Supplementary Table for:

N. Baichoo, T. Wang, R. Ye, and J. D. Helmann. 2002. Global analysis of the Bacillus subtilis Fur Regulon and the Iron Starvation Stimulon. Molecular Microbiology.

Table 1S. Additional genes regulated by iron and/or by mutation of fur.1

Gene / dip/Fe / fur/wt (+Fe) / fur/wt (-Fe) / Function / Group
PerR regulon – derepressed by DP
ahpC / 2.1 / 1.1 / 1.4 / alkyl hydroperoxide reductase / H
ahpF / 2.7 / 1.3 / 0.81 / alkyl hydroperoxide reductase / H
katA / 2.9 / 0.93 / 0.66 / Vegetative catalase / H
mrgA / 2.6 / 0.79 / 0.58 / DNA-binding metalloregulated stress / H
Increased by DP treatment
bmrU / 2.5 / 0.74 / 0.08 / multidrug resistance protein / H
radC / 2.0 / 0.56 / 0.78 / Probable DNA repair protein / H
mmr / 2.2 / 0.79 / 0.70 / methylenomycin A resistance protein / H
htpG / 2.4 / 0.98 / 1.0 / class III heat-shock protein / H
nhaC / 2.1 / 0.59 / 0.74 / Na+/H+ antiporter / H
natA / 2.2 / 0.74 / 0.9 / Na+ ABC transporter / H
Decreased in fur mutant
dctP / 0.88 / 0.02 / 0.03 / C4-dicarboxylate transport protein / F
secY / 1.5 / 0.14 / 0.16 / preprotein translocase subunit / F
lctP / 0.81 / 0.16 / 0.19 / L-lactate permease / F

Decreased by DP treatment

citB / 0.31 / 0.18 / 0.63 / aconitate hydratase / E
citH / 0.55 / 0.74 / 0.83 / Divalent metal-citrate transport / D
gabP / 0.44 / 1.9 / 2.2 / 4-Aminobutyrate transport / D
czcD / 0.35 / 0.86 / 1.0 / cation-efflux membrane protein / D
Cytochromes and related functions
cydA / 0.42 / 0.08 / 0.72 / cytochrome bd ubiquinol oxidase (I) / E
cydB / 0.5 / 0.11 / 0.33 / cytochrome bd ubiquinol oxidase (II) / E
qcrA / 0.5 / 0.43 / 0.77 / cytochrome c oxidoreductase (Fe-S) / E
qcrB / 0.48 / 0.39 / 0.83 / cytochrome c oxidoreductase (cyt B) / E
ctaD / 0.46 / 0.6 / 1.4 / cytochrome caa3 oxidase (subunit I) / D
ctaF / 0.40 / 0.70 / 1.2 / cytochrome caa3 oxidase (subunit IV) / D
ctaG / 0.39 / 0.87 / 1.5 / function unknown / D
Increased in fur mutant / not strongly affected by DP
licA / 1.0 / 11.8 / 12.5 / PTS lichenan-specific enzyme IIA / B
licB / 1.2 / 12.6 / 9.5 / PTS lichenan-specific enzyme IIB / B
licC / 1.2 / 18 / 11.5 / PTS lichenan-specific enzyme IIC / B
licH / 1.3 / 17 / 13 / 6-phospho-beta-glucosidase / B
gltP / 0.84 / 6.0 / 4.7 / H+/glutamate symport protein / B
speA / 1.13 / 6.2 / 5.0 / arginine decarboxylase / B
yybf / 1.02 / 10 / 11 / similar to antibiotic resistance protein / B
yuxI / 1.19 / 6.4 / 3.7 / unknown / B
ytzE / 1.07 / 6.1 / - / similar to transcriptional regulator / B
yerD / 1.92 / 6.1 / 4.9 / similar to glutamate synthase (ferredoxin) / B
ydhR / 1.36 / 5.8 / 4.9 / similar to fructokinase / B

1 Effects that are greater than 2-fold are in bold. Group refers to the gene clusters noted in the Figure 1 legend.