Penicillin G (benzylpenicillin) Sodium salt

Hazardous Substances Policy - Assessment

CHEMICAL HAZARD AND RISK ASSESSMENT

School of Biosciences

Name of supervisor / M. Callow / Assessment Number* / 2066
Signature
Assessor / R Holland / Date of Assessment / 22/8/02

Signature

NotesA School COSHH form in Word is available on the School Server.

Available from the Health and Safety Unit.

Guidance on making an assessment is given in Making a Chemical Hazard and Risk Assessment.

Guidance is also available from Guidance on Completing the Chemical Hazard and Risk Assessment Form.

Use a continuation sheet to expand any section of this form in hard copy version.

1 / LOCATION OF THE WORK ACTIVITY / N114
2 / PERSONS WHO MAY BE AT RISK
List names where possible / M. Stanley, J. Finlay, R.Perry, K Marshall, A. Humphrey, R Holland, M Callow and any other future research group members and project students working in N114.
3 / ACTIVITY ASSESSED / Investigation of effect of antibiotic on growth in algal cells
4 / MATERIALS INVOLVED / Attach copies of data sheet(s)
NAME / AMOUNT
max/stored / HAZARD / RISK PHRASES / HAZDAT NO*** / BIOSCIENCESNO***
Penicillin G
(benzylpenicillin)
Sodium salt / 6060mg / SENSITISER / May cause sensitisation by skin contact or inhalation / R42/43
5 / INTENDED USE**
Give brief details and attach protocol/instructions / 10mg penicillin to be dissolved in 100ml of nutrient-supplemented seawater. Solution to be administered to newly settled algal spores and left in contact with spores for 24 hours.
6 / RISKS to HEALTH and SAFETY from INTENDED USE
From personal exposure or hazardous reactions. Refer to OELs, flash points, etc., as appropriate. Are pregnant women, breast-feeding mothers especially at risk?
Main risk from accidental inhalation or spillage onto skin of powder whilst making up solution
7 / CONCLUSIONS ABOUT RISKS
Is level of risk acceptable? Can risk be prevented or reduced by change of substance/procedure? Are control measures necessary?
As long as good chemical practice is used the risk should be minimal, as the amounts used are small, and solutions weak, the hazards are reduced. Eye protection, gloves and lab. coat should always be worn when handling.
8 / CONTROL MEASURES
Additional to Good Chemical Practice
Handle the stock bottles with care to prevent accidental spillage on a large scale.
Stock bottles kept refrigerated.
9 / INSTRUCTION/TRAINING
Specify course(s) and/or special arrangements.
None
10 / MONITORING
Performance of control measures,
Anyone performing a procedure involving penicillin should contact occupational health, (extn. 45117)
Personal exposure / Health Surveillance
11 / WASTE DISPOSAL PROCEDURE
See School Server for Approved Procedure Document on specific Chemical Waste Disposal.
Dilute concentrations with copious amonuts of tap water and dispose of down sink.
12 / REVIEW
Enter the date or circumstances for review of assessment (maximum review interval 5 years)
5 years or if quantities or procedures change significantly
13 / EMERGENCY ACTION
TO CONTROL HAZARDS / To stabilize situation eg spread absorbant on liquid spill; eliminate sources of ignition, etc.
Wear appropriate protective clothing wash site of spillage with copious amounts of water
TO PROTECT PERSONNEL / Evacuation, protection for personnel involved in clean-up, Special First Aid
Skin: Wash skin with soap and water extensively.
Inhalation: Remove from exposure to fresh air immediately. Obtain medical attention.
TO RENDER SITE OF EMERGENCY SAFE / Clean-up/decontamination
In case of spillage of solution, wash site of spillage with copious amounts of water. In case of spillage of powder, sweep up and place in a suitable container for disposal. Avoid generating dusty conditions.
CONTACT PHONE

10.10.00

* Prefix T is used for Teaching Assessment Number.

** Please include amount of chemicals used and how.

***Hazdat No is the UNICOSHH datasheet report number.

Biosciences No is the Biosciences data sheet number.

UNICOSHH IS A CHEMICAL DATABASE ON THE HEALTH AND SAFETY UNIT SERVER.

BIOSCIENCES DATA SHEETS ARE AVAILABLE IN THE SCHOOL SAFETY OFFICE.