8/09
Fred H. Gage, Ph.D.
Adler Professor
ADDRESS
The Salk Institute
Laboratory of Genetics
10010 N. Torrey Pines Rd.
La Jolla, CA 92037
Ph: 858-453-4100 x1012
Fax: 858-597-0824
Email:
EDUCATION
1972 B.S. - University of Florida, Gainesville, FL
1975 M.S. - Johns Hopkins University, Baltimore, MD
1976 Ph.D. - Johns Hopkins University, Baltimore, MD
RESEARCH AND PROFESSIONAL EXPERIENCE
9/74-6/76 NIMH Predoctoral Fellow, The Johns Hopkins University
9/76-6/80 Assistant/Associate Professor, Texas Christian University
6/81-6/85 Associate Professor, Dept. of Histology, University of Lund, Lund, Sweden
6/85-6/88 Associate Professor, Dept. of Neurosciences, University of California, San Diego
6/88- Professor, Dept. of Neurosciences, University of California, San Diego
6/95- Professor, Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA
ACADEMIC ACTIVITIES
National and Member of the Wakeman Award Committee (1986-1992)
International Member of the Sid Golding Research Committee (1988-present)
Committees Member of the Committee on Social Issues: Society for Neuroscience (1988-1990)
Organizing Committee for International Neural Grafting Meetings (1988-present)
Bristol-Myers-Squibb Achievement in Neurosciences Award Committee (1987-1993)
Core Committee Member - "Frontiers in the Neurosciences", Office of Technological Assessment,
U.S. Congress (1988-1992)
Scientific Advisory Board - Alzheimer Disease and Related Disorders Association (1988-1992)
Scientific Advisory Board - American Paralysis Association (1988-1999)
Scientific Advisory Board - Hereditary Disease Foundation (1992-present)
Chairperson of the Public Information Committee of the Society for Neuroscience (1993)
Scientific Advisory Board - Encyclopedia of Neuroscience (1993)
Council Member - Society of Neuroscience (1994-1998)
Committee Member for the National Academy of Sciences - Effects of Electromagnetic Fields
on Biologic Systems (1993-1996)
Gene Vector Laboratory - Steering Committee (1995-1996)
National Advisory Council on Aging of the National Institutes of Health (1998-2001)
NIH Working Group on Guidelines for Use of Human ES Cells (1999)
Advisory Board of the American Society of Gene Therapy (1999-2002)
Chair, Scientific Advisory Board - Christopher Reeve Paralysis Foundation (1995-1999)
Ameritec Foundation Prize Technical Advisory Committee (1999-)
President Elect - Society for Neuroscience [2000-2001]
Irvine-Reeve Research Center Steering Committee [2000-2004]
President, Society for Neuroscience, [2001-2002]
Scientific Advisory Board - Center for ALS Research at Johns Hopkins [2002]
Executive Committee of the Dana Alliance for Brain Initiatives [2002]
International Board of the Michael J. Fox Foundation [2002]
Scientific Advisory Board - The Center for ALS Research [2002]
Scientific Advisory Board - Alliance for Aging Research [2002-2003]
Scientific Advisory Board - Keystone Symposia [2002-2003]
Scientific Advisory Board – OLS Neurobiology Research Group [2003]
Award Advisory Board – The Peter Gruber Foundation [2003-2005]
Scientific Advisory Board – National University of Singapore [2003-2006]
Scientific Advisory Board – Zilkha Neurogenetic Institute [2003]
Chair-Elect of the Section on Neuroscience, AAAS [2004]
Scientific Advisory Board – California Department of Health Services [2005-2006]
Scientific Advisory Board - NAS: Beckman Center [2007-2010]
Scientific Advisory Board – NARSD [2009-]
Scientific Advisory Board – ISSCR [2009-]
Editorial Journal of Chemical Neuroanatomy (Wiley and Sons) 1988-present
Boards Comments on Develop. Neurobiol. (Gordon & Breech) 1987-95
Experimental Neurology (Academic Press) 1988-1998
Journal of Neuroscience (Oxford Press) 1989-1995; 1998-2004
Brain Research Bulletin (Pergamon Press) 1988-2002
Neural Plasticity (Freund Press) 1989-present
Neurobiology of Aging (Pergamon Press) 1988-present
Hippocampus (Livingston Press) 1990-present
Research and Perspectives in Alzheimer's Disease (Fondation IPSEN) 1988-present
Neuroreport (Rapid Communications of Oxford Ltd.) 1989-1994
Neurodegeneration (Academic Press) 1991-present
Journal of Neuroscience Methods, 1991-2005
Synapse, 1991-2004
Behavioral and Neural Biology (Academic Press) 1992-present
Journal of Clinical Investigation (Rockefeller University Press) 1993-2004
Gene Therapy (Stockton Press Ltd.) 1993-2003
Brain Research (Elsevier Press) 1994-present
Neuroscience (IBRO) 1994-2006
Journal of Comparative Neurology, 1995-2003
Neuropeptide (Churchill Livingstone) 1997-present
Journal of Neurobiology, 1996-present
Journal of Molecular Neuroscience, 1999
Molecular Therapy, 1999-present
Molecular Medicine Today, 1999-2001
Journal of Neuroscience Research, 1999-present
Current Drug Targets, CNS and Neurological Disorders, 2000
NeuroMolecular Medicine, 2001-present
Trends in Molecular Medicine, 2001-present
Cloning and Stem Cells, 2002-present
Associate Editor, Neuroscience Letters (Elsevier), 2003-present
Proceedings of the National Academy of Sciences, 2005-present
Cell Stem Cell, 2007-present
Genes and Development, 2009
EMBO Molecular Medicine, 2009
Awards, NIMH Predoctoral Fellowship, 1974-76
Fellowships, NIH Postdoctoral Fellowship (Awarded), 1976
Honors Fogarty International Fellowship (NSF) 1980
Visiting Professorship, University of Lund, 1981
McKnight Foundation Development Award, 1987
PEW Foundation Neuroscience's Program Award (co-recipient), 1986
Bristol-Myers Squibb Neuroscience Research Award, 1987
Grass Lecturer for Society for Neuroscience's, 1988, 1989, 1990, 1995
IPSEN Prize in Neuronal Plasticity, 1990
Ameritec Award, 1992
Metropolitan Life Award, 1993
National Institute of Health MERIT award, 1993
Decade of the Brain Medallist, Congress of Neurosurgeons, 1993
Allied Signal Award for Research in Aging, 1993
Charles A. Dana Award for Pioneering Achievement in Health and Education, 1993
The Chancellor's Associate Award, UCSD, 1994
Grass Traveling Scientist Award, 1995
Fellow AAAS, 1996
Burroughs Wellcome Visiting Professorship, 1997
The Christopher Reeve's Second Annual Medal Award, 1997
Third Annual Jus Award, 1997
The Ernst Freese Memorial Lecture, NINDS, 1997
Combined Health Agencies 1999 Health Hero Award, San Diego
The Mathilde Solowey Lecture Award in Neuroscience's, NIH, 1999
The Robert J. and Claire Pasarow Foundation Award, 1999
Max Planck Research Award, 1999
The Flynn Lecture, Yale, 1999
The Theobald Smith Lectureship Award, Albany, 2001
The Florence Mahoney Lecture, NIH, 2001
The Pinckney Harmon (Cajal Society) Lecture, 2001
The Murray Barr Lecture Award, Western Ontario, 2001
Society of Neurological Surgeons, Bass Award, 2001
Vi and John Adler Professor on Age-related Neurodegenerative Diseases, 2001
Member, Institute of Medicine of the National Academy of Sciences, 2001
MetLife Award for Medical Research, 2002
Member, National Academy of Sciences, 2003
Klaus Joachim Zulch-Preis through the Max Planck Society, 2003
Member, American Academy of Arts and Sciences, 2005
Gregory Pincus Award, shared with Alejandro Zaffaroni, 2005
Keio Medical Science Prize Award, shared with Shimon Sakaguchi, 2008
Administrative Vice Chair, Department of Neuroscience, UCSD [1993]
Duties Chair, Animals Investigator's Advisory Committee, Univ. of California, San Diego (1990-1993)
Graduate Council, University of California, San Diego (1991-1993)
Co-director of Laboratory of Genetics at The Salk Institute (1995-)
Academic Council - The Salk Institute (1996-1999)
Chair, Animal Facility Committee at the Salk Institute (1995-)
Chair, Academic Council at the Salk Institute (1998)
President, Society for Neuroscience (2002)
Chair Section V, Neuroscience, AAAS (2004
Chair, Board of Health Science Policy, IOM (2005-8)
Chair- Academic Council at the Salk Institute [2005/2006]
Chair, NAS Section 28 (Systems Neuroscience) NAS (2007-2009)
Member, Institute of Engineering in Medicine ORU (2008-)
Picower Advisory Council [2008-2009]
President Elect of the International Society for Stem Cell Research [2009-2012]
PUBLICATIONS
462. Signaling in adult neurogenesis. Suh, H., Deng, W. and Gage, F.H. Annual Reviews of Cellular Developmental Biology, in press.
461. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Kuwabara, T., Hsieh, J., Muotri, A., Yeo, G., Warashina, M., Lie, D.C., Moore, L., Nakashima, K., Asashima, M. and Gage, F.H. Nature Neuroscience, in press.
460. Overall, R.W., Kempermann, G., Peirce, J., Lu, L., Goldowitz, D., Gage, F.H., Goodwin, S., Smit, A.B., Airey, D.C., Rosen, G.D., Schalkwyk, L.C., Sutter, T.R., Nowakowski, R.S., Whatley, S. and Williams, R.W. Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Frontiers in Neurogenomics, in press. [Not funded by NIH]
459. Coufal, N.G., Garcia-Perez, J., Peng, G.E., Yeo, G.W., Mu, Y., Lovci, M.T., Morell, M., O’Shea, K.S., Moran, J.V., Gage, F.H. L1 retrotransposition in human neural progenitor cells. Nature, in press.
458. Clelland, C.D., Choi, M., Romberg, C., Clemenson Jr., G.D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L.M., Barker, R.A., Gage, F.H. and Bussey, T.J. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science, 325(5937): 210-213, 2009.
457. Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Kessler, T., Saxe, M., Gage, F.H., Song, H. and Lie, D.C. GAGA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. The Journal of Neuroscience, 29(25): 7966-7977, 2009. [Not funded by NIH]
456. Li, Y., Mu, Y. and Gage, F.H. Chapter 5 development of neural circuits in the adult hippocampus. Current Topics in Developmental Biology, 87: 149-74, 2009. [Not funded by NIH]
455. Andrews, M.R., Czvitkovich, S., Dassie, E., Vogelaar, C.F., Faissner, A., Blits, B., Gage, F.H., ffrench-Constant, C. and Fawcett, J.W. Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. Journal of Neuroscience, 29(17): 5546-57, 2009. [Not funded by NIH]
454. Fortun, J., Puzis, R., Pearse, D., Gage, F.H. and Bunge, M. Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. Journal of Neurotrauma, 26: 941-953, 2009. [Not funded by NIH]
453. Rose, J.B., Crews, L., Rockenstein, E., Adame, A., Mante M., Hersh, L.B., Gage, F.H., Spencer, B., Potkar, R., Marr, R.A. and Masliah, E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer’s disease. Journal of Neuroscience, 29(4): 1115-25, 2009.
452. Denli, A.M., Cao, X. and Gage, F.H. MiR-9 and TLX: Chasing tails in neural stem cells. Nat. Struct. Mol. Biol. 16 (4): 346-7, 2009.
451. Thuret, S., Toni, N., Aigner, S., Yeo, G.W. and Gage, F.H. Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus, 19: 658-669, 2009. [Not funded by NIH]
450. Zhao, C., Suh, H. and Gage, F.H. Notch keeps ependymal cells in line. Nature Neuroscience, 12(3): 243-245, 2009.
449. Jessberger, S. and Gage, F.H. Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychology and Aging, 23(4): 684-691, 2008. [Not funded by NIH]
448. Saijo, K., Winner, B., Carson, C.T., Collier, J.G., Boyer, L., Rosenfeld, M.G., Gage, F.H. and Glass, C. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell, 137 (1): 47-59, 2009. [Not funded by NIH]
447. Aimone, J.B., Wiles, J. and Gage, F.H. Computational influence of adult neurogenesis on memory encoding. Neuron, 61: 187-202, 2009. [PMCID: PMC2670434]
446. Jessberger, S. and Gage, F.H. Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. Trends in Pharmacological Sciences, 30(2): 61-65, 2009.
445. Marumoto, T., Tashiro, A., Friedmann-Morvinski, D., Scadeng, M., Soda, Y., Gage, F.H. and Verma. I.M. Development of a novel mouse glioma model using lentiviral vectors. Nature Medicine, 15: 110-116, 2009. [PMCID: PMC2671237]
444. Jessberger, S., Clark, R.E., Broadbent, N.J., Clemenson Jr., G.D., Consiglio, A., Lie, D.C., Squire, L.R. and Gage, F.H. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learning & Memory, 16(3): 147-154, 2009. [PMCID: PMC2661246]
443. Yeo, G.W., Coufal, N.G., Liang, T.Y., Peng, G.E., Fu, X-D. and Gage, F.H. An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nature Structural & Molecular Biology, 16(2): 130-137, 2009. [Not funded by NIH]
442. Thompson, C.L., Pathak, S.D., Jeromin, A., Ng, L.L., MacPherson, C.R., Mortrud, M.T., Cusick, A., Riley, Z.L., Sunkin, S.M., Bernard, A., Puchalski, R.B., Gage, F.H., Jones, A.R., Bajic, V.B., Hawrylcz, M.J. and Lein, E.S. Genomic anatomy of the hippocampus. Neuron, 60(6): 1010-21, 2008. [Accepted for publication prior to April 7, 2008]
441. Marchetto, M.C., Muotri, A.R., Mu, Y., Smith, A.M., Cezar, G.G. and Gage, F.H. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell, 3(6): 649-57, 2008. [Not funded by NIH]
440. Cao, X. Pfaff, S.L. and Gage, F.H. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes & Development, 22(23): 3320-34, 2008. [PMCID: PMC2600760]
439. Spencer, B., Marr, R.A., Rockenstein, E., Crews, L., Adame A., Potkar, R., Patrick, C., Gage, F.H., Verma, I.M. and Masliah, E. Long-term enprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neuroscience, 9: 109, 2008. [PMCID: PMC2596170]
438. Kohyama J., Kojimi, T., Takatsuka, E., Yamashita, T., Namiki, J., Hsieh, J., Gage, F.H., Namihira, M., Okano H., Sawamoto, K., and Nakashima, K. Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Proceedings of the National Academy of Sciences, USA, 105(46): 18012-7, 2008. [PMCID: PMC2584744]
437. Jessberger, S., Aigner, S., Clemenson, G.D., Toni, N., Lie, D.C., Karalay, O., Overall, R., Kempermann, G., and Gage, F.H. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biology, 6(11):e272, 2008. [PMCID: PMC2581629]
436. Gage, F.H. and Selzer, M.E. Experts provide insights into emerging field of brain and spine repair. Interview by Bridget M. Kuehn. JAMA, 300(9): 1013-4, 2008.
435. Li, X., Barkho, B.Z., Luo, Y., Smrt, R.D., Santistevan, N.J., Liu, C., Kuwabara, T., Gage, F.H. and Zhao, X. Epigenic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. Journal of Biological Chemistry, 283(41): 27644-52, 2008. [PMCID: PMC2562066]
434. Yeo, G.W., Coufal, N., Aigner, S., Winner, B., Scholnick, J.A., Marchetto, M.C.N., Muotri, A.R., Carson, C. and Gage, F.H. Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Human Molecular Genetics, 17(1): R67-R75, 2008. [Accepted for publication prior to April 7, 2008]
433. Toni, N., Laplagne, D.A., Zhao, C., Lombardi, G., Ribak, C.E., Gage, F.H. and Schinder, A.F. Neurons born in the adult dentate gyrus form functional synapses with target cells. Nature Neuroscience, 11(8):901-907, 2008. [PMCID: PMC2572641]
432. Jessberger, S., Toni, N., Clemenson G.D., Ray, J. and Gage, F.H. Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nature Neuroscience, 11(8): 888-893, 2008. [Accepted for publication prior to April 7 2008]
431. Zhang, C-L., Zou, Y., He, W., Gage, F.H. and Evans, R.M. A role for adult TLX-positive neuroal stem cells in learning and behavior. Nature, 451:1004-1009, 2008. [Accepted for publication prior to April 7 2008]
430. Zhao, C., Deng, W. and Gage, F.H. Mechanisms and functional implications of adult neurogenesis. Cell, 132(4):645-660, 2008. [Accepted for publication prior to April 7 2008]
429. Cezar, G.G., Quam, J.A., Smith, A.M., Rosa, G.J., Piekarczyk, M.S., Brown, J.F., Gage, F.H. and Muotri, A.R. Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Development, 16(6): 869-882, 2007.
428. Jessberger, S., Zhao, C., Toni, N., Clemenson, G.D., Li, Y and Gage, F.H. Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. Journal of Neuroscience, 27(35):9400-9407, 2007.