Name: ______Per: ______
DNA WebQuest
Part A: DNA Replication
DNA Workshop – Replication and Protein Synthesis
1. Go to www.pbs.org/wgbh/aso/tryit/dna
2. Click “text version of activity”
3. Then click on “DNA Replication”, “All Wound Up” and “Protein Synthesis” as needed.
During what part of the cell cycle does DNA get replicated? ______
Unzip the DNA.
What kind of bonds are broken as the DNA “unzips”? ______
What breaks the rungs of the DNA ladder? ______
Where in the cell does DNA replication take place? ______
Which nitrogenous base does each of the following letters in the DNA molecule represent?
A ______C ______
G ______T ______
Match the bases to make two new DNA strands.
Which nitrogenous base does each of the following letters in the DNA molecule pair with?
A ______C ______
G ______T ______
How many base pairs does the Human Genome contain? ______
How many complete molecules of DNA do you begin with in DNA replication? ______
How many DNA molecules do you end up with? ______
Is the new DNA molecules completely new? Explain. ______
______
1. Go to http://nobelprize.org/educational_games/medicine/dna_double_helix/
2. Click on “Play DNA Game”; Click “next” and reading each page, continue to click next until you come to the game.; Click on organism #1 and match the base pairs as fast as you can! It is hard.
3. Click Next and then click on each organism until you identify the one that belongs to chromosome #1; continue playing the game with the other two chromosomes, filling in the chart below.
Be careful, other people may get different results.
Chromosome # / How many chromosomes? / How many base pairs? / How many genes? / What is the organism?1
2
3
Part B: DNA Transcription and Translation
From Gene to Protein
1. Go to http://learn.genetics.utah.edu/content/begin/dna/transcribe/
2. Press “Click here to begin!”
What is the two-step process by which cells read a gene and produce a string of amino acids that
will eventually become a protein is called: ______and ______
How are rules for pairing bases different in transcription than they were in replication? ______
______
How many genes does the Human Genome contain? ______
Use the keyboard to type in the corresponding base pairs to transcribe the section of DNA.
Describe transcription in your own words. ______
______
How is mRNA different from DNA? ______
______
What happens to DNA after transcription is complete? ______
Translate the mRNA into a protein.
Describe translation in your own words. ______
______
What is the correct starting position on mRNA for translation? ______
Write the amino acids used to assemble your protein in order below. ______
______
Where does translation take place? ______
Once assembled, what is the key to a protein’s unique function? ______
1. Go to: http://www.wisc-online.com/objects/index_tj.asp?objid=AP1302
2. Read the animation page by page – just click the “next” button when you are ready to move on.
How does the mRNA leave the nucleus? ______
Is just one mRNA molecule made? Explain.______
______
How many amino acids does each codon code for?______
Describe the structure of a tRNA molecule. ______
______
Can a single mRNA be read more than once? Explain. ______
______
Part C: Mutations
1. Go to http://evolution.berkeley.edu/evolibrary/article/mutations_01
2. In your own words, describe each type of mutation:
Substitution: ______
Insertion: ______
Deletion: ______
Frameshift: ______
Deletion: ______
What causes a mutation?
The effects of mutations
Where may mutations occur?
What are somatic mutations?
What are the effects of germ line mutations?
1.
2.
3.
What are Hox genes?
What is the effect of a mutation in the Hox gene?
Weird Fact: What happened to the fly with a H ox mutation?
Part D: EXTRA CREDIT
Go to http://learn.genetics.utah.edu/content/begin/dna/firefly/
Explain What Makes a Firefly Glow in your own words, using all of the words below:
RNA Polymerase LUC gene Transcription mRNA
Luciferase Enzyme Ribosome Translation Amino Acids
Three dimensional Luciferin Oxyluciferin
Functional Luciferase Enzyme
______