Electronic Supplementary Material
Supplement Table
Supplement TableDetailed patients’ characteristics and microbiological findings
Presented are demographic characteristics, admissions reasons, comorbidities duration and used antimicrobial treatment as well as microbiological findings including hemofilter results and dialysis data. CVVHD, continuous veno-venous hemodialysis; CoNS, coagulase-negative Staphylococci; CVI, central venous line; AD, admission day; AP, ascites puncture; S, serology; SD, study day – day of collection of hemofilters; APACHE II, Acute Physiology and Chronic Health Evaluation II score was calculated at ICU admission; SOFA, sequential organ failure assessment scores of the hemofilters sampling date; SLEDD, slow extended daily dialysis; TS, tracheal secretion; UC, urine culture; WS, wound swab; BAL, bronchoalveolar lavage; BC, blood culture.
1
Patient No.1 / 2 / 3 / 4 / 5
Gender, male / female / male / male / male / female / male
Age (years) / 48 / 71 / 48 / 75 / 74
Reason(s) for admission / aortic dissection / respiratory insufficiency / phlegmon/necrotic hand / respiratory insufficiency / pneumonia
ARDS / phlegmon / wound healing deficit / pneumonia / mitral valve repair
Comorbidities / hypertension / heart transplantation / chronic renal failure / left ventricular failure / hypertension
GERD / ESRD / cholecystitis / ESRD / chronic renal failure
SOFA score at SD / 6 / 12 / 12 / 12 / 11
APACHE II score at AD / 31 / 27 / 24 / 23 / 26
Mortality on ICU / no / yes / no / no / no
Vasoactive drugs at SD / none / norepin / norepin / none / epinephrin
Antibiotic treatment at SD / none / carbapeneme (8) / tetrazycline (9) / penicillin (4) / penicillin (5)
(# of days) / chinolone (12) / aminoglycoside (5)
antimycotica (6)
Duration between first antibiotic / 31 / 27 / 28 / 4 / 8
treatment and SD (days)
Dialysis / CCVHD citrat / CCVHD citrat / CCVHD citrat / CCVHD citrat / CCVHD heparin
All blood culture findings / Enterococcus / Staphylococcus epidermidis / Staphylococcus epidermidis, / - / Staphylococcus epidermidis
Staphylococcus aureus
Blood culture findings / Enterococcus / Staphylococcus epidermidis / Staphylococcus epidermidis / - / Staphylococcus epidermidis
(± 5 days SD)
Other microbiology findings / TS: Enterococcus, / TS: CoNS, Stenotrophomonas / BAL: Pseudomonas / CVI: CoNS, / CVI: Enterococcus
Candidaspp.,CoNS / Candidaspp. / CVI: Staphylococcus epidermidis / Enterococcus / BAL: Candidaspp.,
UC: Enterococcus / WS: CoNS / WS: Enterococcus / Enterococcus
Hemofilters findings / Enterococcus / negative / Enterococcus / Bacillus / negative
Classification / True positive / True positive / False positive
6 / 7 / 8 / 9 / 10 / 11
female / male / male / female / male / female
74 / 69 / 56 / 68 / 57 / 70
vegetation at / cardiogenic shock / respiratory insufficiency / ARDS / pulmonary and circulatory / acute left ventricular failure
pacemaker wire / pulmonary edema / lung transplantation / after abdominal surgery / deterioration / pneumonia
left ventricular failure / coronary heart disease / diarrhea / NYHA III-IV / NYHA III / aortic valvular stenosis
chronic renal failure / diabetes mellitus / peripheral arterial disease / hypertension / kidney transplantation / diabetes mellitus
13 / 16 / 11 / 9 / 5 / 6
30 / 28 / 27 / 20 / 19 / 20
no / yes / no / yes / no / no
norepin / norepin / norepin / norepin / none / norepin
epinephrin
glycopeptide (7) / cephalosporine (4) / glycopeptide (1) / penicillin (11) / none / penicillin (3)
carbapeneme (1) / others (2) / carbapeneme (1) / others (21) / glycopeptide (3)
aminoglycoside (7) / antimycotica (2)
others (2) / others (1)
7 / 4 / 1 / 48 / 27 / 22
CCVHD heparin / CCVHD citrat / SLEDD Genius heparin / SLEDD Genius citrate / SLEDD Genius heparin / SLEDD Genius heparin
- / - / - / Enterococcus, / Enterococcus / Enterococcus,
CoNS / Staph. haemol., CoNS
- / - / - / - / - / Enterococcus,
Staph. haemol.
CoNS
CVI: Pseudomonas, / TS: Enterococcus, / S: Clamydia / CVI: Enterococcus, / CVI: Serratia marcescens, / CVI: Enterococcus
CoNS / CoNS, Candida spp., / Pseudomonas, CoNS / CoNS / TS: Enterococcus
Klebsiella / WS: Pseudomonas / WS: Enterococcus, CoNS / BAL: Enterococcus
BAL: Enterococcus
negative / negative / Viridans streptococci / Bacillus / Bacillus / negative
True positive, unknown impact / False positive / False positive
12 / 13 / 14 / 15 / 16
male / male / female / female / male
59 / 43 / 63 / 71 / 44
sepsis due to diabetic ulcer / gastric perforation / rectal bleeding / septic shock / STEMI
pneumonia / respiratory insufficiency / liver cirrhosis / dental abscess / abdominal compartment syndrome
hepatic cirrhosis / gastric resection / stroke / atrial fibrillation / mitral valve
diabetes mellitus / chronic renal failure / Child C / insufficiency
9 / 13 / 12 / 16 / 11
15 / 28 / 17 / 26 / 28
no / no / no / no / no
norepin / norepin / none / norepin / norepin
penicillin (9) / tetracycline (3) / cephalosporine (2) / glycopeptide (1) / carbapeneme (4)
chinolone (9) / carbapeneme (1) / oxacolidinone (4)
others (9) / others (3)
9 / 9 / 13 / 3 / 17
SLEDD Genius heparin / SLEDD Genius heparin / CCVHD Genius / SLEDD Genius heparin / SLEDD Genius heparin
Staphylococcus aureus, / Staphylococcus epidermidis / - / Staphylococcus epidermidis / Candida albicans,
Bacteroides fragilis, / Staphylococcus epidermidis
Staphylococcus epidermidis
Staphylococcus epidermidis / - / - / - / -
CVI: Enterococcus, / CVI: Enterococcus / CVI: CoNS, / WS: Acinetobacter, / CVI: CoNS
Candidaspp. / AP: Enterococcus, CoNS / Enterococcus, / Streptococcus / BAL: Candidaspp.
AP: Enterococcus / BAL: Candida spp. / WS: Enterococcus, / BAL: CoNS,
TS: CoNS, Enterococcus / WS: Streptococcus / Candidaspp. / Candidaspp.
WS: S. aureus,
Enterococcus / Streptococcus / negative / negative / negative
True positive / True positive
1
1