Supplementary Table 1 Correlations between clinicopathologic features and survival in 321 patients with pleural retraction (univariate analysis)

Variables / No. of Patients / 5-year Survival (%) / P
Age
<65 Years old / 170 / 64.9 / 0.224
≧65 Years old / 151 / 73.6
Sex
Male / 140 / 63.6 / 0.122
Female / 181 / 73.5
Comorbidity
With / 64 / 74.6 / 0.986
Without / 257 / 67.9
ECOG performance score
0 / 173 / 71.0 / 0.020
1 / 148 / 66.9
Adjuvant therapy
With / 37 / 52.3 / 0.037
Without / 284 / 71.1
Tumor size
≤3 cm / 152 / 73.6 / 0.059
3 cm / 169 / 65.0
Histological type
Adenocarcinoma / 286 / 72.8 / <0.001
Squamous cell carcinoma / 27 / 50.8
Adenosquamous carcinoma / 8 / 15.0
Differentiation
Well-differentiated / 78 / 84.4 / 0.004
Moderately differentiated / 238 / 63.7
Poorly differentiated / 5 / 60.0
Vascular invasion
Positive / 73 / 60.2 / 0.266
Negative / 248 / 71.3
VPSI
Positive / 170 / 57.9 / <0.001
Negative / 151 / 83.0
Lymph node metastasis
N2 / 51 / 33.6 / <0.001
N1 / 37 / 48.8
N0 / 233 / 80.8
Extranodal extension
Positive / 54 / 40.4 / 0.667
Negative / 34 / 37.6

ECOG: Eastern Cooperative Oncology Group; VPSI, visceral pleural surface invasion
Supplementary Table 2 Correlations between clinicopathologic features and survival in226 stage I patients with pleural retraction (univariate analysis)

Variables / No. of Patients / 5-year Survival (%) / P
Age
<65 Years old / 120 / 79.9 / 0.668
≧65 Years old / 106 / 84.1
Sex
Male / 97 / 70.3 / 0.015
Female / 129 / 91.2
Comorbidity
With / 44 / 79.4 / 0.076
Without / 182 / 82.7
ECOG performance score
0 / 125 / 83.0 / 0.034
1 / 101 / 80.3
Tumor size
≤3 cm / 125 / 83.0 / 0.178
3 cm / 101 / 80.6
Histological type
Adenocarcinoma / 203 / 85.3 / <0.001
Squamous cell carcinoma / 19 / 64.6
Adenosquamous carcinoma / 4 / 25.0
Differentiation
Well-differentiated / 70 / 89.5 / 0.045
Moderately differentiated / 153 / 78.3
Poorly differentiated / 3 / 66.7
Vascular invasion
Positive / 36 / 88.0 / 0.846
Negative / 190 / 81.3
VPSI
Positive / 98 / 74.3 / 0.001
Negative / 128 / 88.5

ECOG: Eastern Cooperative Oncology Group; VPSI, visceral pleural surface invasion