Program
WMC 2003 International Conference on Health Sciences Simulation
Orlando, Florida
January 19-23, 2003
Monday, 10:30am -12:00 noon
Health Care Policy
Chair: Godefridus G. van Merode, Ph.D., Maastricht University, The Netherlands
“A State Space Dynamic Modes Model of Health Care Prices, 1900-1950”
George W. Pasdirtz, Ph.D.
University of Wisconsin-Madison
1210 W. Dayton Street, Room 2149
Madison, WI 53706
“Correlation and Health Care Research”
William C. Conley, Ph.D.
Professor of Business Administration (Statistics)
University of Wisconsin-Green Bay
Green bay, WI 54311-7001
Monday, 1:30-3:00pm
Health Services
Chair: Ruth Davies, Ph.D., University of Southampton, UK
“Using Simulation for Planning Services for End-Stage Renal Failure”
Ruth Davies¹, Paul Roderick, and Chris Jones
University of Southampton
¹School of Management
Highfield, Southampton,
SO17 1BJ, U.K.
“Treating Ailing Emergency Departments with Simulation: an Integrated Perspective”
S.C. Brailsford¹, L. Churilov², and S-K Liew²
¹School of Management
University of Southampton, UK
²School of Business Systems
Monash University, Australia
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“Stimulation of Demand for Health Care: Evidence from a Model-Based Study of Shifts in Cardiac Catheterization Provision”
K.S. Taylor and B.C. Dangerfield
London School of Economics and Political Science
University of Salford, UK
Monday, 3:30-5:00pm
Tutorial
Ruth M. Davies, Ph.D., Senior Lecturer, University of Southampton UK will offer a tutorial on "The Use of Monte Carlo Simulation, Discrete Event Simulation and System Dynamics in Health Systems Modeling." The purpose of the tutorial is to provide an understanding of commonly used simulation approaches and how they may be used in hospitals and health services planning. Simulation software will be demonstrated and the different approaches compared.
Tuesday, 8:30-10:00am
Health Services
Chair: George W. Pasdirtz, Ph.D., University of Wisconsin, Madison
“Hospitals as Complexes of Queuing Systems”
Department of Health Organization
Godefridus G. van Merode² and Siebren Groothuis¹
¹Department of Medical Informatics
Maastricht University, P.O. Box 616
6200 MD Maastricht, The Netherlands
²Department of Health Organization
Policy and Economics
Maastricht University, P.O. Box 616
6200 MD Maastricht, The Netherlands
"Simulation at the Emergency Department"
Siebren Groothuis¹, Godefridus G. van Merode², Yvonne J.M. Koppelman, and
Arie Hasman1
¹Department of Medical Informatics
Maastricht University, P.O. Box 616
6200 MD Maastricht, The Netherlands
²Department of Health Organization
Policy and Economics
Maastricht University, P.O. Box 616
6200 MD Maastricht, The Netherlands
“Computer-Based Physician Order Entry in a Hospital: A Simulation Study”
James G. Anderson, Ph.D.¹ and Marilyn M. Anderson, B.A.²
¹Purdue University
1365 Stone Hall
West Lafayette, IN 47907
²Anderson Consulting
West Lafayette IN 47906
Tuesday, 10:30am-12:00 noon
Modeling Epidemics
Chair: B.C. Dangerfield, Ph.D., University of Salford, UK
“Using Discrete Event Simulation to Select Affordable Intervention Programs for Vertical HIV Transmission in Developing Countries”
Marion S. Rauner¹, Sally C. Brailsford², and Steffen Flessa³
¹University of Vienna
School of Business, Economics and Computer Science
Bruenner Str. 72, A-1210
Vienna, Austria
²University of Southampton
School of Management
Southampton SO17 1BJ, Great Britain
³Evangelical University of Applies Sciences Nuernberg,
Baerenschanzstraße 4, D-90429
Nuernberg, Germany
"A Model-Based Analysis of AIDS Treatment"
Felippe De Souza
Department of Electromechanical Engineering
UBI-Universidade Beira Interior
6201-001-Covilha
Portugal
Tuesday, 1:30-3:00pm
Modeling Epidemics
Chair: Marion S. Rauner, Ph.D., University of Vienna, Austria
“The Impact of Social Isolation, on STD-Transmission. A Micro-Modeling Approach to Modeling Epidemics in a Network of Heterogeneous Actors”
Christoph Weismayer¹, Riaz Abdullah, and James G. Anderson1
¹Purdue University
1365 Stone Hall
West Lafayette, IN 47907
"A Simulation Model of Schistosomiasis Transmission Dynamics and Control: Uncertainty and Sensitivity Analysis, and Model Calibration"
Song Liang
EHS/School of Public Health
U.C. Berkeley
Tuesday, 3:30-5:00pm
Tutorial
Jignesh Shah, a grad Student at the Computer Engineering Department at Virginia Technical University, will present a tutorial on "Simulation and Reverse Engineering of Bio-chemical Networks". In this presentation a simulation project related to the development of new methods to aid in the identification of gene regulatory networks will be presented. Using biochemical network simulator GEPASI (http://www.gepasi.org) time series of simulated DNA microarray data are produced. A gene regulatory network can be represented as a discrete dynamical system on a finite set of states. With the appropriate choice of state set each such system can be represented by a collection of polynomial functions with values in a finite field. That is, the gene regulatory network is represented as a collection of nodes, and the state of each node is a function of one or more genes in the network. Each gene has a polynomial function associated with it, which takes in the present state of the network as an input and outputs the next stage of the gene. Using tools from computational algebra all such systems consistent with a given data set can be determined. Using the polynomial system simulato, PolyNet, the behavior of such networks can be studied and compared to the behavior of the Gepasi system that produced the data.
The goal of the project is to study the limiting behavior of such systems, and its relationship to the structure of the polynomials. In this poster we present an overview of our approach and some preliminary experimental results.
Wednesday, 8:30-10:00am
Pharmocometric Applications
Chair: James Hargrove, Ph.D., University of Georgia, Athens, GA
"Adrenal Dynamics and Corticosteroids"
Meyer Katzper
Center for Drug and Evaluation Research, FDA
Rockville, MD 20857
“Optimal Design of a Clinical Test for Measuring Glomerular Filtration Rate in Patients with Borderline Renal Function"
Karl Thomaseth
LADSEB-CNR
Corso Stati Uniti, 4, 35127
Padova, Italy
"Mathematical Models of Glucose and Free Fatty Acids Kinetics During Glucose Tolerance Tests"
Karl Thomaseth¹, Alessandra Pavan, Giovanni Pacini¹, Alexandra Kautzy-Willer, Angelo-Avogaro
Karl Thomaseth
¹LADSEB-CNR
Corso Stati Uniti, 4, 35127
Padova, Italy
Wednesday, 10:30am-12:00 noon
Biomedical Applications
Chair: Karl Thomaseth, Ph.D., LADSEB-CNR, Padova, Italy
“Human Respiratory System: Simulation of Breathing Mechanics and Gas Mixing Processes Based on a Non-Linear Mathematical Model”
Bernhard Qautember
Institut fuer Informatik
Der Universitaet Innsbruck
Technikerstrasse 25
A-6020 Innsbruck
Austria
"Mathematical Modeling: A Tool for Nutritional Genomics and Bioinformatics"
James L. Hargrove, Ph.D. and Diane K. Hartle, Ph.D.
Associate Professor
Department of Foods and Nutrition
Dawson Hall
The University of Georgia
Athens, GA 30602-3622
"A CAT-scan Slice Matrix Approach to Simulation Based Dental Training"
Dr. Gerald Pitts¹ and Mr. Chris Smith²
¹Caruth Distinguished Professor
Chair of Computer Science Department
Trinity University
715 Stadium Drive
San Antonio, Texas 78212
²Trinity University
San Antonio, TX 78212
Wednesday, 1:30-3:00pm
Tutorial
Roger W. Jelliffe, M.D., Professor of Medicine, USC, will offer a workshop on "Principles of Pharmocokinetics-New Unified Approaches to Parametric and Nonparametric Population PK and PD Modeling-Applications to Therapeutic Drug Monitoring and to Optimal Individualization of Drug Therapy and Cancer Chemotherapy." This course is intended for biomedical scientists, physicians, pharmacists, and those with an interest in drug development and evaluation, medical decison making, clinical trials, population pharmocokinetic/pharmocodynamic modeling and simulation, and therapeutic drug monitoring and individualization of drug therapy for optimally precise patient care. The course will examine and review current and new methods of parametric and nonparametric population PK/PD modeling, with special emphasis on the FOCE parametric Iterative 2-Stage Bayesian (IT2B) and the nonparametric adaptive grid (NPAG) programs. Statistical and mathematical consistency and efficiency of methods in population PK/PD modeling will be discussed, evaluated, and compared.
Wednesday, 3:30-5:00pm
Tutorial (continued)
Description above.