Supplementary Table S1. Successfully genotyped p53RE SNPs for this study. The p53RE SNPs were predicted using a Position-Weight Matrix developed by our group (Bandele et al. 2011).

rs / genTrain / p53RE / A1 / PWM1 / A2 / PWM2 / spacer / dist_TSS / location / gene
rs3809268 / 0.545 / CGGCRAGCCCcaGAGCCTGTCT / A / 16 / G / 13.2 / 2 / -100 / upstream / WNT5B
rs7946259 / 0.673 / AGGCATGTCTGCCCGTCYTG / C / 6.8 / T / 6.5 / 0 / 10164 / coding / COMMD9
rs1048990 / 0.480 / GTGCTTSTACCAACATGTCC / G / 14.6 / C / 9.5 / 0 / 102 / coding / PSMA6
rs35190455 / 0.770 / GGGCCCGTTTaccccaggtaacagaGSAGTAGTTC / G / 7.1 / C / 5 / 15 / 1039 / coding / NFE2
rs2286748 / 0.769 / TGGCAGGTCAGAMCTTGCCC / A / 14.2 / C / 11.2 / 0 / 10458 / coding / TRIM8
rs1190596 / 0.343 / GGGCGTGGTGGCACAYGCCT / T / 11.9 / C / 7.6 / 0 / 10461 / coding / HSP90AA1
rs4793661 / 0.779 / AGACAAGCCAgGGRCACGTGA / G / 12.1 / A / 11.6 / 1 / 10470 / coding / EPN3
rs33961871 / 0.829 / GCACATGTCYAGGGCCGGCC / C / 6.8 / T / 5.7 / 0 / 10547 / coding / STK25
rs7513082 / 0.821 / RCACTTGGTAtagGAACTTCTTC / G / 8.5 / A / 7.8 / 3 / -10588 / upstream / SSR2
rs431295 / 0.793 / TTGCTRATTTAAACTTGCTC / A / 7.3 / G / 6.2 / 0 / 1068 / coding / SPTA1
rs11921580 / 0.802 / TGGCATGAYCccaGGGCTAGCTC / C / 15.3 / T / 14.6 / 3 / -10707 / upstream / MIR548AC
rs6763378 / 0.346 / GAACAAGCCTtTACCTYGCAC / T / 12.7 / C / 9.9 / 1 / 1071 / coding / EDEM1
rs35317661 / 0.863 / TGGCTGGAACtTGACTAGNCC / C / 8.1 / - / 7.7 / 1 / -1083 / upstream / UBE2T
rs5746081 / 0.805 / CCACTTAYCGgaAGCCTAGTCA / C / 5.1 / T / 4.6 / 2 / -1101 / upstream / SOD2
rs700588 / 0.921 / GTCCATCCAGGAACAAGTYT / C / 7.2 / T / 5.8 / 0 / 11170 / coding / MEF2C
rs9380152 / 0.843 / AGACTYGGTGAATCCAGACA / T / 5.4 / C / 1.4 / 0 / -1120 / upstream / NEDD9
rs6091109 / 0.874 / AGCYTACCCAgcagaggcGGGCAAGTGG / C / 7.1 / T / 2.5 / 8 / -1130 / upstream / CEBPB
rs17881711 / 0.921 / AAAYGAGGCTGGAATAGCTT / C / 5.8 / T / 1.3 / 0 / -1134 / upstream / SOD1
rs416824 / 0.487 / TGACAAKTCTCAGACTGGGC / G / 6.5 / T / 0.7 / 0 / -1143 / upstream / SERPINB1
rs292512 / 0.758 / AAGCTTGTCAAGACTAGTYT / C / 15.5 / T / 14.1 / 0 / -1156 / upstream / C7orf49
rs831626 / 0.800 / CAGCATGTCAtgGGATCAGCTR / G / 6.4 / A / 4.9 / 2 / 11675 / coding / CD59
rs9926088 / 0.781 / ARTCAGGTATacttcagagaaataaCTGGATGTCT / G / 5.2 / A / 5 / 15 / -1168 / upstream / MT1JP
rs1042546 / 0.883 / GCACATGTCTtGTRCATGTGT / G / 14.1 / A / 13.9 / 1 / 11799 / coding / LCK
rs3737717 / 0.827 / GAACATGYTTGCACATGTGT / C / 14.4 / T / 13.8 / 0 / 1185 / coding / ACAP3
rs347519 / 0.549 / GGACAGGCATGGACAYGCAC / T / 13.7 / C / 10.9 / 0 / 11893 / coding / KCNN4
rs12532832 / 0.845 / AGACTAGCCCagatatttTYCCATGTAA / C / 9.6 / T / 9.1 / 8 / -1190 / upstream / AKR1B1
rs10912561 / 0.865 / GGACAAGTACAAAGYAGGCT / T / 9.3 / C / 8.2 / 0 / 11906 / coding / TNFSF4
rs6697996 / 0.803 / GCACATGCTTcaKGACATGTTG / G / 16.6 / T / 14 / 2 / 12079 / coding / PLOD1
rs7149838 / 0.253 / CCMCAGGTTGgacccTGACGTGCCT / A / 7.9 / C / 5.8 / 5 / -12161 / upstream / RPS6KL1
rs12051889 / 0.867 / TGACAAGCTCaGGACAAGAYT / C / 16.8 / T / 16.6 / 1 / 12230 / coding / TNFRSF13B
rs7103034 / 0.260 / GCTCAAGCTCtggTAAYATGCTT / C / 12.4 / T / 7.6 / 3 / 1229 / coding / HNRNPUL2-BSCL2
rs3808888 / 0.826 / TCCCTTGCYTatatccatATTCATGCTC / C / 7.8 / T / 7.1 / 8 / -1234 / upstream / TXN
rs2072684 / 0.720 / ATTGTTGCTAtaAGSCTGGTCA / G / 5.9 / C / 2.7 / 2 / 1266 / coding / GFER
rs6679106 / 0.726 / TAGCTTRTGTaacCAGCGTGTCC / G / 10.1 / A / 5 / 3 / -1271 / upstream / ALG14
rs10415386 / 0.823 / GGTCYTGTCTGCACTGGGTC / T / 11.6 / C / 8 / 0 / -1275 / upstream / DNAJB1
rs4815359 / 0.655 / CAGGATGGCTTAMCATGTCT / A / 10.4 / C / 7.4 / 0 / -1325 / upstream / APMAP
rs11554870 / 0.776 / TAGCCAGCCCtcMGTCACCTCT / A / 6.9 / C / 5.5 / 2 / 133 / coding / FTH1
rs831629 / 0.783 / CCCYAAGCTTTGGCTTCTTT / C / 6.7 / T / 2.2 / 0 / 13361 / coding / CD59
rs16879398 / 0.785 / TGACAASCTCAAACTGGCCT / G / 13.3 / C / 8.3 / 0 / 1341 / coding / LPCAT1
rs12411 / 0.358 / CTGCTTGWCTGTGCAGAGCC / T / 8.1 / A / 7 / 0 / 13424 / coding / PGF
rs10187388 / 0.793 / GGRCAAGTGGcttACACAAGTGT / A / 12 / G / 11.8 / 3 / 13614 / coding / PLEK
rs7214615 / 0.706 / GGGAAYGTAGGGGCTTGTGG / T / 8.5 / C / 4.6 / 0 / 1367 / coding / MYO1C
rs3783598 / 0.749 / AAGCTAGTATttcctgAAKCAATTTT / G / 7.5 / T / 5.8 / 6 / -1377 / upstream / VCAM1
rs884171 / 0.928 / GAGCAATWTTgattcaaAGACTGATTT / T / 5.4 / A / 4.3 / 7 / -13851 / upstream / MIR3190
rs7855 / 0.802 / AGACAGGACRtTATCTTGCTG / G / 6.1 / A / 5.8 / 1 / 14051 / coding / SOD2
rs755946 / 0.766 / GTGCTGGCAGgtGAACRCGGCG / A / 5.6 / G / 1.6 / 2 / 14093 / coding / TMPRSS3
rs11553248 / 0.873 / TCTCMTGCTTctgGGACCTGCCA / A / 11 / C / 7 / 3 / 142 / coding / FTL
rs16853859 / 0.879 / GAAAAKGCCAgtCATCTTGGTG / T / 5.5 / G / 2.3 / 2 / -1438 / upstream / SOAT1
rs7726892 / 0.845 / CAGCAGGTTTatttagcctcaCTGCTTTTTK / T / 6.2 / G / 4.2 / 11 / 1486 / coding / PHAX
rs10780004 / 0.902 / TACCATRCTCaAAACAAGTCA / G / 12.2 / A / 7.3 / 1 / 14881 / coding / RFTN1
rs4645851 / 0.862 / AGACAGGAAMtgCGAAATGCTC / C / 5.7 / A / 3.2 / 2 / -149 / upstream / FOS
rs3731056 / 0.822 / GAGCTTCCTTtagGGGCGWGACT / T / 8.9 / A / 7 / 3 / -15 / upstream / XPC
rs7240884 / 0.762 / CAACATRTTTGATCTTGTAG / G / 10.3 / A / 5.5 / 0 / 1502 / coding / PMAIP1
rs770087 / 0.226 / CKCCCTGCATtgcgagaccAATCTAGACG / G / 6 / T / 1.7 / 9 / 1523 / coding / DUSP6
rs10819442 / 0.813 / GAASATGTCCaCATCCAGAAA / C / 9.5 / G / 4.7 / 1 / 15241 / coding / TBC1D13
rs6020349 / 0.821 / TSCCATTTTGcagtgaggaaGGGCTGGCCG / G / 5.2 / C / 3.8 / 10 / -1551 / upstream / CEBPB
rs6058421 / 0.743 / GAGGAGGTAGgSGACAAGGTT / G / 5.2 / C / 2.9 / 1 / 15643 / coding / BCL2L1
rs7011050 / 0.450 / GCCCAGGCCCctttattACAGAGGTCY / C / 5.4 / T / 5 / 7 / 1572 / coding / TPD52
rs4657690 / 0.874 / AAGCTAGACTctGTGCTTGCCR / A / 14.5 / G / 13.9 / 2 / 1588 / coding / RCSD1
rs1077667 / 0.864 / GTGCRTGTACCCACATGTCC / A / 12.5 / G / 9.7 / 0 / 1627 / coding / TNFSF14
rs35882418 / 0.879 / TCCCGAGNTCtTGGTCATGTT / - / 5.5 / A / -11.8 / 1 / -1637 / upstream / GGT1
rs3759490 / 0.504 / CARCAAGTGTTTGCATGCCT / G / 12.1 / A / 11.8 / 0 / -1687 / upstream / LCP1
rs2282439 / 0.811 / CACCRTGCCCcAAGCAAGCTT / A / 15.1 / G / 10.8 / 1 / 17032 / coding / BCCIP
rs2301559 / 0.623 / GTACATAYATttaaAAACTGGCTA / C / 6 / T / 5.4 / 4 / 17113 / coding / CYP51A1
rs34976217 / 0.834 / GACCAAGNCCataaataAATACTTGCT / - / 11 / C / 1.3 / 7 / -1759 / upstream / PMAIP1
rs11090141 / 0.837 / GAACATCTCCtacWTACCTGGCA / A / 5.9 / T / 3.8 / 3 / -1763 / upstream / BIK
rs3760657 / 0.818 / CRGCAAGACCgagGCCCTTGGTT / G / 8.2 / A / 8 / 3 / -1770 / upstream / CYP2B6
rs12364970 / 0.660 / GAGCAGSCTTtATTCTTGTTT / G / 10.2 / C / 5.2 / 1 / 17729 / coding / CD59
rs7744352 / 0.873 / GARCTACACAggaactAAAGTTGTCT / G / 5.1 / A / 4.9 / 6 / -1776 / upstream / GABRR2
rs2093406 / 0.820 / CRACTAGTTTaCGGCATGTTA / G / 13.3 / A / 13.1 / 1 / -18114 / upstream / MIR4753
rs9724673 / 0.866 / CAACRTGGTAcAGTCATGCTC / A / 11 / G / 6.7 / 1 / 18205 / coding / ACBD3
rs6690928 / 0.691 / TGASAGGCCAgGGTCAAGTTC / C / 12.6 / G / 7.8 / 1 / 18208 / coding / RERE
rs11658168 / 0.858 / TGTCTTGCACtaGAGCTTRCCT / G / 13.8 / A / 9.1 / 2 / 18437 / coding / POLR2A
rs2302459 / 0.444 / GTGCTTGGCAgagcccRGGCACCTCA / G / 6.1 / A / 5 / 6 / 18592 / coding / MYO1C
rs11062386 / 0.711 / CACTCYGCTCtccttcccAGGCACGACC / T / 5.4 / C / 1.4 / 8 / 18703 / coding / LOC100507424
rs17207127 / 0.948 / GGGCATGYGCacAAGGCTGACC / C / 10.3 / T / 10.2 / 2 / 1878 / coding / LTA
rs1555522 / 0.858 / AGTCCAGCAGtttacagcacacaGTGYGTGCTC / C / 5.8 / T / 0.8 / 13 / -1882 / upstream / GALNT12
rs16959641 / 0.876 / GAGSAAGTCCgCTGCAAGTCT / C / 15.8 / G / 11 / 1 / 18823 / coding / USB1
rs6689232 / 0.853 / AAGCAYGAGCaGAGCTAGTAC / T / 10.8 / C / 7.9 / 1 / 19202 / coding / KIF14
rs737777 / 0.663 / AGGCTGGGGAaCAGCCTGTKC / T / 5.8 / G / 3.5 / 1 / 1931 / coding / MCM5
rs2978663 / 0.259 / CGTCCTRTGCaCATCATGTTC / G / 7.6 / A / 2.7 / 1 / 19541 / coding / GSR
rs8112853 / 0.858 / GTGCAGSTGAtgGTGCCTGCCT / G / 8.3 / C / 3.3 / 2 / -1961 / upstream / GAPDHS
rs2072195 / 0.700 / GGCCAWGTCTGGCCAGCCTG / T / 6.3 / A / 6.1 / 0 / 19664 / coding / TCN2
rs8073498 / 0.807 / GAMCATGTCTGCCATAGGTT / A / 5.9 / C / 3.7 / 0 / -19690 / upstream / WRAP53
rs3132424 / 0.527 / GGCCTGGCCTGGCCTKGCCT / T / 14.3 / G / 12.3 / 0 / 19754 / coding / CTTN
rs729437 / 0.712 / GATCTTGCCGagatgatggaacAGGCAGARAT / A / 8.3 / G / 8.3 / 12 / -2003 / upstream / KLC1
rs9577504 / 0.744 / SAATTTGGACaAGACTGGCCG / G / 6.2 / C / 4.9 / 1 / 20453 / coding / LAMP1
rs10915234 / 0.822 / AAACAARTTAcaAGACTTGTCA / G / 14.1 / A / 9 / 2 / 20590 / coding / SRSF4
rs228944 / 0.388 / ATCRGGGCCAGGGCATGTCC / G / 6.7 / A / 6.4 / 0 / 20592 / coding / IL2RB
rs13145111 / 0.476 / ACACAYGCCTGCACATGTAT / T / 12.8 / C / 9.9 / 0 / 20666 / coding / NUDT9
rs22908 / 0.920 / AAACAARCCTaaAAGCCTTGCT / G / 8.6 / A / 3.8 / 2 / 20758 / coding / PEX3
rs10917431 / 0.607 / AGACCTGAGTGGACAKGCCC / T / 14 / G / 11.9 / 0 / 20766 / coding / FUCA1
rs2083918 / 0.822 / AAACATGGCCcacCAGCTATCAY / C / 8 / T / 7.3 / 3 / 2106 / coding / CDS2
rs10098474 / 0.442 / AGGCAGGTCCtcttctatcTTACTGGGYA / C / 7.7 / T / 6.3 / 9 / -212 / upstream / MSRA
rs2677896 / 0.840 / ATACTTGCTTGATCYTGTCG / T / 12.4 / C / 9.4 / 0 / 2141 / coding / METTL4
rs2399888 / 0.828 / AGGCAAGATTcAGRCTCATGT / G / 5.9 / A / 5.3 / 1 / 2174 / coding / 6-Mar
rs17631747 / 0.744 / AGACTTGCTAgGGTCAYGTAC / T / 13.9 / C / 11.1 / 1 / 21867 / coding / STAP1
rs14391 / 0.494 / AGGGTGGTCCtTGGCAGGTKA / T / 6.2 / G / 3.9 / 1 / 21882 / coding / INPP5K
rs166232 / 0.728 / TAACYTGTCCtAAGCCAAAAC / T / 7.2 / C / 7 / 1 / 21957 / coding / USP7
rs12130085 / 0.328 / CAGGARGAATatggatagcagaGAGCATGACA / A / 5.2 / G / 4.1 / 12 / 2227 / coding / NFIA
rs1904415 / 0.829 / AKACATGTTTAAGCTATTCT / G / 12.4 / T / 8 / 0 / 2242 / coding / CDK1
rs10732646 / 0.889 / AAGYATGTTATGACTGTTTC / C / 7.4 / T / 2.9 / 0 / -2249 / upstream / LUM
rs17885780 / 0.823 / CACCAGGTCGgcgagAATCCTGWCT / T / 5.8 / A / 4.5 / 5 / 225 / coding / WRAP53
rs3761654 / 0.903 / KAGGAAGCAAaaggAAACAAGTAT / G / 7.2 / T / 5.4 / 4 / -2293 / upstream / FAP
rs7524763 / 0.655 / GAGCMTGCCTcACACCAGCCC / A / 15.2 / C / 13.2 / 1 / 2334 / coding / SLC9A1
rs2054393 / 0.622 / CRAAATGTATgtgcatAGACATGAAT / G / 7.8 / A / 6.3 / 6 / -2344 / upstream / SLC39A8
rs9622402 / 0.774 / GGCTTAGTCMcAAGCAGGCTC / C / 9 / A / 6.5 / 1 / -2357 / upstream / TXN2
rs1643257 / 0.784 / GGGCATGTTGCGGCAAGRTT / A / 15.6 / G / 14.8 / 0 / 2367 / coding / PODXL
rs11574552 / 0.300 / CACCTTGGTTtAGCCACGYCT / T / 6.7 / C / 6.5 / 1 / -237 / upstream / SPN
rs6050287 / 0.295 / CTGCARGTCTgaaGACCATGCGT / A / 10.6 / G / 9.5 / 3 / 2491 / coding / ACSS1
rs2542604 / 0.899 / ATCCATGSCCaAAACATGTGG / C / 11.7 / G / 8.5 / 1 / 25076 / downstream / MIR1276
rs34852311 / 0.617 / ATACATGTTCaaGGGCATRTAT / G / 14.7 / A / 10.2 / 2 / -2510 / upstream / SLC15A4
rs1003619 / 0.800 / GGGCTTGGTGGGGCTTGSGG / C / 11.7 / G / 9.7 / 0 / -2553 / upstream / RANGAP1
rs202447 / 0.668 / AGACAGKATGatagAGCCTTGGTT / G / 7.6 / T / 2.5 / 4 / -2560 / upstream / SOD1
rs4256746 / 0.775 / GAGAARGCTActagatAACCAAGTAG / A / 6.7 / G / 3.7 / 6 / 2568 / coding / IKBKG
rs6764088 / 0.786 / AGCCTRTTTAaAGGCATGTTA / A / 5.9 / G / 2.9 / 1 / 26253 / coding / EXOSC7
rs10896066 / 0.795 / AAACATCACCctGCACCYGACC / T / 5.5 / C / 2.6 / 2 / -2627 / upstream / FOSL1
rs1216970 / 0.847 / CAACAAGTACAGASAAGCCT / C / 14.7 / G / 9.7 / 0 / -2645 / upstream / ESD
rs13386455 / 0.552 / GGGCATGTGCaARGCAAGCAA / G / 15.2 / A / 14.3 / 1 / 26469 / coding / LBH
rs4898375 / 0.716 / AAGARGGCGCagAGGCGTGTCT / A / 6.8 / G / 3.9 / 2 / -26599 / upstream / MIR3202-2
rs3761438 / 0.844 / TGACTKGGGAaaaTGACTTATCC / T / 5.5 / G / 3.4 / 3 / -2661 / upstream / HMOX1
rs10010062 / 0.816 / AGAAAGGTTAagCAGCTTGCCY / C / 8 / T / 7.3 / 2 / -2753 / upstream / NSG1
rs17047438 / 0.858 / CAGCATGAATaAGACYTGTTC / T / 14.2 / C / 11.2 / 1 / -2848 / upstream / DDX18
rs17197936 / 0.900 / ATAYAAGTCAttcatgaAAACTAAATG / C / 5.1 / T / 0.4 / 7 / -2858 / upstream / POSTN
rs11203035 / 0.668 / CAGCCTGCTTtgtccatactctcCCCCKTGACT / T / 6.2 / G / 4.3 / 13 / -2864 / upstream / CH25H
rs11185792 / 0.850 / CAACAAGAMCcAAACAAGCTA / C / 10.9 / A / 8.2 / 1 / 28681 / coding / PANK1
rs2297216 / 0.594 / ACACCAGCCCtccaaaagggaAATCGTGGGY / C / 7.5 / T / 6.8 / 11 / 295 / coding / DNAJA1
rs11991697 / 0.955 / GTTCTTGCTYacTGTCATGGCT / T / 10 / C / 9.5 / 2 / -2962 / upstream / NBN
rs10867187 / 0.886 / YGACATGTGCaaAGGCCATGGC / T / 6.7 / C / 6.1 / 2 / 29689 / coding / TJP2
rs4293461 / 0.637 / TGGYATATTGatttaaaattggtctttATGCCAGACC / C / 6.4 / T / 1.8 / 17 / 2973 / coding / AQP4-AS1
rs276685 / 0.729 / AAAAAARTCTgaaacacctctggtctgAAGCATTTCA / G / 6.7 / A / 1.7 / 17 / -29744 / upstream / MYO6
rs9998405 / 0.767 / CAACAAGYCTgaaGTGCAAGTTT / C / 14.1 / T / 13.5 / 3 / 29777 / downstream / RASL11B
rs34263388 / 0.730 / GCATTTGTTGaACACTTGTYT / C / 8.8 / T / 7.4 / 1 / 29886 / coding / RCSD1
rs2235930 / 0.529 / AGAYTTGTAGcGAGCAAGCAG / C / 11.4 / T / 6.8 / 1 / 30522 / coding / SDHB
rs28371212 / 0.450 / GAGCTARCCTACACATGTCA / G / 15.5 / A / 10.5 / 0 / -3072 / upstream / HLA-DQB1
rs5755711 / 0.879 / GGGGAAGTCAggaggctgaatCAGCATGSGA / C / 8.6 / G / 6.2 / 11 / -3118 / upstream / HMOX1
rs762670 / 0.738 / TCACAAGCCTGGTCTTGCGY / C / 11.6 / T / 11 / 0 / 3125 / coding / LMF2
rs3768710 / 0.858 / AAGCRTGTTGgtAAACTTGCAG / A / 12.8 / G / 8.5 / 2 / 32192 / coding / BARD1
rs1058932 / 0.779 / ATGCTAGCCCatctggCTGCYGATCT / T / 7.2 / C / 4.2 / 6 / 32393 / coding / CYP2C8
rs6504187 / 0.792 / GAGCRTGCTTTGCCCTGCCC / A / 13.2 / G / 8.9 / 0 / 3252 / coding / SMARCD2
rs2254343 / 0.794 / CSTCATGTCTtCGGCCTGGAG / G / 7.3 / C / 3.5 / 1 / 328 / coding / C19orf54
rs9325613 / 0.825 / CAGCATGCMTGTGCAGTGCC / C / 9.9 / A / 7.2 / 0 / 33193 / coding / WDR4
rs337253 / 0.638 / AATCATGACCtAGACACAKTC / T / 6.8 / G / 4.7 / 1 / 33294 / coding / SLC30A5
rs2234130 / 0.392 / GGGCCTGCCAgAGACCAASGC / C / 9.5 / G / 7.2 / 1 / 3334 / coding / TNFAIP2
rs1874618 / 0.758 / GAGCTTGGCCcTCTCTTGYCC / T / 10.2 / C / 10 / 1 / -3345 / upstream / MGST2
rs4151132 / 0.862 / GGACAAGGAGGGYCAGGTCA / C / 8.5 / T / 7.8 / 0 / 3353 / coding / FGF11
rs2065001 / 0.858 / GGGCCAGASGaAGACAAGAGA / C / 7.7 / G / 4.7 / 1 / 33571 / coding / SLC35D1
rs17721905 / 0.781 / GGACTAGTAAGGACAAGACR / G / 11.5 / A / 10 / 0 / 33645 / coding / TRUB1
rs7210579 / 0.784 / GCGCGTGTCTgtRGACTTGATG / G / 10.5 / A / 9.4 / 2 / 3370 / coding / RSAD1
rs34621770 / 0.843 / CTGCTTGTCAaactGCCCTTGWCA / T / 9.1 / A / 5.6 / 4 / -3389 / upstream / LAPTM5
rs4520110 / 0.861 / STGCAAAGTCcctgaaacagaaggAGGCCAGCGT / G / 5.1 / C / 2.7 / 14 / 33893 / coding / POR
rs2301263 / 0.368 / GCAGGGGCTTgGGGCRTGCCT / A / 10.1 / G / 6.1 / 1 / 34291 / coding / GPI
rs9270078 / 0.488 / TATCATRTTCTCACTTGCCC / G / 10.4 / A / 5.4 / 0 / 3434 / coding / HLA-DRB1
rs1057556 / 0.719 / KTTGAAGCTCAGACTTGGTC / G / 7.7 / T / 4.9 / 0 / 3460 / coding / EEF1D
rs4135233 / 0.848 / AGACTGGTRTattCTACAAGGCA / G / 6.1 / A / 5.7 / 3 / -34904 / upstream / C9orf152
rs4616574 / 0.793 / GGGCAGGACTggagattgaggctgTGACTTARGC / G / 5.8 / A / 4.4 / 14 / -3505 / upstream / IL2RB
rs10870122 / 0.797 / ATCCAAGCACAGGCATSCTC / G / 13.1 / C / 8.1 / 0 / 3536 / coding / LCN15
rs17705633 / 0.605 / GACBGAGGCCtgcaattcaaGGACAAGAAG / C / 6.2 / T / 1.5 / 10 / 3601 / coding / SBSN
rs3794964 / 0.432 / GTGCGTGTCCgctgGAACTTGRGG / G / 8.4 / A / 7.1 / 4 / 364 / coding / LOC100131691
rs12020988 / 0.405 / CCACATGCATGSACAGATAC / G / 6.2 / C / 3.1 / 0 / 36543 / coding / XPO4
rs1648282 / 0.708 / TGCCATGTCTcccccacTGARCAGCTT / A / 6.8 / G / 6.8 / 7 / 3673 / coding / DUOX1
rs5952513 / 0.848 / ASCCAGGGGTgGGGCAGGTCC / G / 11.5 / C / 10.1 / 1 / 3674 / coding / WDR45
rs938733 / 0.676 / TATCAGGTCASGACTTGGCC / G / 11.2 / C / 8.8 / 0 / 36943 / coding / GYPC
rs17658295 / 0.559 / GTACAAGTCAcctagatcttTGTCRTACTC / A / 7.2 / G / 4.4 / 10 / -3771 / upstream / DUSP1
rs2145028 / 0.755 / AAACATGTWAgatAGTCTTGCCT / T / 14.6 / A / 12.6 / 3 / 37822 / coding / BAZ1A
rs2472649 / 0.817 / GGAAATGTGCgttAAAAAYGTTC / T / 8.1 / C / 5.3 / 3 / -3801 / upstream / PPBP
rs1076438 / 0.496 / GAGCTGGTCAGGGTTYGCAG / T / 5.8 / C / 1.5 / 0 / 38016 / coding / LASP1
rs6583658 / 0.122 / AGACAGGCCGGGGCRTGGTT / A / 14.8 / G / 10.8 / 0 / 38089 / coding / RXRA
rs35224572 / 0.846 / AGTATAGCCCaGGTCNTTGCT / - / 7.7 / C / -0.2 / 1 / 3814 / coding / TPP1
rs2285452 / 0.784 / CACCTGCCCTGTRCATGTCT / G / 8.8 / A / 8.6 / 0 / 3817 / coding / IL21R-AS1
rs2033654 / 0.674 / GATCATGAGGGACCTKGCCT / T / 11.4 / G / 9.3 / 0 / 38947 / coding / ADCY3
rs6928414 / 0.586 / CCTCATGCYCtAAGCCTGCCT / C / 12.6 / T / 11.7 / 1 / -3906 / upstream / FOXC1
rs494791 / 0.662 / GAGMAAGAGCCGCCAAGCCT / C / 9.7 / A / 4.9 / 0 / 391 / coding / CCDC90B
rs12276987 / 0.547 / AGCCCAGTTCCTAACAGCYC / C / 5.4 / T / 5.2 / 0 / -3941 / upstream / TP53AIP1
rs7571060 / 0.317 / ATAYATGCATtgcccttaGAGCCAGTAG / C / 7.9 / T / 3.3 / 8 / -3986 / upstream / CYP1B1
rs6922865 / 0.498 / AGGCTAGCTAggaAGACAAKGCA / G / 11.1 / T / 5.9 / 3 / -4072 / upstream / MAPK13
rs13092196 / 0.868 / AGACAGGCTGgtGACCCAKGAT / G / 6.1 / T / 0.8 / 2 / -415 / upstream / SLC6A1
rs2256974 / 0.783 / TAKGAAGCCCattccttctccagcgtACCCCAGCCT / G / 7.1 / T / 3.8 / 16 / 416 / coding / LST1
rs3806624 / 0.425 / GGCCTGTCTCCAACTYGCCC / T / 8.4 / C / 4.1 / 0 / -417 / upstream / EOMES
rs7223966 / 0.768 / ACACTRGCCTaAAGCCTGCTG / A / 11.2 / G / 8.2 / 1 / 41850 / coding / DDX42
rs34303686 / 0.761 / AGGCAARCGCTGCCATGTTT / G / 13.7 / A / 8.9 / 0 / 4207 / coding / PIP4K2A
rs11878322 / 0.910 / GGTCTTGCTTtTTGGAYGTGC / T / 6.4 / C / 2.1 / 1 / 43216 / coding / ANKRD27
rs7922341 / 0.832 / GGACTAGATTTAMCCTCCCA / A / 5.6 / C / 2.5 / 0 / 43302 / coding / DCLRE1C
rs35531692 / 0.818 / TATCTTATCCctAAWCATGTAG / A / 5.1 / T / 4 / 2 / 43771 / coding / AKR1C3
rs3082211 / 0.836 / GCTCAGGCACcAGCCTAGNCC / - / 8.3 / AA / 0.6 / 1 / -438 / upstream / RFC4
rs7623898 / 0.848 / CCTCAGGGGGtGGAYAGGCCT / C / 8.1 / T / 3.2 / 1 / 43819 / coding / CCDC12
rs12123077 / 0.750 / AACTGGGCCCaGAACTTRTTC / G / 7.5 / A / 2.8 / 1 / 44404 / coding / SLC9A1
rs459112 / 0.813 / AGACGAGCGCggtaacggaGCWCTTGAAG / A / 6.7 / T / 5.6 / 9 / -449 / upstream / OXSR1
rs28425205 / 0.670 / AAACATGAACYGGCAAGGCC / C / 10.9 / T / 10.6 / 0 / 4493 / coding / GRIN1
rs34676151 / 0.831 / AGGCCTGGGCtccGCTNCCTGAT / - / 5.5 / C / -4.6 / 3 / -4501 / upstream / KRT1
rs11157930 / 0.852 / TGGCCTGTTTgaccctcctactgctcCAAATTKCTT / G / 7.3 / T / 2.1 / 16 / -4510 / upstream / PRMT5
rs12434608 / 0.665 / GGCSAAGTGCaGGGCAAGTTG / C / 14.9 / G / 10.1 / 1 / 4535 / coding / MTHFD1
rs28451322 / 0.794 / CAGTTTGCTCttcgtgacacgtgactCGGCAAGGRG / A / 5.2 / G / 5.1 / 16 / -46 / upstream / S100A6
rs464962 / 0.893 / AAACKTGGCAAAGCAAGCCT / T / 13 / G / 10.5 / 0 / -461 / upstream / MCCC2
rs17885721 / 0.805 / AGGTAAGTTGtagtcatACTCCTGGCY / C / 6.1 / T / 5.4 / 7 / -4641 / upstream / PON1
rs1484994 / 0.833 / GAACCTGTTCggcTGTCYTGTCC / T / 13.8 / C / 12.7 / 3 / 4681 / coding / BCL2L1
rs2857109 / 0.362 / RGGCGTGTTGaaGGCCTTGGCT / G / 11.4 / A / 10.7 / 2 / 469 / coding / HLA-DOB
rs7253411 / 0.329 / GGCCCCGCCTccaAGACCAGGRT / A / 6.5 / G / 6.4 / 3 / -4719 / upstream / ZNF611
rs17880932 / 0.835 / GCAGAAGWGTGAGCAGGTGT / T / 5.8 / A / 4.7 / 0 / 475 / coding / C1QA
rs16963989 / 0.938 / GGGCTTGCACtcGGGGTCRCCC / G / 9.9 / A / 5.2 / 2 / -481 / upstream / HERPUD1
rs1358851 / 0.835 / TGGCAASCGGgctaCAGCATAGTC / G / 6.2 / C / 1.1 / 4 / 4828 / coding / UBE2J1
rs7331784 / 0.893 / AGCCAGCCTCKGGCATGTAC / G / 9.5 / T / 7.8 / 0 / -4866 / upstream / CDC16
rs11218941 / 0.457 / AAGCACGCCAAGAACRGCTC / A / 6.5 / G / 2.8 / 0 / 492 / coding / HSPA8
rs11585809 / 0.837 / AAACAGGCGGcccGCSCCGGGCT / G / 5.5 / C / 2.3 / 3 / 493 / coding / PQLC2
rs4304716 / 0.860 / CTGCACGTGTAAACAGGCTR / A / 7.3 / G / 6.7 / 0 / -4965 / upstream / MSMB
rs4995341 / 0.517 / AGTCAYGTAGTGACTAGGGC / T / 6.4 / C / 2.4 / 0 / -498 / upstream / CCL3
rs354678 / 0.866 / AGGCATGGAAAAGCAYGCCC / T / 13.3 / C / 9 / 0 / 50424 / coding / ARHGAP15
rs12151019 / 0.718 / GAACCTGTGTgcttcaagagacAGAGARGAGG / A / 5.1 / G / 1.4 / 12 / -508 / upstream / GAPDHS
rs2230267 / 0.287 / CTTCTTCCGCGAAYTGGCCG / C / 5.1 / T / 0.2 / 0 / 522 / coding / FTL
rs1391221 / 0.657 / ASTCTAGTCTcataatgttaGGATATTTCT / G / 8.8 / C / 7.4 / 10 / -526 / upstream / EED
rs686402 / 0.715 / YAGCATGTGCttAGAGGAGATC / T / 6 / C / 5.4 / 2 / 5277 / coding / COQ9
rs35794739 / 0.853 / GTGCAGGTARcgtGGTCAGGCCG / G / 6.5 / A / 5.8 / 3 / 529 / coding / PRDX6
rs1693507 / 0.676 / CMGCAAGTCGtTAACAGGCCT / A / 12.6 / C / 11.4 / 1 / 5301 / coding / MYO5A
rs7524624 / 0.917 / ATCCGTGTTTTTGCATGWCT / T / 8.8 / A / 5.3 / 0 / -5352 / upstream / STX12
rs2276361 / 0.391 / GGGCRTGACCCACCCAACCG / A / 6.2 / G / 1.9 / 0 / 5432 / coding / NADSYN1
rs34774688 / 0.362 / GGAGATGCTCAAWCAATGCT / A / 7.6 / T / 6.5 / 0 / -547 / upstream / ADH1C
rs9790624 / 0.908 / AGGCAYGTAAttTAAGATGTTG / T / 6.7 / C / 2.8 / 2 / 54901 / coding / MND1
rs4654103 / 0.295 / TTACTACTKTAGACATGCTG / T / 5.6 / G / 3.3 / 0 / 55095 / coding / SMYD3
rs10993994 / 0.729 / AATGAYGTCGaatgcGTGGTTGCCC / T / 5.6 / C / 2.7 / 5 / -56 / upstream / MSMB
rs3778515 / 0.825 / MCCCAGGTCTtGGGCACCTCA / A / 5.1 / C / 4.4 / 1 / 5606 / coding / BAG2
rs35451939 / 0.879 / ATGCTTACYCAGGCAAGCCT / C / 11.7 / T / 10.9 / 0 / -568 / upstream / MBL2
rs8176384 / 0.862 / CAGCCTNTGCcAGGCACCCTC / G / 5.8 / - / -11.4 / 1 / 57 / coding / TNFAIP2
rs4810688 / 0.663 / GRGCAGGTGTcttGGACAGGCCC / G / 15.9 / A / 15.7 / 3 / 5718 / coding / SULF2
rs2280750 / 0.569 / GGCCATGTCAGGACWTGTGA / A / 12.7 / T / 11.7 / 0 / 5722 / coding / CYP4F3
rs680083 / 0.806 / CAGCAAGCCTCGCCCTRGTT / G / 8.7 / A / 4.2 / 0 / 5782 / coding / PEA15
rs3781981 / 0.705 / ATGCATRTATaAGACATGTGG / G / 10.6 / A / 5.7 / 1 / 57866 / coding / CEP164
rs896817 / 0.784 / GACRAGGCCCGTGCTAGCTT / A / 6.3 / G / 6.3 / 0 / 5822 / coding / SPI1
rs2224933 / 0.809 / GATTCTGTTCaCAACRTGTTT / A / 6.7 / G / 3.8 / 1 / -59408 / upstream / LAMC2
rs2233026 / 0.841 / GGGCAGGCCAGGGCCYAGCC / T / 8.9 / C / 4.6 / 0 / 6002 / coding / MAD2L2
rs2010659 / 0.660 / GAACATGTMTgaTAACTAGTTG / C / 13.7 / A / 11.1 / 2 / 6056 / coding / APOL2
rs12219246 / 0.774 / GGCCTAGGCRacaGAACAAGACT / G / 9.2 / A / 8.5 / 3 / -611 / upstream / C10orf32
rs2235108 / 0.658 / TACCAYGCCAaaGGGCCTGTCC / T / 12.4 / C / 8.4 / 2 / 6227 / coding / TRIB1
rs34231866 / 0.851 / TGACYGGGCGggggtctcagctttcAGTCATGGCC / T / 6.7 / C / 3.1 / 15 / 624 / coding / PRDX2
rs11865 / 0.861 / CCACRTGTTTcACACAAGTGT / A / 9.5 / G / 5.2 / 1 / 62475 / coding / GSE1
rs12105811 / 0.822 / GATCCTGCTTGGTCRTGTCC / A / 12.6 / G / 8.6 / 0 / 6270 / coding / CFLAR-AS1
rs10414710 / 0.743 / GTGCTGGKGAcacagagGGGCTGGTGT / T / 8.1 / G / 6.4 / 7 / 62846 / coding / ZFR2
rs4806174 / 0.507 / AACCTTGCCGgGGACGTGCTS / C / 12.4 / G / 10 / 1 / 633 / coding / GAPDHS
rs1359882 / 0.675 / AAATGTGCAGGGGCTGRCCC / G / 8.1 / A / 3.5 / 0 / 63326 / coding / PALM2
rs1867726 / 0.817 / GGGCMGTCCTtgcgggagcGCCCAGGGCT / A / 5.2 / C / 1.2 / 9 / 636 / coding / MZF1
rs1678199 / 0.763 / GGTCATGCCAATACKTGCCA / T / 13.2 / G / 9.5 / 0 / 64690 / coding / SP100
rs28565256 / 0.821 / AGGCAGGCTGCCYCAGGGCC / C / 5.4 / T / 4.6 / 0 / -650 / upstream / OGG1
rs4791711 / 0.798 / GGACATGTYTGAGCTGCAGG / C / 6.2 / T / 5.5 / 0 / 66884 / downstream / NDEL1
rs3087367 / 0.629 / GGACTYGCCTGGGCCTGATG / T / 14.5 / C / 10.6 / 0 / 6961 / coding / POLD2
rs16853678 / 0.838 / CAGYATGTATgaGCTCATGTTT / C / 9.7 / T / 5 / 2 / 69694 / coding / BBX
rs12453963 / 0.785 / AGACTGGCCCcaTTTCCAGGGY / C / 5.1 / T / 4.4 / 2 / -7022 / upstream / EIF1
rs194850 / 0.748 / GGCCATGGTCccTSGCTAGTGC / G / 12 / C / 9.8 / 2 / 70608 / coding / ORC5
rs3918022 / 0.311 / GGGCTGGTCCccGGGCACSCTG / G / 12.8 / C / 7.8 / 2 / 714 / coding / SETD3
rs6732518 / 0.522 / CCACAAGCACatAYACATGCTC / C / 11.1 / T / 10.6 / 2 / 72036 / coding / BCL11A
rs7034509 / 0.768 / RGACTAGTCTTTGCTAGTTT / G / 12.6 / A / 12.2 / 0 / 72104 / coding / SPTLC1
rs1895320 / 0.779 / TGGCATGGCTATGAYAGGCC / T / 5.4 / C / 4.3 / 0 / 722 / coding / PTTG1
rs17761666 / 0.735 / CTGCTGCTCCtgGGGCAASCTT / G / 8.2 / C / 3.3 / 2 / 7263 / coding / AK3
rs10797056 / 0.735 / AGGCTTRCTAgGAGCTTGGTT / G / 14.2 / A / 9.2 / 1 / 7326 / coding / CHTOP
rs2005618 / 0.879 / GGACATGACYtcTGTCTTGTTA / C / 11.2 / T / 10 / 2 / 7355 / coding / MBD4
rs3806370 / 0.842 / GGCCTTGCATcagaAGTCACRTGG / G / 7.8 / A / 3.3 / 4 / -741 / upstream / FCGR3A
rs4808105 / 0.563 / TATCTTGTTCcTGGYATGTCC / C / 13.8 / T / 8.9 / 1 / 7436 / coding / CCDC124
rs6066438 / 0.805 / AGACATGTCCCCSCCATGCC / G / 9 / C / 6.7 / 0 / 74899 / coding / SULF2
rs618369 / 0.641 / GGGCAGGTGTGGGCTCTKAC / T / 6.4 / G / 3.4 / 0 / 75250 / coding / PTPRF
rs8006147 / 0.788 / CTTAATGCCCCAGCRTGTCT / A / 9.7 / G / 5.7 / 0 / -7566 / upstream / PGF
rs757694 / 0.807 / CAGCATTAACtgMCACAGGCCC / A / 5.1 / C / 4 / 2 / -7578 / upstream / PURB
rs6107581 / 0.700 / GGGCTGGTGTtATCMGTGTTC / C / 5.6 / A / -0.3 / 1 / 7630 / coding / CDS2
rs5746086 / 0.855 / ARTGAGGAAGgtggGAACTAGTCC / G / 5.1 / A / 4.9 / 4 / -773 / upstream / SOD2
rs34272846 / 0.852 / GGCCCAGTGAtgactgaGNTGCAAGCA / - / 5.3 / C / -8.5 / 7 / -780 / upstream / ANXA3
rs12602273 / 0.840 / GCTSTTTCTGcaattgttctattTCACTTGTTC / C / 5.1 / G / 0.1 / 13 / 7855 / coding / TP53
rs12686320 / 0.847 / ACCYGTGCCCCAGCATGCCC / C / 12.1 / T / 7.6 / 0 / 7951 / downstream / MIR601
rs4630 / 0.922 / TGGCTTGCYTaAGACTTGCCC / C / 18.2 / T / 17.3 / 1 / 7962 / coding / GSTT1
rs1407885 / 0.627 / TAACTTGYCCGGCCCAAGCT / C / 5.4 / T / 5.2 / 0 / 800 / coding / LAPTM5
rs10735003 / 0.832 / ACGCATGCACACACAYGTGC / T / 11.7 / C / 8.8 / 0 / 80139 / coding / ADIPOR2
rs1610376 / 0.848 / GGGCAAGCTAaAGGCCTGCRC / A / 16 / G / 16 / 1 / 80552 / coding / SULF2
rs3759067 / 0.820 / GGGCAGATTAagtgataTAGCATRAGC / G / 5.4 / A / 0.9 / 7 / -819 / upstream / HBE1
rs2301242 / 0.331 / CAGCTGGWGTgcGAGCTGGGCT / T / 10.9 / A / 9.8 / 2 / -82 / upstream / TXN
rs2070709 / 0.246 / CCACAYGTTCTGGCAGAACC / T / 5.4 / C / 2.6 / 0 / 8261 / coding / SERPINA1
rs28363301 / 0.724 / TCACTTGTNGcACATCTCTCT / TGT / 7.1 / - / -4.6 / 1 / 845 / coding / RAD51C
rs2279013 / 0.844 / GTACRAGTCCACACATTTTA / A / 7.1 / G / 4.3 / 0 / 84521 / coding / CEP164
rs10838171 / 0.666 / AGACATRTAGacAAGCATGTAC / G / 15.1 / A / 10.2 / 2 / -84994 / upstream / ALKBH3
rs4772468 / 0.244 / AAGGCAGTTGtcaGGRCCAGTGT / G / 5.7 / A / 5.1 / 3 / -8513 / upstream / FGF14
rs16889347 / 0.694 / CGACTTGTCAaTGACCYGCCC / T / 12.3 / C / 8 / 1 / 8546 / coding / MTCH1
rs667676 / 0.456 / GGGGRAGCACcaGAACCTGGTG / A / 7.3 / G / 3 / 2 / 85670 / coding / PTPRF
rs7037941 / 0.795 / CKTCTAGCTCATGCTTGTCC / G / 13.6 / T / 12.2 / 0 / 86217 / coding / MLLT3
rs2073083 / 0.740 / AGGCMAGTGCtCAGCATGCAT / A / 14.8 / C / 12.7 / 1 / 8750 / coding / SAMM50
rs12195078 / 0.657 / AGGYATGAGGcctattaaaGTTCTTTTCC / C / 5.6 / T / 1.1 / 9 / -8774 / upstream / GABRR2
rs12330842 / 0.699 / GGAYTTGTTCTGAAGTGTTC / C / 9.4 / T / 4.7 / 0 / -88185 / upstream / LINC00636
rs2344436 / 0.828 / GYACGTGCTCGCACTTGCAC / T / 9.3 / C / 9.2 / 0 / -88274 / upstream / AKAP13
rs7741729 / 0.692 / TTACAAGTCAaaggagcagAAGGAGRCCC / G / 5.9 / A / 1.2 / 9 / -8828 / upstream / STK38
rs2076433 / 0.467 / GGAAASGGAAcactgggcttctgtaGAGCAGGCCT / G / 5.1 / C / 4.3 / 15 / 887 / coding / EME2
rs3853255 / 0.828 / AGTCTYGGAGtgAGACAGCCCT / T / 5.5 / C / 2.6 / 2 / -888 / upstream / SQLE
rs2274227 / 0.808 / AACCTTGMCAcaCAACTTGTCA / C / 12.2 / A / 10.5 / 2 / 895 / coding / TOR3A
rs3027450 / 0.505 / ACRCTTGTTGaatatGTGCAAGTGA / G / 7.9 / A / 7.6 / 5 / 90526 / coding / MAOB
rs861528 / 0.663 / GGGCAACTCCtgccgtgtctggGCCCATRGGA / G / 5.9 / A / 1.4 / 12 / 918 / coding / ZFYVE21
rs17883018 / 0.776 / AGACTTTCTCAGGMTTTTTA / C / 6.1 / A / 0.2 / 0 / 941 / coding / HMOX1
rs35926783 / 0.311 / TGACATGTCTRGGCATGTAG / A / 16.9 / G / 16.5 / 0 / 975 / coding / TRIM22
rs12886469 / 0.852 / AGGCTAGCCTaAGTAYTGGTT / T / 8.4 / C / 7.3 / 1 / 977 / coding / ZFYVE1
rs1329588 / 0.833 / CGAGTAGCCCcggggcgggctGCGMCTGTCA / C / 6.7 / A / 0.8 / 11 / -98 / upstream / IER5L
rs2290847 / 0.852 / AGACRTGCTAatAAGCCTGTTT / A / 15.4 / G / 11.1 / 2
rs13426605 / 0.842 / GGACCAGYGCAAGCCCATAT / C / 5.3 / T / 5.1 / 0
rs7894550 / 0.761 / AGCCATGTGTGACCAKCTTG / T / 5.7 / G / 1.8 / 0
rs6605241 / 0.847 / AAACTTRTGCACACATGTTC / G / 13.1 / A / 8.2 / 0
rs1321881 / 0.492 / GGGCRTGTCCcCAGCCAGAGG / A / 13.8 / G / 9.5 / 1
rs11656941 / 0.673 / GGTCAMGCCTaAATCATGTGG / A / 12.6 / C / 8.9 / 1
rs12075850 / 0.927 / GAACAAGCCAcTGCCTTGTTM / C / 13.1 / A / 10.3 / 1
rs7591636 / 0.915 / AACAARGCCTGAACATGGTT / A / 8.8 / G / 7.7 / 0
rs7834854 / 0.707 / GCTCCTCTCTGCACRTGCTC / A / 5.8 / G / 1.8 / 0
rs6477730 / 0.682 / AGTCTTGCCYGGACTGGTTC / T / 16.7 / C / 16.3 / 0
rs12130070 / 0.901 / GCTCTTGTCTtGGTCATRTTC / G / 13.9 / A / 9.3 / 1
rs10924618 / 0.726 / CAGAATGTTCtGACCAYGTCA / T / 8.7 / C / 4.4 / 1
rs1853495 / 0.570 / GTGAAAGCCTcKGGCAAGTTT / G / 11.9 / T / 9.4 / 1
rs1365047 / 0.728 / CAACTAGAGTttGGGCWTGCTG / A / 12.2 / T / 12 / 2
rs142167 / 0.882 / GAGCATGATGgAAAGCTGRCC / G / 6.5 / A / 5.1 / 1

Supplemental Table S2. The p53RE SNPs associated with gene expression. The linear regression model was used to evaluate the association between log2-transformed expression values of a probe-set and genotypes of a SNP. One SNP can display association with multiple probe sets and multiple nearby genes. An association was considered significant if the p-value from the analysis of the observed data was lower than the threshold of the 0.05 tail of the distribution of the minimal p-values from 10,000 permutations.

rs / SNP to TSS / location / probe / gene / p (mperm)
rs2301559 / 33838 / intron / 215483_at / AKAP9 / 0.0011
rs12276987 / 116650 / downstream / 210791_s_at / ARHGAP32 / 0.0293
rs2286748 / 50538 / downstream / 202641_at / ARL3 / 0.0244
rs1391221 / -57989 / upstream / 219979_s_at / C11orf73 / 0.0054
rs4630 / -31442 / upstream / 202624_s_at / CABIN1 / 0.0343
rs12364970 / 17469 / downstream / 200985_s_at / CD59 / 0.0053
rs12364970 / 31481 / downstream / 200983_x_at / CD59 / 0.0068
rs12364970 / 31481 / downstream / 200984_s_at / CD59 / 0.0158
rs831629 / -651 / upstream / 200985_s_at / CD59 / 0.0084
rs831629 / 13361 / intron / 200983_x_at / CD59 / 0.0403
rs652941 / 12301 / downstream / 202870_s_at / CDC20 / 1.00E-04
rs6107581 / 7558 / intron / 212864_at / CDS2 / 0.0199
rs12105811 / 21657 / intron / 211862_x_at / CFLAR / 0.0377
rs12105811 / 21657 / downstream / 209939_x_at / CFLAR / 0.0065
rs12105811 / 35338 / intron / 209508_x_at / CFLAR / 0.0346
rs686402 / 5227 / intron / 212228_s_at / COQ9 / 0.0082
rs2302459 / -10947 / upstream / 202225_at / CRK / 0.0309
rs2472649 / 5397 / downstream / 214974_x_at / CXCL5 / 0.037
rs1058932 / 89322 / downstream / 214421_x_at / CYP2C9 / 0.0246
rs7223966 / 23508 / intron / 201788_at / DDX42 / 0.0113
rs6504187 / 47209 / downstream / 201788_at / DDX42 / 1.00E-04
rs1648282 / 3673 / rs1648282 / 219597_s_at / DUOX1 / 0.0115
rs17658295 / -3771 / upstream / 201041_s_at / DUSP1 / 0.0064
rs1057556 / 3478 / rs1648282 / 203113_s_at / EEF1D / 0.0216
rs2274227 / 56976 / downstream / 202916_s_at / FAM20B / 0.0097
rs12364970 / 69518 / downstream / 218432_at / FBXO3 / 0.0055
rs831626 / 49712 / downstream / 218432_at / FBXO3 / 0.0139
rs11062386 / 60478 / downstream / 200895_s_at / FKBP4 / 0.0382
rs2230267 / 478 / coding / 213187_x_at / FTL / 0.0041
rs2230267 / 522 / coding / 212788_x_at / FTL / 0.0185
rs3737717 / -20891 / upstream / 220734_s_at / GLTPD1 / 0.0061
rs11157930 / 23149 / downstream / 218383_at / HAUS4 / 0.0067
rs28371212 / -3186 / upstream / 211656_x_at / HLA-DQB1 / 0.0067
rs28371212 / -2944 / upstream / 209480_at / HLA-DQB1 / 0.0191
rs28371212 / -3081 / upstream / 209823_x_at / HLA-DQB1 / 0.0211
rs17883018 / 914 / intron / 203665_at / HMOX1 / 0.0235
rs737777 / 20960 / downstream / 203665_at / HMOX1 / 0.0128
rs11218941 / 398 / intron / 210338_s_at / HSPA8 / 0.0435
rs14391 / 21669 / 3'UTR / 202782_s_at / INPP5K / 0.0045
rs12453963 / -57295 / upstream / 205157_s_at / JUP / 0.0344
rs12453963 / -57298 / upstream / 212236_x_at / JUP / 0.0144
rs1407885 / 800 / Intron / 201721_s_at / LAPTM5 / 0.05
rs17705633 / 16590 / downstream / 222280_at / LOC100506469 / 0.0098
rs2290847 / 189432 / intron / 214109_at / LRBA / 0.0023
rs2256974 / 586 / intron / 214181_x_at / LST1 / 0.04
rs2256974 / 1401 / intron / 215633_x_at / LST1 / 0.0161
rs6922865 / 98272 / downstream / 211561_x_at / MAPK14 / 0.0063
rs1042546 / 50137 / downstream / 200644_at / MARCKSL1 / 0.0196
rs1643257 / 226369 / downstream / 204423_at / MKLN1 / 0.0347
rs7037941 / 86154 / intron / 204917_s_at / MLLT3 / 0.0041
rs12602273 / 95888 / downstream / 209208_at / MPDU1 / 0.0213
rs3737717 / 100543 / downstream / 220526_s_at / MRPL20 / 0.0092
rs10993994 / -56 / upstream / 207430_s_at / MSMB / 0.0203
rs10098474 / -208 / upstream / 219281_at / MSRA / 0.0335
rs3737717 / 51829 / downstream / 213422_s_at / MXRA8 / 0.038
rs2072195 / -34858 / upstream / 202212_at / PES1 / 0.042
rs3132424 / 147551 / downstream / 210235_s_at / PPFIA1 / 0.0285
rs7223966 / -11702 / upstream / 209503_s_at / PSMC5 / 0.027
rs10797056 / -14773 / upstream / 202598_at / S100A13 / 0.0113
rs884171 / 82216 / downstream / 217946_s_at / SAE1 / 0.0237
rs2073083 / 8662 / intron / 201570_at / SAMM50 / 0.0035
rs8073498 / 102888 / downstream / 203871_at / SENP3 / 0.0403
rs276685 / 84744 / downstream / 214790_at / SENP6 / 0.043
rs337253 / 22556 / intron / 218989_x_at / SLC30A5 / 0.0456
rs2054393 / -2435 / upstream / 219869_s_at / SLC39A8 / 0.0053
rs2297216 / 51141 / downstream / 218393_s_at / SMU1 / 0.0442
rs7741729 / -15598 / upstream / 202951_at / STK38 / 0.0408
rs12151019 / -12736 / upstream / 202475_at / TMEM147 / 0.049
rs11658168 / -56025 / upstream / 209500_x_at / TNFSF12 / 0.0311
rs2072684 / -63201 / upstream / 215735_s_at / TSC2 / 0.0218
rs1358851 / 4805 / intron / 217824_at / UBE2J1 / 0.0132
rs7744352 / 35802 / downstream / 217824_at / UBE2J1 / 0.001
rs12195078 / 28640 / downstream / 217826_s_at / UBE2J1 / 0.0487
rs729437 / -88559 / upstream / 219929_s_at / ZFYVE21 / 0.049

Supplementary Table S3. Oligonucleotide sequencesfor testing differential p53 binding to SNP alleles

Oligo NameLuminex Bead #Tag Sequence Oligonucleotide Sequence

WRNC15-TACACTTTCTTTCTTTCTTTCTTTCTTTCTGGCCATCATGAAAGGTGGATTTAGGTGGAAGCTCTGGCATAGAA

P21wt20-CTTTTACAATACTTCAATACAATC CTTTCTGGCCATCATGAACATGTCCCAACATGTTGAGCTCTGGCATAGAA

P21mt73-TTTTACAATACTTCAATACAATC CTTTCTGGCCATCATGAACATTTCCCAACATGTTGAGCTCTGGCATAGAA

ACBD3 Strong89-TATACTATCAACTCAACAACATATCTTTCTGGCCATCATCAACATGGTAcAGTCATGCTCAGCTCTGGCATAGAA

ACBD3 Weak89-TATACTATCAACTCAACAACATATCTTTCTGGCCATCATCAACGTGGTAcAGTCATGCTCAGCTCTGGCATAGAA

C10orf26 Strong33-TCAATTACTTCACTTTAATCCTTT CTTTCTGGCCATCATTGGCAGGTCAGAACTTGCCCAGCTCTGGCATAGAA

C10orf26 Weak33-TCAATTACTTCACTTTAATCCTTT CTTTCTGGCCATCATTGGCAGGTCAGACCTTGCCCAGCTCTGGCATAGAA

C19orf54 Strong25-CTTTTCAATTACTTCAAATCTTCA CTTTCTGGCCATCATCGTCATGTCTtCGGCCTGGAGAGCTCTGGCATAGAA

C19orf54 Weak25-CTTTTCAATTACTTCAAATCTTCA CTTTCTGGCCATCATCCTCATGTCTtCGGCCTGGAGAGCTCTGGCATAGAA

CD59 Strong11-TACAAATCATCAATCACTTTAATCCTTTCTGGCCATCATCCCCAAGCTTTGGCTTCTTTAGCTCTGGCATAGAA

CD59 Weak11-TACAAATCATCAATCACTTTAATCCTTTCTGGCCATCATCCCTAAGCTTTGGCTTCTTTAGCTCTGGCATAGAA

CFLAR Strong33-TCAATTACTTCACTTTAATCCTTTCTTTCTGGCCATCATGATCCTGCTTGGTCATGTCCAGCTCTGGCATAGAA

CFLAR Weak33-TCAATTACTTCACTTTAATCCTTTCTTTCTGGCCATCATGATCCTGCTTGGTCGTGTCCAGCTCTGGCATAGAA

CTTN Strong64-CTACATATTCAAATTACTACTTAC CTTTCTGGCCATCATGGCCTGGCCTGGCCTTGCCTAGCTCTGGCATAGAA

CTTN Weak64-CTACATATTCAAATTACTACTTAC CTTTCTGGCCATCATGGCCTGGCCTGGCCTGGCCTAGCTCTGGCATAGAA

DDX18 Strong66-TAACATTACAACTATACTATCTAC CTTTCTGGCCATCATCAGCATGAATaAGACTTGTTCAGCTCTGGCATAGAA

DDX18 Weak66-TAACATTACAACTATACTATCTAC CTTTCTGGCCATCATCAGCATGAATaAGACCTGTTCAGCTCTGGCATAGAA

DDX42 Strong01-CTTTAATCTCAATCAATACAAATCCTTTCTGGCCATCATACACTAGCCTaAAGCCTGCTGAGCTCTGGCATAGAA

DDX42 Weak01-CTTTAATCTCAATCAATACAAATCCTTTCTGGCCATCATACACTGGCCTaAAGCCTGCTGAGCTCTGGCATAGAA

EEF1D Strong11-TACAAATCATCAATCACTTTAATCCTTTCTGGCCATCATGTTGAAGCTCAGACTTGGTCAGCTCTGGCATAGAA

EEF1D Weak11-TACAAATCATCAATCACTTTAATCCTTTCTGGCCATCATTTTGAAGCTCAGACTTGGTCAGCTCTGGCATAGAA

FAM20B Strong01-CTTTAATCTCAATCAATACAAATCCTTTCTGGCCATCATTGACAAGTTGtgTGGCAAGGTTAGCTCTGGCATAGAA

FAM20B Weak01-CTTTAATCTCAATCAATACAAATCCTTTCTGGCCATCATTGACAAGTTGtgTGTCAAGGTTAGCTCTGGCATAGAA

GLTPD1 Strong74-TACACATCTTACAAACTAATTTCA CTTTCTGGCCATCATGAACATGTTTGCACATGTGTAGCTCTGGCATAGAA

GLTPD1 Weak74-TACACATCTTACAAACTAATTTCA CTTTCTGGCCATCATGAACATGCTTGCACATGTGTAGCTCTGGCATAGAA

HLA-DQB1 Strong31-TTCACTTTTCAATCAACTTTAATC CTTTCTGGCCATCATGAGCTAGCCTACACATGTCAAGCTCTGGCATAGAA

HLA-DQB1 Weak31-TTCACTTTTCAATCAACTTTAATC CTTTCTGGCCATCATGAGCTAACCTACACATGTCAAGCTCTGGCATAGAA

LAPTM5 Strong65-CTTTTCATCAATAATCTTACCTTT CTTTCTGGCCATCATTAACTTGCCCgGCCCAAGCTCAGCTCTGGCATAGAA

LAPTM5 Weak65-CTTTTCATCAATAATCTTACCTTTCTTTCTGGCCATCATTAACTTGTCCgGCCCAAGCTCAGCTCTGGCATAGAA

LRBA Strong12-TACACTTTCTTTCTTTCTTTCTTTCTTTCTGGCCATCATAAACAGGCTTatTAGCACGTCTAGCTCTGGCATAGAA

LRBA Weak12-TACACTTTCTTTCTTTCTTTCTTTCTTTCTGGCCATCATAAACAGGCTTatTAGCATGTCTAGCTCTGGCATAGAA

MARCKSL1 Strong50-CAATATACCAATATCATCATTTAC CTTTCTGGCCATCATGCACATGTCTtGTGCATGTGTAGCTCTGGCATAGAA

MARCKSL1 Weak50-CAATATACCAATATCATCATTTAC CTTTCTGGCCATCATGCACATGTCTtGTACATGTGTAGCTCTGGCATAGAA

MFAP2 Strong02-CTTTATCAATACATACTACAATCACTTTCTGGCCATCATAGACTTGTAGcGAGCAAGCAGAGCTCTGGCATAGAA

MFAP2 Weak02-CTTTATCAATACATACTACAATCACTTTCTGGCCATCATAGATTTGTAGcGAGCAAGCAGAGCTCTGGCATAGAA

MLLT3 Strong02-CTTTATCAATACATACTACAATCACTTTCTGGCCATCATCGTCTAGCTCATGCTTGTCCAGCTCTGGCATAGAA

MLLT3 Weak02-CTTTATCAATACATACTACAATCACTTTCTGGCCATCATCTTCTAGCTCATGCTTGTCCAGCTCTGGCATAGAA

NEDD9 Strong39-TACACAATCTTTTCATTACATCAT CTTTCTGGCCATCATGGGCAAGACTgAGACTTGGTGAGCTCTGGCATAGAA

NEDD9 Weak39-TACACAATCTTTTCATTACATCAT CTTTCTGGCCATCATGGGCAAGACTgAGACTCGGTGAGCTCTGGCATAGAA

PGF Strong01-CTTTAATCTCAATCAATACAAATC CTTTCTGGCCATCATCTTAATGCCCCAGCATGTCTAGCTCTGGCATAGAA

PGF Weak01-CTTTAATCTCAATCAATACAAATC CTTTCTGGCCATCATCTTAATGCCCCAGCGTGTCTAGCTCTGGCATAGAA

PLAUR Strong47-CTTCTCATTAACTTACTTCATAAT CTTTCTGGCCATCATGGACAGGCATGGACATGCACAGCTCTGGCATAGAA

PLAUR Weak47-CTTCTCATTAACTTACTTCATAAT CTTTCTGGCCATCATGGACAGGCATGGACACGCACAGCTCTGGCATAGAA

PMAIP1 Strong48-AAACAAACTTCACATCTCAATAAT CTTTCTGGCCATCATCAACATGTTTGATCTTGTAGAGCTCTGGCATAGAA

PMAIP1 Weak48-AAACAAACTTCACATCTCAATAAT CTTTCTGGCCATCATCAACATATTTGATCTTGTAGAGCTCTGGCATAGAA

PSMC5 Strong26-TTACTCAAAATCTACACTTTTTCA CTTTCTGGCCATCATACACTAGCCTaAAGCCTGCTGAGCTCTGGCATAGAA

PSMC5 Weak26-TTACTCAAAATCTACACTTTTTCA CTTTCTGGCCATCATACACTGGCCTaAAGCCTGCTGAGCTCTGGCATAGAA

PTPRF Strong72-TCATTTACCTTTAATCCAATAATC CTTTCTGGCCATCATGGGCAGGTGTGGGCTCTTACAGCTCTGGCATAGAA

PTPRF Weak72-TCATTTACCTTTAATCCAATAATC CTTTCTGGCCATCATGGGCAGGTGTGGGCTCTGACAGCTCTGGCATAGAA

SBF1 Strong12-TACACTTTCTTTCTTTCTTTCTTT CTTTCTGGCCATCATTCACAAGCCTGGTCTTGCGCAGCTCTGGCATAGAA

SBF1 Weak12-TACACTTTCTTTCTTTCTTTCTTT CTTTCTGGCCATCATTCACAAGCCTGGTCTTGCGTAGCTCTGGCATAGAA

TMEM140 Strong02-CTTTATCAATACATACTACAATCACTTTCTGGCCATCATAAGCTTGTCAAGACTAGTTTAGCTCTGGCATAGAA

TMEM140 Weak02-CTTTATCAATACATACTACAATCACTTTCTGGCCATCATAAGCTTGTCAAGACTAGTCTAGCTCTGGCATAGAA

WDTC1 Strong57-CAATATCATCATCTTTATCATTAC CTTTCTGGCCATCATGAGCATGCCTcACACCAGCCCAGCTCTGGCATAGAA

WDTC1 Weak57-CAATATCATCATCTTTATCATTAC CTTTCTGGCCATCATGAGCCTGCCTcACACCAGCCCAGCTCTGGCATAGAA

Supplementary Table S4. The eQTL databases used for confirming the replication of our SNP-gene association

Reference / Web site / Cells or Tissues and sample size
(Liang et al. 2013) / / Lymphoblastoid cell lines (LCLs) from (1) 400 sib pairs from the MRCA family panel, (2) 550 additional individuals from the MRCE family panel
(Grundberg et al. 2012) / / Adipose, LCLs, and skin from 856 female individuals of European descent recruited from the TwinsUK adult registry
[4] / Peripheral blood samples from 5,311 individuals in European
[5] / Monocytes from 1490 individuals in Germany

References

Bandele OJ, Wang X, Campbell MR, Pittman GS, Bell DA (2011) Human single-nucleotide polymorphisms alter p53 sequence-specific binding at gene regulatory elements. Nucleic Acids Res 39: 178-89. doi: 10.1093/nar/gkq764

Grundberg E, Small KS, Hedman AK, Nica AC, Buil A, Keildson S, Bell JT, Yang TP, Meduri E, Barrett A, Nisbett J, Sekowska M, Wilk A, Shin SY, Glass D, Travers M, Min JL, Ring S, Ho K, Thorleifsson G, Kong A, Thorsteindottir U, Ainali C, Dimas AS, Hassanali N, Ingle C, Knowles D, Krestyaninova M, Lowe CE, Di Meglio P, Montgomery SB, Parts L, Potter S, Surdulescu G, Tsaprouni L, Tsoka S, Bataille V, Durbin R, Nestle FO, O'Rahilly S, Soranzo N, Lindgren CM, Zondervan KT, Ahmadi KR, Schadt EE, Stefansson K, Smith GD, McCarthy MI, Deloukas P, Dermitzakis ET, Spector TD (2012) Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet 44: 1084-9. doi: 10.1038/ng.2394

ng.2394 [pii]

Liang L, Morar N, Dixon AL, Lathrop GM, Abecasis GR, Moffatt MF, Cookson WO (2013) A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines. Genome Res 23: 716-26. doi: 10.1101/gr.142521.112

gr.142521.112 [pii]

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