Osterberg, L., & Blaschke, T. (2005). Adherence to Medication. New England Journal of Medicine

Osterberg, L., & Blaschke, T. (2005). Adherence to Medication. New England Journal of Medicine

תאריך הגשה 3.4.17

ספרות חובה

הגדרת היענות/סקירה כללית

  • Osterberg, L., & Blaschke, T. (2005). Adherence to medication. New England Journal of Medicine ;353:487-97.
  • DiMatteo, M. R. (2004). Variations in Patients’ Adherence to Medical Recommendations: A Quantitative Review of 50 Years of Research. Medical Care, 42, NO 3,pp 200-209. DOI: 10.1097/01.mlr.0000114908.90348.f9

גורמים המשפיעים על היענות

  • Ingersoll, K. S., & Cohen, J. (2008). The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behavior Med (2008) 31:213–224. DOI 10.1007/s10865-007-9147-y
  • Franklin, J. M., Krumme, A., Shrank, W. H., Matlin, O. S., Brennan, T. A., & Choudhry, N. K.(2015). Predicting Adherence Trajectory Using Initial Patterns of Medication Filling. Am J Manag Care.21(9):e537-e544
  • Jin, J., Sklar, G. E., Min Sen Oh, V., & Li. S. H. (2008). Factors affecting therapeutic compliance: A review from the patient’s perspective. Therapeutics and Clinical Risk Management, 4, (1), 269–286.

תיאוריות המסבירות היענות

  • Horne R, Chapman SCE, Parham R, Freemantle N, Forbes A, et al. (2013) Understanding Patients’ Adherence-Related Beliefs about Medicines Prescribed for Long-Term Conditions: A Meta-Analytic Review of the Necessity-Concerns Framework. PLoS ONE 8(12): e80633. doi:10.1371/journal.pone.0080633
  • Gearing, R. R., Townsend, L., MacKenzie, M., & Charach, A. (2011).Reconceptualizing Medication Adherence: Six Phases of Dynamic Adherence.Harv Rev Psychiatry, 19, 4, pp 177-189. DOI: 10.3109/10673229.2011.602560

אומדן היענות

  • Tan, X., Patel, I., & Chang, J. (2014).Review of the four item Morisky Medication Adherence Scale (MMAS-4) and eight item Morisky Medication Adherence Scale (MMAS-8). Innovations in Pharmacy, vol 5, no 3, article 165 ,pp 1-8.
  • Lam, W. Y., & Fresco, P. (2015). Medication adherence measures: An overview. BioMed Research InternationalVolume 2015, Article ID 217047, 12 pages

ראיון מוטיבציוני

  • Bisono, A. M., Manuel, J. K., & Forcehimes, A. A. (2006). Promoting treatment adherence through motivational interviewing.

תפקיד הרוקח ביחס להיענות

  • Rickles, N. M., MacLean, L. G., Hess, K., Farmer, K. C., Yurkon, A. M., Ha, C. C., Schwartzman, E., Law, A. V., Milani, P. A., Trotta, K., Labella, S. R., & Designor, R. J.(2012). Teaching Medication Adherence in US Colleges and Schools of Pharmacy. . American Journal of Pharmaceutical Education, 76 (5) Article 79,pp 1-9.

רשימת מאמרים לצורך הצגה בשיעור, במסגרת מטלה 1:

הגדרת היענות

Hugtenburg, J. G., Timmers, L., JM Elders, P., Vervloet, M., & van Dijk, L. (2013).

Definitions, variants, and causes of nonadherence with medication: a challenge for tailored interventions. Patient Preference and Adherence, 7, 675–682.

Joyce A. Cramer, J. A., Roy, A., Burrell, A., Fairchild, C, J., Fuldeore, M., J Ollendorf, D, A., Peter K. & Wong, P, K. (2008) Medication Compliance and Persistence: Terminology and Definitions. International Society for Pharmacoeconomics and Outcomes Research, 44-47.

פאקטורים המשפיעים על היענות

Minn, S. (2009).Health Literacy and Medication Adherence.Doctor of Nursing Practice (DNP) Projects.Paper 9.

HaskardZolnierek,K .B., & DiMatteo, R. M. ( 2009). Physician Communication and Patient Adherence to Treatment A Meta-Analysis. Med Care ;47: 826–834

Porteous, T., Francis, J., BondC., Hannaford, P. (2010). Temporal stability of beliefs about medicines: implications for optimising adherence. Patient Education and Counseling 2010 79; 225-230.

Ross, S., Walker, A., & MacLeod, MJ. (2004). Patient compliance in hypertension: role of

illness perceptions and treatment beliefs Journal of Human Hypertension, 18, 607–613.

Heckmana,B. W., Mathewa, A. R., & Carpenter, M. J. (2015). Treatment Burden and Treatment Fatigue as Barriers to Health.CurrOpin Psychol. 5: 31–36. doi:10.1016/j.copsyc.2015.03.004.

מודלים ותיאוריות

M. Robin DiMatteo, Kelly B. Haskard-Zolnierek & Leslie R. Martin (2011).Improving patient adherence: a three-factor model to guide practice, Health Psychology Review, DOI:10.1080/17437199.2010.537592

Johnson, M. J. (2002). The Medication Adherence Model: A Guide for Assessing Medication Taking. Research and Theory for Nursing Practice: An International Journal, Vol. 16, No. 3,179-192

Unni, Elizabeth Jisha. "Development of models to predict medication non-adherence based on a new typology." PhD thesis, University of Iowa, 2008.

Dominika Kwasnicka, Stephan U Dombrowski, Martin White & FalkoSniehotta (2016) Theoretical explanations for maintenance of behavior change: a systematic review of behaviour theories, Health Psychology Review, 10:3, 277-296, DOI: 10.1080/17437199.2016.1151372

Scheurer, D., Choudhry, N., Swanton, K. A., Matlin, O., & Shrank, W. (2012). Association Between Different Types of Social Support and Medication Adherence. Am J ManagCare.18(12):e461-e467

Klein, D. E ,. Wustrack. G., & Schwartz, A. (2006).Medication adherence: Many conditions a common problem. Proceedings of the Human Factors and Ergonomics Society 50th Annual Meeting.

הערכת/אומדן היענות

Geers, H. (2012). Measuring and predicting medication adherence using dispensing data and patient beliefs.

Mishali M, Omer H, Vaknin YS & Heymann AD.(2007). Conceptualization and measurement of resistance to treatment: the resistance to treatment questionnaire for people with diabetes. Family Practice, 24: 610–615.

Boskovic,J., Leppée,M., Culig, J., Fuckar, S., Mandic-Zovko,N., Ratz, A., & Jakovljevic, M. (2014). Comparison of two different methods (patient questionnaire and medication possession ratio- MPR)for measuring the chronic patient's behavior. PsychiatriaDanubina, Vol. 26, Suppl. 3, pp 498–508

Sidorkiewicz S, Tran V-T, Cousyn C, et al. (2016). Development and validation of an instrument to assess treatment adherence for each individual drug taken by a patient. BMJ Open, ;6: e010510. doi:10.1136/ bmjopen-2015-010510


Haynes, R. B. , Yao, X., Degani, A., Kripalani, S., Garg, A., & McDonald, H. P. (2006). Interventions for enhancing medication adherence (Review). Published by John Wiley & Sons, Ltd.

Reach, G. (2009). Can Technology Improve Adherence to Long-Term Therapies? Journal of Diabetes Science and Technology, 3, 3, 492-499.

Patient Apps for improved healthcare.(2013). IMS Institute for healthcare informatics.

Stawarz, K., Cox, A.L., & Blandford, A. (2014).Don’t Forget Your Pill! Designing Effective Medication Reminder Apps That Support Users’ Daily Routines. doi.org/10.1145/2556288.2557079

היענות: כוח ההרגל

PhillippaLally & Benjamin Gardner (2013) Promoting habit formation,

Health Psychology Review, 7:sup1, S137-S158, DOI: 10.1080/17437199.2011.603640

Reach, G. (2004). Role of habit in adherence to medical treatment.Diabet Med. 22, 415-420. DOI: 10.1111/j.1464-5491.2004.01449.x

Bolman, C., Arwert, T. G., & Trijntje Vo¨ llink, T. (2011). Adherence to prophylactic asthma medication: Habit strength and cognitions. Heart & lung: the journal of critical care. 1-14. DOI: 10.1016/j.hrtlng.2010.02.003