Supplementary Table 2.List of Mutations, Detected by Targeted Sequencing Analysis

Supplementary Table 2.List of mutations, detected by targeted sequencing analysis.

Sample ID / Annotated gene / Mutation type / RefSeq / Nucleotide change / Amino Acid Change / VAFs in tumors / VAFs in cell-free DNAs at diagnosis
PTCL14 / DNMT3A / Nonsynonymous / NM_175629 / c.T2264C / p.F755S / 0.270 / 0.116
PTCL14 / TET2 / Nonsynonymous / NM_001127208 / c.A3443G / p.Y1148C / 0.181 / 0.140
PTCL94 / DNMT3A / Nonsynonymous / NM_175629 / c.G2645T / p.R882H / 0.311 / 0.527
PTCL94 / IDH2 / Nonsynonymous / NM_002168 / c.G515A / p.R172K / 0.066 / 0.015
PTCL94 / RHOA / Nonsynonymous / NM_001614 / c.G50T / p.G17V / 0.041 / 0.018
PTCL163 / IDH2 / Nonsynonymous SNV / NM_002168 / c.A514G / p.R172G / 0.153 / 0.016
PTCL163 / RHOA / Nonsynonymous / NM_001614 / c.G50T / p.G17V / 0.130 / 0.022
PTCL163 / TET2 / Frameshift deletion / NM_001127208 / c.822delC / p.I274fs / 0.178 / 0.021
PTCL163 / TET2 / Stopgain / NM_001127208 / c.C1648T / p.R550X / 0.174 / 0.017
PTCL232 / RHOA / Nonsynonymous / NM_001614 / c.G50T / p.G17V / 0.173 / 0.108
PTCL232 / TET2 / Nonsynonymous / NM_001127208 / c.3812dupG / p.C1271fs / 0.369 / 0.204
PTCL234 / DNMT3A / Nonsynonymous / NM_175629 / c.T2264C / p.F755S / 0.198 / 0.000
PTCL234 / TET2 / Nonsynonymous / NM_001127208 / c.C3116T / p.S1039L / 0.673 / 0.470
PTCL234 / TET2 / Nonsynonymous / NM_001127208 / c.A3443G / p.Y1148C / 0.042 / 0.000
PTCL234 / TET2 / Stopgain / NM_001127208 / c.G4213T / p.E1405X / 0.358 / 0.000
PTCL235 / TET2 / Nonsynonymous / NM_001127208 / c.G4133T / p.C1378F / 0.032 / 0.000
PTCL236 / DNMT3A / Nonsynonymous / NM_175629 / c.G2645A / p.R882H / 0.450 / 0.551
PTCL236 / RHOA / Nonsynonymous / NM_001614 / c.G50T / p.G17V / 0.066 / 0.106
PTCL236 / TET2 / Stopgain / NM_001127208 / c.C1954T / p.Q652X / 0.496 / 0.478
PTCL236 / TET2 / Stopgain / NM_001127208 / c.C3025T / p.Q1009X / 0.075 / 0.136
PTCL236 / TET2 / Frameshift deletion / NM_001127208 / c.4312delA / p.K1438fs / 0.063 / 0.056
PTCL237 / TET2 / Frameshift deletion / NM_001127208 / c.2873delA / p.Q958fs / 0.140 / 0.000
PTCL238 / TET2 / Nonsynonymous / NM_001127208 / c.G652A / p.V218M / 0.386 / 0.439
PTCL239 / DNMT3A / Nonsynonymous / NM_175629 / c.C2644T / p.R882C / 0.047 / 0.022
PTCL239 / RHOA / Nonsynonymous / NM_001614 / c.G50T / p.G17V / 0.025 / 0.016
PTCL239 / TET2 / Frameshift deletion / NM_001127208 / c.874_877del / p.V292fs / 0.058 / 0.034
PTCL239 / TET2 / Nonsynonymous SNV / NM_001127208 / c.A5603C / p.H1868P / 0.060 / 0.012
PTCL241 / RHOA / Nonsynonymous / NM_001614 / c.G50T / p.G17V / 0.162 / 0.010
PTCL241 / TET2 / Stopgain / NM_001127208 / c.C3646T / p.R1216X / 0.591 / 0.587

VAF, variant allele frequencies.