Table S2. List of top 10 significant KEGG and GeneGo pathways in gene component GC2.

KEGG pathways
Pathways / Genes implicated / p-value / q-value
Arrhythmogenic right ventricular cardiomyopathy / ITGA8, ITGA9, RYR2, ITGA1, ITGA3, ITGA4, ITGA6, ITGA11, SGCG, CACNB2, CACNB1, CACNA1C, CTNNA2, SLC8A1, CDH2, LAMA2, CACNA2D3, CACNA2D1, CTNNA1, CACNA2D4, CTNNA3, CACNA1S, TCF7L2, CACNG1, CACNG2, CACNG3, CACNG4 / 1.2×10-23 / 2.3×10-21
Pathways in cancer / PDGFRB, ITGA3, IGF1R, ITGA6, IKBKB, PLCG2, AKT3, MAPK10, LAMB1, ETS1, TGFA, ZBTB16, STAT1, FAS, BID, DCC, FLT3, GLI2, GLI3, SMAD2, FGF18, PML, FGF12, DAPK2, DAPK1, FGF14, TGFBR2, LAMA2, PRKCA, COL4A4, TPR, SUFU, LAMC2, LAMC3, CTNNA1, CTNNA2, CTNNA3, EGLN3, PIK3R5, PLD1, WNT2, TCF7L2, CTBP2, BCL2, COL4A2 / 2.2×10-19 / 2.2×10-17
Focal adhesion / ITGA8, PDGFRB, CCND2, COL11A2, ITGA9, ITGA1, ITGA3, ITGA4, LAMA2, ITGA6, ITGA11, MAPK10, LAMB1, CAV3, CAV1, PIK3R5, RELN, PARVG, SHC4, IGF1R, PDGFD, COL4A4, SHC3, PRKCA, COL5A1, COL4A2, LAMC2, LAMC3, FLNB, RASGRF1, VAV2, AKT3, COL1A2, PAK6, PAK7, BCL2 / 4.2×10-19 / 2.7×10-17
Dilated cardiomyopathy / ITGA8, ITGA9, CACNA1C, ITGA1, ITGA3, ITGA4, ITGA6, ITGA11, SGCG, CACNB2, CACNB1, RYR2, SLC8A1, CACNA1S, LAMA2, CACNA2D3, CACNA2D1, CACNA2D4, ADCY2, PRKACB, CACNG1, CACNG2, CACNG3, CACNG4 / 1.6×10-17 / 6.9×10-16
MAPK signaling / PDGFRB, NGF, NFATC1, CHP2, IKBKB, AKT3, MAPK10, NTRK2, ARRB1, MAP3K8, CACNA1A, CACNB1, CACNA1C, GNG12, FGF18, FGF12, CACNA1S, FGF14, TGFBR2, PRKCA, PRKACB, PPP3CA, CACNA2D3, PLA2G4A, CACNA2D1, CACNG2, CACNA2D4, RPS6KA2, PPP3CC, RASGRF1, MEF2C, FAS, CACNB2, CACNG1, FLNB, CACNG3, CACNG4, MAP2K6 / 1.7×10-17 / 6.9×10-16
Hypertrophic cardiomyopathy / ITGA8, ITGA9, CACNA1C, ITGA1, PRKAG2, ITGA4, ITGA6, ITGA11, SGCG, CACNB2, CACNB1, RYR2, SLC8A1, CACNA1S, LAMA2, ITGA3, CACNA2D3, CACNA2D1, CACNA2D4, CACNG1, CACNG2, CACNG3, CACNG4 / 3.1×10-17 / 1.0×10-15
Calcium signaling / PDGFRB, CACNA1C, NOS1, CHP2, PLCG2, PTK2B, CALM3, PDE1C, CACNA1A, RYR3, RYR2, PTGER1, PTGER3, SLC8A1, CACNA1S, GRM1, PLCB1, ERBB4, PRKCA, CHRNA7, ITPR2, ITPR3, ITPR1, TACR1, ADRA1A, ADCY2, NTSR1, DRD1, PRKACB, GNAL, PPP3CA, PPP3CC / 4.3×10-17 / 1.2×10-15
PI3K-Akt signaling / ITGA8, PDGFRB, NGF, COL11A2, PPP2R1A, ITGA1, ITGA3, ITGA4, LAMA2, ITGA6, G6PC2, IKBKB, ITGA11, LAMB1, ITGA9, GNG12, PIK3R5, FGF18, RELN, FGF12, OSMR, YWHAE, IGF1R, PDGFD, PRKCA, CREB5, PPP2R2A, PPP2R2C, COL4A4, COL4A2, LAMC2, LAMC3, CCND2, AKT3, COL5A1, COL1A2, FGF14, BCL2 / 2.7×10-13 / 6.8×10-12
Vascular smooth muscle contraction / ADRA1A, PLCB1, CACNA1S, CALM3, ADCY2, PRKCH, PRKCA, CACNA1C, PRKCE, KCNMA1, PLA2G6, PRKCQ, GUCY1A3, GUCY1A2, PRKG1, PLA2G3, PRKACB, ITPR2, ITPR3, PLA2G4A, ITPR1 / 1.5×10-11 / 3.4×10-10
Long-term depression / PLCB1, IGF1R, PPP2R1A, PRKCA, CACNA1A, GRID2, GUCY1A3, GUCY1A2, PRKG1, ITPR2, ITPR3, PLA2G4A, ITPR1, NOS1, GRM1 / 5.8×10-11 / 1.1×10-09
GeneGo Pathways
p-value / q-value
Signal transduction_Activation of PKC via G-Protein coupled receptor / PRKCA, PRKCH, PRKCE, PRKCQ, NFATC1, PPP3CA, SQSTM1, MEF2C, IKBKB, NFKBIE, CALM1, ITPR1, ITPR2, ITPR3, PLCB1 / 1.0×10-09 / 6.3×10-07
Immune response_Fc epsilon RI / MKK7, PPP3CA, PPP3CC, IKBKB, PRKCQ, NFKBIE, PLCG2, MAP2K6, CALM3, LCP2, ITPR1, ITPR2, ITPR3, AKT3, PLA2G4A / 2.5×10-08 / 6.1×10-06
Immune response_CD28 signaling / MKK7, NFATC1, PPP3CA, PPP3CC, IKBKB, PRKCQ, NFATC1, NFKBIE, CALM3, LCP2, PIP5K1A, PIP5K1B, ITPR1, ITPR2, ITPR3, AKT3 / 3.1×10-08 / 6.1×10-06
Immune response_CCR5 signaling in macrophages and T lymphocytes / MKK7, NFATC1, TIAM1, PPP3CA, PPP3CC, PTK2B, PRKCA, PLCB1, CALM1, STAT1, ITPR1, ITPR2, ITPR3, PIK3R5, AKT3 / 4.8×10-08 / 7.0×10-06
Long-term depression in cerebellum / RYR2, PLA2G4A, PRKCA, IGF1R, GRID2, CACNA1A, GRM1, ITPR1, ITPR2, ITPR3, PRKG1, PLA2G4A, PLCB1 / 7.2×10-08 / 8.4×10-06
Immune response_NFAT in immune response / PPP3CA, PPP3CC, IKBKB, PRKCQ, NFATC1, NFKBIE, CALM1, LCP2, ITPR1, ITPR2, ITPR3, AKT3, HLA-DMA, PLCG2 / 1.1×10-07 / 1.0×10-05
Immune response_T cell receptor signaling / NFATC1, PPP3CA, PPP3CC, IKBKB, PRKCQ, NFKBIE, CALM1, LCP2, ITPR1, ITPR2, ITPR3, CD4, CARD11, HLA-DMA / 1.7×10-07 / 1.4×10-05
NMDA-dependent postsynaptic long-term potentiation in CA1 hippocampal neurons / RYR2, RYR3, PRKACB, RASGRF1, RPS6KA2, PTK2B, PRKCA, PLCB1, CALM1, GRM1, ITPR1, ITPR2, ITPR3, PRKG1, AKT3 / 2.6×10-07 / 1.9×10-05
Glutamate regulation of Dopamine D1A receptor signaling / DRD1, PRKACB, PPP3CA, PPP3CC, PLCB1, CALM1, GRM1, ITPR1, ITPR2, ITPR3, PPP2R2A, PPP2R2C, PPP2R1A, GABRB3 / 3.1×10-07 / 2.0×10-05
Ca(2+)-dependent NF-AT signaling in cardiac hypertrophy / SLC8A1, CACNA1C, PRKCA, PRKACB, PPP3CA, PPP3CC, MEF2C, ADRA1A, PLCB1, CALM3, ITPR1, ITPR2, ITPR3 / 3.7×10-07 / 2.1×10-05

Table lists genes in the current study that are involved in these KEGG and GeneGo pathways. Both uncorrected and FDR corrected p-values are reported in the table. KEGG: Kyoto Encyclopedia of Genes and Genomes.