil did he tske if there are no instructions in the prescription?
A * 15,0
B 10,0
C 30,0
D 5,0
E 20,0
40. What amount of Aethacridini lactas should pharmacist weigh out for compounding of 200 ml of Aethacridini lactas solution (1:1000)?
A * 0,2
B 0,1
C 0,02
D 0,04
E 2,0
41. It is necessary to compound for patient suspension with 2.0 g of Menthol. What amount of 5% solution of Methylcellulose should be added for suspension stabilizing?
A * 4,0
B 0,5
C 1,0
D 0,4
E 2,0
42. Solution of Formalini 5%-100ml is prescribed. What amount of 37\% Formaldehidum should pharmacist use for compounding of solution.
A * 5 ml
B 12,5 ml
C 4,5 ml
D 10 ml
E 15 ml
43. In prescription mixture with 3.0 of Sodium benzoate is prescribed. Choose the correct amount of 10% solution-concentrate necessary for medicine compounding:
A * 30 ml
B 10 ml
C 20 ml
D 3 ml
E 5 ml
44. Pharmacist compounds suspension with 2.0 of Phenylii salysylas. Choose correct amount of 5% solution of Methylcellulose necessary for suspension stabilization:
A * 2,0
B 1,0
C 3,0
D 4,0
E 5,0
45. In prescription 100.0 of oil emulsion is prescribed. Choose amounts of oil, gelatos and purified water necessary for primary emulsion compounding according to Continental method:
A * 10,0; 5,0; 7,5 ml
B 20,0; 10,0; 30 ml
C 5,0; 10,0; 7,5 ml .
D 10,0; 5,0; 1,5 ml
E 5,0; 5,0; 5 ml .
46. Pharmacist compounded medicine according to prescription: Rp.: Sol. Protargoli 0,3% - 10 ml Glycerini 1,0 D.S. For irrigation. Choose correct technology:
A *Protargolum is grinded in the mortar with Glycerinum, then water is added.
BGlycerinum is dissolved in water and Protargolum is added.
CProtargolum is dissolved in the glass, then Glycerinum is added.
DProtargolum is weighed out in the vial, dissolved in water, then Glycerinum is added.
EProtargolum, water, Glycerinum are weighed out in the vial.
47. Pharmacist compounded suspension with hydrophobic substance. Choose the stabilizer of disperse system:
A *Twin-80
BSodium chloride
CSolution of Hydrochloric acid
DSolution of Sodium hydroxide
EEsylonum
48. For dosing of small amounts of liquids pipette is used. Choose number of drops in 1 ml of purified water according to standard pipette:
A 20
B 50
C 30
D 40
E 10
49. Patient doses mixture by the table spoon. Choose its volume:
A *15 ml
B 25 ml
C 10 ml
D 20 ml
E 5 ml
50. Doctor prescribed 100 ml of infusion with 0.25 g of Thermopsis herb. What amount of dry extract-concentrate should pharmacist weigh out?
A * 0,25 g
B 0,5 g
C 0,3 g
D0,2 g
E 0,1 g
51. Mint leaves (Folia Menthae) are handled for patient from pharmacy. What advices for compounding of infusion should pharmacist give to patient?
A * To compound the infusion in tightly closed pot
BTo compound the infusion on opened fire.
CTo compound the infusion at room temperature.
DTo collate extraction immediately after preparing.
EAfter 15 minutes of extraction to cool the infusion.
52. Solution with Boric acid and Camfor should be compounded for patient. What solvent should doctor prescribe for physical incompatibility prevention?
A * Alcohol 70%.
BPurified water.
CSunflower oil.
DGlycerin.
EAlcohol 40%.
53. Solution of Furacillini (1:5000) should be compounded in pharmacy. Choose the feature of dissolving of Furacillinum:
A * In boiling purified water with Sodium chloride
BIn cold purified water.
CIn minimal amount of alcohol.
DIn purified water after grinding
EIn pre-filtered purified water.
54. Mixture contains 3.0 of Sodium benzoate. What volume of 10% concentrated solution should be used?
A * 30 ml.
B 2 ml.
C 8 ml.
D 10 ml.
E 20 ml.
55. Solution of Hydrogen peroxide is handled from pharmacies in different concentrations. Solution of what concentration should be handled to patient if concentration is not denoted in the prescription?
A * 3%.
B 30 \%.
C 20 \%.
D 10 \%.
E 2 \%.
56. The medicine is prescribed for patient: Rp.: Sol. Liquoris Burovi 10\%-100 ml Da.Signa. Lotion. What volume of Liquoris Burovi should be measured for compounding this medicine?
A * 10 ml.
B 90 ml.
C 20 ml.
D 80 ml.
E 50 ml.
57. The mixture is prescribed for patient:Rp.: Sol. Асіdi hydrochlorici 2%-100 ml Da.Signa. 1 table spoon 3 t.p.d. before meals. What volume of Acidum hydrochloricum dilutum (1:10) should be measured for its compounding?
A * 20 ml.
B 25 ml.
C 15 ml.
D 10 ml.
E 5 ml.
58. 3% solution of Boric acid is prescribed for patient. What concentration of alcohol should be used for compounding of this solution?
A * 70%.
B 95 \%.
C 90 \%.
D 60 \%.
E 40 \%.
59. When suspension is compounded, medicinal matter is grinded with small amount of liquid. Choose correct volume of liquid according to Deryagin’s rule, that is necessary for grinding 20.0 g of Zinc oxide.
A * 10 ml.
B 5ml.
C 2ml.
D 1ml.
E 0,5 ml.
60. Stability of suspensions increases when substances that increase density of disperse environment are added. Choose the substance which has such properties.
A * Glycerin.
BPurified water.
CAlcohol.
DDimexidum
EEther.
61. The method of suspension compounding depends on properties of its components. Choose hydrophobic substances:
A * Camphor, Menthol.
BSodium hydrocarbonate, Sodium sulfate.
CBoric acid, Calcium carbonate.
DZink oxide, Talcum.
EBolus alba, Bentonite.
62. The doctor prescribed emulsion of Olive oil (Oleum olivarum) with Anaesthesinum. Choose the feature of adding Anaesthesinum:
A * To solve Anaesthesinum in oil before emulsion compounding
BTo solve Anaesthesinum in ready-made emulsion
CTo solve Anaesthesinum in purified waterу
DTo solve Anaesthesinum in primary emulsion.
ETo solve Anaesthesinum in alcohol, then add to primary emulsion
63. Althea roots infusion is compounded for patient. What regime of infusion should pharmacist use for this mixture compounding?
A * 30 minutes at room temrepature.
B 60 minutes at room temrepature.
C 15 minutes infusion in a water bath and 45 minutes cooling at room temrepature.
D 30 minutes infusion in a water bath and 10 minutes cooling at room temrepature.
E 30 minutes infusion in a water bath and immediate collating without cooling.
64. The doctor prescribed mixture with several types of medicinal plant material. Choose medicinal plant material that can be extracted in one infunder.
A * Mint leaves (Folia Menthae), Chamomile flowers (Flores Chamomillae).
BMint leaves (Folia Menthae), Folia Uvae ursi.
CMint leaves (Folia Menthae), Althea roots (Radices Altheae).
DMint leaves (Folia Menthae), Cortex Frangulae.
EMint leaves (Folia Menthae), Flax seeds (Semina Lini).
65. Pharmacy received the prescription for compounding of infusion. What medicinal plant material can be used for compounding of this medicinal form?
A * Rhizomes with roots of Valerian (Rhizomata cum radices Valerianae)
BRoots of Rheum (Radices Rhei)
COak bark (Cortex Quercus)
DViburnum bark (Cortex Viburni)
EFrangula bark (Cortex Frangulae)
66. According to doctor’s prescription in the pharmacy should be compounded emulsion with Phenylii salysilas in its composition. What is the correct way of adding of medicinal matter to the emulsion?
A * to grind according to the Deryagin’s rule with the ready-made emulsion
Bto grind with the emulsifier and oil
Cto dissolve in the ready-made emulsion
Dto dissolve in the water for diluting of primary emulsion
Eto dissolve in oil
67. Pharmacist compounded solution of Ichthyolum. Choose the feature of dissolving of Ichthyolum
ATo weigh out Ichthyolum in the porcelain cup, then add water with mixing, to collate to the vial
BTo weigh out Ichthyolum in tared vial, to add water, to filtrate
CTo weigh out Ichthyolum in tared mortar and to grind with water
DTo put water into the vial, to add Ichthyolum, to filtrate
ETo weigh out Ichthyolum in the glass, to add water, to dissolve and to collate to the vial
68. Emulsions as heterogeneous systems can flake under the influens of different factors. What factor causes flaking of emulsions faster then others?
A *Adding of strong electrolytes
BDiluting with water
CDiluting with oil
DAdding of an excess of emulsifier
E Adding of syrups
69. Pharmacist compounded medicine by the prescription:
Rp.: Acidi borici 0,1
Glycerini 10,0
M.D.S. Ear drops.
What technology should he choose?
A * To put to the vial for handling Boric acid, then Glycerin and to heat up