European Journal of Nutrition - Electronic supplementary material

Challenges to estimate validity of dietary acrylamide measurements.

Pietro Ferrari, Heinz Freisling, Eric J Duell, Rudolf Kaaks, Leila Lujan-Barroso, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Laura Nailler, Silvia Polidoro, Amalia Mattiello, Domenico Palli, Rosario Tumino, Sara Grioni, Sven Knüppel, Anne Tjønneland, Anja Olsen, Kim Overvad, Philippos Orfanos, Michail Katsoulis, Antonia Trichopoulou, Jose Ramón Quirós, Eva Ardanaz, José María Huerta, Pilar Amiano Etxezarreta, María José Sánchez, Francesca Crowe, Kay-Tee Khaw, Nicholas J Wareham, Marga Ocke, Bas Bueno-de-Mesquita, Petra HM Peeters, Ulrika Ericson, Elisabet Wirfält, Göran Hallmans, Ingegerd Johansson, Dagrun Engeset, Geneviève Nicolas, Valentina Gallo, Teresa Norat, Elio Riboli, Nadia Slimani.

Pietro Ferrari (corresponding Author), Nutritional Epidemiology Group, International Agency for Research on Cancer, 150, cours Albert Thomas, 69372 Lyon Cedex 08, France; Tel +33(0)472738031, Fax +33(0)472738361; e-mail:

Online Resource 2. Country-specific individual level correlation coefficients between log-transformed values of dietary questionnaire (DQ), 24-hour dietary recall (R) measurements and Hb adducts of acrylamide (AA), glycidamide (GA), and their ratio (GA/AA), overall and by smoking status.

Country / Sample size / rDQ,R / rDQ,AA / rR,AA / rDQ,GA / rDQ,GA/AA
Alla
France / 30 / 0.25 (-0.12, 0.56) / 0.26 (-0.11, 0.57) / 0.48 (0.14, 0.72) / 0.19 (-0.18, 0.52) / -0.12 (-0.46, 0.25)
Italy / 60 / 0.19 (-0.07, 0.42) / -0.16 (-0.40, 0.10) / -0.09 (-0.34, 0.17) / -0.11 (-0.35, 0.15) / 0.06 (-0.20, 0.31)
Spain / 60 / 0.21 (-0.05, 0.44) / -0.03 (-0.28, 0.23) / 0.10 (-0.16, 0.35) / -0.15 (-0.39, 0.11) / -0.21 (-0.44, 0.05)
UK / 60 / 0.28 (0.03, 0.50) / 0.10 (-0.16, 0.35) / 0.17 (-0.09, 0.41) / 0.18 (-0.08, 0.41) / 0.14 (-0.12, 0.38)
The Netherlands / 60 / 0.25 (0.01, 0.47) / 0.21 (-0.05, 0.44) / 0.10 (-0.16, 0.35) / 0.32 (0.07, 0.53) / 0.15 (-0.11, 0.39)
Greece / 60 / 0.02 (-0.24, 0.27) / 0.10 (-0.16, 0.35) / -0.15 (-0.39, 0.11) / 0.10 (-0.16, 0.35) / 0.01 (-0.24, 0.26)
Germany / 60 / -0.02 (-0.27, 0.24) / 0.01 (-0.24, 0.26) / 0.07 (-0.19, 0.32) / 0.08 (-0.18, 0.33) / 0.15 (-0.11, 0.39)
Sweden / 60 / 0.25 (0.01, 0.47) / 0.11 (-0.15, 0.35) / 0.15 (-0.11, 0.39) / 0.13 (-0.13, 0.37) / 0.06 (-0.20, 0.31)
Denmark / 60 / 0.23 (-0.03, 0.46) / 0.19 (-0.07, 0.42) / -0.01 (-0.26, 0.24) / 0.15 (-0.11, 0.39) / -0.08 (-0.33, 0.18)
Totalb / 510 / 0.17 (0.08, 0.25) / 0.08 (-0.01, 0.17) / 0.06 (-0.03, 0.15) / 0.09 (0.01, 0.18) / 0.01 (-0.08, 0.09)
Never smokersc
France / 15 / 0.24 (0.31, 0.67) / 0.40 (-0.14, 0.76) / 0.42 (-0.12, 0.77) / 0.47 (-0.06, 0.79) / -0.01 (-0.52, 0.50)
Italy / 30 / 0.18 (-0.19, 0.51) / -0.14 (-0.48, 0.23) / -0.17 (-0.50, 0.20) / -0.17 (-0.50, 0.20) / -0.14 (-0.48, 0.23)
Spain / 30 / 0.35 (-00.1, 0.63) / 0.17 (-0.20, 0.50) / 0.23 (-0.14, 0.55) / -0.13 (-0.47, 0.24) / -0.36 (-0.64, 0.01)
UK / 30 / 0.29 (-0.08, 0.59) / 0.13 (-0.24, 0.47) / 0.20 (-0.17, 0.52) / 0.21 (-0.16, 0.53) / 0.14 (-0.23, 0.48)
The Netherlands / 30 / 0.24 (-0.13, 0.55) / 0.01 (-0.35, 0.37) / -0.32 (-0.61, 0.05) / 0.02 (-0.34, 0.38) / 0.02 (-0.34, 0.38)
Greece / 30 / 0.01 (-0.35, 0.37) / 0.24 (-0.13, 0.55) / -0.18 (-0.51, 0.19) / 0.15 (-0.22, 0.48) / -0.07 (-0.42, 0.30)
Germany / 30 / -0.07 (-0.42, 0.30) / -0.16 (-0.49, 0.21) / 0.20 (-0.17, 0.52) / -0.10 (-0.44, 0.27) / 0.08 (-0.29, 0.43)
Sweden / 30 / 0.49 (0.16, 0.72) / 0.15 (-0.22, 0.48) / 0.22 (-0.15, 0.54) / 0.15 (-0.22, 0.48) / 0.03 (-0.33, 0.39)
Denmark / 30 / 0.29 (-0.08, 0.59) / 0.07 (-0.30, 0.42) / -0.11 (-0.45, 0.26) / -0.08 (-0.43, 0.29) / -0.28 (-0.58, 0.09)
Totald / 255 / 0.19 (0.07, 0.31) / 0.09 (-0.03, 0.21) / 0.02 (-0.10, 0.14) / 0.03 (-0.09, 0.15) / -0.09 (-0.21, 0.03)
Smokersc
France / 15 / 0.32 (-0.23, 0.72) / 0.33 (-0.22, 0.72) / 0.30 (-0.25, 0.70) / 0.06 (-0.47, 0.56) / -0.25 (-0.68, 0.30)
Italy / 30 / 0.25 (-0.12, 0.56) / -0.20 (-0.52, 0.17) / -0.01 (-0.37, 0.35) / -0.05 (-0.40, 0.32) / 0.37 (0.01, 0.64)
Spain / 30 / 0.11 (-0.26, 0.45) / -0.13 (-0.47, 0.24) / -0.06 (-0.41, 0.31) / -0.11 (-0.45, 0.26) / -0.03 (-0.39, 0.33)
UK / 30 / 0.28 (-0.09, 0.58) / 0.13 (-0.24, 0.47) / 0.16 (-0.21, 0.49) / 0.22 (-0.15, 0.54) / 0.16 (-0.21, 0.49)
The Netherlands / 30 / 0.22 (-0.15, 0.54) / 0.35 (-0.01, 0.63) / 0.39 (0.03, 0.66) / 0.48 (0.14, 0.72) / 0.23 (-0.14, 0.55)
Greece / 30 / 0.08 (-0.29, 0.43) / -0.08 (-0.43, 0.29) / -0.08 (-0.43, 0.29) / 0.01 (-0.35, 0.37) / 0.19 (-0.18, 0.52)
Germany / 30 / 0.05 (-0.32, 0.40) / 0.16 (-0.21, 0.49) / 0.03 (-0.33, 0.39) / 0.23 (-0.14, 0.55) / 0.22 (-0.15, 0.54)
Sweden / 30 / 0.05 (-0.32, 0.40) / 0.07 (-0.30, 0.42) / 0.07 (-0.30, 0.42) / 0.10 (-0.27, 0.44) / 0.06 (-0.31, 0.41)
Denmark / 30 / 0.24 (-0.13, 0.55) / 0.23 (-0.14, 0.55) / 0.10 (-0.27, 0.44) / 0.29 (-0.08, 0.59) / 0.11 (-0.26, 0.45)
Totald / 255 / 0.16 (0.04, 0.28) / 0.08 (-0.04, 0.20) / 0.09 (-0.03, 0.21) / 0.14 (0.02, 0.26) / 0.11 (-0.01, 0.23)

aUsing the residual method, data were adjusted by energy intake, alcohol intake, smoking status, number of cigarettes; bAs in (a) with additional adjustment by country; cUsing smoking status-specific residual models, data were adjusted by energy intake, alcohol intake, number of cigarettes (in smokers only); dAs in (c) with additional adjustment by country.