Supplementary data - EJCL-D-16-00573
Table S1: Genetic predictors of response to methotrexate treatment
Genes / Genotypes / Responders(n=132) / Non-Responders (n=57) / p value* / OR / 95% CI
HLA-A2 / Positive / 86 / 41 / 0.46 / 0.73 / 0.37 - 1.44
Negative / 46 / 16
HLA-B17 / Positive / 87 / 37 / 0.89 / 1.05 / 0.54 - 2.01
Negative / 45 / 20
HLA-Cw6 / HO / 34 / 6 / 0.004 / 4.47 / 1.66- 12.06
HT / 60 / 21 / 0.031 / 2.26 / 1.13 - 4.50
W / 38 / 30
IL-12B
(rs3212227) / TT / 68 / 24 / 0.02 / 2.83 / 1.25 - 6.42
GT / 47 / 16 / 0.03 / 2.94 / 1.22 - 7.08
GG / 17 / 17
IL-23R
(rs2201841) / CC / 41 / 17 / 0.49 / 1.46 / 0.64 - 3.35
CT / 63 / 23 / 0.27 / 1.66 / 0.77 - 3.59
TT / 28 / 17
IL-23R
(rs10889677) / CC / 28 / 10 / 0.96 / 1.13 / 0.47 - 2.70
AC / 47 / 24 / 0.62 / 0.79 / 0.40 - 1.58
AA / 57 / 23
IL-23R
(rs11805303) / CC / 36 / 18 / 0.97 / 0.91 / 0.42 - 1.96
CT / 50 / 18 / 0.66 / 1.27 / 0.60 - 2.68
TT / 46 / 21
IFN-γ
(rs2430561) / TT / 20 / 7 / 0.97 / 0.98 / 0.37 - 2.64
AT / 48 / 28 / 0.17 / 0.59 / 0.30 - 1.15
AA / 64 / 22
IL-2
(rs2069762) / TT / 25 / 8 / 0.64 / 1.46 / 0.53 - 4.04
GT / 77 / 35 / 0.95 / 1.03 / 0.49 - 2.17
GG / 30 / 14
IL-4
(rs2243250) / TT / 3 / 1 / 0.85 / 0.80 / 0.08 - 8.30
CT / 80 / 43 / 0.07 / 0.49 / 0.24 - 1.01
CC / 49 / 13
IL10 (rs1800896) / CC / 5 / 3 / 0.81 / 0.61 / 0.14 - 2.70
CT / 37 / 21 / 0.27 / 0.65 / 0.33 - 1.26
TT / 90 / 33
IL-10
(rs1800871) / CC / 26 / 9 / 0.68 / 1.40 / 0.52 - 3.76
CT / 77 / 34 / 0.97 / 1.09 / 0.51 - 2.33
TT / 29 / 14
TNFAIP3
(rs610604) / GG / 19 / 4 / 0.16 / 2.64 / 0.82 - 8.48
GT / 59 / 23 / 0.37 / 1.43 / 0.74 - 2.75
TT / 54 / 30
TNIP1
(rs17728338) / AA / 15 / 5 / 0.85 / 1.11 / 0.37 - 3.37
AG / 47 / 26 / 0.31 / 0.67 / 0.35 - 1.30
GG / 70 / 26
FOXP3
(rs3761548) / AA / 48 / 8 / 0.003 / 3.67 / 1.59 - 8.47
AC / 12 / 5 / 0.68 / 1.47 / 0.48 - 4.45
CC / 72 / 44
LCE3C/3B
Deletion / del/del / 68 / 16 / 0.01 / 2.69 / 1.33 - 5.45
del/int / 15 / 10 / 0.91 / 0.95 / 0.38 - 2.37
int/int / 49 / 31
*p < 0.005 considered statistically significant after adjusting for multiple testing.