Supplementary TableIMain effect of SNPs in one-carbon metabolism genes on NHL risk in Australia: SNPs for which little indication of a statistically significant association with NHL
All NHL / Follicular / DLBCLSNPs / Controls
(n=506) / Cases
(n=561) / OR (95% CI) a / P / Cases
(n=211) / OR (95% CI) a / P / Cases
(n=180) / OR (95% CI) a / P
CBS Ex9+33C>T (Y233Y)
CC / 223 (44.6) / 242 (43.4) / Ref. / 94 (44.6) / Ref. / 78 (43.6) / Ref.
CT / 224 (44.8) / 251 (45.0) / 1.09 (0.84-1.41) / 0.54 / 93 (44.1) / 1.05 (0.74-1.51) / 0.76 / 85 (47.5) / 1.19 (0.82-1.72) / 0.37
TT / 53 (10.6) / 65 (11.7) / 1.20 (0.80-1.81) / 0.38 / 24 (11.4) / 1.18 (0.68-2.05) / 0.56 / 16 (8.9) / 0.92 (0.49-1.72) / 0.79
CT/TT / 277 (55.4) / 316 (56.6) / 1.11 (0.86-1.42) / 0.42 / 117 (55.5) / 1.08 (0.77-1.51) / 0.66 / 101 (56.4) / 1.13 (0.79-1.62) / 0.49
Trend / 1.09 (0.91-1.31) / 0.35 / 1.08 (0.84-1.38) / 0.56 / 1.04 (0.79-1.35) / 0.80
CBS Ex13+41C>T (A360A)
CC / 188 (39.1) / 214 (39.1) / Ref. / 79 (38.2) / Ref. / 65 (53.1) / Ref.
CT / 224 (46.6) / 272 (49.7) / 1.05 (0.81-1.37) / 0.72 / 100 (48.3) / 1.05 (0.73-1.50) / 0.80 / 94 (53.1) / 1.17 (0.80-1.70) / 0.41
TT / 69 (14.4) / 61 (11.2) / 0.72 (0.48-1.09) / 0.12 / 28 (13.5) / 0.88 (0.52-1.50) / 0.64 / 18 (10.2) / 0.65 (0.35-1.21) / 0.17
TC/TT / 293 (60.9) / 333 (60.9) / 0.97 (0.76-1.26) / 0.84 / 128 (61.8) / 1.01 (0.72-1.42) / 0.96 / 112 (63.3) / 1.05 (0.73-1.51) / 0.79
Trend / 0.91 (0.75-1.09) / 0.29 / 0.97 (0.76-1.24) / 0.78 / 0.91 (0.70-1.19) / 0.48
FTHFD Ex10-40G>T
GG / 343 (68.2) / 373 (67.1) / Ref. / 151 (72.6) / Ref. / 114 (63.3) / Ref.
GT / 150 (29.8) / 168 (30.2) / 1.04 (0.80-1.36) / 0.77 / 50 (24.0) / 0.76 (0.52-1.12) / 0.17 / 62 (34.4) / 1.32 (0.91-1.92) / 0.14
TT / 10 (2.0) / 15 (2.7) / 1.50 (0.66-3.41) / 0.33 / 7 (3.4) / 2.11 (0.76-5.90) / 0.15 / 4 (2.2) / NCb
GT/TT / 160 (31.8) / 183 (32.9) / 1.07 (0.82-1.39) / 0.62 / 57 (27.4) / 0.83 (0.58-1.20) / 0.33 / 66 (36.6) / 1.31 (0.91-1.89) / 0.14
Trend / 1.09 (0.86-1.38) / 0.47 / 0.93 (0.67-1.29) / 0.67 / 1.26 (0.91-1.74) / 0.17
MTHFS IVS2-14111T>G
TT / 200 (40.2) / 223 (40.4) / Ref. / 83 (39.9) / Ref. / 72 (40.5) / Ref.
TG / 219 (44.1) / 246 (44.6) / 0.98 (0.75-1.28) / 0.87 / 89 (42.8) / 0.99 (0.69-1.43) / 0.97 / 86 (48.3) / 1.01 (0.69-1.47) / 0.96
GG / 78 (15.7) / 83 (15.0) / 0.96 (0.67-1.39) / 0.84 / 36 (17.3) / 1.18 (0.73-1.91) / 0.51 / 20 (11.2) / 0.71 (0.40-1.26) / 0.24
TG/GG / 297 (59.8) / 329 (59.6) / 0.97 (0.76-1.25) / 0.83 / 125 (60.1) / 1.04 (0.74-1.46) / 0.82 / 106 (59.6) / 0.93 (0.65-1.33) / 0.69
Trend / 0.98 (0.82-1.17) / 0.82 / 1.07 (0.84-1.35) / 0.59 / 0.89 (0.69-1.15) / 0.36
MTR Ex26-20A>G
AA / 304 (60.2) / 364 (65.1) / Ref. / 139 (65.8) / Ref. / 116 (64.4) / Ref.
AG / 180 (35.6) / 173 (31.0) / 0.82 (0.63-1.06) / 0.13 / 65 (30.8) / 0.82 (0.58-1.18) / 0.29 / 54 (30.0) / 0.79 (0.54-1.16) / 0.23
GG / 21 (4.2) / 22 (3.9) / 0.87 (0.46-1.62) / 0.65 / 7 (3.3) / 0.66 (0.27-1.63) / 0.37 / 10 (5.6) / 1.40 (0.63-3.12) / 0.42
AG/GG / 201 (39.8) / 195 (34.9) / 0.82 (0.64-1.06) / 0.13 / 72 (34.1) / 0.81 (0.57-1.14) / 0.22 / 64 (35.6) / 0.85 (0.59-1.22) / 0.38
Trend / 0.86 (0.70-1.07) / 0.17 / 0.82 (0.61-1.10) / 0.19 / 0.94 (0.69-1.28) / 0.70
SHMT1 Ex12+138C>T
CC / 251 (50.4) / 252 (45.6) / Ref. / 96 (45.9) / Ref. / 82 (46.3) / Ref.
CT / 195 (39.2) / 236 (42.7) / 1.21 (0.93-1.57) / 0.15 / 88 (42.1) / 1.15 (0.81-1.64) / 0.44 / 73 (41.2) / 1.18 (0.81-1.72) / 0.39
TT / 52 (10.4) / 65 (11.8) / 1.29 (0.86-1.94) / 0.22 / 25 (12.0) / 1.29 (0.74-2.23) / 0.37 / 22 (12.4) / 1.35 (0.77-2.40) / 0.30
CT/TT / 247 (49.6) / 301 (54.4) / 1.23 (0.96-1.57) / 0.10 / 113 (54.1) / 1.18 (0.84-1.64) / 0.33 / 95 (53.7) / 1.22 (0.85-1.73) / 0.28
Trend / 1.16 (0.97-1.39) / 0.11 / 1.14 (0.89-1.46) / 0.30 / 1.17 (0.90-1.51) / 0.24
SLC19A1 Ex4-254T>C
CC / 166 (33.5) / 187 (33.8) / Ref. / 70 (33.5) / Ref. / 54 (30.3) / Ref.
CT / 248 (50.1) / 272 (49.2) / 0.96 (0.73-1.27) / 0.79 / 107 (51.2) / 1.01 (0.70-1.46) / 0.96 / 94 (52.8) / 1.14 (0.77-1.69) / 0.52
TT / 81 (16.4) / 94 (17.0) / 1.00 (0.69-1.44) / 0.99 / 32 (15.3) / 0.92 (0.55-1.53) / 0.75 / 30 (16.9) / 1.03 (0.61-1.76) / 0.90
CT/TT / 329 (66.5) / 366 (66.2) / 0.97 (0.75-1.26) / 0.83 / 139 (66.5) / 0.99 (0.70-1.41) / 0.95 / 124 (69.7) / 1.11 (0.76-1.62) / 0.58
Trend / 0.99 (0.83-1.19) / 0.94 / 0.97 (0.76-1.24) / 0.80 / 1.04 (0.80-1.34) / 0.79
TCN1 IVS+372T>C
TT / 284 (57.6) / 290 (53.1) / Ref. / 105 (51.0) / Ref. / 92 (51.7) / Ref.
TC / 172 (34.9) / 221 (40.5) / 1.27 (0.98-1.66) / 0.07 / 86 (41.8) / 1.39 (0.98-1.98) / 0.07 / 77 (43.3) / 1.39 (0.96-2.00) / 0.08
CC / 37 (7.5) / 35 (6.4) / 0.94 (0.57-1.54) / 0.81 / 15 (7.3) / 1.05 (0.54-2.03) / 0.88 / 9 (5.1) / 0.80 (0.37-1.74) / 0.57
TC/CC / 209 (42.4) / 256 (46.9) / 1.21 (0.95-1.56) / 0.13 / 101 (49.0) / 1.33 (0.95-1.86) / 0.10 / 86 (48.3) / 1.28 (0.90-1.83) / 0.16
Trend / 1.10 (0.90-1.34) / 0.34 / 1.17 (0.90-1.52) / 0.24 / 1.11 (0.84-1.47) / 0.46
aadjusted for age, sex, state of residence and ethnicity
bNC: not calculated for sparse data.
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Supplementary Table IICase-control frequencies by MTHFREx5+79 (a.k.a., 677)genotype from Caucasian studiesused in meta-analyses
All NHL / Cases / ControlsNo / Author / Year / Country / CC / CT / TT / Total / CC / CT / TT / Total
1 / Gonzalez Ordonez / 2000 / Spain / 21 / 21 / 5 / 47 / 92 / 88 / 20 / 200
2 / Lincz / 2003 / Australia / 73 / 58 / 17 / 148 / 145 / 133 / 21 / 299
3 / Toffoli / 2003 / Italy / 44 / 49 / 18 / 111 / 147 / 233 / 85 / 465
4 / Linnebank / 2004 / Germany / 13 / 12 / 6 / 31 / 66 / 52 / 24 / 142
5 / Gemmati / 2004 / Italy / 60 / 101 / 39 / 200 / 78 / 128 / 51 / 257
6 / Skibola / 2004 / US / 122 / 160 / 52 / 334 / 288 / 350 / 84 / 722
7 / Rudd / 2004 / UK / 361 / 381 / 90 / 832 / 383 / 397 / 106 / 886
8 / Lightfoot / 2005 / UK / 247 / 270 / 72 / 589 / 356 / 316 / 83 / 755
9 / Deligezer / 2006 / Turkey / 31 / 30 / 5 / 66 / 66 / 72 / 16 / 154
10 / Niclot / 2006 / French / 66 / 86 / 20 / 172 / 92 / 88 / 24 / 204
11 / Timuragaoglu / 2006 / Turkey / 31 / 22 / 5 / 58 / 36 / 36 / 10 / 82
12 / Lim / 2006 / US / 499 / 477 / 127 / 1,103 / 443 / 396 / 86 / 925
13 / Our study / Australia / 253 / 227 / 74 / 554 / 256 / 190 / 57 / 503
All Caucasian Studies / 4,245 / 5,594
European Origin / 4,121 / 5,358
DLBCL
1 / Lincz / 2003 / Australia / 37 / 25 / 10 / 72 / 145 / 133 / 21 / 299
2 / Skibola / 2004 / US / 37 / 51 / 19 / 107 / 288 / 350 / 84 / 722
3 / Lightfoot / 2005 / UK / 119 / 118 / 33 / 270 / 356 / 316 / 83 / 755
4 / Lim / 2006 / US / 152 / 156 / 35 / 343 / 443 / 396 / 86 / 925
5 / Our study / Australia / 77 / 85 / 17 / 179 / 256 / 190 / 57 / 503
Total / 971 / 3,204
FL
1 / Lincz / 2003 / Australia / 21 / 20 / 6 / 47 / 145 / 133 / 21 / 299
2 / Skibola / 2004 / US / 44 / 55 / 23 / 122 / 288 / 350 / 84 / 722
3 / Lightfoot / 2005 / UK / 82 / 101 / 24 / 207 / 356 / 316 / 83 / 755
4 / Lim / 2006 / US / 131 / 100 / 33 / 264 / 443 / 396 / 86 / 925
5 / Our study / Australia / 107 / 69 / 33 / 209 / 256 / 190 / 57 / 503
Total / 849 / 3,204
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