Supplemental Table 1. Summary of Nssnps That Were Analyzed by Five Computational Methods

Supplemental Table 1. Summary of nsSNPs that were analyzed by five computational methods

SIFT, PolyPhen, PANTHER, I-mutant2.0 and MuStab

Rs IDs &
variants / AA changes / SIFT / PolyPhen / PANTHER / I-mutant / MuStab /
Reference
rs80358405 / T3414A / 0.44 / 1.131 / -0.73543 / -2.22 / D
rs1801426 / I3412V / 0.32 / 0.941 / -1.08133 / -0.11 / D / [40,41]
rs80358404 / D3410E / 0.15 / 1.078 / -1.41881 / -0.52 / D
rs80358401 / N3407S / 0.89 / 1.282 / -2.27195 / 0.1 / I
rs55853199 / T3401M / 0.01 / 1.357 / -1.14491 / -0.31 / I
rs80358400 / K3392T / 0.05 / 1.486 / -1.70299 / -1.84 / D
rs80358399 / C3386F / 0.7 / 2.557 / -1.57217 / -0.12 / I
rs80358398 / R3385H / 0.58 / 0.68 / -1.24984 / 0.56 / I
rs80358397 / R3384Q / 0.2 / 1.355 / -2.98477 / -1.7 / D
rs80358395 / T3374A / 0.47 / 1.344 / -1.24274 / -2.27 / D
VAR_020745 / T3374I / 0.03 / 1.749 / -2.08014 / 0.15 / D / [42]
rs80358394 / T3371S / 0.43 / 1.261 / -1.89362 / -0.22 / D
rs80358393 / T3371A / 0.28 / 1.486 / -1.8355 / -1.09 / D
rs80358392 / T3369A / 0.43 / 1.48 / -1.66721 / -1.31 / D
rs80358390 / I3363M / 0.13 / 0.504 / -1.32439 / -0.52 / D
rs80358389 / E3359G / 0.26 / 0.338 / -1.27791 / -2.41 / D
rs80358388 / T3357I / 0.38 / 0.977 / -1.45158 / -0.86 / I
VAR_005111 / T3357R / 0.05 / 1.371 / -1.65855 / -0.54 / I
rs80358387 / T3349A / 0 / 1.687 / -2.51933 / -3.8 / D
rs28897761 / E3342K / 0 / 1.47 / -2.96087 / -1.86 / I
rs80359256 / N3318H / 0.03 / 1.584 / -3.10026 / -1.11 / D
rs80359255 / I3312M / 0.18 / 1.09 / -1.29348 / -1.05 / D
rs80359254 / I3312V / 1 / 0.959 / -1.56427 / -1.68 / D
rs80359251 / E3309K / 0.64 / 1.314 / -1.66675 / -1.72 / D
rs80359250 / T3306K / 0.35 / 1.912 / -2.5065 / -1 / D
rs80359249 / R3302K / 0.05 / 1.37 / -2.55893 / -0.97 / D
VAR_032735 / P3300S / 0.04 / 2.274 / -3.19216 / -1.01 / D / [43]
rs80359248 / A3297G / 0.09 / 0.039 / -2.30115 / -1.33 / D
rs56121817 / P3292L / 0 / 2.724 / -2.57771 / 0.34 / I
rs80359246 / P3280H / 0 / 2.274 / -4.72347 / -1.72 / D
rs80359245 / R3276S / 0.42 / 2.045 / -2.62113 / -1.85 / D
rs80359244 / L3274V / 0.02 / 1.21 / -2.94404 / 0.55 / I
rs56111359 / D3272E / 0.35 / 1.389 / -1.97526 / -0.07 / D
rs80359243 / R3269K / 0.62 / 0.36 / -1.15235 / -1.52 / I
rs55847618 / K3257R / 0.56 / 0.111 / -2.19393 / -1.6 / I
rs11571831 / V3244I / 0.39 / 0.954 / -1.42275 / -0.71 / D
rs80359241 / P3243L / 0.13 / 2.19 / -1.72053 / 0.35 / I
rs80359240 / V3240I / 0.45 / 0.859 / -2.17014 / 0.79 / I
rs80359239 / K3236E / 0.58 / 1.344 / -1.68481 / 0.51 / I
rs80359238 / L3230F / 0.37 / 1.435 / -3.51573 / 0.4 / I
rs80359237 / Y3226C / 0.05 / 2.616 / -4.30729 / -3.1 / D
rs80359236 / P3220S / 0.27 / 2.274 / -1.29737 / -2.1 / D
rs55775473 / G3212R / 0.33 / 2.172 / -2.45026 / -1.34 / D
rs80359233 / Q3206E / 1 / 1.368 / -1.52188 / 0.01 / I
rs80359232 / T3204S / 0.83 / 1.197 / -1.16132 / -1.57 / D
rs80359231 / T3204A / 0.69 / 0.502 / -3.16196 / -1.47 / D
rs80359229 / C3198R / 0.36 / 0.01 / -2.39903 / -0.4 / D
rs80359228 / K3196E / 0.18 / 1.477 / -2.68354 / -1.05 / I / [44]
rs80359227 / T3195A / 0.88 / 1.188 / -1.10742 / -1.76 / D
rs28897760 / P3194Q / 0.22 / 2.274 / -2.55177 / -1.31 / D
rs80359226 / D3188N / 0.53 / 1.014 / -1.61096 / -1.78 / D
rs80359225 / M3181R / 0.54 / 2.207 / -1.79868 / -0.53 / D
rs80359224 / D3170G / 0.4 / 0.517 / -2.55816 / -1.44 / D
rs80359223 / E3167A / 0.17 / 1.92 / -2.72734 / -2.62 / D
rs80359221 / F3159l / 0.16 / 1.376 / -1.98146 / 0.58 / I
rs80359220 / G3153A / 0.71 / 0.183 / -1.15833 / -0.29 / D
rs80359219 / E3152G / 0.12 / 2.145 / -2.89758 / -1.71 / D
rs80359218 / E3152K / 0.38 / 1.47 / -2.50295 / -1.17 / I
rs80359217 / P3150L / 0 / 2.724 / -3.77248 / 1.31 / I
rs80359216 / D3142G / 0.02 / 1.648 / -2.02852 / -1.62 / D
rs80359215 / G3134V / 0.02 / 2.055 / -3.21061 / 1.29 / I
rs80359213 / P3129A / 0.63 / 2.274 / -2.00833 / -1.72 / D
rs80359209 / L3125H / 0 / 2.11 / -4.40824 / -0.36 / D
rs28897759 / N3124I / 0 / 2.599 / -5.27751 / 0.37 / D / [44]
rs80359208 / S3123G / 0.06 / 1.548 / -3.20604 / -0.87 / D
VAR_005110 / M3118T / 1 / 0.617 / -1.33121 / -0.81 / D / [45]
rs80359206 / H3117P / 0.21 / 2.38 / -3.07676 / -1.07 / D
rs80359204 / I3103M / 0 / 1.26 / -3.86522 / 0.02 / I
rs80359203 / I3103V / 0.62 / 0.3 / -1.78538 / -1.2 / D
rs28897758 / L3101R / 0 / 1.885 / -3.01525 / -0.11 / D
rs80359202 / L3101V / 0.34 / 1.21 / -2.12284 / 0.9 / I
rs41293521 / Y3098H / 0.58 / 0.326 / -1.16726 / -0.54 / D / [46,47]
rs80359198 / D3095E / 0 / 1.389 / -4.35937 / -2.07 / I / [48,49]
rs80359195 / Y3092C / 0.01 / 2.616 / -4.68185 / -3.22 / D
rs80359195 / Y3092S / 0.01 / 2.616 / -5.61472 / -3.91 / D
rs80359194 / V3091I / 0.17 / 0.088 / -2.06391 / -1.07 / D
rs80359193 / A3088V / 0.51 / 1.413 / -1.95724 / 0.14 / I
rs80359191 / K3083N / 0.44 / 1.702 / -2.52902 / -4.24 / D
rs80359190 / K3083E / 0.57 / 1.477 / -2.17658 / -2.46 / D
rs80359189 / V3081A / 0.78 / 1.51 / -3.75222 / -3.05 / D
rs55933907 / V3079I / 0.47 / 0.835 / -1.5075 / -1.38 / D
VAR_020742 / G3076E / 0 / 2.172 / -3.98164 / -0.61 / D / [50]
rs80359185 / V3072E / 0.01 / 1.96 / -3.92782 / -1.13 / D
rs80359184 / E3071D / 0.02 / 1.245 / -3.53198 / -1.63 / D
rs80359180 / Q3066E / 0.97 / 1.471 / -2.08032 / 0.08 / I
rs80359179 / F3065L / 0.28 / 2.001 / -1.88884 / -0.1 / D
rs80359177 / D3064N / 0.56 / 1.504 / -1.72631 / -0.01 / D
rs80359177 / D3064Y / 0.28 / 2.09 / -2.86295 / 1.38 / I
VAR_020741 / P3063S / 0.06 / 2.274 / -2.31067 / -1.39 / D / [51]
rs80359174 / K3059E / 0.63 / 1.344 / -2.12112 / -1.44 / D
rs80359173 / S3058G / 0.3 / 1.331 / -1.54524 / 0.54 / I
rs80359172 / P3054H / 0.54 / 2.008 / -3.23492 / -1.78 / D
rs45580035 / R3052W / 0 / 2.495 / -6.23098 / -0.04 / D / [52]
rs80359171 / R3052Q / 0.01 / 1.595 / -3.79172 / -2.41 / D
rs80359167 / P3039L / 0.34 / 2.724 / -3.56572 / 0.6 / I
rs80359165 / Y3035S / 0 / 2.616 / -4.99455 / -0.93 / D
rs80359165 / Y3035C / 0 / 2.616 / -5.8794 / -0.89 / D
rs80359164 / Q3034R / 0.77 / 1.696 / -1.65018 / 0.03 / I
rs80359162 / A3029V / 0.01 / 0.173 / -2.64444 / -0.7 / I
rs56179254 / A3029T / 0.32 / 1.164 / -3.30114 / -2.16 / D
rs80359161 / A3028P / 0.02 / 1.129 / -2.0323 / -1.57 / D
rs80359159 / Q3026E / 0.21 / 1.471 / -3.37352 / 0.37 / I
rs80359157 / S3020C / 0.17 / 1.572 / -3.80279 / -1.16 / I
rs28897755 / T3013I / 0.22 / 0.913 / -2.80811 / -0.61 / I / [47, 53]
rs80359155 / L3011P / 0.01 / 2.11 / -5.00496 / -1.38 / D
rs80359153 / E3002D / 0.01 / 1.245 / -3.58875 / -2.43 / I
rs80359152 / E3002K / 0 / 1.47 / -3.94329 / -2.5 / I
rs80359150 / R2991H / 0.04 / 1.82 / -3.97054 / -2.87 / D
rs80359147 / S2988G / 0.01 / 1.534 / -3.51061 / -4.04 / D
rs80359145 / K2982Q / 0.3 / 1.477 / -2.52542 / -0.71 / I
rs80359143 / R2973H / 0.03 / 1.82 / -4.05464 / -0.01 / D
rs454669092 / R2973C / 0.01 / 2.495 / -4.15809 / 0.07 / I
rs80359142 / L2972W / 0 / 1.609 / -5.74949 / 0.09 / I
rs59004709 / V2969M / 0.15 / 1.285 / -3.49639 / -0.93 / I
rs80359141 / D2965H / 0.04 / 2.064 / -4.15564 / -0.41 / I
rs11571769 / A2951T / 0.17 / 1.413 / -2.8096 / 0.49 / I
rs28897754 / K2950N / 0.06 / 1.702 / -3.01824 / 0.23 / I / [47]
rs4987047 / I2944F / 0.05 / 1.635 / -3.77748 / -0.26 / D / [53]
rs80359139 / A2942T / 0.53 / 1.413 / -2.03803 / 0.18 / I
rs80359138 / L2936F / 0.21 / 1.435 / -2.79707 / 0.84 / I
rs80359137 / L2936M / 0.22 / 0.985 / -2.18358 / -0.27 / D
rs80359136 / Q2925H / 0 / 1.921 / -4.78922 / -0.29 / D
rs80359135 / Q2925R / 0.01 / 1.696 / -4.24814 / 0.74 / I
rs80359132 / S2922G / 0.05 / 1.548 / -3.79159 / -3.6 / D
rs80359131 / G2919V / 0.13 / 1.127 / -2.58989 / -2.14 / D
rs80359130 / A2911V / 0.1 / 1.413 / -1.99412 / -0.11 / D
rs80359129 / G2901D / 0.04 / 1.947 / -4.74867 / -1.06 / D
rs80359128 / R2896H / 0.28 / 0.637 / -1.30014 / -0.75 / D
rs80359127 / L2890I / 0.32 / 0.985 / -2.39368 / 0.37 / I
rs80359126 / A2889S / 0.85 / 0.939 / -2.16469 / -1.25 / D
rs80359124 / R2888P / 0.21 / 2.048 / -4.21065 / -1.6 / D
rs80359124 / R2888L / 0.21 / 1.868 / -3.60853 / 0.18 / I
rs80359123 / R2888C / 0.11 / 0.507 / -2.94163 / -0.84 / D
rs80359122 / P2883S / 0.55 / 1.398 / -1.36872 / 0.14 / I
rs80359120 / F2873C / 0.05 / 2.071 / -4.5838 / 0.87 / I
rs80359119 / T2867P / 0.16 / 1.725 / -3.25756 / -0.91 / D
rs80359117 / L2865V / 0.04 / 1.21 / -3.28249 / 0.78 / I
rs80359116 / A2864V / 0.21 / 0.173 / -2.47654 / -1.07 / I
rs80359114 / Q2858R / 0.45 / 1.696 / -2.34926 / 0.26 / I
rs80359112 / Q2858K / 0.27 / 1.696 / -2.47351 / -0.64 / D
rs11571747 / E2856A / 0.29 / 1.92 / -2.16842 / -2.7 / D / [47, 54]
rs80359110 / E2850K / 0.16 / 1.47 / -2.28147 / -0.82 / I
rs80359109 / K2849E / 0.25 / 1.344 / -2.50901 / 0.08 / I
rs80359108 / E2847K / 0.01 / 1.47 / -3.0046 / -1.79 / D
rs80359107 / N2843S / 0.42 / 0.575 / -1.65551 / -1.71 / D
rs80359105 / R2842H / 0 / 1.82 / -5.75199 / -1.58 / D
rs80359105 / R2842L / 0.01 / 2.27 / -5.52128 / 1.34 / D
rs80359104 / R2842C / 0.01 / 2.495 / -6.6272 / -0.96 / D / [43]
rs80359103 / I2840V / 0.7 / 0.96 / -1.15344 / -0.39 / D
rs11571746 / S2835P / 0.06 / 0.381 / -2.29835 / 0.58 / I / [54]
rs80359100 / Q2829L / 0.06 / 2.371 / -2.25287 / 0.45 / I
rs80359098 / I2828V / 0.47 / 0.929 / -1.96342 / 0.04 / I
rs80359096 / I2821T / 0.15 / 1.614 / -2.86043 / -1.66 / D
rs80359095 / V2820L / 0.15 / 1.047 / -2.47422 / -1.17 / D
rs80359094 / V2818I / 0.6 / 0.835 / -1.86886 / -1.54 / D
rs80359093 / V2815I / 0.44 / 0.835 / -2.24746 / -1.29 / D
rs80359092 / G2813E / 0 / 2.172 / -5.91988 / -0.55 / D
rs80359091 / G2812E / 0 / 2.172 / -5.91988 / -0.96 / D
rs80359090 / D2811G / 0.19 / 2.064 / -2.32733 / -4.15 / I
rs80359089 / S2810G / 0.34 / 1.548 / -3.20902 / -3.73 / D
rs55763607 / S2807L / 0.04 / 1.998 / -3.12032 / -0.88 / D
rs80359087 / P2800R / 0 / 2.499 / -4.35803 / -0.52 / D
rs80359086 / P2800S / 0.04 / 2.274 / -3.49933 / -1.51 / D
rs80359084 / F2794L / 0.19 / 2.001 / -2.81262 / -1.42 / D
rs80359083 / G2793E / 0 / 2.172 / -5.79479 / -0.12 / D / [42]
rs80359082 / G2793R / 0 / 2.172 / -6.06311 / 0.31 / D
rs28897751 / L2792P / 0 / 2.11 / -5.99719 / -1.71 / D
rs80359081 / T2790S / 0.53 / 0.056 / -1.53294 / -2.94 / D
rs80359080 / W2788S / 0 / 3.757 / -4.56907 / -0.62 / D
rs80359079 / W2788R / 0.01 / 3.757 / -4.41141 / -0.28 / D
rs41293517 / R2787C / 0.19 / 0.507 / -2.4949 / -1.64 / D / [55]
rs80359078 / R2787H / 0.17 / 1.732 / -3.07052 / -1.43 / D
rs80359077 / A2786P / 0 / 1.638 / -4.65639 / -1.23 / D
rs80359076 / R2784Q / 0.06 / 1.595 / -3.72822 / -0.42 / D
rs80359075 / R2784W / 0 / 2.495 / -5.80863 / -0.26 / D
rs80359073 / M2775T / 0.39 / 1.904 / -2.70616 / -0.84 / D
rs80359073 / M2775R / 0.44 / 0.532 / -1.75955 / -0.05 / D
rs80359072 / I2752F / 0.38 / 1.529 / -2.91687 / 1.01 / I
rs80359071 / G2748D / 0 / 1.947 / -5.87134 / 0.4 / I / [49]
rs80359069 / V2739I / 0.17 / 0.782 / -1.28523 / -0.94 / D
rs80359067 / A2730V / 0.09 / 1.413 / -3.11192 / -1.04 / I
rs80359066 / A2730P / 0.01 / 1.638 / -4.57807 / -3.17 / D
rs80359065 / K2729N / 0.28 / 1.485 / -2.84615 / -1.39 / D / [56]
rs28897749 / V2728I / 1 / 0.3 / -1.25984 / 0.2 / I / [57,58]
rs28897749 / V2728L / 0.2 / 0.819 / -1.67213 / 0.62 / I
rs80359064 / Y2726C / 0 / 2.616 / -6.50256 / -1.69 / D
rs80359063 / G2724V / 0 / 2.397 / -4.92518 / -0.6 / D
rs41293513 / D2723A / 0 / 2.289 / -5.17185 / -3.58 / D
rs41293513 / D2723G / 0 / 2.064 / -5.04093 / -3.24 / D / [49,52]
rs41293511 / D2723H / 0 / 2.064 / -5.88658 / -1.8 / D
rs80359062 / T2722R / 0 / 1.912 / -4.85035 / 0.14 / I / [59]
rs80359061 / L2721H / 0 / 2.11 / -5.94386 / -2.62 / D
rs80359060 / I2718T / 0.78 / 0.288 / -1.54017 / -1.24 / D
rs80359059 / Q2714R / 0.44 / 1.098 / -2.16068 / -1.28 / I
rs80359057 / D2712V / 0.27 / 2.2 / -2.647 / -0.52 / I
rs80359056 / D2712N / 0.46 / 1.384 / -2.17938 / -1.46 / I
rs80359055 / N2706S / 1 / 1.893 / -1.35076 / -0.53 / I / [60]
rs80359054 / S2704F / 0.05 / 1.998 / -4.00852 / -1.06 / I
rs80359053 / I2700L / 0.35 / 0.242 / -1.66834 / -0.41 / D
rs80359052 / A2698T / 1 / 0.512 / -1.36283 / -2.11 / D
rs80359051 / S2697N / 0.54 / 1.323 / -1.71215 / -1.9 / D
rs80359048 / S2695L / 0.08 / 1.998 / -3.33345 / -0.95 / D
rs80359047 / S2691F / 0 / 1.998 / -5.70343 / -0.91 / D
rs80359045 / L2688P / 0 / 2.11 / -6.09947 / -1.35 / D
rs80359044 / V2687F / 0 / 1.735 / -5.13412 / -0.05 / D
rs28897746 / L2686P / 0 / 2.11 / -5.74703 / 0.17 / I
rs80359043 / K2684R / 0.2 / 1.252 / -2.28742 / -0.69 / D
rs80359042 / D2680G / 0.06 / 2.064 / -3.62226 / -0.5 / D
rs80359041 / D2679G / 0 / 2.064 / -5.04093 / -0.43 / D
rs80359040 / D2679Y / 0 / 2.514 / -6.40732 / 0.13 / I
rs80359039 / R2678G / 0.26 / 2.27 / -2.96158 / -2.24 / D
rs80359038 / M2676T / 0.48 / 2.288 / -1.19831 / -0.22 / D
rs80359037 / I2672V / 0.12 / 0.929 / -2.66543 / -1.03 / D
rs80359035 / S2670L / 0.01 / 1.998 / -4.89814 / -0.67 / I
rs80359033 / R2666T / 0.2 / 1.416 / -2.05342 / -2.31 / I
rs28897745 / D2665G / 0.06 / 2.064 / -3.91705 / -0.52 / D
rs80359031 / E2663V / 0 / 2.145 / -5.90373 / -0.69 / D / [49,52]
rs80359030 / E2663K / 0 / 1.47 / -5.00102 / -1.89 / D
rs80359029 / Y2660D / 0 / 2.841 / -5.6525 / -0.85 / D
rs80359027 / R2659K / 0.06 / 1.37 / -2.90574 / -2.7 / D
rs80359027 / R2659T / 0 / 2.045 / -4.18419 / -0.77 / D / [49]
rs80359026 / R2659G / 0 / 2.27 / -4.53783 / -0.6 / D
rs80359024 / Q2655R / 0.06 / 1.696 / -3.33299 / -1.47 / D
rs80359023 / L2654P / 0.26 / 2.11 / -4.14275 / -1.65 / D
rs80359022 / L2653P / 0 / 2.11 / -5.72001 / -0.32 / D / [49]
rs80359021 / L2647P / 0 / 2.11 / -6.04614 / -0.8 / D
rs80359020 / N2644S / 0.78 / 1.699 / -2.67114 / -1.59 / D
rs80359018 / A2643G / 0.21 / 1.413 / -2.66574 / -1.32 / D