SAI AN
PERSONAL INFORMATION
Name Sai An Birthday 1989.07.26
Mobile Phone +86-18217689456 Email
Address Room 721 Research Building, No.826 Zhangheng Road, Shanghai, 201203, P.R. China
EDUCATION BACKGROUND
Fudan University September 2011 – Now
Ph.D. in Pharmaceutics (Expected Graduation: June 2016)
Work supervised by Prof. Chen Jiang
University of Munich, Germany November 2012 – January 2013
Visiting Scholar in Pharmaceutical Biotechnology, Center for Nanoscience
Shenyang Pharmaceutical University September 2007 – June 2011
B.S. in National Science Base Class (GPA 3.89/4.0, 1st)
ENGLISH & COMPUTER SKILLS
Proficiency in English: CET-4 653; CET-6 586; BEC Vantage A
Computer Skills: National Computer Rank Examination (Band II, VB) Excellence; MS Office Suites
RESEARCH FIELDS
Targeting delivery and responsive release of genetic or chemical drugs by nanoparticles for cerebral disease therapy:
One nanomedical strategy for efficient cerebral ischemia reperfusion injury prevention.
Four nanomedical strategies for efficient glioma therapy.
KEY PUBLICATIONS
SCI paper
An S, Lu X, Zhao W, Zhang Y, Lu Y, Jiang C*. Amino acid translocation expressway LAT1 mediated a unipath smuggling of glioma-targeting nanoparticles for RNAi therapy. Biomaterials, Under Review (IF 8.557)
An S, He D, Wagner E*, Jiang C*. Peptide-like polymers exerting effective glioma-targeted siRNA delivery and release for therapeutic application. Small 2015; 11(38): 5142-5150. (IF 8.368)
An S, Jiang X, Shi J, He X, Li J, Guo Y, Zhang Y, Ma H, Lu Y, Jiang C*. Single-component self-assembled RNAi nanoparticles functionalized with tumor-targeting iNGR delivering abundant siRNA for efficient glioma therapy. Biomaterials 2015; 53: 330-340. (IF 8.557)
An S, Kuang Y, Shen T, Li J, Ma H, Guo Y, He X, Jiang C*. Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury. Biomaterials 2013; 34(35): 8949-8959. (IF 8.557)
Liu Y, An S, Li J, Kuang Y, He X, Guo Y, Ma H, Zhang Y, Ji B, Jiang C*. Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice. Biomaterials. 2016; 80: 33-45. (IF 8.557)
Kuang Y, An S, Guo Y, Huang S, Shao K, Liu Y, Li J, Ma H, Jiang C*. T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting. Int J Pharm 2013; 454(1): 11-20. (IF 3.650)
Wang Q, Li J, An S, Chen Y, Jiang C, Wang X*. Magnetic resonance-guided regional gene delivery strategy using a tumor stroma-permeable nanocarrier for pancreatic cancer. Int J Nanomedicine 2015; 10: 4479-4490. (IF 4.383)
He X, Li J, An S, Jiang C*. pH-sensitive drug-delivery systems for tumor targeting. Ther Deliv 2013; 4(12): 1499-1510.
Liu Y, Guo Y, An S, Kuang Y, He X, Ma H, Li J, Lu J, Zhang N, Jiang C*. Targeting caspase-3 as dual therapeutic benefits by RNAi facilitating brain-targeted nanoparticles in a rat model of Parkinson's disease. PLoS One 2013; 8(5): e62905. (IF 3.234)
Li J, Jiang X, Guo Y, An S, Kuang Y, Ma H, He X, Jiang C*.Linear-dendritic copolymer composed of polyethylene glycol and all-trans-retinoic acid as drug delivery platform for paclitaxel against breast cancer. Bioconjug Chem 2015; 26(3): 418-426. (IF 4.513)
Li J, Guo Y, Kuang Y, An S, Ma H, Jiang C*. Choline transporter-targeting and co-delivery system for glioma therapy. Biomaterials 2013; 34(36): 9142-9148. (IF 8.557)
Book chapter
An S, He X, Kuang Y, Li J, Guo Y, Ma H, Jiang C*. “Nanoparticles and other Vectors for Delivering Targeted Therapeutics to Malignant Gliomas”, Gliomas: Classification, Symptoms, Treatment and Prognosis. (Nova Publisher, USA)
Chinese Patent
An S, Jiang C*. A kind of amino acid derivative modified glioma-targeting self-assembled RNAi nanoscaled drug delivery system and its preparation method. CN Patent
An S, Jiang C*. A kind of iNGR modified glioma-targeting self-assembled RNAi nanoscaled drug delivery system and its preparation method. CN Patent
RESEARCH PROJECTS
Research on demorphin mediated brain-targeting RNAi prevention for cerebral ischemia reperfusion injury. (Supported by the grant from National Natural Science Foundation of China (81072594), and Program for New Century Excellent Talents inUniversity)
Researches on a multifunctional peptide-like polymer and Angiopep2 mediated glioma-targeting RNAi therapy for glioma. (Supported by the grant from National Natural Science Foundation of China (81172993))
Researches on a novel single-component self-assembled RNAi therapeutic system and iNGR mediated glioma-targeting RNAi therapy for glioma. (Supported by the grant from National Basic Research Program of China (973 Program, 2013CB932500))
Researches on a novel LAT1 substrate 3CDIT as promising glioma-targeting molecule and 3CDIT mediated glioma-targeting RNAi therapy for glioma. (Supported by the grant from National Science Fund for Distinguished Young Scholars (81425023))
Researches on an ATP and GSH dual sensitive chemical therapeutic system and 3CDIT mediated glioma-targeting chemical therapy for glioma. (Supported by the grant from National Science Fund for Distinguished Young Scholars (81425023))
Research on pharmacokinetics evaluation of a new drug on rats. (Supported by the grant from National Natural Science Foundation of China (81172993))
INTERNATIONAL COMMUNICATION
Student representative of Fudan University for Global Young Scientists Summit@one-north 2016
National selection for “Lindau Nobel laureate Meeting”, final round 2015
2015 AAPS Annual Meeting and Exposition, poster 2015
Student representative of Fudan University for “U21 Graduate Research Conference”, oral presentation 2014
Student representative of Fudan University for “AAPS@China Symposium”, oral presentation, poster 2013
Academic exchange in University of Munich, Germany 2012
AWARDS AND SCHOLARSHIPS
Shanghai Outstanding Graduates 2016
“One Health” Funding for Outstanding Graduate Student 2016
Fudan University “Star of the Academic” (10 were selected university-wide) 2015
Fudan University “Outstanding Students Pacesetter” (10 were selected university-wide) 2015
“985 Phase 3” Key Disciplinary & Interdisciplinary Outstanding Ph.D. Award 2013
National Scholarship 2013
Fudan University Academic Scholarship First Prize 2014
Fudan University Academic Scholarship Second Prize 2012
Fudan University International Conference Funding 2013
Fudan University Short-term International Visiting Funding 2012
Fudan University Summer Scientific Training Funding 2011
Fudan University “Pharmaceutical Experiment Skills Contest”, Individual First Prize 2013
安 赛
个人信息
姓名 安赛 生日 1989.07.26
手机 +86-18217689456 邮箱
地址 上海市浦东新区张衡路826号科研楼721室
教育背景
复旦大学 2011年9月 至今
药剂学博士研究生（预计毕业时间：2016年6月）
德国慕尼黑大学 2012年11月 – 2013年1月
医药生物技术纳米科学中心实验室交换生
沈阳药科大学 2007年9月 - 2011年6月
药学院国家理科基地班 (班长，GPA 3.89/ 4.0，1st)
英语及计算机技能
英语： CET-4 653; CET-6 586; BEC Vantage A
计算机: National Computer Rank Examination (Band II, VB) Excellence; MS Office Suites
研究背景
构建多种纳米递药系统实现对基因或化学药物的靶向递送及响应性释放以有效治疗脑部疾病
• 开发一种纳米医疗策略以实现对脑缺血再灌注损伤的有效预防
• 开发四种纳米医疗策略以实现对脑胶质瘤疾病的有效治疗
学术成果
SCI论文
An S, Lu X, Zhao W, Zhang Y, Lu Y, Jiang C*. Amino acid translocation expressway LAT1 mediated a unipath smuggling of glioma-targeting nanoparticles for RNAi therapy. Biomaterials, Under Review (IF 8.557)
An S, He D, Wagner E*, Jiang C*. Peptide-like polymers exerting effective glioma-targeted siRNA delivery and release for therapeutic application. Small 2015; 11(38): 5142-5150. (IF 8.368)
An S, Jiang X, Shi J, He X, Li J, Guo Y, Zhang Y, Ma H, Lu Y, Jiang C*. Single-component self-assembled RNAi nanoparticles functionalized with tumor-targeting iNGR delivering abundant siRNA for efficient glioma therapy. Biomaterials 2015; 53: 330-340. (IF 8.557)
An S, Kuang Y, Shen T, Li J, Ma H, Guo Y, He X, Jiang C*. Brain-targeting delivery for RNAi neuroprotection against cerebral ischemia reperfusion injury. Biomaterials 2013; 34(35): 8949-8959. (IF 8.557)
Liu Y, An S, Li J, Kuang Y, He X, Guo Y, Ma H, Zhang Y, Ji B, Jiang C*. Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice. Biomaterials. 2016; 80: 33-45. (IF 8.557)
Kuang Y, An S, Guo Y, Huang S, Shao K, Liu Y, Li J, Ma H, Jiang C*. T7 peptide-functionalized nanoparticles utilizing RNA interference for glioma dual targeting. Int J Pharm 2013; 454(1): 11-20. (IF 3.650)
Wang Q, Li J, An S, Chen Y, Jiang C, Wang X*. Magnetic resonance-guided regional gene delivery strategy using a tumor stroma-permeable nanocarrier for pancreatic cancer. Int J Nanomedicine 2015; 10: 4479-4490. (IF 4.383)
He X, Li J, An S, Jiang C*. pH-sensitive drug-delivery systems for tumor targeting. Ther Deliv 2013; 4(12): 1499-1510.
Liu Y, Guo Y, An S, Kuang Y, He X, Ma H, Li J, Lu J, Zhang N, Jiang C*. Targeting caspase-3 as dual therapeutic benefits by RNAi facilitating brain-targeted nanoparticles in a rat model of Parkinson's disease. PLoS One 2013; 8(5): e62905. (IF 3.234)
Li J, Jiang X, Guo Y, An S, Kuang Y, Ma H, He X, Jiang C*.Linear-dendritic copolymer composed of polyethylene glycol and all-trans-retinoic acid as drug delivery platform for paclitaxel against breast cancer. Bioconjug Chem 2015; 26(3): 418-426. (IF 4.513)
Li J, Guo Y, Kuang Y, An S, Ma H, Jiang C*. Choline transporter-targeting and co-delivery system for glioma therapy. Biomaterials 2013; 34(36): 9142-9148. (IF 8.557)
书籍编写
An S, He X, Kuang Y, Li J, Guo Y, Ma H, Jiang C*. “Nanoparticles and other Vectors for Delivering Targeted Therapeutics to Malignant Gliomas”, Gliomas: Classification, Symptoms, Treatment and Prognosis. (Nova Publisher, USA)
中国专利
安赛，蒋晨*。 “一种氨基酸衍生物修饰的脑胶质瘤靶向自组装RNAi纳米给药系统及其制备方法”
安赛，蒋晨*。 “一种iNGR修饰的脑胶质瘤靶向自组装RNAi纳米给药系统及其制备方法”
参与课题
• 皮啡肽介导脑靶向RNA干扰预防脑缺血再灌注损伤的研究。（该课题受到国家自然科学基金（81072594）和新世纪人才奖资助）。
• Angiopep2修饰多功能多肽类似聚合物介导脑胶质瘤靶向RNA干扰治疗脑胶质瘤的研究。（该课题受到国家自然科学基金（811729930）资助）。
iNGR修饰一种新型单组份自组装RNA干扰纳米递药系统介导脑胶质瘤靶向RNA干扰治疗脑胶质瘤的 研究。（该课题受到中国国家基础研究计划（973计划，2013CB932500）资助）。
一种新型LAT1底物3CDIT作为有潜力的脑胶质瘤靶向分子的开发研究及3CDIT介导脑胶质瘤靶向 RNA干扰治疗脑胶质瘤的研究。（该课题受到国家杰出青年科学基金（81425023）资助）。
一种3CDIT修饰的ATP和GSH双响应性纳米递药系统介导的脑胶质瘤靶向化学治疗脑胶质瘤的研究。（该课题受到国家杰出青年科学基金（81425023）资助）。
一种新药在大鼠体内的药代动力学研究。（该课题受到国家自然科学基金（811729930）资助）。
学术交流
新加坡全球青年科学家峰会 2016
德国林岛诺贝尔奖获得者大会，决赛选拔 2015
2015 美国药学会年会，海报展示 2015
U21研究生科研大会，英语演示汇报 2014
美国药学会亚洲论坛，英语演示汇报，海报展示 2013
德国慕尼黑大学短期学术交流 2012
获得荣誉
上海市优秀毕业生 2016
“一健康基金”优秀研究生一等奖（全校仅1人） 2016
复旦大学“学术之星”（全校仅10人） 2015
复旦大学“优秀学生标兵”（全校仅10人） 2015
“985三期”重点学科、交叉学科优秀博士生科研资助 2013
国家奖学金（2次） 2013, 2015
复旦大学学业一等奖学金 2014
复旦大学学业二等奖学金 2012
复旦大学国际会议资助（3次） 2013
复旦大学国际交流短期访学资助 2012
复旦大学暑期科研训练资助 2011
复旦大学药学实验技能大赛，个人一等奖 2013