Supplemental Table 1 Main Characteristics of All Studies Included in the Meta-Analysis
Supplemental Table 1 Main characteristics of all studies included in the meta-analysis
First author/year / Country / Ethnicity / CC / SC / Cancer type / HWEDuell [11] 2001 / USA / African / 155–160 / PB / Breast cancer / Y
Duell [11] 2001 / USA / Caucasian / 233–221 / PB / Breast cancer / Y
Kim [12] 2002 / Korea / Asian / 205–205 / HB / Breast cancer / Y
Smith [13] 2003 / USA / Caucasian / 246–266 / HB / Breast cancer / Y
Moullan [14] 2003 / France / Caucasian / 254–312 / PB / Breast cancer / Y
Smith [15] 2003 / USA / Caucasian / 162–301 / HB / Breast cancer / Y
Han [16] 2003 / USA / Mixed / 998–1,369 / PB / Breast cancer / Y
Deligezer [17] 2004 / Turkey / Caucasian / 151–133 / HB / Breast cancer / Y
Patel [18] 2005 / USA / Mixed / 485–485 / PB / Breast cancer / Y
Chacko [19] 2005 / India / Indian / 123–123 / HB / Breast cancer / Y
Shen [20] 2005 / USA / Mixed / 1,066–1,108 / PB / Breast cancer / Y
Brewster [21] 2006 / USA / Mixed / 309–317 / PB / Breast cancer / Y
Zhang[22] 2006 / USA / Caucasian / 1,580–1,253 / PB / Breast cancer / Y
Pachkowski[23] 2006 / USA / Caucasian / 1,281–1,135 / PB / Breast cancer / Y
Pachkowski[23] 2006 / USA / African / 774–682 / PB / Breast cancer / Y
Jin[24] 2006 / China / Asian / 83–251 / PB / Breast cancer / Y
Thyagarajan[25] 2006 / USA / Mixed / 432–322 / PB / Breast cancer / Y
Silva [26] 2007 / Portugal / Caucasian / 240–453 / HB / Breast cancer / Y
Sangrajrang [27] 2008 / Thailand / Asian / 506–425 / HB / Breast cancer / Y
Loizidou [28] 2008 / Cyprus / Caucasian / 1,097–1,164 / PB / Breast cancer / Y
Smith [29] 2008 / USA / Caucasian / 324–411 / HB / Breast cancer / Y
Smith [29] 2008 / USA / African / 53–75 / HB / Breast cancer / Y
Mitra [30] 2008 / India / Indian / 151–225 / PB / Breast cancer / Y
Sterpone[31] 2010 / Italy / Caucasian / 43–31 / HB / Breast cancer / Y
Ming-Shiean [32] 2010 / China / Asian / 401–533 / HB / Breast cancer / Y
Liu [33] 2011 / China / Asian / 995–1,004 / HB / Breast cancer / Y
Zipprich [34] 2010 / USA / Mixed / 525–632 / FB / Breast cancer / Y
Qian [35] 2010 / China / Asian / 594–620 / PB / Breast cancer / Y
Sobczuk [36] 2009 / Poland / Caucasian / 150–106 / HB / Breast cancer / Y
Forsti [37] 2004 / Finland / Caucasian / 223–298 / PB / Breast cancer / Y
Romanowicz-Makowska [173] 2007 / Poland / Caucasian / 100–106 / HB / Breast cancer / Y
Ratnasinghe [38] 2001 / China / Asian / 108–210 / PB / Lung cancer / Y
David-Beabes [39] 2001 / USA / Caucasian / 180–461 / PB / Lung cancer / Y
David-Beabes [39] 2001 / USA / African / 154–243 / PB / Lung cancer / Y
Chen [40] 2002 / China / Asian / 103–102 / PB / Lung cancer / Y
Hung [41] 2005 / Multiple / Caucasian / 2,147–2,132 / HB / Lung cancer / Y
Schneider [42] 2005 / German / Caucasian / 446–622 / HB / Lung cancer / Y
Shen [43] 2005 / China / Asian / 118–112 / PB / Lung cancer / Y
Chan [44] 2005 / China / Asian / 75–162 / HB / Lung cancer / Y
Hu [45] 2005 / China / Asian / 710–710 / HB / Lung cancer / Y
Zienolddiny [46] 2006 / Norway / Caucasian / 336–405 / PB / Lung cancer / Y
Matullo[47] 2006 / Multiple / Caucasian / 116–1,094 / PB / Lung cancer / Y
Hao[48] 2006 / China / Asian / 1,024–1,118 / PB / Lung cancer / Y
Landi [49] 2006 / Multiple / Caucasian / 296–316 / HB / Lung cancer / Y
De Ruyck [50] 2007 / Belgium / Caucasian / 110–110 / HB / Lung cancer / Y
Pachouri [51] 2007 / India / Indian / 103–122 / HB / Lung cancer / Y
Yin [52] 2007 / China / Asian / 241–249 / HB / Lung cancer / Y
Improta [53] 2008 / Italy / Caucasian / 94–121 / HB / Lung cancer / Y
Li [54] 2008 / China / Asian / 350–350 / HB / Lung cancer / Y
Tanaka [56] 2010 / Japan / Asian / 50–50 / HB / Lung cancer / Y
Janik [57] 2011 / Poland / Caucasian / 88–79 / HB / Lung cancer / Y
Wang [166] 2012 / China / Asian / 209–256 / HB / Lung cancer / Y
Chang [181] 2009 / USA / Caucasian / 113–299 / PB / Lung cancer / Y
Chang [181] 2009 / USA / African / 255–280 / PB / Lung cancer / Y
Buch [192] 2012 / USA / Caucasian / 720-928 / HB / Lung cancer / Y
Guo [193] 2013 / China / Asian / 684-602 / HB / Lung cancer / Y
Abdel-Rahman [92] 2000 / Egypt / African / 48–48 / HB / Colorectal cancer / Y
Hong [91] 2005 / Korea / Asian / 209–209 / HB / Colorectal cancer / Y
Stern [95] 2005 / USA / Mixed / 738–788 / HB / Colorectal cancer / Y
Moreno[88] 2006 / Spain / Caucasian / 363–323 / HB / Colorectal cancer / Y
Skjelbred[59] 2006 / Norway / Caucasian / 156–399 / HB / Colorectal cancer / Y
Berndt [94] 2007 / USA / Caucasian / 692–722 / PB / Colorectal cancer / Y
Berndt [94] 2007 / USA / Mixed / 47–48 / PB / Colorectal cancer / Y
Jin [87] 2007 / China / Asian / 202–616 / PB / Colorectal cancer / Y
Stern [96] 2007 / China / Asian / 305–1,162 / PB / Colorectal cancer / Y
Improta [89] 2008 / Italy / Caucasian / 109–121 / HB / Colorectal cancer / Y
Sliwinski [58] 2008 / Poland / Caucasian / 100–100 / HB / Colorectal cancer / Y
Pardini [189] 2008 / Czech / Mixed / 532-530 / HB / Colorectal cancer / Y
Curtin [90] 2009 / Canada / Mixed / 1,582–1,950 / PB / Colorectal cancer / Y
Brevik [150] 2010 / USA / Mixed / 305–360 / FB / Colorectal cancer / Y
Gsur [147] 2011 / Austria / Caucasian / 85–1,663 / PB / Colorectal cancer / Y
Yin [137] 2012 / Japan / Asian / 685–776 / PB / Colorectal cancer / Y
Muñiz-Mendoza [146] 2012 / Mexico / Caucasian / 107–120 / HB / Colorectal cancer / Y
Gil [93] 2012 / Poland / Caucasian / 133–100 / HB / Colorectal cancer / Y
Li [190] 2013 / China / Asian / 451–628 / HB / Colorectal cancer / Y
Narter [60] 2009 / Turkey / Caucasian / 57–36 / HB / Bladder cancer / Y
Sak [61] 2007 / UK / Caucasian / 535–562 / HB / Bladder cancer / Y
Matullo [62] 2005 / Italy / Caucasian / 315–313 / HB / Bladder cancer / Y
Figueroa [63] 2007 / Spain / Caucasian / 1,096–1,022 / HB / Bladder cancer / Y
Wu [64] 2006 / USA / Caucasian / 614–600 / HB / Bladder cancer / Y
Stern [65] 2001 / USA / Caucasian / 213–197 / HB / Bladder cancer / Y
Stern [65] 2001 / USA / African / 19–13 / HB / Bladder cancer / Y
Wang [67] 2010 / China / Asian / 234–253 / HB / Bladder cancer / Y
Andrew [68] 2008 / USA / Caucasian / 978–1,203 / HB / Bladder cancer / Y
Mittal [129] 2012 / India / Indian / 212–250 / PB / Bladder cancer / Y
Fontana [130] 2008 / France / Caucasian / 51–45 / HB / Bladder cancer / Y
Matullo [175] 2006 / Multiple / Caucasian / 124–1,094 / PB / Bladder cancer / Y
Hsu [158] 2008 / China / Asian / 208–218 / HB / Bladder cancer / Y
Huang [191] 2007 / USA / Caucasian / 614-600 / HB / Bladder cancer / Y
Sturgis [82] 1999 / USA / Mixed / 203–424 / HB / HNC / Y
Olshan [85] 2002 / USA / Caucasian / 98–161 / HB / HNC / Y
Varzim [76] 2003 / Portugal / Caucasian / 88–178 / HB / HNC / Y
Zhu [194] 2004 / China / Asian / 105–105 / HB / HNC / Y
Tae [77] 2004 / Korea / Asian / 120–145 / HB / HNC / Y
Rydzanicz [160] 2005 / Poland / Caucasian / 182–143 / HB / HNC / Y
Demokan [71] 2005 / Turkey / Caucasian / 95–98 / HB / HNC / Y
Gajecka [176] 2005 / Poland / Caucasian / 290–324 / PB / HNC / Y
Matullo [175] 2006 / Multiple / Caucasian / 82–1,094 / PB / HNC / Y
Kietthubthew [72] 2006 / Thailand / Asian / 106–164 / HB / HNC / Y
Ramachandran [86] 2006 / India / Indian / 110–110 / HB / HNC / Y
Cao[73] 2006 / China / Asian / 417–495 / HB / HNC / Y
Majumder [79] 2007 / India / Indian / 307–387 / HB / HNC / Y
Ho [120] 2007 / USA / Mixed / 137–503 / HB / HNC / Y
Yang [83] 2007 / China / Asian / 153–168 / PB / HNC / Y
Chiang [75] 2008 / China / Asian / 283–469 / HB / HNC / Y
Yen [84] 2008 / China / Asian / 103–98 / HB / HNC / Y
Harth[140] 2008 / German / Caucasian / 258–300 / HB / HNC / Y
Sigurdson [195] 2009 / Russia / Mixed / 25–906 / HB / HNC / Y
Kowalski[74] 2009 / Poland / Caucasian / 92–124 / HB / HNC / Y
Ruwali [78] 2009 / India / Indian / 350–350 / HB / HNC / Y
Applebaum [80] 2009 / USA / Caucasian / 484–549 / PB / HNC / Y
Csejtei [125] 2009 / Hungarian / Caucasian / 108–102 / HB / HNC / Y
Ho [128] 2009 / USA / Mixed / 251–503 / HB / HNC / Y
Mahimkar [197] 2010 / India / Indian / 58–57 / HB / HNC / Y
Fard-Esfahani [126] 2011 / Iran / Caucasian / 157–187 / HB / HNC / Y
Gugatschka [131] 2011 / Austria / Caucasian / 168–463 / PB / HNC / Y
Ryu[168] 2011 / Korea / Asian / 111–100 / HB / HNC / Y
Laantri [177] 2011 / Multiple / African / 551–512 / HB / HNC / Y
Kumar [122] 2012 / India / Indian / 278–278 / HB / HNC / Y
Santos [149] 2012 / Portugal / Caucasian / 109–217 / HB / HNC / Y
Dos Reis [196] 2013 / Brazil / Mixed / 150–150 / HB / HNC / Y
Xu [99] 2007 / China / Asian / 207–235 / HB / Prostate cancer / Y
van Gils[100] 2002 / USA / Caucasian / 76–182 / PB / Prostate cancer / Y
Hamano [101] 2008 / Japan / Asian / 142–119 / HB / Prostate cancer / Y
Agalliu [102] 2010 / USA / Caucasian / 1,246–1,235 / PB / Prostate cancer / Y
Agalliu [102] 2010 / USA / African / 146–83 / PB / Prostate cancer / Y
Hirata[103] 2007 / Japan / Asian / 165–165 / HB / Prostate cancer / Y
Mittal [129] 2011 / India / Indian / 195–250 / PB / Prostate cancer / Y
Gao [169] 2010 / USA / Caucasian / 452–158 / HB / Prostate cancer / Y
Mandal [178] 2010 / India / Indian / 171–200 / HB / Prostate cancer / Y
Lee [104] 2001 / China / Asian / 105–264 / HB / Esophageal cancer / Y
Casson [105] 2005 / Canada / Caucasian / 56–95 / HB / Esophageal cancer / Y
Xing [106] 2002 / China / Asian / 433–524 / PB / Esophageal cancer / Y
Hao [107] 2004 / China / Asian / 411–478 / PB / Esophageal cancer / Y
Yu [108] 2004 / China / Asian / 135–152 / HB / Esophageal cancer / Y
Ratnasinghe [109] 2004 / USA / Caucasian / 125–429 / PB / Esophageal cancer / N
Yu[144] 2011 / China / Asian / 432–915 / PB / Esophageal cancer / Y
Ratnasinghe [109] 2004 / USA / Caucasian / 86–429 / PB / Gastric cancer / N
Shen [110] 2000 / China / Asian / 188–166 / PB / Gastric cancer / Y
Palli[111] 2010 / Italy / Caucasian / 295–546 / PB / Gastric cancer / Y
Wen [112] 2012 / China / Asian / 307–307 / HB / Gastric cancer / Y
Duarte [113] 2005 / Brazil / Mixed / 160–150 / HB / Gastric cancer / Y
Yan [114] 2009 / China / Asian / 455–650 / HB / Gastric cancer / Y
Capellá [115] 2008 / Multiple / Caucasian / 245–1,175 / PB / Gastric cancer / Y
Shen [116] 2009 / China / Asian / 503–503 / HB / Gastric cancer / Y
Lee [117] 2002 / Korea / Asian / 190–172 / HB / Gastric cancer / Y
Yuan [127] 2011 / China / Asian / 190–180 / HB / Gastric cancer / Y
Seedhouse [174] 2002 / UK / Caucasian / 126–87 / HB / Leukemia / Y
Joseph [133] 2005 / India / Indian / 117–117 / HB / Leukemia / Y
Zhu [171] 2005 / China / Asian / 63–66 / HB / Leukemia / Y
Pakakasama [136] 2007 / Thailand / Asian / 108–317 / HB / Leukemia / Y
Celkan [182] 2008 / Turkey / Caucasian / 52–60 / HB / Leukemia / Y
Ganster[118] 2009 / Australia / Caucasian / 439–439 / HB / Leukemia / Y
Batar [132] 2009 / Turkey / Caucasian / 70–75 / HB / Leukemia / Y
Meza-Espinoza [167] 2009 / Mexico / Caucasian / 120–120 / HB / Leukemia / Y
Tumer [170] 2010 / Turkey / Caucasian / 167–190 / HB / Leukemia / Y
Canalle[142] 2011 / Brazil / Caucasian / 173–223 / HB / Leukemia / Y
Canalle[142] 2011 / Brazil / African / 28–138 / HB / Leukemia / Y
Duman [145] 2011 / Turkey / Caucasian / 73–50 / HB / Leukemia / Y
Annamaneni [198] 2013 / India / Indian / 350–343 / HB / Leukemia / Y
Banescu [199] 2013 / Romania / Caucasian / 69–147 / HB / Leukemia / Y
Kim [200] 2012 / Korea / Asian / 413–1676 / PB / Leukemia / Y
Matullo [175] 2006 / Multiple / Caucasian / 169–1094 / PB / Leukemia / Y
Shi [201] 2011 / China / Asian / 307–558 / HB / Leukemia / Y
Zhu [202] 2008 / China / Asian / 105–108 / HB / Leukemia / Y
Baris [124] 2009 / Turkey / Caucasian / 33–52 / HB / NHL / Y
Liu [134] 2009 / China / Asian / 221–254 / HB / NHL / Y
Kim [135] 2010 / Korea / Asian / 145–515 / HB / NHL / Y
Shen [152] 2007 / Australia / Caucasian / 556–497 / PB / NHL / Y
Smedby[162] 2006 / DS / Caucasian / 428–601 / PB / NHL / Y
Chiyomaru [164] 2012 / Japan / Asian / 197–93 / HB / Skin cancer / N
Kang [70] 2007 / Korea / Asian / 210–206 / HB / Skin cancer / Y
Han[139] 2004 / USA / Mixed / 215–863 / PB / Skin cancer / Y
Yin [179] 2003 / Denmark / Caucasian / 20–20 / HB / Skin cancer / Y
Goncalves [143] 2011 / Braze / Mixed / 190–207 / HB / Skin cancer / Y
Winsey [69] 2000 / UK / Caucasian / 125–211 / HB / Skin cancer / Y
McWilliams [97] 2008 / USA / Mixed / 466–602 / HB / Pancreatic cancer / Y
Jiao[98] 2006 / USA / Mixed / 182–338 / HB / Pancreatic cancer / Y
Wang[156] 2006 / China / Asian / 101–337 / HB / Pancreatic cancer / Y
Barbisan[172] 2011 / Argentine / Mixed / 103–114 / HB / Cervical cancer / N
Huang [161] 2007 / China / Asian / 473–800 / HB / Cervical cancer / Y
Settheetham-Ishida[138] 2011 / Thailand / Asian / 111–118 / HB / Cervical cancer / Y
Farkasova [180] 2008 / Slovakia / Caucasian / 17–30 / HB / Cervical cancer / NA
Kiuru [163] 2008 / Multiple / Caucasian / 700–1,556 / PB / Glioma / Y
Zhou [153] 2011 / China / Asian / 271–289 / HB / Glioma / Y
Liu [123] 2009 / USA / Caucasian / 373–364 / PB / Glioma / Y
Custodio [183] 2011 / Brazil / Mixed / 80–100 / PB / Glioma / N
Rajaraman [184] 2010 / USA / Caucasian / 342–469 / HB / Glioma / Y
Hu [185] 2011 / China / Asian / 127–249 / HB / Glioma / N
McKean-Cowdin [186] 2009 / USA / Caucasian / 962–1922 / HB / Glioma / Y
Wang [187] 2012 / China / Asian / 624–580 / HB / Glioma / Y
Liu [188] 2012 / China / Asian / 444–442 / HB / Glioma / N
Pan [205] 2013 / China / Asian / 444–443 / HB / Glioma / Y
Luo [203] 2013 / China / Asian / 202–415 / HB / Glioma / N
Huang [119] 2008 / China / Asian / 410–888 / PB / biliary tract cancer / Y
Hirata[121] 2006 / Japan / Asian / 112–180 / HB / RCC / N
Monroy [141] 2011 / USA / Mixed / 196–218 / PB / HL / Y
Kiran [148] 2009 / India / Indian / 63–317 / HB / Liver cancer / N
Han [159] 2012 / China / Asian / 150–159 / HB / Liver cancer / N
Dianzani [151] 2006 / Italy / Caucasian / 81–110 / PB / MM / Y
Sobczuk [154] 2012 / Poland / Caucasian / 94–114 / HB / Endometrial cancer / Y
Bianchino [155] 2011 / Italy / Caucasian / 290–242 / HB / Multiple cancers / Y
Srivastava [157] 2009 / India / Indian / 173–204 / HB / Gallbladder cancer / Y
HNC Head and neck cancer, RCCRenal cell carcinoma, MM Malignant mesothelioma, UTCC urinary transitionalcell carcinoma, DS Denmark and Sweden, HL Hodgkin lymphoma, NHL Non-Hodgkin lymphoma, CC Case–control