The reasons for exclusion of thearticles which were shown in Figure 1

1.Romerius P,Giwercman A,Moëll C,Relander T,Cavallin-Ståhl E,Wiebe T,Halldén C,Giwercman YL: Estrogen receptor α single nucleotide polymorphism modifies the risk of azoospermia in childhood cancer survivors.Pharmacogenet Genomics2011, 21:263-269.

(This article is not about male infertility.)

2.Zhang QF,Feng HL,Zhao L,Liu P,Li L,Yan J,Qiao J: Alteration of ERβ gene RsaIpolymorphismmay contribute to reduced fertilization rate and embryonic developmental competence.Asian J Androl 2011,13:317-321.

(This article is not a case control study.)

3.Massart F, Saggese G:Sex steroidal targets &geneticsusceptibility to idiopathic cryptorchidism.Pediatr Endocrinol Rev 2009, 6:481-490.

(This article is a review.)

4.Lee IW,Kuo PH,Su MT,Kuan LC,Hsu CC,Kuo PL:Quantitative trait analysis suggests polymorphisms ofestrogen-related genes regulate human sperm concentrations and motility.Hum Reprod 2011,26:1585-1596.

(In this article, we can’t get the genotype frequencies.)

5.Su MT1,Chen CH,Kuo PH,Hsu CC,Lee IW,Pan HA,Chen YT,Kuo PL: Polymorphisms ofestrogen-related genes jointly confer susceptibility to human spermatogenic defect.Fertil Steril 2010,93:141-149.

(This article’s data is not independent.)

6.Krausz C, Giachini C:Geneticrisk factors inmale infertility. Arch Androl2007,53:125-133.

(This article is a review.)

7.Corbo RM,Ulizzi L,Piombo L,Martinez-Labarga C,De Stefano GF,Scacchi R: Estrogen receptoralpha polymorphisms and fertility in populations with different reproductive patterns.Mol Hum Reprod 2007,13:537-540.

(This article is not a case control study.)

8.Watanabe M,Yoshida R,Ueoka K,Aoki K,Sasagawa I,Hasegawa T,Sueoka K,Kamatani N,Yoshimura Y,Ogata T: Haplotype analysis of theestrogen receptor1 gene inmalegenital and reproductive abnormalities.Hum Reprod2007, 22:1279-1284.

(The SNP in this article is a different one from the four in my article.)

9.Galan JJ,Guarducci E,Nuti F,Gonzalez A,Ruiz M,Ruiz A,Krausz C:Molecular analysis ofestrogen receptoralpha gene AGATA haplotype and SNP12 in European populations: potential protective effect for cryptorchidism and lack of association withmale infertility.Hum Reprod 2007,22:444-449.

(The SNP in this article is a different one from the four in my article.)

10.Feng Z,Zhang C,Kang HJ,Sun Y,Wang H,Naqvi A,Frank AK,Rosenwaks Z,Murphy ME,Levine AJ,Hu W: Regulation of female reproduction by p53 and its family members.FASEB J 2011,25:2245-2255.

(This article is not about male infertility.)

11.Guarducci E,Nuti F,Becherini L,Rotondi M,Balercia G,Forti G,Krausz C: Estrogen receptoralpha promoterpolymorphism: strongerestrogenaction is coupled with lower sperm count.Hum Reprod2006,21:994-1001.

(This article is about (TA)n repeats.)

12.Galan JJ,Buch B,Cruz N,Segura A,Moron FJ,Bassas L,Martinez-Pineiro L,Real LM,Ruiz A: Multilocus analyses ofestrogen-related genes reveal involvement of the ESR1 gene inmale infertilityand the polygenic nature of the pathology.Fertil Steril 2005,84:910-918.

(The SNP in this article is a different one from the four in my article.)

13.Suzuki Y,Sasagawa I,Itoh K,Ashida J,Muroya K,Ogata T: Estrogen receptoralpha genepolymorphismis associated with idiopathic azoospermia.Fertil Steril2002, 78:1341-1343.

(The SNP in this article is a different one from the four in my article.)

14.Heimdal K,Andersen TI,Skrede M,Fosså SD,Berg K,Børresen AL: Association studies ofestrogen receptorpolymorphisms in a Norwegian testicular cancer population.Cancer Epidemiol Biomarkers Prev 1995, 4:123-126.

(This article is not about male infertility.)