Multivariable Logistic Regression Analysis: Postoperative Outcomes Stratified by Extent
Supplemental Table 1.
Multivariable Logistic Regression Analysis: Postoperative outcomes stratified by extent of resection.
Comparison / Odds Ratio / 95% Confidence Interval / P ValueMinor Hepatectomy
30 Day Mortality
High Risk Diagnosis vs Low Risk Diagnosis / 3.14 / 1.86-5.30 / <0.001
65-74 vs <50 / 3.45 / 1.16-10.42 / 0.026
Age 75+ vs <50 / 5.57 / 1.79-17.4 / 0.003
Serum Albumin
<3.5 vs 3.5/Unknown / 2.85 / 1.63-5.00 / <0.001
Partially or Totally Dependent vs Independent/Unknown / 4.17 / 1.36-12.8 / 0.012
Pre-op Platelet
<100K vs 101K-450K/Unknown / 2.99 / 1.40-6.37 / 0.005
Pre-op Creatinine
>1.5 vs 1.0 / 3.18 / 1.50-6.73 / 0.003
4th Quartile Total Operative Time 4.5 hours vs 1st Quartile Total Operative Time <2.5 hours / 6.59 / 2.91-14.9 / <0.001
BMI 30 vs <30 / 1.72 / 1.05-2.84 / 0.033
Major Morbidity
High Risk Diagnosis vs Low risk Diagnosis / 1.47 / 1.21-1.78 / <0.001
Age 75+ vs <50 / 1.55 / 1.12-2.13 / 0.007
Serum Albumin
<3.5 vs 3.5 / 1.43 / 1.10-1.87 / 0.009
Pre-op Total Bilirubin 2.0 vs 1.0 / 1.86 / 1.19-2.90 / 0.006
ASA class 3-4 vs ASA class 1-2 / 1.36 / 1.11-1.68 / 0.003
4th Quartile Total Operative Time 4.5 hours vs 1st Quartile Total Operative Time <2.5 hours / 3.19 / 2.53-4.04 / <0.001
Prolonged Length of Stay
(Days from operation to discharge <7 vs 7+ Days)
High Risk Diagnosis vs Low Risk Diagnosis / 1.42 / 1.22-1.65 / <0.001
Age 65-74 vs <50 / 1.57 / 1.28-1.93 / <0.001
Age 75+ vs <50 / 2.42 / 1.90-3.08 / <0.001
Serum Albumin
<3.5 vs >= 3.5 / 1.57 / 1.26-1.96 / <0.001
Partially or Totally Dependent vs Independent/Unknown / 2.52 / 1.42-4.47 / 0.002
Pre-op Total Bilirubin 2.0 vs 1.0 / 1.62 / 1.07-2.46 / 0.022
2nd Quartile Total Operative Time 2.5-<3.25 hours vs 1st Quartile Total Operative Time <2.5 hours / 1.84 / 1.50-2.27 / <0.001
3rd Quartile Total Operative Time 3.25-<4.5 hours vs 1st Quartile Total Operative Time <2.5 hours / 2.53 / 2.09-3.07 / <0.001
4th Quartile Total Operative Time 4.5 hours vs 1st Quartile Total Operative Time <2.5 hours / 5.08 / 4.19-6.15 / <0.001
Renal Failure/ Renal Insufficiency
Age 75+ vs <50 / 4.77 / 1.25-18.18 / 0.022
Serum Albumin
<3.5 vs 3.5 / 2.39 / 1.23-4.65 / 0.010
BMI 30 vs <30 / 2.05 / 1.19-3.53 / 0.010
Pre-op Platelet
100K vs 101K-450K / 2.72 / 1.12-6.65 / 0.028
Pre-op Total Bilirubin 2.0 vs 1.0 / 3.25 / 1.23-8.57 / 0.017
Pre-op Creatinine
>1.5 vs 1.0 / 6.39 / 3.07-13.31 / <0.001
ASA class 3-4 vs ASA class 1-2 / 3.21 / 1.13-9.12 / 0.028
4th Quartile Total Operative Time 4.5 hours vs 1st Quartile Total Operative Time <2.5 hours / 3.73 / 1.79-7.77 / <0.001
Major Hepatectomy
30-Day Mortality
High Risk Diagnosis vs Low Risk Diagnosis / 3.16 / 1.93-5.17 / <0.001
Age 75+ vs <50 / 2.92 / 1.25-6.85 / 0.014
Diabetes (Requiring Insulin or Non-insulin/oral) vs No Diabetes / 1.93 / 1.18-3.16 / 0.009
Serum Albumin
<3.5 vs 3.5 / 2.01 / 1.19-3.41 / 0.009
Partially or Totally Dependent vs Independent/Unknown / 5.73 / 1.95-16.85 / 0.002
Pre-op Platelet
100K vs 101K-450K / 3.31 / 1.27-8.65 / 0.015
INR1.5 vs <1.5 / 3.94 / 1.10-14.2 / 0.036
ASA class 3-4 vs ASA class 1-2 / 3.02 / 1.46-6.24 / 0.003
Major Morbidity
High Risk Diagnosis vs Low Risk Diagnosis / 1.53 / 1.22-1.91 / <0.001
Diabetes (Requiring Insulin or Non-insulin/oral) vs No Diabetes / 1.36 / 1.03-1.80 / 0.031
Serum Albumin
<3.5 vs 3.5 / 1.51 / 1.13-2.04 / 0.006
Pre-op Total Bilirubin 2.0 vs 1.0 / 2.13 / 1.36-3.34 / 0.001
ASA class 3-4 vs ASA class 1-2 / 1.42 / 1.11-1.81 / 0.006
2nd Quartile Total Operative Time 3.5-<4.5 hours vs 1st Quartile Total Operative Time <3.5 hours / 1.55 / 1.13-2.13 / 0.007
3rd Quartile Total Operative Time 4.5-<6.0 hours vs 1st Quartile Total Operative Time <3.5 hours / 2.08 / 1.55-2.79 / <0.001
4th Quartile Total Operative Time 6.0 hours vs 1st Quartile Total Operative Time <3.5 hours / 2.63 / 1.95-3.55 / <0.001
Prolonged Length of Stay
(Days for operation to discharge <10 vs 10+)
High Risk Diagnosis vs Low Risk Diagnosis / 1.40 / 1.11-1.77 / 0.005
Age 50-64 vs <50 / 1.55 / 1.13-2.12 / 0.006
Age 65-74 vs <50 / 1.80 / 1.28-2.54 / <0.001
Age 75+ vs <50 / 2.37 / 1.59-3.55 / <0.001
Serum Albumin
<3.5 vs 3.5 / 2.00 / 1.48-2.69 / <0.001
Partially or Totally Dependent vs Independent/Unknown / 3.07 / 1.25-7.56 / 0.015
Pre-op Total Bilirubin 2.0 vs 1.0 / 1.81 / 1.14-2.86 / 0.012
ASA class 3-4 vs ASA class 1-2 / 1.45 / 1.12-1.88 / 0.005
2nd Quartile Total Operative Time 3.5-<4.5 hours vs 1st Quartile Total Operative Time <3.5 hours / 1.69 / 1.21-2.36 / 0.002
3rd Quartile Total Operative Time 4.5-<6.0 hours vs 1st Quartile Total Operative Time <3.5 hours / 2.46 / 1.80-3.36 / <0.001
4th Quartile Total Operative Time >6.0 hours vs 1st Quartile Total Operative Time <3.5 hours / 2.95 / 2.15-4.04 / <0.001
Renal Failure/Renal Insufficiency
High Risk Diagnosis vs Low Risk Diagnosis / 2.77 / 1.67-4.60 / <0.001
Diabetes (Requiring Insulin or Non-insulin/oral) vs No Diabetes / 2.44 / 1.46-4.08 / <0.001
Pre-op Platelet
<100K vs 101K-450K / 6.15 / 2.74-13.8 / <0.001
Partially or Totally Dependent vs Independent/Unknown / 3.42 / 1.02-11.5 / 0.047
ASA class 3-4 vs ASA class 1-2 / 2.17 / 1.10-4.29 / 0.026
4th Quartile Total Operative Time >6.0 hours vs 1st Quartile Total Operative Time <3.5 hours / 1.96 / 1.03-3.71 / 0.040
*Multivariable models adjusted for, age, BMI, diabetes, functional status, preoperative chemotherapy within 30 days of operation, preoperative serum albumin, preoperative platelet count, preoperative total bilirubin, preoperative INR, preoperative serum creatinine, ASA class, and operative time quartile for respective extent of resection.