Rendeiro AF, Schmidl C, Strefford JC, Walewska R, Davis Z, Farlik M, Oscier D, Bock C

Haematology

Rendeiro AF, Schmidl C, Strefford JC, Walewska R, Davis Z, Farlik M, Oscier D, Bock C.

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks

Nat Commun. 2016 Jun 27;7:11938. doi: 10.1038/ncomms11938.

Robles EF, Mena-Varas M, Barrio L, Merino-Cortes SV, Balogh P, Du MQ, Akasaka T, Parker A, Roa S, Panizo C, Martin-Guerrero I, Siebert R, Segura V, Agirre X, Macri-Pellizeri L, Aldaz B, Vilas-Zornoza A, Zhang S, Moody S, Calasanz MJ, Tousseyn T, Broccardo C, Brousset P, Campos-Sanchez E, Cobaleda C, Sanchez-Garcia I, Fernandez-Luna JL, Garcia-Muñoz R, Pena E, Bellosillo B, Salar A, Baptista MJ, Hernandez-Rivas JM, Gonzalez M, Terol MJ, Climent J, Ferrandez A, Sagaert X, Melnick AM, Prosper F, Oscier DG, Carrasco YR, Dyer MJ, Martinez-Climent JA.

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.

Nat Commun. 2016 Jun 14;7:11889. doi: 10.1038/ncomms11889.

Br J Haematol. 2016 Jun 13. doi: 10.1111/bjh.14172. [Epub ahead of print]

Type C TP53-CDKN1A pathway dysfunction occurs independently of CDKN1A gene polymorphisms in chronic lymphocytic leukaemia and is associated with TP53 abnormalities.

Tracy I, Tapper W, Parker A, Gardiner A, Sadullah S, Pratt G, Copplestone A, Oscier D, Best OG.

Balaji A, Mercer R, Mainwaring J.

Venous thromboembolism: a role for weight-stratified thromboprophylaxis?

Clin Med (Lond). 2015 Dec;15(6):598-9. doi: 10.7861/clinmedicine.15-6-598a.

Quek L, Otto GW, Garnett C, Lhermitte L, Karamitros D, Stoilova B, Lau IJ, Doondeea J, Usukhbayar B, Kennedy A, Metzner M, Goardon N, Ivey A, Allen C, Gale R, Davies B, Sternberg A, Killick S, Hunter H, Cahalin P, Price A, Carr A, Griffiths M, Virgo P, Mackinnon S, Grimwade D, Freeman S, Russell N, Craddock C, Mead A, Peniket A, Porcher C2, Vyas P.

Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.

J Exp Med. 2016 Jul 25;213(8):1513-35. doi: 10.1084/jem.20151775. Epub 2016 Jul 4.

Eyre TA, Clifford R, Bloor A, Boyle L, Roberts C, Cabes M, Collins GP, Devereux S, Follows G, Fox CP, Gribben J, Hillmen P, Hatton CS, Littlewood TJ, McCarthy H, Murray J, Pettitt AR, Soilleux E, Stamatopoulos B, Love SB, Wotherspoon A, Schuh A.

NCRI phase II study of CHOP in combination with ofatumumab in induction and maintenance in newly diagnosed Richter syndrome.

Br J Haematol. 2016 Jul 5. doi: 10.1111/bjh.14177. [Epub ahead of print]

Parry M, Rose-Zerilli MJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker A, Davis Z, Gardiner A, McIver-Brown N, Kalpadakis C, Xochelli A, Anagnostopoulos A, Fazi C, Gonzalez de Castro D, Dearden C, Pratt G, Rosenquist R, Ashton-Key M, Forconi F, Collins A, Ghia P, Matutes E, Pangalis G, Stamatopoulos K, Oscier D Strefford JC.

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.

Clin Cancer Res. 2015 Sep 15;21(18):4174-83. doi: 10.1158/1078-0432.CCR-14-2759. Epub 2015 Mar 16.

Navrkalova V, Young E, Baliakas P, Radova L, Sutton LA, Plevova K, Mansouri L, Ljungström V, Ntoufa S, Davies Z, Juliusson G, Smedby KE, Belessi C, Panagiotidis P, Touloumenidou T, Davi F, Langerak AW, Ghia P, Strefford JC, Oscier D, Mayer J, Stamatopoulos K, Pospisilova S, Rosenquist R, Trbusek M.

ATM mutations in major stereotyped subsets of chronic lymphocytic leukemia: enrichment in subset #2 is associated with markedly short telomeres.

Haematologica. 2016 Jun 16. pii: haematol.2016.142968. [Epub ahead of print]

Larrayoz M, Blakemore SJ, Dobson RC, Blunt MD , Rose-Zerilli MJ, Walewska R, Duncombe A, Oscier D, Koide K, Forconi F, Packham G, Yoshida M, Cragg MS, Strefford JC, Steele AJ.

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.

Leukemia. 2016 Feb;30(2):351-60. doi: 10.1038/leu.2015.286. Epub 2015 Oct 21.

Fonte E, Agathangelidis A, Reverberi D, Ntoufa S, Scarfò L, Ranghetti P, Cutrona G, Tedeschi A, Xochelli A, Caligaris-Cappio F, Ponzoni M, Belessi C, Davis Z Piris MA, Oscier D, Ghia P, Stamatopoulos K, Muzio M.

Toll-like receptor stimulation in splenic marginal zone lymphoma can modulate cell signaling, activation and proliferation.

Haematologica. 2015 Nov;100(11):1460-8. doi: 10.3324/haematol.2014.119933. Epub 2015 Aug 20.

Parry M, Rose-Zerilli MJ, Ljungström V, Gibson J, Wang J, Walewska R, Parker H, Parker A, Davis Z, Gardiner A, McIver-Brown N, Kalpadakis C, Xochelli A, Anagnostopoulos A, Fazi C, Gonzalez de Castro D, Dearden C, Pratt G, Rosenquist R, Ashton-Key M, Forconi F, Collins A, Ghia P, Matutes E, Pangalis G, Stamatopoulos K, Oscier D, Strefford JC

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.

Clin Cancer Res. 2015 Sep 15;21(18):4174-83. doi: 10.1158/1078-0432.CCR-14-2759. Epub 2015 Mar 16

Mead AJ, Milojkovic D, Knapper S, Garg M, Chacko J, Farquharson M, Yin J, Ali S, Clark RE, Andrews C, Dawson MK, Harrison C.

Response to ruxolitinib in patients with intermediate-1-, intermediate-2-, and high-risk myelofibrosis: results of the UK ROBUST Trial.

Br J Haematol. 2015 Jul; 170(1):29-39.

doi: 10.1111/bjh.13379. Epub 2015 Mar 30

Roy NB, Myerson S, Schuh AH, Bignell P, Patel R, Wainscoat JS, McGowan S, Marchi E, Atoyebi W, Littlewood T, Chacko J, Vyas P, Killick SB.

Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes.

Br J Haematol. 2011 Aug; 154(4):521-4.

doi: 10.1111/j.1365-2141.2011.08749.x. Epub 2011 Jun 21

Dimopoulos M, Cheung M, Roussell M, Liu T, Gamberi B, Kolb B, Derigs H, Eom H, Belhad K, Lenain P, van der Jagt R, Rigaudeau S, Dib M, Hall R et al.

Impact of Renal Impairment (RI) on Outcomes after Treatment (Tx) with Lenalidomide and Low-Dose Dexamethasone (Rd) in Newly Diagnosed Multiple Myeloma (NDMM) Patients (Pts): FIRST Trial Results.

Blood 2014; 124 (21): 2112

Hall R, Lasebai M, Radvan J, Patel R, Wechalekar A.

Cardiac AL Amyloid; a single centre experience in incidence and outcome.

Clinical Lymphoma, Myeloma and Leukaemia. S1, 2013.

Chacko J, Boyce S, Killick S, Hall R, McCarthy H, Walewska R, Wallis L.

Are outcomes worse for patients with Polycythaemia vera (PV) compared with polycythaemia of undetermined cause?

Blood 2013; 122 (21): 4079.

Gordon Cook, Effie Liakopoulou, Rachel Pearce, Jim Cavet, Gareth J Morgan, Keiren Kirkland, Julia Lee, Faith E Davies, Rachel Hall, Amin Rahemtulla, Nigel Russell, David I Marks.

Factors influencing the outcome of a second autologous stem cell transplant (ASCT) in relapsed multiple myeloma: A study from the British Society of Blood and Marrow Transplantation Registry.

Biol Blood Marrow Transplant 2011; 17 (11):1638-1645

doi: 10.1016/j.bbmt.2011.04.005. Epub 2011 Apr 23.

Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hill A, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A, Marsh JC; British Society for Standards in Haematology.

Guidelines for the diagnosis and management of adult aplastic anaemia.

Br J Haematol. 2015 Nov 16. doi: 10.1111/bjh.13853. [Epub ahead of print]

Bello E, Pellagatti A, Shaw J, Mecucci C, Kušec R, Killick S, Giagounidis A, Raynaud S, Calasanz MJ, Fenaux P, Boultwood J.

CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q)

Br J Haematol. 2015 Jun 18.

doi: 10.1111/bjh.13563. [Epub ahead of print]

Gerstung M, Pellagatti A, Malcovati L, Giagounidis A, Porta MG, Jädersten M, Dolatshad H, Verma A, Cross NC, Vyas P, Killick S, Hellström-Lindberg E, Cazzola M, Papaemmanuil E, Campbell PJ, Boultwood J.

Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes,

Nat Commun. 2015 Jan 9; 6:590.

doi: 10.1038/ncomms6901

Killick SB, Carter C, Culligan D, Dalley C, Das-Gupta E, Drummond M, Enright H, Jones GL, Kell J, Mills J, Mufti G, Parker J, Raj K, Sternberg A, Vyas P, Bowen D; British Committee for Standards in Haematology.

Guidelines for the diagnosis and management of adult myelodysplastic syndromes.

Br J Haematol. 2014 Feb; 164(4):503-25.

doi: 10.1111/bjh.12694. Epub 2013 Dec 23

Pellagatti A, Benner A, Mills KI, Cazzola M, Giagounidis A, Perry J, Malcovati L, Della Porta MG, Jädersten M, Verma A, McDonald EJ, Killick S, Hellström-Lindberg E, Bullinger L, Wainscoat JS, Boultwood J.

Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes.

J Clin Oncol. 2013 Oct 1; 31(28):3557-64.

doi: 10.1200/JCO.2012.45.5626. Epub 2013 Sep 3

Fernandez-Mercado M, Burns A, Pellagatti A, Giagounidis A, Germing U, Agirre X, Prosper F, Aul C, Killick S, Wainscoat JS, Schuh A, Boultwood J.

Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del(5q) myelodysplastic syndromes.

Haematologica. 2013 Dec; 98(12):1856-64.

doi: 10.3324/haematol.2013.086686. Epub 2013 Jul 5

Fernandez-Mercado M, Yip BH, Pellagatti A, Davies C, Larrayoz MJ, Kondo T, Pérez C, Killick S, McDonald EJ, Odero MD, Agirre X, Prósper F, Calasanz MJ, Wainscoat JS, Boultwood J.

Mutation patterns of 16 genes in primary and secondary acute myeloid leukemia (AML) with normal cytogenetics.

PLoS One. 2012; 7(8):e42334.

doi: 10.1371/journal.pone.0042334. Epub 2012 Aug 9.

Marsh JC, Bacigalupo A, Schrezenmeier H, Tichelli A, Risitano AM, Passweg JR, Killick SB, Warren AJ, Foukaneli T, Aljurf M, Al-Zahrani HA, Höchsmann B, Schafhausen P, Roth A, Franzke A, Brummendorf TH, Dufour C, Oneto R, Sedgwick P, Barrois A, Kordasti S, Elebute MO, Mufti GJ, Socie G; European Blood and Marrow Transplant Group Severe Aplastic Anaemia Working Party.

Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party.

Blood. 2012 Jun 7; 119(23):5391-6. doi: 10.1182/blood-2012-02-407684. Epub 2012 Apr 27. Erratum in: Blood. 2013 Jun 20;121(25):5104.

Larrayoz M, Blakemore SJ, Dobson RC, Blunt MD, Rose-Zerilli MJ,Walewska R, Duncombe A, Oscier D, Koide K, Forconi F, Packham G, Yoshida M, Cragg MS, Strefford JC, Steele AJ.

Leukemia. 2015 Oct 21.

The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.

doi: 10.1038/leu.2015.286. [Epub ahead of print]

Parry M, Rose-Zerilli MJ, Ljungström V, Gibson J, Wang J,Walewska R, Parker H, Parker A, Davis Z, Gardiner A, McIver-Brown N, Kalpadakis C, Xochelli A, Anagnostopoulos A, Fazi C, Gonzalez de Castro D, Dearden C, Pratt G, Rosenquist R, Ashton-Key M, Forconi F, Collins A, Ghia P, Matutes E, Pangalis G, Stamatopoulos K, Oscier D, Strefford JC.

Genetics and Prognostication in Splenic Marginal Zone Lymphoma: Revelations from Deep Sequencing.

Clin Cancer Res. 2015 Sep 15;21(18):4174-83.

doi: 10.1158/1078-0432.CCR-14-2759. Epub 2015 Mar 16.

Parry M, Rose-Zerilli MJ, Gibson J, Ennis S,Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC.

Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.

PLoS One. 2013 Dec 13;8(12):e83244.

doi: 10.1371/journal.pone.0083244. eCollection 2013.