Supplemental Table1: Summary of the Five Case-Control Studies

Supplemental Table1: Summary of the five case-control studies.

Study / Cases / Controls
CPS-II / 1,450 / 1,354
PLCO / 678 / 722
ATBC / 908 / 837
CeRePP / 368 / 343
CONOR / 118 / 82
Total / 3,522 / 3,338

The cohort studies were: the Prostate, Lung, Colon and Ovarian (PLCO) Cancer Screening Trial, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC), the American Cancer Society Prevention Study II Nutrition Cohort (CPS-II) and the Cohort of Norway (CONOR). The case-control study was the French Prostate Case-Control Study (CeRePP).

Supplemental Table2: Genotype tagging and SNP selection in the KLK3 region

dbSNP rs number / Position on Chromosome 19 / Major allele /Minor allele / MAFa / Bin / Disposition / r2 with rs2735839
rs1058205 / 56055210 / T/C / 0.173 / 1 / alternate-tag, typed-bin / 0.928
rs2569735 / 56056081 / G/A / 0.156 / 1 / alternate-tag, typed-bin / 1.000
rs2735839 / 56056435 / G/A / 0.162 / 1 / typed-tag, typed-bin / 1.000
rs62113226 / 56059256 / T/C / 0.069 / 2 / candidate-tag / 0.006
rs8104556 / 56056192 / C/T / 0.147 / 3 / candidate-tag / 0.028
rs34750956 / 56053808 / C/T / 0.081 / 4 / other / 0
rs62113212 / 56052652 / C/T / 0.104 / 5 / other / 0.630
rs17632542 / 56053569 / T/C / 0.103 / 5 / other / 0.608
rs62113214 / 56054349 / T/G / 0.080 / 5 / candidate-tag / 0.604
CGF_34700 / 56054527 / T/G / 0.060 / 5 / candidate-tag / 0.644
rs62113216 / 56056615 / T/A / 0.118 / 5 / other / 0.705
rs8112276* / 56057764 / G/A / 0.426 / 6 / candidate-tag / -
rs11084034 / 56054116 / C/T / 0.367 / 7 / candidate-tag / 0.093
rs1058274 / 56055260 / A/G / 0.301 / 8 / candidate-tag / 0.062
rs266875 / 56053749 / A/G / 0.480 / 9 / singleton-tag / 0.097
rs3180017* / 56052163 / G/T / 0.467 / 10 / singleton-tag / -
rs4802755 / 56056052 / C/T / 0.461 / 11 / singleton-tag / 0.181
rs266876 / 56052630 / T/C / 0.256 / 12 / singleton-tag / 0.488
rs2659122 / 56054838 / T/C / 0.219 / 13 / singleton-tag / 0.598
rs55799315 / 56056035 / C/G / 0.156 / 14 / singleton-tag / 0.023
CGF_17249 / 56037076 / T/C / 0.090 / - / - / 0.423
rs56397626 / 56038334 / T/C / 0.090 / - / - / 0.423
rs11665698 / 56046223 / C/A / 0.283 / - / - / 0.372
rs2659124 / 56046409 / T/A / 0.117 / - / - / 0.498
rs266878 / 56050926 / C/G / 0.115 / - / - / 0.498
rs174776 / 56051664 / C/T / 0.118 / - / - / 0.497

aMinor allele frequencies and r2 values are from (Parikh et al. 2010). Coordinates are based on NCBI genome build 36.3. *These two SNPs failed design for a TaqMan genotyping assay. CGF denotes novel SNPs.

Supplemental Table 3: Characteristics of the 24 genotyped SNPs in the KLK3 region

dbSNP rs number / Position on Chromosome 19 / Gene Location / Major allele /Minor allele / MAF in controls / The 1000 Genomes CEU MAF / P
CGF_17249 / 56037076 / 5’ of KLK3 / T/C / 0.094 / 0.058 / 0.238
rs56397626 / 56038334 / 5’ of KLK3 / T/C / 0.093 / 0.058 / 0.256
rs11665698 / 56046223 / 5’ of KLK3 / C/A / 0.305 / 0.308 / 1.000
rs2659124 / 56046409 / 5’ of KLK3 / T/A / 0.128 / 0.092 / 0.292
rs266878 / 56050926 / KLK3-intron 1 / C/G / 0.128 / 0.092 / 0.297
rs174776 / 56051664 / KLK3-intron 2 / C/T / 0.128 / 0.092 / 0.296
rs266876 / 56052630 / KLK3-intron 2 / T/C / 0.256 / 0.225 / 0.498
rs62113212 / 56052652 / KLK3-intron 2 / C/T / 0.072 / 0.067 / 0.977
rs17632542 / 56053569 / KLK3-exon 4 / T/C / 0.072 / 0.067 / 0.962
rs266875 / 56053749 / KLK3-intron 4 / A/G / 0.465 / 0.475 / 0.902
rs34750956 / 56053808 / KLK3-intron 4 / C/T / 0.107 / 0.133 / 0.429
rs11084034 / 56054116 / KLK3-intron 4 / C/T / 0.354 / 0.350 / 1.000
rs62113214 / 56054349 / KLK3-intron 4 / T/G / 0.072 / 0.067 / 0.955
CGF_34700 / 56054527 / KLK3-intron 4 / T/G / 0.079 / 0.067 / 0.747
rs2659122 / 56054838 / KLK3-intron 4 / T/C / 0.242 / 0.225 / 0.741
rs1058205 / 56055210 / KLK3-3’ UTR / T/C / 0.168 / 0.117 / 0.172
rs1058274 / 56055260 / KLK3-3’ UTR / A/G / 0.332 / 0.333 / 1.000
rs55799315 / 56056035 / 3’ of KLK3 / C/G / 0.172 / 0.125 / 0.214
rs4802755 / 56056052 / 3’ of KLK3 / C/T / 0.469 / 0.525 / 0.263
rs2569735 / 56056081 / 3’ of KLK3 / G/A / 0.135 / 0.100 / 0.333
rs8104556 / 56056192 / 3’ of KLK3 / C/T / 0.158 / 0.208 / 0.172
rs2735839 / 56056435 / 3’ of KLK3 / G/A / 0.136 / 0.100 / 0.315
rs62113216 / 56056615 / 3’ of KLK3 / T/A / 0.096 / 0.067 / 0.361
rs62113226 / 56059256 / 3’ of KLK3 / T/C / 0.069 / 0.100 / 0.261

Abbreviations: MAF, Minor allele frequency; P, a two group χ2 test of equal proportionsP value comparing counts of alleles in control subjects to the 1000G project. Coordinates are based on NCBI genome build 36.3.A CGF prefix denotes novel SNP.

Supplemental Table4: Genotype quality control assessment

Study / CPS-II / ATBC / PLCO / CeRePP / CONOR / Subtotal / CGEMS* / Combined
All samples / 3,177 / 1,902 / 1,577 / 998 / 385 / 8,039 / 10,180
Samples from cases / 1,507 / 927 / 730 / 372 / 118
Samples from control subjects / 1,438 / 952 / 776 / 351 / 83
QC samples / 232 / 23 / 71 / 275 / 184
Samples with completion less than 80% / 27 / 23 / 100 / 277 / 185 / 6
Samples after removing completion < 80% / 3,210 / 1,879 / 1,492 / 721 / 200 / 10,174
Discordant duplicate pairs / 0 / 2 / 2 / 0 / 0
Before merging into subject level / 3,210 / 1,877 / 1,490 / 721 / 200
After merging into subject level / 3,061 / 1,790 / 1,460 / 721 / 200
Excludesa / 29 / 0 / 0 / 0 / 0
Unique subject counts / 3,032 / 1,790 / 1,460 / 721 / 200 / 7,203 / 10,174
Combining with CGEMS (unique counts) / 11,355
Remove subjects only appearing in CGEMS / 4,246
Final cleaned data / 7,109
Excludesa / 159
Non CEUb / 90
Subjects used in association analysis / 6,860

*Genotypes for rs2735839 were previously genotyped as part of CGEMS for all studies apart from CONOR. aParticipants that did not meet eligibility requirements, bPortion of HapMap CEU ancestry >0.80 by STRUCTURE.

Supplemental Table 5: Association results for aggressive prostate cancer cases (Gleason score ≥ 7 or disease stage ≥ III) as compared to control subjects for the three highly correlated SNPs and rs2735839.

dbSNP rs number / Position / Allelesa / MAFb / Subjects / χ2 / Pc / Allelic OR
(95% C.I.) / Genotype ORHet
(95% C.I.) / Genotype ORHom
(95% C.I.)
Control / Case / Control / Case
rs62113212 / 56052652 / C/T / 0.072 / 0.071 / 3325 / 1465 / 0.31 / 0.580 / 0.95 (0.80-1.13) / 0.98 (0.82-1.18) / 0.58 (0.21-1.57)
rs17632542 / 56053569 / T/C / 0.072 / 0.070 / 3325 / 1460 / 0.72 / 0.395 / 0.93 (0.78-1.10) / 0.96 (0.80-1.15) / 0.50 (0.17-1.49)
rs62113214 / 56054349 / T/G / 0.072 / 0.070 / 3321 / 1468 / 0.64 / 0.423 / 0.93 (0.78-1.11) / 0.97 (0.80-1.16) / 0.48 (0.16-1.45)
rs2735839 / 56056435 / G/A / 0.136 / 0.144 / 2980 / 1350 / 0.06 / 0.814 / 1.02 (0.89-1.16) / 1.05 (0.91-1.23) / 0.81 (0.47-1.39)

aMajor allele/ minor allele; bMinor allele frequency;c1 d.f. score test; OR, odds ratio; Het, heterozygous; Hom, homozygous for minor allele; CI, 95% confidence interval. Coordinates are based on NCBI genome build 36.3.Aggressive prostate cancer is defined by a Gleason score of ≥ 7 or disease stage ≥ III.

Supplemental Table 6: Association results for nonaggressive prostate cancer (Gleason score <7 and disease stage < III)as compared to advanced prostate cancer (Gleason score ≥ 8 or disease stage ≥ III) for the three highly correlated SNPs and rs2735839

dbSNP rs number / Position / Allelesa / MAFb / Subjects / χ2 / Pe / Allelic OR
(95% C.I.) / Genotype ORHet
(95% C.I.) / Genotype ORHom
(95% C.I.)
Adv.c / Non-agg.d / Adv. / Non-agg.
rs62113212 / 56052652 / C/T / 0.085 / 0.053 / 674 / 1652 / 17.28 / 3.23 x 10-05 / 0.59 (0.46-0.76) / 0.58 (0.44-0.75) / 0.49 (0.11-2.21)
rs17632542 / 56053569 / T/C / 0.081 / 0.054 / 671 / 1652 / 13.62 / 2.24 x 10-04 / 0.62 (0.48-0.80) / 0.60 (0.46-0.78) / 0.77 (0.14-4.24)
rs62113214 / 56054349 / T/G / 0.084 / 0.054 / 676 / 1644 / 16.02 / 6.26 x 10-05 / 0.60 (0.47-0.77) / 0.59 (0.45-0.77) / 0.51 (0.11-2.32)
rs2735839 / 56056435 / G/A / 0.154 / 0.122 / 603 / 1422 / 7.85 / 0.005 / 0.75 (0.61-0.92) / 0.72 (0.57-0.91) / 0.70 (0.33-1.50)

aMajor allele/ minor allele; bMinor allele frequency; cAdvanced prostate cancer; dNonaggressive prostate cancer;e1 d.f. score test; OR, odds ratio; Het, heterozygous; Hom, homozygous for minor allele; CI, 95% confidence interval. Coordinates are based on NCBI genome build 36.3.

Supplemental Table 7: Association results for imputed and genotyped SNPs in prostate cancer cases vs. control subjects in the KLK3 region in the PLCO cohort

dbSNP rs number / Position / Category / Allelic OR (95% C.I.) / P
rs3212810 / 56020548 / Imputed / 0.95 (0.83-1.10) / 0.520
rs3212853 / 56020606 / Imputed / 0.74 (0.47-1.16) / 0.187
rs3212808 / 56021084 / Imputed / 0.99 (0.69-1.42) / 0.961
rs10403407 / 56021820 / Imputed / 0.04 (0-1.03) / 0.052
rs3212852 / 56021941 / Imputed / 0.87 (0.63-1.20) / 0.389
rs61752560 / 56022235 / Imputed / 0.95 (0.81-1.11) / 0.518
rs3745522 / 56022744 / Genotyped / 0.94 (0.81-1.09) / 0.387
19-56023011 / 56023011 / Imputed / 0.93 (0.47-1.84) / 0.843
19-56023016 / 56023016 / Imputed / 0.91 (0.68-1.22) / 0.519
19-56023017 / 56023017 / Imputed / 1.12 (0.89-1.41) / 0.341
rs266112 / 56023401 / Imputed / 0.88 (0.66-1.17) / 0.374
19-56024123 / 56024123 / Imputed / 0.86 (0.74-1.01) / 0.060
rs266113 / 56024293 / Imputed / 0.91 (0.78-1.05) / 0.204
rs266114 / 56024482 / Genotyped / 0.87 (0.75-1.01) / 0.069
rs266115 / 56025050 / Imputed / 0.82 (0.64-1.05) / 0.113
19-56025254 / 56025254 / Imputed / 1.00 (0.36-2.77) / 0.995
rs7246740 / 56025486 / Imputed / 1.04 (0.54-1.99) / 0.913
19-56025987 / 56025987 / Imputed / 1.71 (0.37-7.83) / 0.487
rs11879167 / 56026053 / Imputed / 3.25 (1.51-6.98) / 0.003
rs2560935 / 56026167 / Genotyped / 1.09 (0.86-1.37) / 0.477
rs3745523 / 56026702 / Imputed / 0.99 (0.83-1.18) / 0.877
rs55786312 / 56026861 / Imputed / 0.95 (0.81-1.10) / 0.483
rs2659057 / 56027057 / Imputed / 0.98 (0.87-1.10) / 0.730
rs2659056 / 56027755 / Genotyped / 1.01 (0.88-1.16) / 0.870
rs266850 / 56028009 / Genotyped / 0.96 (0.79-1.18) / 0.715
rs266851 / 56028151 / Genotyped / 1.05 (0.86-1.28) / 0.638
rs60621230 / 56028278 / Imputed / 0.86 (0.57-1.32) / 0.502
rs2659055 / 56029044 / Imputed / 0.96 (0.85-1.09) / 0.553
rs2163861 / 56029204 / Genotyped / 0.96 (0.85-1.08) / 0.455
rs266854 / 56029630 / Imputed / 1.01 (0.85-1.20) / 0.910
rs190552 / 56030005 / Imputed / 1.09 (0.88-1.34) / 0.425
rs266855 / 56030196 / Imputed / 1.01 (0.85-1.20) / 0.909
rs266856 / 56030318 / Imputed / 1.11 (0.90-1.37) / 0.318
rs2739442 / 56030985 / Imputed / 1.02 (0.86-1.20) / 0.825
rs2033496 / 56031019 / Imputed / 1.00 (0.86-1.18) / 0.956
rs266857 / 56031529 / Imputed / 1.05 (0.85-1.30) / 0.656
19-56031628 / 56031628 / Imputed / 1.01 (0.79-1.30) / 0.927
rs266858 / 56031774 / Genotyped / 1.04 (0.84-1.28) / 0.743
rs2569745 / 56032000 / Imputed / 1.07 (0.85-1.36) / 0.547
19-56032355 / 56032355 / Imputed / 1.45 (1.01-2.08) / 0.047
19-56032534 / 56032534 / Imputed / 1.41 (1.01-1.98) / 0.044
rs2659053 / 56032606 / Imputed / 1.02 (0.83-1.25) / 0.839
rs62113172 / 56032607 / Imputed / 1.27 (0.90-1.78) / 0.167
rs2569746 / 56032727 / Imputed / 0.92 (0.75-1.13) / 0.418
rs35711205 / 56032818 / Imputed / 1.16 (0.90-1.49) / 0.253
rs2569747 / 56032875 / Imputed / 0.91 (0.74-1.12) / 0.357
rs62113174 / 56033275 / Imputed / 1.40 (0.91-2.18) / 0.128
rs34988149 / 56033484 / Imputed / 0.94 (0.75-1.18) / 0.610
19-56034564 / 56034564 / Imputed / 0.87 (0.70-1.07) / 0.189
rs11667223 / 56034944 / Imputed / 0.86 (0.70-1.07) / 0.170
19-56035010 / 56035010 / Imputed / 1.08 (0.61-1.92) / 0.781
rs10413296 / 56035271 / Imputed / 1.25 (0.90-1.74) / 0.174
rs2659052 / 56035549 / Imputed / 1.00 (0.82-1.22) / 0.993
rs12984286 / 56035617 / Imputed / 1.06 (0.84-1.33) / 0.633
19-56035906 / 56035906 / Imputed / 1.49 (1.02-2.16) / 0.039
19-56035941 / 56035941 / Imputed / 1.32 (0.86-2.03) / 0.211
rs2569753 / 56035990 / Imputed / 0.98 (0.81-1.18) / 0.812
rs34575650 / 56036295 / Imputed / 1.01 (0.82-1.24) / 0.960
19-56037076 / 56037076 / Imputed / 0.68 (0.49-0.96) / 0.028
rs62113175 / 56037137 / Imputed / 1.24 (0.90-1.70) / 0.182
rs2659051 / 56037380 / Imputed / 1.04 (0.81-1.32) / 0.776
rs2569729 / 56037633 / Genotyped / 1.00 (0.82-1.23) / 0.970
rs56397626 / 56038334 / Imputed / 0.68 (0.49-0.96) / 0.028
rs4802751 / 56040041 / Imputed / 0.96 (0.79-1.16) / 0.663
rs4802752 / 56040109 / Imputed / 0.98 (0.82-1.18) / 0.835
rs4239492 / 56040523 / Imputed / 0.93 (0.79-1.10) / 0.397
rs10402571 / 56040856 / Imputed / 1.24 (0.90-1.69) / 0.184
rs266849 / 56040902 / Genotyped / 1.04 (0.83-1.30) / 0.749
19-56041022 / 56041022 / Imputed / 1.40 (0.42-4.65) / 0.579
rs11878415 / 56041100 / Imputed / 0.98 (0.82-1.18) / 0.830
rs10445554 / 56041528 / Imputed / 0.93 (0.78-1.09) / 0.364
19-56041593 / 56041593 / Imputed / 0.45 (0.10-2.06) / 0.303
rs2411332 / 56042552 / Imputed / 0.97 (0.80-1.16) / 0.732
rs7251465 / 56042603 / Imputed / 0.68 (0.49-0.96) / 0.028
rs2411331 / 56042692 / Imputed / 0.99 (0.82-1.19) / 0.929
19-56042755 / 56042755 / Imputed / 0.78 (0.36-1.67) / 0.517
19-56042756 / 56042756 / Imputed / 0.86 (0.33-2.23) / 0.601
19-56042757 / 56042757 / Imputed / 0.71 (0.25-2.01) / 0.520
rs7256136 / 56043538 / Imputed / 1.23 (0.90-1.68) / 0.186
rs266870 / 56043746 / Genotyped / 0.92 (0.78-1.09) / 0.343
rs266869 / 56043892 / Imputed / 0.88 (0.71-1.10) / 0.264
rs35630056 / 56044315 / Imputed / 0.88 (0.71-1.10) / 0.258
rs266868 / 56044749 / Genotyped / 1.04 (0.86-1.26) / 0.717
rs266867 / 56044839 / Imputed / 0.94 (0.64-1.38) / 0.747
rs62113179 / 56045042 / Imputed / 1.21 (0.90-1.64) / 0.204
rs266866 / 56045214 / Imputed / 0.83 (0.56-1.22) / 0.337
19-56045291 / 56045291 / Imputed / 1.30 (0.49-3.50) / 0.597
rs925013 / 56045413 / Imputed / 0.89 (0.72-1.11) / 0.292
19-56045597 / 56045597 / Imputed / 1.43 (0.72-2.84) / 0.311
19-56045719 / 56045719 / Imputed / 1.39 (0.41-4.72) / 0.597
rs11084033 / 56045767 / Imputed / 0.90 (0.72-1.13) / 0.385
rs266864 / 56046138 / Imputed / 0.95 (0.77-1.17) / 0.619
rs11665748 / 56046209 / Imputed / 1.10 (0.91-1.33) / 0.324
rs11665698 / 56046223 / Imputed / 1.17 (0.96-1.41) / 0.117
rs2659124 / 56046409 / Imputed / 1.39 (1.02-1.89) / 0.036
19-56046464 / 56046464 / Imputed / 0.78 (0.51-1.20) / 0.252
rs3760719 / 56047151 / Imputed / 1.11 (0.92-1.33) / 0.292
rs266863 / 56047462 / Imputed / 0.96 (0.82-1.12) / 0.574
rs3760720 / 56047874 / Imputed / 0.92 (0.76-1.10) / 0.352
rs266862 / 56047919 / Imputed / 1.05 (0.86-1.28) / 0.645
rs266861 / 56047977 / Imputed / 1.01 (0.81-1.25) / 0.935
19-56048548 / 56048548 / Imputed / 1.18 (0.77-1.83) / 0.451
rs266859 / 56048612 / Imputed / 1.00 (0.81-1.23) / 0.985
rs2739450 / 56048899 / Imputed / 1.07 (0.92-1.25) / 0.385
rs2739451 / 56049083 / Imputed / 0.99 (0.85-1.14) / 0.846
rs3760721 / 56049316 / Imputed / 0.92 (0.77-1.10) / 0.378
rs3760722 / 56049628 / Genotyped / 1.27 (0.99-1.63) / 0.057
rs17526278 / 56049699 / Imputed / 1.32 (1.02-1.71) / 0.037
rs4802754 / 56049732 / Imputed / 0.91 (0.77-1.09) / 0.302
rs266882 / 56049825 / Imputed / 1.05 (0.91-1.23) / 0.494
rs266881 / 56050145 / Imputed / 1.02 (0.89-1.18) / 0.755
rs2292186 / 56050206 / Genotyped / 0.92 (0.77-1.10) / 0.362
rs266880 / 56050283 / Imputed / 1.06 (0.92-1.23) / 0.427
rs55661885 / 56050312 / Imputed / 1.32 (1.02-1.70) / 0.035
rs1053972 / 56050441 / Imputed / 0.92 (0.77-1.08) / 0.298
rs266879 / 56050450 / Imputed / 1.01 (0.87-1.17) / 0.906
rs2292185 / 56050500 / Imputed / 1.04 (0.90-1.19) / 0.611
rs266878 / 56050926 / Imputed / 1.14 (0.90-1.46) / 0.280
rs2271095 / 56051265 / Imputed / 0.98 (0.86-1.13) / 0.814
rs11573 / 56051309 / Imputed / 1.05 (0.93-1.19) / 0.430
rs1135766 / 56051315 / Imputed / 1.05 (0.93-1.19) / 0.430
rs174776 / 56051664 / Imputed / 1.31 (0.99-1.74) / 0.061
rs58946822 / 56051894 / Imputed / 1.32 (1.03-1.70) / 0.030
rs1061476 / 56051899 / Genotyped / 1.00 (0.89-1.12) / 0.978
rs1061477 / 56051908 / Imputed / 1.00 (0.89-1.12) / 0.990
rs266877 / 56052580 / Imputed / 0.87 (0.48-1.57) / 0.647
rs266876 / 56052630 / Imputed / 0.99 (0.82-1.18) / 0.876
rs62113212 / 56052652 / Imputed / 0.77 (0.58-1.02) / 0.066
rs12946 / 56053127 / Imputed / 1.27 (0.99-1.63) / 0.060
rs61752561 / 56053194 / Imputed / 1.04 (0.45-2.41) / 0.928
rs2003783 / 56053284 / Imputed / 1.36 (1.06-1.74) / 0.016
rs1810020 / 56053456 / Imputed / 0.96 (0.54-1.71) / 0.902
rs17632542 / 56053569 / Imputed / 0.77 (0.58-1.04) / 0.089
rs61729813 / 56053662 / Imputed / 1.55 (0.85-2.82) / 0.149
rs266875 / 56053749 / Imputed / 0.94 (0.82-1.06) / 0.311
rs34750956 / 56053808 / Imputed / 1.27 (0.99-1.62) / 0.064
rs11084034 / 56054116 / Imputed / 0.99 (0.86-1.13) / 0.834
19-56054137 / 56054137 / Imputed / 1.16 (0.91-1.48) / 0.243
rs62113213 / 56054289 / Imputed / 1.16 (0.91-1.48) / 0.244
rs62113214 / 56054349 / Imputed / 0.75 (0.56-1.02) / 0.067
rs62113215 / 56054397 / Imputed / 0.98 (0.84-1.14) / 0.777
19-56054399 / 56054399 / Imputed / 0.97 (0.83-1.14) / 0.712
19-56054400 / 56054400 / Imputed / 0.99 (0.85-1.15) / 0.905
19-56054527 / 56054527 / Imputed / 0.75 (0.56-1.02) / 0.067
19-56054528 / 56054528 / Imputed / 1.31 (1.02-1.68) / 0.032
rs35192866 / 56054615 / Imputed / 1.31 (1.02-1.67) / 0.032
rs45588133 / 56054767 / Imputed / 1.31 (1.02-1.67) / 0.032
rs2659122 / 56054838 / Genotyped / 0.98 (0.82-1.18) / 0.842
rs1058205 / 56055210 / Genotyped / 1.17 (0.95-1.46) / 0.146
rs1058274 / 56055260 / Imputed / 0.96 (0.84-1.09) / 0.494
rs6998 / 56055473 / Imputed / 0.99 (0.87-1.13) / 0.854
19-56056012 / 56056012 / Imputed / 0.35 (0.12-1.00) / 0.050
rs55799315 / 56056035 / Imputed / 0.90 (0.75-1.07) / 0.224
rs4802755 / 56056052 / Imputed / 0.93 (0.81-1.07) / 0.301
rs2569735 / 56056081 / Imputed / 1.21 (0.94-1.56) / 0.146
rs8104556 / 56056192 / Genotyped / 1.02 (0.87-1.19) / 0.804
rs2735839 / 56056435 / Genotyped / 1.14 (0.91-1.42) / 0.251
rs17632611 / 56056461 / Imputed / 1.19 (0.92-1.54) / 0.176
rs62113216 / 56056615 / Imputed / 0.76 (0.57-1.02) / 0.067
rs55901451 / 56056633 / Imputed / 2.28 (0.70-7.44) / 0.173
rs55887816 / 56056679 / Imputed / 1.02 (0.87-1.19) / 0.813
rs55788344 / 56056873 / Imputed / 0.95 (0.84-1.09) / 0.475
rs266874 / 56057093 / Imputed / 1.51 (0.50-4.55) / 0.273
rs62113217 / 56057357 / Imputed / 1.02 (0.89-1.16) / 0.804
rs8112276 / 56057764 / Genotyped / 0.99 (0.88-1.11) / 0.864
19-56058156 / 56058156 / Imputed / 1.02 (0.87-1.19) / 0.843
19-56058185 / 56058185 / Imputed / 1.02 (0.87-1.19) / 0.843
rs62113221 / 56058308 / Imputed / 0.82 (0.43-1.56) / 0.541
rs62113222 / 56058606 / Imputed / 0.82 (0.43-1.57) / 0.551
19-56058688 / 56058688 / Imputed / 0.82 (0.43-1.57) / 0.552
rs56351139 / 56058721 / Imputed / 1.02 (0.86-1.19) / 0.848
rs62113223 / 56058866 / Imputed / 0.82 (0.43-1.58) / 0.559
19-56058871 / 56058871 / Imputed / 1.19 (0.93-1.51) / 0.162
19-56058872 / 56058872 / Imputed / 1.19 (0.93-1.51) / 0.162
rs62113225 / 56059213 / Imputed / 1.19 (0.93-1.51) / 0.163
rs62113226 / 56059256 / Imputed / 1.19 (0.93-1.51) / 0.163
rs58823125 / 56059479 / Imputed / 0.37 (0.13-1.09) / 0.071
rs61548536 / 56059594 / Imputed / 0.37 (0.13-1.09) / 0.072
rs34532440 / 56059760 / Imputed / 1.66 (1.04-2.63) / 0.033
rs2739458 / 56059915 / Imputed / 0.99 (0.84-1.15) / 0.858
19-56060000 / 56060000 / Imputed / 0.83 (0.43-1.59) / 0.575
rs4141856 / 56060316 / Imputed / 1.08 (0.96-1.22) / 0.211
19-56060497 / 56060497 / Imputed / 1.12 (0.47-2.66) / 0.803
rs2739459 / 56060886 / Imputed / 1.08 (0.96-1.21) / 0.207
rs2739460 / 56060932 / Imputed / 1.06 (0.94-1.20) / 0.365
19-56061133 / 56061133 / Imputed / 0.45 (0.14-1.40) / 0.166
rs2739461 / 56061263 / Imputed / 1.08 (0.96-1.21) / 0.224
rs2569737 / 56061399 / Imputed / 1.09 (0.97-1.23) / 0.164
rs2739462 / 56061436 / Imputed / 1.09 (0.97-1.23) / 0.164
rs10422030 / 56061565 / Imputed / 0.39 (0.13-1.13) / 0.083
rs2569738 / 56061652 / Imputed / 1.02 (0.90-1.15) / 0.776
rs2739464 / 56061660 / Imputed / 1.08 (0.96-1.21) / 0.212
19-56061678 / 56061678 / Imputed / 0.87 (0.30-2.54) / 0.803
rs10401509 / 56061787 / Genotyped / 1.48 (0.60-3.61) / 0.394
rs2739466 / 56062064 / Imputed / 1.08 (0.96-1.21) / 0.212
rs2739468 / 56062355 / Imputed / 1.08 (0.96-1.22) / 0.199
rs2739469 / 56062405 / Imputed / 1.08 (0.96-1.21) / 0.212
rs2739470 / 56062690 / Imputed / 1.06 (0.94-1.19) / 0.356
rs10409302 / 56063187 / Imputed / 0.55 (0.27-1.11) / 0.094
19-56063202 / 56063202 / Imputed / 1.18 (0.73-1.89) / 0.497
rs1506684 / 56063231 / Genotyped / 1.08 (0.96-1.21) / 0.214
19-56064073 / 56064073 / Imputed / 0.88 (0.76-1.02) / 0.092
rs2569739 / 56064207 / Genotyped / 1.08 (0.96-1.21) / 0.214
rs965537 / 56064609 / Imputed / 1.08 (0.96-1.21) / 0.215
rs1997563 / 56065002 / Imputed / 1.08 (0.96-1.21) / 0.215
rs2739472 / 56065091 / Imputed / 1.08 (0.96-1.21) / 0.212
rs62113227 / 56065165 / Imputed / 1.13 (0.90-1.42) / 0.295
rs2739473 / 56065197 / Imputed / 1.08 (0.96-1.21) / 0.212
rs2739475 / 56065438 / Imputed / 1.08 (0.96-1.21) / 0.212
rs12983994 / 56065556 / Imputed / 1.50 (1.01-2.24) / 0.045
rs2739476 / 56065630 / Imputed / 1.08 (0.96-1.21) / 0.213
rs12974899 / 56065711 / Imputed / 1.50 (1.01-2.24) / 0.045
rs3760724 / 56065859 / Imputed / 1.06 (0.88-1.29) / 0.532
rs34314776 / 56065862 / Imputed / 1.50 (1.01-2.24) / 0.045
rs2569741 / 56065909 / Imputed / 1.02 (0.90-1.15) / 0.783
rs2739477 / 56066003 / Imputed / 1.02 (0.90-1.15) / 0.784
rs2569742 / 56066037 / Imputed / 1.08 (0.96-1.21) / 0.216
rs2569743 / 56066049 / Imputed / 1.02 (0.90-1.15) / 0.785
rs2569744 / 56066143 / Imputed / 1.02 (0.90-1.15) / 0.786
rs3760728 / 56066404 / Imputed / 1.02 (0.90-1.16) / 0.715
rs2739478 / 56066453 / Imputed / 0.86 (0.71-1.03) / 0.098
rs3760730 / 56066459 / Imputed / 1.02 (0.90-1.15) / 0.789
19-56066550 / 56066550 / Imputed / 0.84 (0.44-1.61) / 0.599
19-56066560 / 56066560 / Imputed / 0.84 (0.44-1.61) / 0.599
19-56066619 / 56066619 / Imputed / 0.84 (0.44-1.61) / 0.600
rs10424878 / 56066779 / Imputed / 1.07 (0.95-1.22) / 0.271
rs12984666 / 56066912 / Imputed / 1.02 (0.90-1.15) / 0.793
rs12984214 / 56066957 / Genotyped / 1.02 (0.90-1.16) / 0.719
19-56067024 / 56067024 / Imputed / 0.86 (0.55-1.33) / 0.495
19-56067048 / 56067048 / Imputed / 0.95 (0.56-1.60) / 0.844
rs62115062 / 56067338 / Imputed / 1.01 (0.90-1.15) / 0.817
rs7260115 / 56067415 / Imputed / 1.00 (0.88-1.13) / 0.991
rs3760731 / 56067528 / Imputed / 0.55 (0.27-1.12) / 0.097
rs11084038 / 56067904 / Imputed / 1.02 (0.89-1.16) / 0.785
rs11084039 / 56068031 / Imputed / 1.02 (0.89-1.17) / 0.772
rs62113072 / 56068298 / Imputed / 1.19 (0.91-1.55) / 0.210
rs11670728 / 56068301 / Imputed / 1.02 (0.89-1.17) / 0.778
rs12978483 / 56068318 / Imputed / 1.59 (1.02-2.50) / 0.043
19-56068596 / 56068596 / Imputed / 0.39 (0.16-0.95) / 0.039
rs62113073 / 56068649 / Imputed / 1.15 (0.88-1.50) / 0.295
rs2664155 / 56068842 / Imputed / 0.92 (0.80-1.06) / 0.274
rs2664156 / 56068975 / Imputed / 0.94 (0.78-1.13) / 0.518
rs12973367 / 56069121 / Imputed / 1.22 (0.98-1.53) / 0.079
19-56069299 / 56069299 / Imputed / 1.59 (0.72-3.51) / 0.253
rs56297463 / 56069525 / Imputed / 0.76 (0.24-2.40) / 0.637
rs62113074 / 56070085 / Imputed / 1.20 (0.86-1.67) / 0.291
rs1506685 / 56070537 / Imputed / 0.82 (0.64-1.05) / 0.114
rs10403133 / 56070943 / Imputed / 0.88 (0.63-1.21) / 0.425
rs11549920 / 56071368 / Imputed / 2.36 (1.18-4.72) / 0.015
rs198972 / 56071705 / Genotyped / 1.03 (0.80-1.33) / 0.825
rs6070 / 56071922 / Imputed / 1.18 (0.92-1.50) / 0.190
rs34964828 / 56072176 / Imputed / 1.00 (0.71-1.42) / 0.980
rs8105275 / 56072257 / Imputed / 1.32 (0.98-1.78) / 0.064
19-56072356 / 56072356 / Imputed / 1.12 (0.49-2.54) / 0.783
rs8105211 / 56072413 / Imputed / 1.32 (0.98-1.77) / 0.064
rs198974 / 56072414 / Imputed / 1.16 (0.92-1.48) / 0.216
rs198975 / 56072627 / Imputed / 1.16 (0.91-1.48) / 0.219
rs8108845 / 56072895 / Imputed / 1.32 (0.98-1.77) / 0.066
rs198976 / 56072938 / Imputed / 1.16 (0.92-1.47) / 0.218
19-56073392 / 56073392 / Imputed / 1.10 (0.24-5.01) / 0.753
rs198977 / 56073589 / Genotyped / 1.17 (0.90-1.52) / 0.231
rs198978 / 56074884 / Imputed / 1.16 (0.91-1.46) / 0.224
19-56075012 / 56075012 / Imputed / 1.46 (0.85-2.53) / 0.174
19-56075013 / 56075013 / Imputed / 1.46 (0.85-2.53) / 0.173
rs187930 / 56075162 / Imputed / 1.08 (0.60-1.95) / 0.793
rs198979 / 56075992 / Genotyped / 1.05 (0.72-1.53) / 0.793

OR, odds ratio; CI, 95% confidence interval. Coordinates are based on NCBI genome build 36.3. In cases where SNPs from the 1000 Genomes project have not been assigned rs numbers, the chromosome and location are provided.

Supplemental Table 8: Association of imputed and genotyped SNPs in nonaggressive prostate cancer cases vs. control subjects in the KLK3 region in the PLCO cohort

dbSNP rs number / Position / Category / Allelic OR (95% C.I.) / P
rs3212810 / 56020548 / Imputed / 0.98 (0.81-1.18) / 0.822
rs3212853 / 56020606 / Imputed / 0.89 (0.50-1.56) / 0.678
rs3212808 / 56021084 / Imputed / 1.07 (0.67-1.72) / 0.770
rs3212852 / 56021941 / Imputed / 1.02 (0.67-1.54) / 0.941
rs61752560 / 56022235 / Imputed / 0.99 (0.81-1.22) / 0.946
rs3745522 / 56022744 / Genotyped / 0.96 (0.80-1.17) / 0.712
19-56023011 / 56023011 / Imputed / 1.23 (0.53-2.86) / 0.636
19-56023016 / 56023016 / Imputed / 0.99 (0.68-1.45) / 0.964
19-56023017 / 56023017 / Imputed / 1.09 (0.81-1.47) / 0.582
rs266112 / 56023401 / Imputed / 0.85 (0.59-1.21) / 0.371
19-56024123 / 56024123 / Imputed / 0.90 (0.74-1.09) / 0.273
rs266113 / 56024293 / Imputed / 0.94 (0.77-1.14) / 0.533
rs266114 / 56024482 / Genotyped / 0.90 (0.74-1.10) / 0.306
rs266115 / 56025050 / Imputed / 0.81 (0.59-1.11) / 0.185
19-56025254 / 56025254 / Imputed / 1.44 (0.38-5.39) / 0.590
rs7246740 / 56025486 / Imputed / 1.21 (0.54-2.73) / 0.642
19-56025987 / 56025987 / Imputed / 14.64 (1.7-126.02) / 0.015
rs11879167 / 56026053 / Imputed / 3.41 (1.12-10.39) / 0.031
rs2560935 / 56026167 / Genotyped / 0.97 (0.72-1.30) / 0.839
rs3745523 / 56026702 / Imputed / 0.88 (0.70-1.10) / 0.261
rs55786312 / 56026861 / Imputed / 1.04 (0.86-1.26) / 0.688
rs2659057 / 56027057 / Imputed / 1.08 (0.93-1.27) / 0.320
rs2659056 / 56027755 / Genotyped / 1.08 (0.90-1.28) / 0.414
rs266850 / 56028009 / Genotyped / 1.06 (0.82-1.38) / 0.651
rs266851 / 56028151 / Genotyped / 0.93 (0.71-1.20) / 0.565
rs60621230 / 56028278 / Imputed / 0.62 (0.36-1.05) / 0.077
rs2659055 / 56029044 / Imputed / 1.08 (0.92-1.26) / 0.353
rs2163861 / 56029204 / Genotyped / 1.07 (0.92-1.24) / 0.380
rs266854 / 56029630 / Imputed / 1.16 (0.94-1.44) / 0.173
rs190552 / 56030005 / Imputed / 1.00 (0.77-1.31) / 0.982
rs266855 / 56030196 / Imputed / 1.16 (0.94-1.45) / 0.173
rs266856 / 56030318 / Imputed / 1.00 (0.77-1.31) / 0.998
rs2739442 / 56030985 / Imputed / 1.06 (0.86-1.31) / 0.577
rs2033496 / 56031019 / Imputed / 1.01 (0.82-1.24) / 0.937
rs266857 / 56031529 / Imputed / 0.96 (0.73-1.26) / 0.763
19-56031628 / 56031628 / Imputed / 1.31 (0.96-1.78) / 0.094
rs266858 / 56031774 / Genotyped / 0.92 (0.70-1.21) / 0.550
rs2569745 / 56032000 / Imputed / 0.98 (0.73-1.33) / 0.921
19-56032355 / 56032355 / Imputed / 1.04 (0.64-1.70) / 0.862
19-56032534 / 56032534 / Imputed / 1.05 (0.67-1.65) / 0.826
rs2659053 / 56032606 / Imputed / 1.24 (0.95-1.62) / 0.112
rs62113172 / 56032607 / Imputed / 1.30 (0.82-2.04) / 0.262
rs2569746 / 56032727 / Imputed / 0.81 (0.62-1.06) / 0.117
rs35711205 / 56032818 / Imputed / 1.14 (0.82-1.58) / 0.428
rs2569747 / 56032875 / Imputed / 0.80 (0.61-1.05) / 0.110
rs62113174 / 56033275 / Imputed / 1.43 (0.78-2.63) / 0.245
rs34988149 / 56033484 / Imputed / 0.87 (0.65-1.17) / 0.361
19-56034564 / 56034564 / Imputed / 1.01 (0.77-1.32) / 0.942
rs11667223 / 56034944 / Imputed / 1.00 (0.76-1.31) / 0.993
19-56035010 / 56035010 / Imputed / 0.79 (0.37-1.68) / 0.536
rs10413296 / 56035271 / Imputed / 1.29 (0.84-2.00) / 0.246
rs2659052 / 56035549 / Imputed / 0.83 (0.65-1.07) / 0.146
rs12984286 / 56035617 / Imputed / 0.95 (0.71-1.29) / 0.758
19-56035906 / 56035906 / Imputed / 1.16 (0.70-1.93) / 0.563
19-56035941 / 56035941 / Imputed / 1.02 (0.58-1.79) / 0.947
rs2569753 / 56035990 / Imputed / 0.81 (0.63-1.03) / 0.087
rs34575650 / 56036295 / Imputed / 0.91 (0.69-1.19) / 0.485
19-56037076 / 56037076 / Imputed / 0.59 (0.38-0.90) / 0.015
rs62113175 / 56037137 / Imputed / 1.29 (0.84-1.96) / 0.241
rs2659051 / 56037380 / Imputed / 1.07 (0.78-1.48) / 0.660
rs2569729 / 56037633 / Genotyped / 0.94 (0.72-1.22) / 0.642
rs56397626 / 56038334 / Imputed / 0.59 (0.38-0.90) / 0.014
rs4802751 / 56040041 / Imputed / 1.03 (0.80-1.32) / 0.817
rs4802752 / 56040109 / Imputed / 1.04 (0.81-1.33) / 0.771
rs4239492 / 56040523 / Imputed / 1.00 (0.80-1.25) / 0.988
rs10402571 / 56040856 / Imputed / 1.28 (0.85-1.95) / 0.238
rs266849 / 56040902 / Genotyped / 1.08 (0.81-1.46) / 0.595
19-56041022 / 56041022 / Imputed / 1.40 (0.26-7.46) / 0.692
rs11878415 / 56041100 / Imputed / 1.04 (0.81-1.33) / 0.775
rs10445554 / 56041528 / Imputed / 0.99 (0.79-1.23) / 0.922
19-56041593 / 56041593 / Imputed / 0.60 (0.10-3.64) / 0.577
rs2411332 / 56042552 / Imputed / 0.99 (0.78-1.27) / 0.958
rs7251465 / 56042603 / Imputed / 0.58 (0.38-0.89) / 0.013
rs2411331 / 56042692 / Imputed / 1.06 (0.83-1.36) / 0.638
19-56042755 / 56042755 / Imputed / 0.60 (0.23-1.56) / 0.294
19-56042756 / 56042756 / Imputed / 1.49 (0.49-4.53) / 0.331
19-56042757 / 56042757 / Imputed / 1.01 (0.26-3.92) / 0.985
rs7256136 / 56043538 / Imputed / 1.28 (0.85-1.94) / 0.236
rs266870 / 56043746 / Genotyped / 0.97 (0.78-1.20) / 0.751
rs266869 / 56043892 / Imputed / 1.02 (0.77-1.34) / 0.904
rs35630056 / 56044315 / Imputed / 1.02 (0.77-1.34) / 0.910
rs266868 / 56044749 / Genotyped / 0.95 (0.73-1.22) / 0.665
rs266867 / 56044839 / Imputed / 0.74 (0.46-1.21) / 0.231
rs62113179 / 56045042 / Imputed / 1.28 (0.86-1.91) / 0.219
rs266866 / 56045214 / Imputed / 0.66 (0.40-1.08) / 0.095
19-56045291 / 56045291 / Imputed / 1.02 (0.32-3.24) / 0.972
rs925013 / 56045413 / Imputed / 1.01 (0.77-1.34) / 0.918
19-56045597 / 56045597 / Imputed / 3.08 (1.21-7.83) / 0.018
19-56045719 / 56045719 / Imputed / 1.35 (0.25-7.23) / 0.723
rs11084033 / 56045767 / Imputed / 1.03 (0.77-1.38) / 0.826
rs266864 / 56046138 / Imputed / 1.01 (0.77-1.33) / 0.924
rs11665748 / 56046209 / Imputed / 1.27 (0.99-1.62) / 0.064
rs11665698 / 56046223 / Imputed / 1.36 (1.06-1.74) / 0.017
rs2659124 / 56046409 / Imputed / 1.71 (1.15-2.53) / 0.008
19-56046464 / 56046464 / Imputed / 0.60 (0.35-1.03) / 0.065
rs3760719 / 56047151 / Imputed / 1.03 (0.81-1.32) / 0.804
rs266863 / 56047462 / Imputed / 0.98 (0.80-1.21) / 0.855
rs3760720 / 56047874 / Imputed / 1.01 (0.80-1.29) / 0.902
rs266862 / 56047919 / Imputed / 0.94 (0.72-1.22) / 0.646
rs266861 / 56047977 / Imputed / 1.01 (0.76-1.33) / 0.967
19-56048548 / 56048548 / Imputed / 0.91 (0.51-1.61) / 0.740
rs266859 / 56048612 / Imputed / 1.00 (0.76-1.31) / 0.990
rs2739450 / 56048899 / Imputed / 0.99 (0.81-1.21) / 0.906
rs2739451 / 56049083 / Imputed / 0.90 (0.75-1.09) / 0.283
rs3760721 / 56049316 / Imputed / 1.02 (0.81-1.29) / 0.838
rs3760722 / 56049628 / Genotyped / 1.50 (1.09-2.06) / 0.014
rs17526278 / 56049699 / Imputed / 1.59 (1.14-2.22) / 0.007
rs4802754 / 56049732 / Imputed / 1.01 (0.81-1.26) / 0.916
rs266882 / 56049825 / Imputed / 0.98 (0.80-1.19) / 0.806
rs266881 / 56050145 / Imputed / 0.96 (0.80-1.15) / 0.636
rs2292186 / 56050206 / Genotyped / 1.02 (0.81-1.29) / 0.846
rs266880 / 56050283 / Imputed / 1.00 (0.82-1.20) / 0.966
rs55661885 / 56050312 / Imputed / 1.59 (1.14-2.21) / 0.006
rs1053972 / 56050441 / Imputed / 1.02 (0.83-1.27) / 0.825
rs266879 / 56050450 / Imputed / 0.92 (0.76-1.11) / 0.380
rs2292185 / 56050500 / Imputed / 1.20 (1.00-1.43) / 0.054
rs266878 / 56050926 / Imputed / 1.40 (1.01-1.94) / 0.044
rs2271095 / 56051265 / Imputed / 1.05 (0.88-1.26) / 0.583
rs11573 / 56051309 / Imputed / 1.16 (0.99-1.37) / 0.066
rs1135766 / 56051315 / Imputed / 1.16 (0.99-1.37) / 0.066
rs174776 / 56051664 / Imputed / 1.67 (1.16-2.41) / 0.006
rs58946822 / 56051894 / Imputed / 1.58 (1.14-2.19) / 0.006
rs1061476 / 56051899 / Genotyped / 1.05 (0.90-1.22) / 0.515
rs1061477 / 56051908 / Imputed / 1.05 (0.90-1.22) / 0.533
rs266877 / 56052580 / Imputed / 0.79 (0.35-1.78) / 0.574
rs266876 / 56052630 / Imputed / 1.01 (0.80-1.28) / 0.913
rs62113212 / 56052652 / Imputed / 0.61 (0.42-0.87) / 0.007
rs12946 / 56053127 / Imputed / 1.52 (1.11-2.10) / 0.010
rs61752561 / 56053194 / Imputed / 1.34 (0.43-4.16) / 0.614
rs2003783 / 56053284 / Imputed / 1.62 (1.18-2.23) / 0.003
rs1810020 / 56053456 / Imputed / 0.92 (0.43-1.99) / 0.833
rs17632542 / 56053569 / Imputed / 0.61 (0.42-0.90) / 0.012
rs61729813 / 56053662 / Imputed / 2.37 (1.01-5.55) / 0.047
rs266875 / 56053749 / Imputed / 0.84 (0.71-0.99) / 0.043
rs34750956 / 56053808 / Imputed / 1.49 (1.09-2.05) / 0.014
rs11084034 / 56054116 / Imputed / 1.06 (0.89-1.26) / 0.513
19-56054137 / 56054137 / Imputed / 1.23 (0.89-1.69) / 0.206
rs62113213 / 56054289 / Imputed / 1.23 (0.89-1.69) / 0.208
rs62113214 / 56054349 / Imputed / 0.60 (0.41-0.88) / 0.010
rs62113215 / 56054397 / Imputed / 0.90 (0.74-1.09) / 0.293
19-56054399 / 56054399 / Imputed / 0.87 (0.71-1.07) / 0.189
19-56054400 / 56054400 / Imputed / 0.91 (0.75-1.10) / 0.330
19-56054527 / 56054527 / Imputed / 0.60 (0.41-0.88) / 0.010
19-56054528 / 56054528 / Imputed / 1.55 (1.13-2.13) / 0.007
rs35192866 / 56054615 / Imputed / 1.55 (1.13-2.13) / 0.007
rs45588133 / 56054767 / Imputed / 1.55 (1.13-2.13) / 0.007
rs2659122 / 56054838 / Genotyped / 1.01 (0.80-1.28) / 0.930
rs1058205 / 56055210 / Genotyped / 1.35 (1.02-1.80) / 0.035
rs1058274 / 56055260 / Imputed / 0.88 (0.75-1.05) / 0.157
rs6998 / 56055473 / Imputed / 1.07 (0.90-1.27) / 0.445
19-56056012 / 56056012 / Imputed / 0.42 (0.13-1.40) / 0.159
rs55799315 / 56056035 / Imputed / 0.79 (0.63-1.00) / 0.049
rs4802755 / 56056052 / Imputed / 0.94 (0.79-1.13) / 0.501
rs2569735 / 56056081 / Imputed / 1.56 (1.11-2.17) / 0.009
rs8104556 / 56056192 / Genotyped / 1.00 (0.82-1.23) / 0.978
rs2735839 / 56056435 / Genotyped / 1.37 (1.02-1.83) / 0.034
rs17632611 / 56056461 / Imputed / 1.25 (0.89-1.74) / 0.198
rs62113216 / 56056615 / Imputed / 0.60 (0.41-0.86) / 0.006
rs55901451 / 56056633 / Imputed / 3.09 (0.61-15.55) / 0.171
rs55887816 / 56056679 / Imputed / 1.00 (0.82-1.23) / 0.983
rs55788344 / 56056873 / Imputed / 0.88 (0.74-1.04) / 0.145
rs266874 / 56057093 / Imputed / 0.99 (0.25-3.90) / 0.937
rs62113217 / 56057357 / Imputed / 0.95 (0.80-1.13) / 0.585
rs8112276 / 56057764 / Genotyped / 0.92 (0.79-1.08) / 0.297
19-56058156 / 56058156 / Imputed / 1.00 (0.81-1.23) / 0.967
19-56058185 / 56058185 / Imputed / 1.00 (0.81-1.23) / 0.966
rs62113221 / 56058308 / Imputed / 0.67 (0.28-1.57) / 0.354
rs62113222 / 56058606 / Imputed / 0.67 (0.28-1.58) / 0.358
19-56058688 / 56058688 / Imputed / 0.67 (0.28-1.58) / 0.358
rs56351139 / 56058721 / Imputed / 0.99 (0.80-1.23) / 0.949
rs62113223 / 56058866 / Imputed / 0.67 (0.28-1.58) / 0.361
19-56058871 / 56058871 / Imputed / 1.30 (0.95-1.78) / 0.106
19-56058872 / 56058872 / Imputed / 1.30 (0.95-1.78) / 0.106
rs62113225 / 56059213 / Imputed / 1.30 (0.95-1.78) / 0.104
rs62113226 / 56059256 / Imputed / 1.30 (0.95-1.78) / 0.103
rs58823125 / 56059479 / Imputed / 0.44 (0.13-1.49) / 0.186
rs61548536 / 56059594 / Imputed / 0.44 (0.13-1.49) / 0.188
rs34532440 / 56059760 / Imputed / 2.28 (1.22-4.27) / 0.010
rs2739458 / 56059915 / Imputed / 1.02 (0.83-1.26) / 0.825
19-56060000 / 56060000 / Imputed / 0.67 (0.28-1.59) / 0.365
rs4141856 / 56060316 / Imputed / 1.23 (1.05-1.43) / 0.010
19-56060497 / 56060497 / Imputed / 1.52 (0.47-4.92) / 0.481
rs2739459 / 56060886 / Imputed / 1.22 (1.05-1.43) / 0.009
rs2739460 / 56060932 / Imputed / 1.20 (1.02-1.41) / 0.028
19-56061133 / 56061133 / Imputed / 0.34 (0.10-1.19) / 0.092
rs2739461 / 56061263 / Imputed / 1.23 (1.05-1.43) / 0.009
rs2569737 / 56061399 / Imputed / 1.24 (1.06-1.44) / 0.007
rs2739462 / 56061436 / Imputed / 1.24 (1.06-1.44) / 0.007
rs10422030 / 56061565 / Imputed / 0.45 (0.13-1.56) / 0.207
rs2569738 / 56061652 / Imputed / 1.12 (0.96-1.31) / 0.158
rs2739464 / 56061660 / Imputed / 1.22 (1.05-1.42) / 0.010
19-56061678 / 56061678 / Imputed / 2.47 (0.60-10.12) / 0.210
rs10401509 / 56061787 / Genotyped / 1.18 (0.38-3.65) / 0.768
rs2739466 / 56062064 / Imputed / 1.22 (1.05-1.42) / 0.010
rs2739468 / 56062355 / Imputed / 1.23 (1.05-1.43) / 0.009
rs2739469 / 56062405 / Imputed / 1.22 (1.05-1.42) / 0.010
rs2739470 / 56062690 / Imputed / 1.20 (1.03-1.41) / 0.021
rs10409302 / 56063187 / Imputed / 0.77 (0.33-1.79) / 0.538
19-56063202 / 56063202 / Imputed / 1.11 (0.60-2.06) / 0.732
rs1506684 / 56063231 / Genotyped / 1.22 (1.05-1.42) / 0.009
19-56064073 / 56064073 / Imputed / 0.75 (0.62-0.91) / 0.003
rs2569739 / 56064207 / Genotyped / 1.22 (1.05-1.42) / 0.010
rs965537 / 56064609 / Imputed / 1.22 (1.05-1.42) / 0.009
rs1997563 / 56065002 / Imputed / 1.22 (1.05-1.42) / 0.009
rs2739472 / 56065091 / Imputed / 1.22 (1.05-1.42) / 0.010
rs62113227 / 56065165 / Imputed / 1.23 (0.91-1.66) / 0.173
rs2739473 / 56065197 / Imputed / 1.22 (1.05-1.42) / 0.010
rs2739475 / 56065438 / Imputed / 1.22 (1.05-1.42) / 0.010
rs12983994 / 56065556 / Imputed / 2.00 (1.18-3.39) / 0.010
rs2739476 / 56065630 / Imputed / 1.22 (1.05-1.43) / 0.010
rs12974899 / 56065711 / Imputed / 2.00 (1.18-3.40) / 0.010
rs3760724 / 56065859 / Imputed / 1.11 (0.86-1.43) / 0.415
rs34314776 / 56065862 / Imputed / 2.00 (1.18-3.40) / 0.011
rs2569741 / 56065909 / Imputed / 1.12 (0.96-1.31) / 0.160
rs2739477 / 56066003 / Imputed / 1.12 (0.96-1.31) / 0.160
rs2569742 / 56066037 / Imputed / 1.22 (1.05-1.43) / 0.010
rs2569743 / 56066049 / Imputed / 1.12 (0.96-1.31) / 0.160
rs2569744 / 56066143 / Imputed / 1.12 (0.96-1.31) / 0.161
rs3760728 / 56066404 / Imputed / 1.13 (0.96-1.33) / 0.138
rs2739478 / 56066453 / Imputed / 0.72 (0.57-0.92) / 0.007
rs3760730 / 56066459 / Imputed / 1.12 (0.96-1.31) / 0.162
19-56066550 / 56066550 / Imputed / 0.67 (0.28-1.60) / 0.366
19-56066560 / 56066560 / Imputed / 0.67 (0.28-1.60) / 0.366
19-56066619 / 56066619 / Imputed / 0.67 (0.28-1.60) / 0.366
rs10424878 / 56066779 / Imputed / 1.25 (1.06-1.47) / 0.008
rs12984666 / 56066912 / Imputed / 1.12 (0.96-1.31) / 0.163
rs12984214 / 56066957 / Genotyped / 1.13 (0.96-1.32) / 0.131
19-56067024 / 56067024 / Imputed / 1.10 (0.62-1.95) / 0.750
19-56067048 / 56067048 / Imputed / 0.77 (0.40-1.49) / 0.445
rs62115062 / 56067338 / Imputed / 1.12 (0.95-1.32) / 0.166
rs7260115 / 56067415 / Imputed / 1.10 (0.94-1.30) / 0.243
rs3760731 / 56067528 / Imputed / 0.76 (0.32-1.79) / 0.526
rs11084038 / 56067904 / Imputed / 1.13 (0.96-1.33) / 0.154
rs11084039 / 56068031 / Imputed / 1.14 (0.96-1.35) / 0.148
rs62113072 / 56068298 / Imputed / 1.31 (0.93-1.86) / 0.126
rs11670728 / 56068301 / Imputed / 1.14 (0.96-1.36) / 0.148
rs12978483 / 56068318 / Imputed / 2.28 (1.24-4.20) / 0.008
19-56068596 / 56068596 / Imputed / 0.33 (0.13-0.85) / 0.022
rs62113073 / 56068649 / Imputed / 1.26 (0.89-1.78) / 0.197
rs2664155 / 56068842 / Imputed / 0.79 (0.66-0.95) / 0.011
rs2664156 / 56068975 / Imputed / 0.99 (0.78-1.27) / 0.962
rs12973367 / 56069121 / Imputed / 1.38 (1.03-1.85) / 0.030
19-56069299 / 56069299 / Imputed / 2.78 (1.04-7.44) / 0.041
rs56297463 / 56069525 / Imputed / 0.68 (0.15-3.00) / 0.612
rs62113074 / 56070085 / Imputed / 1.32 (0.85-2.05) / 0.216
rs1506685 / 56070537 / Imputed / 0.64 (0.47-0.88) / 0.005
rs10403133 / 56070943 / Imputed / 0.93 (0.61-1.41) / 0.729
rs11549920 / 56071368 / Imputed / 3.40 (1.36-8.49) / 0.001
rs198972 / 56071705 / Genotyped / 1.31 (0.94-1.82) / 0.110
rs6070 / 56071922 / Imputed / 1.44 (1.05-1.98) / 0.023
rs34964828 / 56072176 / Imputed / 0.80 (0.52-1.24) / 0.322
rs8105275 / 56072257 / Imputed / 1.82 (1.23-2.67) / 0.002
19-56072356 / 56072356 / Imputed / 1.04 (0.37-2.96) / 0.940
rs8105211 / 56072413 / Imputed / 1.81 (1.23-2.67) / 0.003
rs198974 / 56072414 / Imputed / 1.41 (1.03-1.92) / 0.031
rs198975 / 56072627 / Imputed / 1.41 (1.04-1.93) / 0.029
rs8108845 / 56072895 / Imputed / 1.81 (1.23-2.66) / 0.003
rs198976 / 56072938 / Imputed / 1.40 (1.03-1.91) / 0.031
19-56073392 / 56073392 / Imputed / 1.78 (0.29-10.83) / 0.340
rs198977 / 56073589 / Genotyped / 1.58 (1.13-2.22) / 0.008
rs198978 / 56074884 / Imputed / 1.39 (1.03-1.89) / 0.033
19-56075012 / 56075012 / Imputed / 2.56 (1.19-5.53) / 0.016
19-56075013 / 56075013 / Imputed / 2.56 (1.19-5.53) / 0.016
rs187930 / 56075162 / Imputed / 1.11 (0.51-2.42) / 0.794
rs198979 / 56075992 / Genotyped / 1.15 (0.71-1.86) / 0.563

OR, odds ratio; CI, 95% confidence interval. Coordinates are based on NCBI genome build 36.3. In cases where SNPs from the 1000 Genomes project have not been assigned rs numbers, the chromosome and location are provided.