1
Supplementary Material for
Genomic Evidence for a Simpler Clotting Scheme in Jawless Vertebrates
Russell F. Doolittle*, Yong Jiang# and Justin Nand
Departments of Chemistry & Biochemistry and Molecular Biology
University of California, San Diego
La Jolla, CA 92093-0314
*Correspondence to: R. F. Doolittle
Department of Chemistry & Biochemistry
University of California, San Diego
La Jolla, California 92093-0314
Tel: (858) 534-4417
Fax: (858) 534-4985
email:
# Current address: UCSD-Moores Cancer Center
SUPPLEMENTARY MATERIAL
Table 1. Index of 257 Trace ID numbers corresponding to 51 “hit groups” for factors V and VIII in the lamprey Trace database and four found only in searches with hephaestin and ceruloplasmin. Note: not every trace is full length. Usually the longest read is given first in the list.
Table 2. Index of 215 Trace ID numbers for sequences used to reconstruct the vitamin K-dependent proteases.
Table 3. Index of 68 Trace ID numbers corresponding to the eight GLA groups in the lamprey Trace database.
Table 1. The 50 factor V-VIII "hit groups" found assembled from 257 hits in the lamprey Trace database. Note: not every trace is full length. Usually the longest read is given first in the list.
Group 1 (n = 3)
|ti|1144910994 PMAH-aaa22e07.g1
|ti|1219688972 PMAH-aaa69b02.g1
|ti|1191315552 PMAC-agg64f07.b1
Group 2 (n = 2)
|ti|1161837201 PMAC-abk94b05.b1
|ti|1445879516 PMAC-beu60c10.g1
Group 3 (n = 15)
|ti|1166060437 PMAC-aca94f12.b1
|ti|1209785548 PMAC-amv66f10.g1
|ti|1209568274 PMAC-amv36g07.g1
|ti|1380512450 PMAC-avz46f11.g1
|ti|1161939527 PMAC-aam13c04.b1
|ti|1188916373 PMAC-ahk90c11.b1
|ti|1489899517 PMAC-bsi95f07.b1
|ti|1226339236 PMAC-aqf94f11.g1
|ti|1212490564 PMAC-anr83d02.b1
|ti|1437349750 PMAC-bbw59c01.b1
|ti|1179087346 PMAC-aeq39c01.g1
|ti|1194334855 PMAC-aix67f04.b1
|ti|1200279792 PMAC-akj85h07.g1
|ti|1470301392 PMAC-bmw56e07.b1
|ti|1482758537 PMAC-boj50c12.g1
Group 4 (n = 11)
|ti|1179508609 PMAC-aer38f05.b1
|ti|1179811864 PMAC-aed31d04.g1
|ti|1191882671 PMAC-aie24f11.g1
|ti|1188908741 PMAC-aip48f11.g1
|ti|1193857125 PMAC-ahf29e08.b1
|ti|1219907045 PMAC-ape93b05.b1
|ti|1218999183 PMAC-anv50f06.b1
|ti|1277036932 PMAC-arh87c12.g1
|ti|1371963634 PMAC-atx36c08.g1
|ti|1388855620 PMAC-axq81c10.g1
|ti|1483665269 PMAC-bqv11a02.b1
Group 5 (n = 29)
|ti|1179543873 PMAC-adz59h06.g1
|ti|1219719345 PMAC-apf61g03.g1
|ti|1446955710 PMAC-bel86b04.g1
|ti|1450273788 PMAC-bhb82f12.b1
|ti|1464382163 PMAC-bjw86b09.g1
|ti|1482652460 PMAC-boo81d07.g1
|ti|1209538041 PMAC-alv84f11.g1
|ti|1207818947 PMAC-alj91g07.b1
|ti|1220051540 PMAC-apd79g07.b1
|ti|1219121315 PMAC-anv83e10.g1
|ti|1219719345 PMAC-apf61g03.g1
|ti|1378362868 PMAC-auj91c01.g1
|ti|1382205029 PMAC-awc23b03.g1
|ti|1382222706 PMAC-awu56e06.g1
|ti|1392025449 PMAC-aww95c01.b1
|ti|1422284429 PMAC-axt37h07.b1
|ti|1431559667 PMAC-azy77h09.g1
|ti|1431737424 PMAC-ayv89c09.g1
|ti|1439961455 PMAC-bbp43g08.g1
|ti|1442734088 PMAC-beb87d03.b1
|ti|1446955710 PMAC-bel86b04.g1
|ti|1194415940 PMAC-aiw03b12.b1
|ti|1196549748 PMAC-ais88f05.g1
|ti|1438088752 PMAC-beg97b08.b1
|ti|1449595836 PMAC-bgn00c01.b1
|ti|1482636523 PMAC-bns34a02.b1
|ti|1482758537 PMAC-boj50c12.g1
|ti|1484433077 PMAC-bqo28d12.b1
|ti|1483983281 PMAC-bre31a12.g1
Group 6 (n = 4)
|ti|1210966149 PMAC-amu14d06.b1
|ti|1222288616 PMAC-apl70b10.g1
|ti|1443548359 PMAC-bew60a09.b1
|ti|1468780345 PMAC-bmu18b09.b1
Group7 (n = 13)
|ti|1208286829 PMAC-alv15a04.b1
|ti|1372562449 PMAC-aua85b09.b1
|ti|877231368 PMAC-aah78e02.b1
ti|1160817944 PMAC-acd62d04.b1
|ti|877231368 PMAC-aah78e02.b1
|ti|1383101727 PMAC-awd00g08.g1
|ti|1438143983 PMAC-bbu61b09.b1
|ti|1443869011 PMAC-bfk36c06.g1
|ti|1444472425 PMAC-bej20h11.b1
|ti|1172022788 PMAC-add75h01.b1
|ti|1193755395 PMAC-ahx50g01.b1
|ti|1483700017 PMAC-bqr60e05.b1
|ti|1490149352 PMAC-brp93d04.b1
Group 8 (n = 9)
|ti|1208287491 PMAC-ams45b09.b1
|ti|1291975057 PMAC-asn98d06.g1
|ti|1386269218 PMAC-axl47f03.b1
|ti|1450559338 PMAC-bho94d08.b1
|ti|1290491980 PMAC-asl62c12.g1
|ti|1161786140 PMAC-aba84b07.b1
|ti|1431669969 PMAC-azr96a02.g1
|ti|1483700017 PMAC-bqr60e05.b1
|ti|1490149352 PMAC-brp93d04.b1
Group 9 (n = 6)
|ti|1221434160 PMAC-apk05b05.b1
|ti|1449831806 PMAC-bhn07a10.b1
|ti|1464209724 PMAC-bku93a12.b1
|ti|1219912175 PMAC-ape00f05.b1
|ti|1377882596 PMAC-aum92a08.g1
|ti|1198924484 PMAC-ajd59a06.g1
Group 10 (n = 0)
Merged with group 3
Group 11 (n = 3)
|ti|1263850486 PMAC-ark14c06.g1
|ti|1463545425 PMAC-bjj05a07.b1
|ti|1171771949 PMAC-acj38b04.g1
Group 12 (n = 6)
|ti|1159496018 PMAC-aba85h06.b1
|ti|1209567594 PMAC-amt60c08.g1
|ti|1388861046 PMAC-awy94g12.b1
|ti|1459582656 PMAC-bkx40h12.g1
|ti|1196752685 PMAC-agt41d03.g1
|ti|1196752686 PMAC-agt41d04.g1
Group 13 (n = 8)
|ti|1160139644 PMAC-abz13e06.b1
|ti|1179226369 PMAC-aen04c06.g1
|ti|1383868439 PMAC-awc04g08.g1
|ti|1438148579 PMAC-bcj06c09.b1
|ti|1438782065 PMAC-bdd04g07.g1
|ti|1444204680 PMAC-bfe48g04.b1
|ti|1447201611 PMAC-bgc73e09.g1
|ti|1451016839 PMAC-bhv98a06.b1
Group 14 (n = 12)
|ti|1158450988 PMAC-abx53c08.b1
|ti|1161417823 PMAC-aal83g04.b1
|ti|1217739544 PMAC-aoj22d12.g1
|ti|1450254607 PMAC-bhv95g12.b1
|ti|1482662201 PMAC-bpe57c09.b1
|ti|1164495290 PMAC-abo29h11.g1
|ti|1181939006 PMAC-aej65f04.g1
|ti|1255552261 PMAC-afw00g02.b1
|ti|1217739544 PMAC-aoj22d12.g1
|ti|1389728756 PMAC-axj01g02.b1
|ti|1436629420 PMAC-bcd00d01.b1
|ti|1213514581 PMAC-and32g12.g1
Group 15 (n = 1)
|ti|1431663064 PMAC-ayu64g01.g1
Group 16 (n = 5)
|ti|1435383240 PMAC-bdb69h11.g1
|ti|1289645422 PMAC-ars18h06.b1
|ti|1380652680 PMAC-avf65a04.g1
|ti|1450053789 PMAC-bhb88g03.b1
|ti|1468872558 PMAC-bly98d08.g1(
Group 17 (n = 3)
|ti|1437913754 PMAC-bei34e06.g1
|ti|1464117711 PMAC-blc72b03.g1(
|ti|1482634811 PMAC-boi35g10.b1(
Group 18 (n = 7)
|ti|1194186043 PMAC-ahi83g08.b1
|ti|1162869442 PMAC-abt07a10.b1
|ti|1291934773 PMAC-atd95a03.b1
|ti|1383905580 PMAC-aws55g06.b1
|ti|1437631385 PMAC-bco71b03.b1
|ti|1174850978 PMAC-adg54b11.b1
Group 19 ( n = 9)
|ti|1194381298 PMAC-ain20f09.b1
|ti|1179095484 PMAC-aem55e06.g1
|ti|1221156776 PMAC-aqa43e06.g1
|ti|1290070177 PMAC-asj36a10.b1
|ti|1383851780 PMAC-awp11e03.b1
|ti|1179095484 PMAC-aem55e06.g1
|ti|1179704484 PMAC-aei46g05.b1
|ti|1213528119 PMAC-anv37h10.b1
|ti|1290932901 PMAC-ass50d03.g1
Group 20 (n = 8)
|ti|1194079372 PMAC-aie47f04.g1
|ti|1179720222 PMAC-adu12g10.g1
|ti|1484278711 PMAC-bqy63h02.g1
|ti|1482311375 PMAC-bos67d10.b1
|ti|1466985423 PMAC-blp27g09.b1
|ti|1437631385 PMAC-bco71b03.b1
|ti|1391721420 PMAC-axm42h07.b1
|ti|1193826133 PMAC-ain97a06.b1
Group 21 (n = 10)
|ti|1194186043 PMAC-ahi83g08.b1
|ti|1179720222 PMAC-adu12g10.g1
|ti|1207519202 PMAC-aob28b12.g1
|ti|1225725675 PMAC-apu75e05.g1
|ti|1427238002 PMAC-aye60c03.b1
|ti|1386264888 PMAC-axk84c11.b1
|ti|1391721420 PMAC-axm42h07.b1
|ti|1463439414 PMAC-bjf26c11.b1
|ti|1464271775 PMAC-bkk49f11.b1
|ti|1386282541 PMAC-axp33a10.b1
Group 22 (n = 3)
|ti|1464098538 PMAC-bjx61a07.g1
|ti|1425466722 PMAC-ayl09d08.g1
|ti|1289917127 PMAC-asj97f10.b1
Group 23 (n = 7)
|ti|1289818516 PMAC-arx15f04.g1
|ti|1191983521 PMAC-ahg75a02.g1
|ti|1181939006 PMAC-aej65f04.g1
|ti|1266009263 PMAC-arh65f08.g1
|ti|1372377902 PMAC-atv54e06.g1
|ti|1385143100 PMAC-axg17h02.b1
|ti|1450254607 PMAC-bhv95g12.b1
Group 24(n = 2)
|ti|1199240016 PMAC-akv54c11.b1
|ti|1484815731 PMAC-brd93g02.g1
Group 25 (n = 1)
|ti|1201249130 PMAC-alg54g10.b1
Group 26 (n = 3)
|ti|1201226761 PMAC-alm64d09.b1
|ti|1181617669 PMAC-aey89h01.b1
|ti|1466831769 PMAC-bme23e01.b1
Group 27 (n = 2)
|ti|1207828235 PMAC-alh57e07.g1
|ti|1205394602 PMAC-alp32b05.b1
Group 28 (n = 1)
|ti|1202772702 PMAC-alg54g10.g1
Group 29 (n = 7)
|ti|1207818947 PMAC-alj91g07.b1
|ti|1482528639 PMAC-boo81d07.b1
|ti|1470808434 PMAC-bnb08d12.b1
|ti|1438093182 PMAC-bbp43g08.b1
|ti|1436451995 PMAC-bah90b04.g1
|ti|1217745189 PMAC-anv75d04.g1
|ti|1168815340 PMAC-acr12c02.g1
Group 30 (n = 4)
|ti|1205173067 PMAC-akc41f06.b1
|ti|1175529446 PMAC-aes50b03.g1
|ti|1219866820 PMAC-aom53f08.b1
|ti|1212882990 PMAC-amf41g07.g1
Group 31 (n = 1)
|ti|1210630486 PMAC-amu14d06.g1
Group32 (n = 7)
|ti|1219685949 PMAC-aoy80d05.g1
|ti|1175518095 PMAC-adu19d12.b1
|ti|1182073896 PMAC-ags23d09.g1
|ti|1267266352 PMAC-arb86c12.b1
|ti|1292926707 PMAC-asz04d11.b1
|ti|1483467651 PMAC-bpn16h10.b1
|ti|1489793622 PMAC-brn31f09.g1
Group 36 (n = 1)
|ti|1223199860 PMAC-apw89e03.g1
Group 37 (n = 1)
|ti|1255502482 PMAC-afx82f11.g1
Group 40 (n = 4)
|ti|1255552261 PMAC-afw00g02.b1
|ti|1427213927 PMAC-ayu06a05.g1
|ti|1445041292 PMAC-bej67d10.g1
|ti|1483945440 PMAC-bqy95b01.g1
Group 46 (n = 2)
|ti|1438173505 PMAC-bew83d12.b1
|ti|1443841415 PMAC-bed56f01.g1
Group 47 (n = 4)
|ti|1443511946 PMAC-bfb21c03.b1
|ti|1168815340 PMAC-acr12c02.g1
|ti|1217745189 PMAC-anv75d04.g1
|ti|1436451995 PMAC-bah90b04.g1
Group 48 (n = 3)
|ti|1445055041 PMAC-bcx04h02.g1
|ti|1191983521 PMAC-ahg75a02.g1
|ti|1490162504 PMAC-bqo88h11.b1
Group 49 (n = 2)
|ti|1444488630 PMAC-bet32e12.g1
|ti|1444294365 PMAC-bet64a06.g1
Group 51 (n = 1)
|ti|1444221360 PMAC-bdv08d11.b1
Group 52 (n = 1)
|ti|1446326143 PMAC-bfb30f09.g1
Group 54 (n = 4)
|ti|1449744158 PMAC-bhd01f08.g1
|ti|1437913754 PMAC-bei34e06.g1
|ti|1483019965 PMAC-boi35g10.g1
|ti|1430847986 PMAC-axx88h12.g1
Group 63 (n = 3)
|ti|1468575783 PMAC-bnr03d04.b1
|ti|1484278711 PMAC-bqy63h02.g1
|ti|1191983163 PMAC-aev20a04.g1
Group 67 (n = 3)
|ti|1179506702 PMAC-adu59h03.g1
|ti|1181463480 PMAC-act65b02.g1
|ti|1482095160 PMAC-boi08c09.g1
Group 69 (n = 3)
|ti|1181448727 PMAC-afc14c11.b1
|ti|1290335310 PMAC-asp27c04.g1
|ti|1377117551 PMAC-aus09c04.b1
Group 72 (n = 2)
|ti|1191983163 PMAC-aev20a04.g1
|ti|1430760652 PMAC-bav73e05.g1
Group 75 (n = 1)
|ti|1373792487 PMAC-atw10h05.b1
Group 76 (n = 1)
|ti|1377699240 PMAC-avg68e09.b1
Group 80 (n = 1)
|ti|1383885054 PMAC-awe21h09.b1
Group 87 (n = 1)
|ti|1483590463 PMAC-bqf95h03.b1
Table 2. Index of Trace ID numbers for 215 Trace sequences (reduced to 38 "hit-groups") used in identification of vitamin K-dependent proteases in lamprey. Eight EST sequences are denoted EST.
A. Prothrombin
group S1 (n = 16)
gnl|ti|1463318380 PMAO-aad73a01.g1 EST
gnl|ti|1371066388 PMAO-aad15d04.g1 EST
gnl|ti|1427744717 PMAC-azt97d11.g1
gnl|ti|1424614273 PMAC-axt39e04.g1
gnl|ti|1386362834 PMAC-axo64f11.b1
gnl|ti|1386291873 PMAC-awc37d11.b1
gnl|ti|1198677997 PMAC-ajg38c09.b1
gnl|ti|1191300515 PMAC-ahm89e10.g1
gnl|ti|1163825609 PMAC-acn84b03.g1
gnl|ti|1436624537 PMAC-bby95g04.b1
gnl|ti|1482417226 PMAC-bor19b05.g1
gnl|ti|1445340987 PMAC-bel21d01.b1
gnl|ti|1222053544 PMAC-apl67d03.g1
gnl|ti|1212906955 PMAC-ank63g02.b1
gnl|ti|1193488960 PMAC-ahs39g06.b1
gnl|ti|1208524362 PMAC-amn35c01.b1
group S13 (n = 7)
gnl|ti|1373604714 PMAC-aug30a09.b1
gnl|ti|1373604711 PMAC-aug30a06.b1
gnl|ti|1373604460 PMAC-aug30a09.b2
gnl|ti|1373604457 PMAC-aug30a06.b2
gnl|ti|1373605366 PMAC-aug20a09.b1
gnl|ti|1484632024 PMAC-bqw43b06.b1
gnl|ti|1489983741 PMAC-brt94b05.b1
group S19 (aka J4, junction peptide)
gnl|ti|1489983741 PMAC-brt94b05.b1
gnl|ti|1483362260 PMAC-bpn28g05.b1
gnl|ti|1470716377 PMAC-bnl74f04.b1
gnl|ti|1200421793 PMAC-ala44e03.b1
gnl|ti|1191878648 PMAC-ags18g11.g1
gnl|ti|1181152379 PMAC-agp58c05.b1
gnl|ti|1292510061 PMAC-atf15c11.g1
gnl|ti|1430758974 PMAC-bbg16c06.b1
gnl|ti|1436488377 PMAC-bcd86f07.b1
gnl|ti|1209316655 PMAC-anm01c08.b1
gnl|ti|1384159534 PMAC-awj05e12.g1
group K1 (kringle) (n = 5)
gnl|ti|1386294003 PMAC-axl63e05.b1
gnl|ti|1170752522 PMAC-adc76b02.b1
gnl|ti|1289913507 PMAC-arz30a01.b1
gnl|ti|1422361656 PMAC-axs32c07.b1
gnl|ti|813242595 PMAD-aae86b07.g1
group K2 (kringle)a (n = 2)
gnl|ti|1469395913 PMAC-boo79g06.g1
gnl|ti|1267268789 PMAC-arb44a04.b1
B. Factor 10A
group S2 (n = 13)
gnl|ti|1483113091 PMAC-boz03h03.g1
gnl|ti|1472068046 PMAC-bnr03g09.g1
gnl|ti|1446096856 PMAC-bfn13a09.b1
gnl|ti|1387373542 PMAC-awz32f09.b1
gnl|ti|1193862801 PMAC-agh99b06.g1
gnl|ti|1467092811 PMAC-blp03b02.g1
gnl|ti|1482742799 PMAC-bop37b02.g1
gnl|ti|1224433303 PMAC-apt29a05.b1
gnl|ti|1464098487 PMAC-bjx60e03.g1
gnl|ti|1483416934 PMAC-bpm55g01.b1
gnl|ti|1463543546 PMAC-bkk31e02.b1
gnl|ti|1443369931 PMAC-bdx34e08.b1
gnl|ti|1468873892 PMAC-bly85h08.g1
Group S8 (n = 11)
gnl|ti|1193817925 PMAC-aig20e07.b1
gnl|ti|1437914465 PMAC-bef89a09.g1
gnl|ti|1191888108 PMAC-ahg48b01.b1
gnl|ti|1199531207 PMAC-ajg73e04.g1
gnl|ti|1381441718 PMAC-avb25h06.g1
gnl|ti|1439791048 PMAC-bbx36g10.b1
gnl|ti|1377875653 PMAC-avd31b11.b1
gnl|ti|1289735354 PMAC-ary50b10.b1
gnl|ti|1188595121 PMAC-afn49a09.b1
gnl|ti|1483053173 PMAC-bqo01a10.g1
gnl|ti|1448165034 PMAC-bge75d10.g1
Group S14 (n = 9)
gnl|ti|1483108890 PMAC-boz03h03.b1
gnl|ti|1438650854 PMAC-bbm46d10.b1
gnl|ti|1435655074 PMAC-bax71a07.b1
gnl|ti|1287200218 PMAC-arr57b10.b1
gnl|ti|1229606292 PMAC-aqg06d06.b1
gnl|ti|1193826510 PMAC-ait35b01.g1
gnl|ti|1422343354 PMAC-axr66e07.g1
gnl|ti|1385144097 PMAC-axi43f07.b1
gnl|ti|1183710586 PMAC-afd86b06.g1
group J5 (junction) (n = 7)
gnl|ti|1449693370 PMAC-bgt11a06.b1
gnl|ti|1444591271 PMAC-bdx93e09.g1
gnl|ti|1424730724 PMAC-axv72b06.g1
gnl|ti|1292536973 PMAC-atf11c12.g1
gnl|ti|1286296274 PMAO-aab69d10.g1 EST
gnl|ti|1210655211 PMAC-ami41c03.g1
gnl|ti|1197586271 PMAC-ajv75g11.b1
Group EGF1 (n = 3)
gnl|ti|1267602169 PMAC-arm61e11.b1
gnl|ti|1439559311 PMAC-bdh46f11.b1
gnl|ti|1449690822 PMAC-bfn13a09.g1
Group EGF2 (n = 7)
gnl|ti|1165258157 PMAC-acp25g09.g1
gnl|ti|1380533552 PMAC-avb07h01.b1
gnl|ti|1374899215 PMAC-atr57c06.b1
gnl|ti|1179228961 PMAC-adn16c02.g1
gnl|ti|1437536892 PMAC-bcr90a02.b1
gnl|ti|1425035593 PMAC-axv72b06.b1
gnl|ti|1290481761 PMAC-ask09c12.g1
C. Factor 10B (inactive)
group S3 (n = 9)
gnl|ti|1442220941 PMAL-aab63e07.g1 EST
gnl|ti|1207520968 PMAL-aaa64c09.b1 EST
gnl|ti|1219447984 PMAC-apd03h04.g1
gnl|ti|1160824814 PMAC-abw57c10.g1
gnl|ti|1483547432 PMAC-bpx31d04.b1
gnl|ti|1464344150 PMAC-bjz71f02.b1
gnl|ti|1200671667 PMAC-akl10f10.g1
gnl|ti|1175102439 PMAC-aeo72f09.b1
gnl|ti|1387041321 PMAC-awz47h07.g1
group S15 (n = 1)
gnl|ti|1309473648 PMAL-aab22d06.g1 EST
group J6 (n = 9)
gnl|ti|1482111796 PMAC-bol89a08.b1
gnl|ti|1464225852 PMAC-bko64b08.b1
gnl|ti|1443536372 PMAC-ber22d05.g1
gnl|ti|1267812806 PMAC-arh11c05.g1
gnl|ti|1226523063 PMAC-apz36a01.g1
gnl|ti|1207832137 PMAC-akf71e02.b1
gnl|ti|1201306763 PMAC-alc58d04.b1
gnl|ti|1199032522 PMAC-akb93g08.g1
gnl|ti|1184102150 PMAC-adt95c01.g1
group E3 (EGF domain) (n = 5)
gnl|ti|1482510685 PMAC-bpd48a09.g1
gnl|ti|1464296063 PMAC-bkj81g06.g1
gnl|ti|1449905462 PMAC-bhy94c12.g1
gnl|ti|1439549196 PMAC-bbc71f11.g1
gnl|ti|1438172636 PMAC-bch21h02.b1
group E4 (EGF domain) (n = 10)
gnl|ti|1482454586 PMAC-bog54c09.b1
gnl|ti|1464410281 PMAC-bkq42d02.b1
gnl|ti|1437354981 PMAC-bbb21f11.b1
gnl|ti|1381384035 PMAC-ave91c01.b1
gnl|ti|1380655322 PMAC-avu21f03.b1
gnl|ti|1225475044 PMAC-apz36a01.b1
gnl|ti|1212955687 PMAC-anm10d05.b1
gnl|ti|1210763606 PMAC-amy99e09.g1
gnl|ti|1199916111 PMAC-alc58d04.g1
gnl|ti|1179816330 PMAC-aeb64d09.b1
group terminus (n = 2)
gnl|ti|1206036344 PMAL-aaa79f02.g1 EST
gnl|ti|1309472470 PMAL-aab42e01.g1 EST
D. Protein C
group S7 (n = 8)
gnl|ti|1483449046 PMAC-bpc01h01.b1
gnl|ti|1482691084 PMAC-bri74g11.b1
gnl|ti|1468980620 PMAC-blj97h12.b1
gnl|ti|1293691811 PMAC-atm51e12.g1 (mate-pair, group J2)
gnl|ti|1186306352 PMAC-afj40f12.g1
gnl|ti|1179033219 PMAC-acl79d01.g1
gnl|ti|1443861590 PMAC-bfb69f04.b1
gnl|ti|1442756092 PMAC-bel77e03.g1
group S18 (n = 5)
gnl|ti|1470031914 PMAC-bms16c09.b1
gnl|ti|1442864333 PMAC-bga26c04.b1
gnl|ti|1210753367 PMAC-amk00b04.b1
gnl|ti|1197131134 PMAC-ahp68c06.g1
gnl|ti|1183177128 PMAC-agc26h06.b1
group S20 (n = 7)
gnl|ti|1449641347 PMAC-bgy22b08.b1
gnl|ti|1384157383 PMAC-awf45a07.b1
gnl|ti|1213497130 PMAC-ang04b01.g1
gnl|ti|1201405737 PMAC-akt31g07.b1
gnl|ti|1183718627 PMAC-aie09b10.b1
gnl|ti|1430857274 PMAC-bam27b08.g1
gnl|ti|1456506068 PMAC-bht24h07.b1
group J2 (junction) (n = 3)
gnl|ti|1293718001 PMAC-atm51e12.b1
gnl|ti|1223414232 PMAC-apw43b12.g1
gnl|ti|1201087472 PMAC-alk04a07.g1
group E11 (EGF domain)
gnl|ti|1482294687 PMAC-bom26c12.g1
group E12 (EGF domain)
gnl|ti|1383942163 PMAC-awm15d01.b1
E. Factor 7A
group S4 (n = 4)
gnl|ti|1483888900 PMAC-brc12c05.b1 (mate-pair group S11)
gnl|ti|1466672902 PMAC-bls54e07.g1
gnl|ti|1193489367 PMAC-aih79b08.g1
gnl|ti|1483849194 PMAC-bpy27g12.g1
group S10 (n = 7)
gnl|ti|1483822330 PMAC-brc12c05.g1
gnl|ti|1435011771 PMAC-azl18h08.b1
gnl|ti|1459583297 PMAC-bkx46h02.g1
gnl|ti|745176942 PMAC-aad00c05.b1
gnl|ti|1438755245 PMAC-bdg21g07.b1
gnl|ti|1188770791 PMAC-ahp48g12.g1
gnl|ti|1210941303 PMAC-amk34g05.g1
group J3 (junction) (n = 9)
gnl|ti|1217472576 PMAC-aou13h03.g1
gnl|ti|1483575072 PMAC-bqd16f07.g1
gnl|ti|1422326393 PMAC-axw02g03.b1
gnl|ti|1387852987 PMAC-axb76d05.g1
gnl|ti|1371974755 PMAC-atv20c09.g1
gnl|ti|1267591120 PMAC-ard07b12.g1
gnl|ti|1266788039 PMAC-arg19e06.b1
gnl|ti|1220347873 PMAC-aou14a05.g1
gnl|ti|1444783221 PMAC-beo94e07.b1
group E5 (EGF domain)
gnl|ti|1372390727 PMAC-atw70d12.b1
group E6 (EGF domain)
gnl|ti|1439267273 PMAC-bbn77a09.b1
F. Factor 7B
group S5 (n = 2)
gnl|ti|1489628493 PMAC-brs87f06.g1
gnl|ti|1211903986 PMAC-ang87g06.g1
group S9 (n = 1)
gnl|ti|1193723919 PMAC-aip86a04.b1
group S11 (n = 1)
gnl|ti|1172200894 PMAC-add58c05.b1
group J1 (junction) (n = 4)
gnl|ti|1179075764 PMAC-aem85h11.b1
gnl|ti|1424118007 PMAC-ayg29b04.g1
gnl|ti|1209544677 PMAC-anb61e03.g1
gnl|ti|1372383900 PMAC-aua70d02.g1
group E7 (EGF domain) (n = 15)
gnl|ti|1489899983 PMAC-bqs26g10.b1
gnl|ti|1464225388 PMAC-bku03b11.b1
gnl|ti|1464168703 PMAC-bkh89a04.g1
gnl|ti|1450571101 PMAC-bho32h10.b1
gnl|ti|1449706261 PMAC-bgp84e08.b1
gnl|ti|1449600055 PMAC-bgu31a01.g1
gnl|ti|1443479594 PMAC-bff60g07.b1
gnl|ti|1431536583 PMAC-bae42e09.g1
gnl|ti|1385150859 PMAC-awq72f11.g1
gnl|ti|1383246697 PMAC-awd10h09.g1
gnl|ti|1223442024 PMAC-apu35a11.g1
gnl|ti|1220560951 PMAC-apa32d07.g1
gnl|ti|1213558994 PMAC-ann95e12.g1
gnl|ti|1195361833 PMAC-ajl32h02.b1
gnl|ti|1194250218 PMAC-ahn34b02.g1
group E8 (EGF domain) (n = 5)
gnl|ti|1497390178 PMAC-bsn82h12.g1
gnl|ti|1436436355 PMAC-bas88b04.g1
gnl|ti|1255781682 PMAC-ajr68d07.b1
gnl|ti|1255374032 PMAC-agt36h06.b1
gnl|ti|1212490056 PMAC-amd04d08.b1
G. Factor 7C
group S6 (n = 8)
gnl|ti|1292198074 PMAC-ata96c01.g1
gnl|ti|1179039743 PMAC-aep70g06.g1
gnl|ti|1209789520 PMAC-ami15f09.b1
gnl|ti|1210982190 PMAC-aml79h01.g1
gnl|ti|1370746029 PMAC-att04e09.g1
gnl|ti|1179706233 PMAC-aha23a11.b1
gnl|ti|1179066195 PMAC-aer80h01.g1
gnl|ti|1483822406 PMAC-brc14a09.g1
group S12 (n = 3)
gnl|ti|1449635819 PMAC-bfv82f04.b1
gnl|ti|1266014235 PMAC-are96h12.b1
gnl|ti|1255502629 PMAC-aiq19d02.g1
group E9 (EGF domain)
gnl|ti|1463436897 PMAC-bjg73c02.b1
group E10 (EGF domain)
gnl|ti|1424818611 PMAC-axy79h11.b1
H. Junctions (summary of individual groups above)
group J1 (n = 4)
gnl|ti|1179075764 PMAC-aem85h11.b1
gnl|ti|1424118007 PMAC-ayg29b04.g1
gnl|ti|1209544677 PMAC-anb61e03.g1
gnl|ti|1372383900 PMAC-aua70d02.g1
group J2 (n = 3)
gnl|ti|1293718001 PMAC-atm51e12.b1 (mate-pair Group S16)
gnl|ti|1223414232 PMAC-apw43b12.g1
gnl|ti|1201087472 PMAC-alk04a07.g1
group J3 (n = 9)
gnl|ti|1217472576 PMAC-aou13h03.g1
gnl|ti|1483575072 PMAC-bqd16f07.g1
gnl|ti|1422326393 PMAC-axw02g03.b1
gnl|ti|1387852987 PMAC-axb76d05.g1
gnl|ti|1371974755 PMAC-atv20c09.g1
gnl|ti|1267591120 PMAC-ard07b12.g1
gnl|ti|1266788039 PMAC-arg19e06.b1
gnl|ti|1220347873 PMAC-aou14a05.g1
gnl|ti|1444783221 PMAC-beo94e07.b1
group J4 (n = 7)
gnl|ti|1489983741 PMAC-brt94b05.b1
gnl|ti|1483362260 PMAC-bpn28g05.b1
gnl|ti|1470716377 PMAC-bnl74f04.b1
gnl|ti|1200421793 PMAC-ala44e03.b1
gnl|ti|1191878648 PMAC-ags18g11.g1
gnl|ti|1181152379 PMAC-agp58c05.b1
gnl|ti|1292510061 PMAC-atf15c11.g1
group J5 (n = 7)
gnl|ti|1449693370 PMAC-bgt11a06.b1
gnl|ti|1444591271 PMAC-bdx93e09.g1
gnl|ti|1424730724 PMAC-axv72b06.g1
gnl|ti|1292536973 PMAC-atf11c12.g1
gnl|ti|1286296274 PMAO-aab69d10.g1
gnl|ti|1210655211 PMAC-ami41c03.g1
gnl|ti|1197586271 PMAC-ajv75g11.b1
group J6 (n = 10)
gnl|ti|1309473648 PMAL-aab22d06.g1
gnl|ti|1482111796 PMAC-bol89a08.b1
gnl|ti|1464225852 PMAC-bko64b08.b1
gnl|ti|1443536372 PMAC-ber22d05.g1
gnl|ti|1267812806 PMAC-arh11c05.g1
gnl|ti|1226523063 PMAC-apz36a01.g1
gnl|ti|1207832137 PMAC-akf71e02.b1
gnl|ti|1201306763 PMAC-alc58d04.b1
gnl|ti|1199032522 PMAC-akb93g08.g1
gnl|ti|1184102150 PMAC-adt95c01.g1
Table 3. The eight GLA "hit groups" found in the lamprey Trace database.
Group 1 (n = 15)
|ti|1489805119 PMAC-bsb01d02.b1
|ti|1438610430 PMAC-bbk55f01.g1
|ti|1427842964 PMAC-ayn08g08.b1
|ti|1212951095 PMAC-aqd12c10.b1
|ti|1212918461 PMAC-amz60h06.b1
|ti|1200423549 PMAC-ala64h03.b1
|ti|1195349722 PMAC-aiv30g11.b1
|ti|1175519736 PMAC-aef54d08.b1
|ti|1174570192 PMAC-adx46e08.b1
|ti|1438610434 PMAC-bbk55f05.g1
|ti|1160825999 PMAC-acf11b04.b1
|ti|1197130025 PMAC-ajj68f12.g1
|ti|1445569497 PMAC-ber44a01.b1
|ti|1445872160 PMAC-ber45a01.b1
Group 2 (n = 6)
|ti|1387016721 PMAC-axl77f02.b1
|ti|1263856686 PMAC-arb34g07.g1
|ti|1208539610 PMAC-aok65c09.b1
|ti|1483556401 PMAC-bpy36h11.b1
|ti|1483556401 PMAC-bpy36h11.b1
|ti|1220459255 PMAC-aow06b05.g1
Group 3 (n = 3)
|ti|1449842544 PMAC-bhl84a05.g1
|ti|1210515753 PMAC-anr09e05.g1
|ti|1266760009 PMAC-arn70e08.b1
Group 4 (n = 9)
|ti|1436774763 PMAC-bai71b08.g1
|ti|1427760708 PMAC-axw24a01.b1
|ti|1266012033 PMAC-arb44a04.g1
|ti|1207509951 PMAC-ajw64c08.g1
|ti|1181615702 PMAC-ado18b07.g1
|ti|1179670326 PMAC-adp51f07.b1
|ti|1464749677 PMAC-bjv23h04.g1
|ti|1267527488 PMAC-arp58a05.g1
|ti|1161322287 PMAC-abw93a04.g1
Group 5 (n = 9)
|ti|1483609606 PMAC-bpy55f06.b1
|ti|1289991711 PMAC-asg04c10.g1
|ti|1255734049 PMAL-aaa64c09.g1
|ti|1206036344 PMAL-aaa79f02.g1
|ti|1193855471 PMAC-aic22d03.b1
|ti|1309472470 PMAL-aab42e01.g1
|ti|1483277373 PMAC-bpz80e08.g1
|ti|1439553026 PMAC-bcg02h10.b1
|ti|1181180699 PMAC-agm65e06.b1
Group 6 (n = 8)
|ti|1424123534 PMAC-ayt20g05.b1
|ti|1196745797 PMAC-ait55g03.b1
|ti|813243318 PMAD-aap80l15.b1
|ti|813243000 PMAD-aap80l15.g1
|ti|1466575549 PMAC-blt54a08.b1
|ti|1213406419 PMAC-anm82h03.b1
|ti|1383861994 PMAC-awr09a05.b1
|ti|1201395943 PMAC-akg85g03.b1
Group 7 (n = 8)
|ti|1467287171 PMAC-bli97f02.b1
|ti|1464204817 PMAC-bkv22d03.g1
|ti|1450219125 PMAC-bht64g01.g1
|ti|1439798352 PMAC-bdc25e09.g1
|ti|1430687041 PMAC-azi06e11.g1
|ti|1267405740 PMAC-aro94b07.g1
|ti|1457287810 PMAC-bhv47d02.b1
|ti|1449755731 PMAC-bgu35h01.g1
Group 8
|ti|1383029922 PMAC-awj38f12.g1
|ti|1221060356 PMAC-apd52f04.g1
|ti|1201062204 PMAC-alf09g05.g1
|ti|1196386557 PMAC-akd18h05.b1
|ti|1194087786 PMAC-ahz15a07.b1
|ti|1197326790 PMAC-ajx61e05.g1
|ti|1459583850 PMAC-bkx88c05.g1
|ti|1179678235 PMAC-adp17e08.b1
|ti|1468041882 PMAC-blh33c06.g1
|ti|1464184881 PMAC-bkj27f05.b1
|ti|1450254607 PMAC-bhv95g12.b1