Comparison of 5FU and CPT Treated Cells

Comparison of 5FU and CPT treated cells

Rice University, August 2005

Authors

Rudy Guerra

David Rossell

Clayton Scott

2

COLON CANCER cDNA DATA

COMPARISON OF 5FU vs CPT TREATED CELLS

Table of contents

1 Methods 3

2 Wild type, 24 hours 4

3 Wild type, 48 hours 7

4 Wild type, 96 hours 11

5 Knockout type, 24 hours 20

6 Knockout type, 48 hours 25

7 Knockout type, 96 hours 28

1  Methods

For each spot the difference of mean normalized log-intensities between 5FU and CPT treated cells was used as the test statistic, estimating its standard deviation via David Scott’s L2E method for partial normal mixtures. Both unadjusted and adjusted P-values were obtained, the latter following the method of Benjamini & Hochberg to maintain the False Discovery Rate under 10%.

Results are presented in the form of a Normal QQ plot for the test statistics that indicates the number rejected null hypotheses both using unadjusted and adjusted P-values, as well as the 10 biggest values of the test statistic.

2  Wild type, 24 hours

2.1  Differences between treatments

acc t p rej.BH p.adj
NM_001964 -4.349857 1.362263e-05 TRUE 0.02021598
NM_000389 4.004988 6.202063e-05 TRUE 0.04601931
NM_001625 3.689264 2.249037e-04 FALSE 0.11125238
NM_002231 3.492367 4.787607e-04 FALSE 0.14311322
U02309 3.490461 4.821874e-04 FALSE 0.14311322
NM_006882 3.395044 6.861748e-04 FALSE 0.16336374
AK022745 3.361905 7.740677e-04 FALSE 0.16336374
NM_003992 3.326111 8.806671e-04 FALSE 0.16336374
NM_002432 3.091018 1.994717e-03 FALSE 0.31449391
NM_003258 3.072993 2.119231e-03 FALSE 0.31449391

2.2  Differential expression

The 2 replicates of the normalized log red/green ratios are labeled m1.nn, m2.nn, and the estimated red/green ratio is labeled rg.ratio.

·  FDR 10%

There were 32 differentially expressed genes in the 5FU arm and 19 in the CPT arm.

Differential expression for 5FU

acc rej.BH m1.nn m2.nn t p p.adj rg.ratio
NM_006009 TRUE 6.646 6.910 9.071 0.000 0.000 878.411
NM_001904 TRUE 5.662 5.737 7.628 0.000 0.000 298.763
NM_004346 TRUE 5.520 5.132 7.127 0.000 0.000 205.562
NM_004383 TRUE 5.016 4.784 6.558 0.000 0.000 134.302
BC018126 TRUE 4.482 4.638 6.103 0.000 0.000 95.594
NM_007313 TRUE 4.306 4.709 6.032 0.000 0.000 90.688
J04102 TRUE 4.221 4.475 5.819 0.000 0.000 77.332
NM_002046 TRUE 4.564 3.416 5.339 0.000 0.000 54.047
NM_001903 TRUE -3.444 -3.559 -4.686 0.000 0.000 0.030
M55379 TRUE 0.632 6.142 4.532 0.000 0.001 29.572
NM_003211 TRUE 0.361 6.343 4.485 0.000 0.001 28.552
NM_007314 TRUE 3.385 3.160 4.379 0.000 0.002 26.375
NM_004956 TRUE 3.277 3.257 4.372 0.000 0.002 26.231
NM_001101 TRUE 3.081 3.268 4.248 0.000 0.002 23.914
NM_004004 TRUE 3.497 2.850 4.247 0.000 0.002 23.891
NM_013964 TRUE 3.921 2.205 4.099 0.000 0.004 21.393
NM_012231 TRUE 2.857 2.745 3.749 0.000 0.017 16.462
NM_005163 TRUE 2.823 2.698 3.694 0.000 0.020 15.807
AL157713 TRUE 2.079 3.172 3.513 0.000 0.037 13.810
NM_001016 TRUE 2.871 2.363 3.503 0.000 0.037 13.698
NM_000165 TRUE 2.420 2.718 3.438 0.001 0.045 13.050
NM_006219 TRUE -1.503 -3.580 -3.401 0.001 0.047 0.079
X00173 TRUE -2.801 -2.282 -3.401 0.001 0.047 0.079
M77198 TRUE 2.653 2.413 3.390 0.001 0.047 12.592
NM_001987 TRUE 2.893 2.111 3.348 0.001 0.052 12.205
NM_003406 TRUE -2.714 -2.280 -3.341 0.001 0.052 0.082
NM_004360 TRUE 2.657 2.248 3.282 0.001 0.061 11.616
NM_001168 TRUE 3.935 0.861 3.210 0.001 0.076 11.005
NM_000612 TRUE -1.787 -2.946 -3.167 0.002 0.085 0.094
NM_001719 TRUE 2.211 2.492 3.146 0.002 0.089 10.498
NM_000038 TRUE 2.257 2.424 3.132 0.002 0.090 10.387
S82592 TRUE 2.058 2.573 3.098 0.002 0.098 10.126

Differential expression for CPT

acc rej.BH m1.nn m2.nn t p p.adj rg.ratio
NM_006009 TRUE 5.458 4.028 5.974 0.000 0.000 114.796
NM_001904 TRUE 4.303 3.215 4.734 0.000 0.002 42.892
NM_004346 TRUE -4.082 -3.345 -4.677 0.000 0.002 0.024
NM_004383 TRUE 3.650 3.466 4.481 0.000 0.003 35.089
BC018126 TRUE -2.563 -4.019 -4.145 0.000 0.011 0.037
NM_007313 TRUE -3.862 -2.585 -4.060 0.000 0.014 0.040
J04102 TRUE -2.778 -3.429 -3.909 0.000 0.020 0.045
NM_002046 TRUE 3.949 2.251 3.905 0.000 0.020 22.198
NM_001903 TRUE 2.810 2.994 3.655 0.000 0.047 18.212
NM_032977 TRUE -2.741 -2.952 -3.585 0.000 0.051 0.058
NM_003211 TRUE 3.396 2.291 3.581 0.000 0.051 17.175
NM_007314 TRUE -2.858 -2.754 -3.534 0.000 0.053 0.060
NM_004956 TRUE -1.901 -3.701 -3.528 0.000 0.053 0.061
NM_001101 TRUE -2.589 -2.927 -3.473 0.001 0.054 0.063
NM_004004 TRUE 1.415 4.077 3.459 0.001 0.054 15.581
NM_013964 TRUE -2.500 -2.989 -3.457 0.001 0.054 0.064
NM_012231 TRUE 3.196 2.285 3.452 0.001 0.054 15.496
NM_005163 TRUE 3.494 1.921 3.410 0.001 0.060 14.986
AL157713 TRUE -2.251 -2.938 -3.268 0.001 0.094 0.075

3  Wild type, 48 hours

3.1  Differences between treatments

acc t p rej.BH p.adj
NM_000389 5.541621 2.996835e-08 TRUE 4.714022e-05
NM_001273 4.570109 4.874708e-06 TRUE 3.833958e-03
NM_002231 4.388630 1.140671e-05 TRUE 5.018450e-03
NM_002129 -4.364156 1.276148e-05 TRUE 5.018450e-03
X66087 -3.691517 2.229201e-04 TRUE 5.138201e-02
NM_005245 3.686596 2.272738e-04 TRUE 5.138201e-02
NM_006721 3.685053 2.286548e-04 TRUE 5.138201e-02
NM_000259 -3.554549 3.786276e-04 TRUE 7.444765e-02
NM_002999 3.487723 4.871530e-04 TRUE 8.514351e-02
NM_005343 -3.323514 8.889084e-04 FALSE 1.398253e-01

3.2  Differential expression

The 2 replicates of the normalized log red/green ratios are labeled m1.nn, m2.nn, and the estimated red/green ratio is labeled rg.ratio.

·  FDR 10%

There were 74 differentially expressed genes in the 5FU arm and 31 in the CPT arm.

Differential expression for 5FU

acc rej.BH m1.nn m2.nn t p p.adj rg.ratio
NM_006009 TRUE 7.670 8.699 12.008 0.000 0.000 3585.539
NM_001904 TRUE 5.870 5.043 8.005 0.000 0.000 234.267
NM_004346 TRUE 4.859 5.191 7.372 0.000 0.000 152.143
NM_004383 TRUE 4.828 4.731 7.012 0.000 0.000 119.074
BC018126 TRUE 4.209 4.813 6.618 0.000 0.000 91.004
NM_007313 TRUE 4.382 4.505 6.519 0.000 0.000 85.081
J04102 TRUE 3.920 4.147 5.917 0.000 0.000 56.441
NM_002046 TRUE 3.854 3.983 5.749 0.000 0.000 50.331
NM_001903 TRUE 3.819 3.762 5.561 0.000 0.000 44.285
NM_032977 TRUE -3.248 -3.012 -4.592 0.000 0.001 0.044
M55379 TRUE 3.095 2.963 4.444 0.000 0.001 20.678
NM_003211 TRUE 3.118 2.921 4.430 0.000 0.001 20.480
NM_007314 TRUE 3.448 2.476 4.346 0.000 0.002 19.339
NM_004956 TRUE 3.131 2.480 4.116 0.000 0.005 16.535
NM_001101 TRUE 2.742 2.824 4.083 0.000 0.005 16.173
NM_004004 TRUE -2.721 -2.673 -3.957 0.000 0.008 0.067
NM_013964 TRUE 2.462 2.731 3.810 0.000 0.014 13.422
NM_012231 TRUE -4.503 -0.630 -3.766 0.000 0.015 0.077
NM_005163 TRUE -2.577 -2.520 -3.739 0.000 0.015 0.078
AL157713 TRUE -2.233 -2.864 -3.739 0.000 0.015 0.078
NM_001016 TRUE 2.378 2.666 3.700 0.000 0.017 12.451
NM_000165 TRUE 2.385 2.533 3.607 0.000 0.023 11.692
NM_006219 TRUE 2.601 2.273 3.575 0.000 0.024 11.437
X00173 TRUE -2.623 -2.249 -3.574 0.000 0.024 0.088
NM_001200 TRUE 2.221 2.576 3.519 0.000 0.028 11.008
M77198 TRUE -2.425 -2.364 -3.513 0.000 0.028 0.091
NM_001987 TRUE 2.280 2.489 3.498 0.000 0.029 10.852
NM_003406 TRUE 2.898 1.769 3.423 0.001 0.036 10.314
NM_004360 TRUE 2.224 2.407 3.397 0.001 0.039 10.132
NM_001168 TRUE 2.408 2.144 3.339 0.001 0.044 9.736
NM_000612 TRUE 1.963 2.585 3.336 0.001 0.044 9.718
NM_001719 TRUE 2.625 1.917 3.332 0.001 0.044 9.689
NM_000038 TRUE 2.146 2.386 3.324 0.001 0.044 9.638
S82592 TRUE -2.129 -2.368 -3.298 0.001 0.047 0.106
NM_004183 TRUE 2.215 2.267 3.288 0.001 0.048 9.405
NM_005607 TRUE 2.419 2.039 3.270 0.001 0.049 9.288
NM_004050 TRUE -1.965 -2.459 -3.245 0.001 0.052 0.110
NM_000876 TRUE 2.086 2.296 3.214 0.001 0.056 8.943
NM_001530 TRUE -2.316 -2.058 -3.209 0.001 0.056 0.112
NM_001654 TRUE -2.184 -2.178 -3.199 0.001 0.056 0.113
NM_013986 TRUE 1.836 2.523 3.198 0.001 0.056 8.844
NM_006009 TRUE 2.572 1.774 3.188 0.001 0.056 8.785
NM_000201 TRUE -2.052 -2.266 -3.167 0.002 0.059 0.115
NM_004049 TRUE 2.220 2.049 3.131 0.002 0.065 8.452
NM_000596 TRUE -1.971 -2.244 -3.092 0.002 0.069 0.122
NM_003921 TRUE -2.440 -1.776 -3.092 0.002 0.069 0.122
NM_001664 TRUE -2.237 -1.977 -3.091 0.002 0.069 0.122
NM_005245 TRUE -2.116 -2.097 -3.090 0.002 0.069 0.122
NM_002046 TRUE 2.037 2.151 3.072 0.002 0.072 8.115
NM_000210 TRUE -2.129 -2.033 -3.053 0.002 0.075 0.125
NM_000597 TRUE 2.427 1.694 3.023 0.003 0.080 7.851
NM_014226 TRUE -2.194 -1.920 -3.018 0.003 0.080 0.128
NM_004040 TRUE -1.961 -2.147 -3.013 0.003 0.080 0.128
NM_005246 TRUE 2.725 1.373 3.006 0.003 0.081 7.761
NM_001101 TRUE -1.912 -2.171 -2.996 0.003 0.082 0.130
NM_000213 TRUE -2.267 -1.776 -2.965 0.003 0.088 0.132
NM_032992 TRUE -2.142 -1.899 -2.964 0.003 0.088 0.133
M35878 TRUE 2.004 2.025 2.955 0.003 0.088 7.496
NM_003219 TRUE 1.330 2.699 2.955 0.003 0.088 7.495
NM_005167 TRUE -1.986 -2.003 -2.926 0.003 0.094 0.136
NM_005246 TRUE -1.749 -2.234 -2.922 0.003 0.094 0.136
NM_001016 TRUE -2.293 -1.667 -2.905 0.004 0.095 0.138
X16841 TRUE -0.772 -3.187 -2.904 0.004 0.095 0.138
NM_033340 TRUE 2.051 1.905 2.902 0.004 0.095 7.230
NM_001720 TRUE 1.939 2.007 2.894 0.004 0.095 7.191
NM_021913 TRUE 1.906 2.038 2.893 0.004 0.095 7.186
NM_003406 TRUE 1.853 2.082 2.886 0.004 0.095 7.151
NM_002205 TRUE -1.843 -2.091 -2.886 0.004 0.095 0.140
NM_033357 TRUE 2.047 1.866 2.871 0.004 0.097 7.078
NM_000599 TRUE 1.982 1.929 2.869 0.004 0.097 7.069
NM_004689 TRUE 1.912 1.989 2.862 0.004 0.098 7.034
NM_000633 TRUE -1.133 -2.751 -2.850 0.004 0.099 0.143
NM_002007 TRUE 1.702 2.181 2.848 0.004 0.099 6.969
NM_004183 TRUE 1.766 2.110 2.844 0.004 0.100 6.946

4  Wild type, 96 hours

4.1  Differences between treatments

acc t p rej.BH p.adj
D13804 -6.765253 1.330767e-11 TRUE 2.247665e-08
NM_002649 -5.587211 2.307453e-08 TRUE 1.948644e-05
NM_001668 5.484539 4.145485e-08 TRUE 2.333908e-05
NM_002353 -5.332919 9.664617e-08 TRUE 4.080885e-05
NM_001530 -5.103448 3.335209e-07 TRUE 1.126634e-04
NM_003371 4.995623 5.864600e-07 TRUE 1.365646e-04
NM_000946 -4.991150 6.002098e-07 TRUE 1.365646e-04
NM_002915 -4.942289 7.721053e-07 TRUE 1.365646e-04
NM_002575 -4.937148 7.927336e-07 TRUE 1.365646e-04
NM_003452 4.933292 8.085533e-07 TRUE 1.365646e-04
NM_002194 4.663057 3.115457e-06 TRUE 4.783642e-04
U37251 4.583986 4.561942e-06 TRUE 6.420933e-04
M85079 4.441258 8.943449e-06 TRUE 1.161960e-03
NM_000059 -4.404180 1.061846e-05 TRUE 1.201796e-03
X07109 -4.401594 1.074587e-05 TRUE 1.201796e-03
NM_002846 -4.389050 1.138468e-05 TRUE 1.201796e-03
NM_001664 4.288443 1.799296e-05 TRUE 1.787653e-03
NM_001768 -4.240823 2.227021e-05 TRUE 2.089688e-03
NM_001381 -4.226317 2.375468e-05 TRUE 2.111666e-03
NM_007315 -4.067808 4.745737e-05 TRUE 4.007775e-03
NM_001101 4.012446 6.009279e-05 TRUE 4.732220e-03
NM_001459 -4.006446 6.163934e-05 TRUE 4.732220e-03
NM_005043 -3.992359 6.541926e-05 TRUE 4.804049e-03
NM_000246 -3.944801 7.986612e-05 TRUE 5.543307e-03
U34821 -3.938332 8.205014e-05 TRUE 5.543307e-03
NM_002999 3.910114 9.225255e-05 TRUE 5.992868e-03
X65551 -3.829259 1.285297e-04 TRUE 8.040246e-03
NM_002231 3.813984 1.367442e-04 TRUE 8.248608e-03
NM_005004 3.798405 1.456304e-04 TRUE 8.481715e-03
BC009206 3.789447 1.509830e-04 TRUE 8.500343e-03
NM_003037 -3.749874 1.769235e-04 TRUE 9.547268e-03
NM_002756 3.741244 1.831119e-04 TRUE 9.547268e-03
NM_001458 -3.736585 1.865363e-04 TRUE 9.547268e-03
NM_000378 -3.703080 2.129976e-04 TRUE 1.058097e-02
NM_018492 -3.680568 2.327153e-04 TRUE 1.114823e-02
NM_002290 3.675249 2.376177e-04 TRUE 1.114823e-02
NM_005245 3.657355 2.548314e-04 TRUE 1.163271e-02
NM_004417 3.650205 2.620311e-04 TRUE 1.164659e-02
AL117351 3.609500 3.067873e-04 TRUE 1.328625e-02
NM_001101 3.554871 3.781646e-04 TRUE 1.596800e-02
NM_004277 3.545919 3.912463e-04 TRUE 1.609849e-02
NM_000135 -3.539874 4.003178e-04 TRUE 1.609849e-02
NM_001168 -3.512173 4.444592e-04 TRUE 1.745794e-02
NM_001101 3.496764 4.709387e-04 TRUE 1.807763e-02
NM_003454 -3.485400 4.914014e-04 TRUE 1.844393e-02
NM_003440 -3.473668 5.133968e-04 TRUE 1.864875e-02
NM_002916 -3.470784 5.189409e-04 TRUE 1.864875e-02
NM_007306 -3.437093 5.879932e-04 TRUE 2.069001e-02
NM_002895 -3.430108 6.033408e-04 TRUE 2.079679e-02
NM_003557 -3.423998 6.170715e-04 TRUE 2.084468e-02
NM_001101 3.393047 6.911976e-04 TRUE 2.289084e-02
NM_033360 -3.377301 7.320080e-04 TRUE 2.361786e-02
NM_003886 -3.368949 7.545539e-04 TRUE 2.361786e-02
NM_002229 3.368749 7.551003e-04 TRUE 2.361786e-02
NM_005204 -3.360395 7.783111e-04 TRUE 2.390123e-02
NM_004324 -3.347080 8.166772e-04 TRUE 2.463157e-02
NM_001065 3.291030 9.982136e-04 TRUE 2.920631e-02
NM_005205 -3.289701 1.002940e-03 TRUE 2.920631e-02
NM_005343 -3.276952 1.049342e-03 TRUE 2.999623e-02
NM_004050 -3.269984 1.075535e-03 TRUE 2.999623e-02
NM_002007 3.267937 1.083345e-03 TRUE 2.999623e-02
NM_004791 -3.252508 1.143916e-03 TRUE 3.116248e-02
U56402 3.245905 1.170780e-03 TRUE 3.138805e-02
NM_000110 -3.241007 1.191083e-03 TRUE 3.139503e-02
NM_002448 -3.236933 1.208216e-03 TRUE 3.139503e-02
NM_004448 -3.222478 1.270870e-03 TRUE 3.252271e-02
NM_032996 3.171091 1.518677e-03 TRUE 3.793403e-02
NM_001715 3.167270 1.538776e-03 TRUE 3.793403e-02
BC007323 -3.165211 1.549703e-03 TRUE 3.793403e-02
NM_004956 -3.155312 1.603263e-03 TRUE 3.868444e-02
Y14330 -3.134924 1.718986e-03 TRUE 4.042018e-02
NM_007229 -3.134229 1.723063e-03 TRUE 4.042018e-02
NM_001436 -3.082605 2.051970e-03 TRUE 4.747640e-02
NM_003170 -3.075294 2.102949e-03 TRUE 4.799839e-02
NM_021132 -3.065523 2.172896e-03 TRUE 4.847809e-02
NM_000489 -3.060618 2.208811e-03 TRUE 4.847809e-02
NM_000222 -3.059434 2.217554e-03 TRUE 4.847809e-02
NM_002422 -3.056580 2.238775e-03 TRUE 4.847809e-02
K01884 3.041210 2.356291e-03 TRUE 5.005230e-02
NM_004024 3.036895 2.390288e-03 TRUE 5.005230e-02
NM_000136 3.035625 2.400377e-03 TRUE 5.005230e-02
NM_006586 -3.028433 2.458253e-03 TRUE 5.059057e-02
NM_004544 3.025029 2.486097e-03 TRUE 5.059057e-02
AF123344 -3.014336 2.575424e-03 TRUE 5.178442e-02
NM_004530 -3.003316 2.670549e-03 TRUE 5.306537e-02
NM_002166 -2.991150 2.779285e-03 TRUE 5.441613e-02
NM_005394 2.988559 2.802962e-03 TRUE 5.441613e-02
NM_021833 2.976874 2.912038e-03 TRUE 5.589127e-02
NM_000976 -2.966141 3.015626e-03 TRUE 5.722913e-02
AF012128 -2.958921 3.087185e-03 TRUE 5.793617e-02
BC001061 -2.937636 3.307247e-03 TRUE 6.138395e-02
AB010420 2.933225 3.354608e-03 TRUE 6.158623e-02
NM_001273 2.923181 3.464756e-03 TRUE 6.253598e-02
NM_013387 2.921778 3.480392e-03 TRUE 6.253598e-02
M12824 2.918017 3.522652e-03 TRUE 6.262905e-02
NM_002732 -2.908555 3.631034e-03 TRUE 6.365214e-02
NM_005923 -2.906449 3.655570e-03 TRUE 6.365214e-02
NM_001744 -2.889050 3.864078e-03 TRUE 6.659620e-02
NM_002710 2.882157 3.949628e-03 TRUE 6.738304e-02
NM_002999 2.866687 4.147924e-03 TRUE 7.005844e-02
NM_005354 2.857850 4.265218e-03 TRUE 7.129902e-02
NM_001456 -2.854844 4.305802e-03 TRUE 7.129902e-02
NM_001788 2.830242 4.651283e-03 TRUE 7.505707e-02
NM_002733 -2.829534 4.661584e-03 TRUE 7.505707e-02
NM_000591 2.829226 4.666070e-03 TRUE 7.505707e-02
BC005127 2.821498 4.779987e-03 TRUE 7.563361e-02
NM_005430 2.817726 4.836510e-03 TRUE 7.563361e-02
NM_005437 2.815698 4.867137e-03 TRUE 7.563361e-02
AF091214 -2.814782 4.881032e-03 TRUE 7.563361e-02
NM_000976 -2.810201 4.951062e-03 TRUE 7.602130e-02
NM_004702 -2.806266 5.011931e-03 TRUE 7.602563e-02
NM_002353 -2.804379 5.041368e-03 TRUE 7.602563e-02
NM_001013 -2.793686 5.211105e-03 TRUE 7.788987e-02
U72938 2.775168 5.517312e-03 TRUE 8.174333e-02
NM_006235 -2.768358 5.633948e-03 TRUE 8.274555e-02
NM_016733 -2.745424 6.043271e-03 TRUE 8.767535e-02
NM_005230 -2.743791 6.073425e-03 TRUE 8.767535e-02
NM_002350 -2.739118 6.160420e-03 TRUE 8.817754e-02
NM_001530 2.733860 6.259670e-03 TRUE 8.850364e-02
NM_005248 -2.732056 6.294037e-03 TRUE 8.850364e-02
NM_080918 -2.729637 6.340403e-03 TRUE 8.850364e-02
NM_003036 -2.718566 6.556562e-03 TRUE 9.077077e-02
X83006 -2.705565 6.818823e-03 TRUE 9.363408e-02
NM_002090 2.695628 7.025601e-03 TRUE.569549e-02

4.2  Differential expression

The 2 replicates of the normalized log red/green ratios are labeled m1.nn, m2.nn, and the estimated red/green ratio is labeled rg.ratio.

·  FDR 10%

There were 90 differentially expressed genes in the 5FU arm and 57 in the CPT arm.

Differential expression for 5FU

acc rej.BH m1.nn m2.nn t p p.adj rg.ratio
NM_006009 TRUE -4.786 -6.227 -7.785 0.000 0.000 0.004
NM_001904 TRUE -5.546 -5.080 -7.512 0.000 0.000 0.005
NM_004346 TRUE -5.101 -5.239 -7.309 0.000 0.000 0.006
NM_004383 TRUE 4.292 4.933 6.522 0.000 0.000 100.770
BC018126 TRUE -4.036 -4.731 -6.198 0.000 0.000 0.012
NM_007313 TRUE -4.401 -4.252 -6.117 0.000 0.000 0.013
J04102 TRUE -4.250 -4.324 -6.062 0.000 0.000 0.014
NM_002046 TRUE -3.634 -4.336 -5.634 0.000 0.000 0.019
NM_001903 TRUE 3.668 3.903 5.352 0.000 0.000 44.047
NM_032977 TRUE -3.741 -3.561 -5.162 0.000 0.000 0.026
M55379 TRUE -3.623 -3.568 -5.083 0.000 0.000 0.027
NM_003211 TRUE -3.743 -3.446 -5.082 0.000 0.000 0.027
NM_007314 TRUE -3.552 -3.464 -4.959 0.000 0.000 0.030
NM_004956 TRUE 3.966 2.997 4.922 0.000 0.000 32.500
NM_001101 TRUE 3.679 3.230 4.884 0.000 0.000 31.632
NM_004004 TRUE -3.501 -3.206 -4.741 0.000 0.000 0.035
NM_006705 TRUE -3.135 -3.379 -4.605 0.000 0.000 0.039
NM_013964 TRUE 3.827 2.384 4.391 0.000 0.001 22.318
NM_012231 TRUE -3.840 -2.327 -4.360 0.000 0.001 0.046
NM_005163 TRUE -3.333 -2.829 -4.356 0.000 0.001 0.046
AL157713 TRUE -2.952 -3.087 -4.269 0.000 0.002 0.049
NM_001016 TRUE -3.189 -2.836 -4.259 0.000 0.002 0.049
NM_000165 TRUE 3.296 2.604 4.171 0.000 0.002 19.106
NM_006219 TRUE 3.061 2.777 4.127 0.000 0.003 18.523
X00173 TRUE -3.470 -2.136 -3.963 0.000 0.005 0.061
NM_001200 TRUE 2.832 2.749 3.945 0.000 0.005 16.285
M77198 TRUE -2.932 -2.582 -3.899 0.000 0.006 0.063
NM_001987 TRUE 2.576 2.925 3.889 0.000 0.006 15.656
NM_003406 TRUE -2.752 -2.689 -3.846 0.000 0.007 0.066
NM_004360 TRUE 2.110 3.217 3.766 0.000 0.009 14.345
NM_001168 TRUE 2.526 2.797 3.764 0.000 0.009 14.324
NM_000612 TRUE 3.241 2.083 3.764 0.000 0.009 14.323
NM_001719 TRUE -2.613 -2.605 -3.689 0.000 0.012 0.074
NM_000038 TRUE -2.726 -2.484 -3.683 0.000 0.012 0.074
S82592 TRUE 2.506 2.655 3.648 0.000 0.013 13.203
NM_004183 TRUE -2.801 -2.330 -3.627 0.000 0.014 0.077
NM_005607 TRUE 2.627 2.488 3.616 0.000 0.014 12.904
NM_004050 TRUE -2.604 -2.493 -3.603 0.000 0.014 0.078
NM_000876 TRUE 2.480 2.582 3.579 0.000 0.015 12.567
NM_001530 TRUE 2.595 2.417 3.543 0.000 0.017 12.253
NM_001654 TRUE -2.641 -2.293 -3.488 0.000 0.020 0.085
NM_013986 TRUE 2.661 2.270 3.486 0.000 0.020 11.769
NM_006009 TRUE 2.209 2.687 3.461 0.001 0.021 11.567
NM_000201 TRUE 2.410 2.476 3.454 0.001 0.021 11.509
NM_004049 TRUE 2.295 2.585 3.450 0.001 0.021 11.478
NM_000596 TRUE -2.237 -2.622 -3.435 0.001 0.022 0.088
NM_003921 TRUE -1.505 -3.344 -3.428 0.001 0.022 0.088
NM_001664 TRUE 2.406 2.417 3.409 0.001 0.023 11.146
NM_005245 TRUE 2.493 2.285 3.378 0.001 0.026 10.903
NM_002046 TRUE -2.236 -2.521 -3.363 0.001 0.026 0.093
NM_000210 TRUE 2.760 1.995 3.361 0.001 0.026 10.778
NM_004347 TRUE 2.421 2.325 3.355 0.001 0.026 10.730
NM_000597 TRUE -2.668 -2.062 -3.344 0.001 0.027 0.094
NM_014226 TRUE 2.349 2.371 3.337 0.001 0.027 10.590
NM_004040 TRUE 3.129 1.581 3.330 0.001 0.027 10.537
NM_005246 TRUE 2.348 2.311 3.293 0.001 0.030 10.271
NM_001101 TRUE -2.342 -2.314 -3.291 0.001 0.030 0.098
NM_000213 TRUE 2.229 2.401 3.273 0.001 0.032 10.124
NM_032992 TRUE 2.266 2.357 3.268 0.001 0.032 10.088
M35878 TRUE -2.231 -2.386 -3.263 0.001 0.032 0.099
NM_003219 TRUE -1.979 -2.602 -3.238 0.001 0.034 0.101
NM_005167 TRUE 1.952 2.597 3.216 0.001 0.036 9.723
NM_005246 TRUE 2.234 2.259 3.176 0.001 0.041 9.453
NM_001016 TRUE 2.357 2.097 3.149 0.002 0.044 9.272
X16841 TRUE 2.262 2.173 3.135 0.002 0.045 9.186
NM_033340 TRUE -1.150 -3.249 -3.110 0.002 0.049 0.111
NM_001552 TRUE -2.310 -2.060 -3.089 0.002 0.051 0.113
NM_001720 TRUE -2.349 -2.014 -3.084 0.002 0.051 0.113
NM_021913 TRUE -2.165 -2.195 -3.082 0.002 0.051 0.113
AL049634 TRUE -2.227 -2.112 -3.068 0.002 0.052 0.114
NM_003406 TRUE -2.140 -2.197 -3.066 0.002 0.052 0.114
NM_002205 TRUE 2.635 1.696 3.062 0.002 0.052 8.721
NM_033357 TRUE -2.210 -2.103 -3.049 0.002 0.054 0.116
NM_000599 TRUE 2.245 2.064 3.046 0.002 0.054 8.623
NM_004689 TRUE 1.883 2.394 3.023 0.003 0.057 8.483
NM_000633 TRUE -2.069 -2.193 -3.013 0.003 0.058 0.119
NM_002007 TRUE -2.174 -2.083 -3.009 0.003 0.058 0.119
NM_004183 TRUE 2.110 2.116 2.988 0.003 0.062 8.275
BC020057 TRUE 2.325 1.865 2.963 0.003 0.066 8.128
NM_001165 TRUE 1.916 2.271 2.960 0.003 0.066 8.112
NM_002178 TRUE 0.077 -4.261 -2.957 0.003 0.066 0.123
AL109614 TRUE 2.091 2.069 2.941 0.003 0.069 8.003
NM_005178 TRUE -2.576 -1.541 -2.911 0.004 0.075 0.128
NM_020996 TRUE -2.105 -1.940 -2.860 0.004 0.087 0.132
NM_002360 TRUE -1.932 -2.102 -2.852 0.004 0.088 0.133
NM_002880 TRUE 2.153 1.837 2.820 0.005 0.096 7.351
NM_000269 TRUE 2.279 1.707 2.817 0.005 0.096 7.334
D38503 TRUE -1.913 -2.062 -2.810 0.005 0.097 0.137
NM_006027 TRUE -1.900 -2.062 -2.801 0.005 0.097 0.138
NM_001935 TRUE -1.345 -2.617 -2.801 0.005 0.097 0.138

Differential expression for CPT