CURRICULUM VITAE

Dr. Karan Singh
Associate Professor
Department of Chemistry
Akal College of Basic Sciences
Eternal University
Baru Sahib- 173101,
Dist. Sirmour (Himachal Pradesh)
Mob: 09882226019
Email: /

CAREER HIGHLIGHTS

·  ~7.5 years of Research & Development experience in Contract Research Organization (CRO)

·  ~2.5 years of experience in New Chemical Entity at Lupin Limited (Research Park)

·  ~5 years of experience in teaching at graduate and post graduate levels

·  Ph.D. (Organic Chemistry) from Kurukshetra University, Kurukshetra, Haryana, India

·  Research Assistant in Collaborative project with Ranbaxy Lab during Ph.D.

·  Expertise includes Design & Synthesis of Small Molecules (Custom Synthesis, Building Blocks, Reference Compounds and Impurity Synthesis), Parallel Medicinal Chemistry, Library Synthesis, Structure Elucidation using Analytical Techniques, Group & Project Management • Competent in Synthetic Organic Chemistry encompassing design, costing, synthesis, purification of chemical intermediates and target compounds

·  Holds the merit of working for major pharmaceutical companies across USA and Europe

·  Well versed with Scientific Software and Laboratory Safety Practices

·  Deft at managing the validation & calibration of systems and reviewing of departmental documentation

·  Familiar with state-of-the-art research techniques, technologies & systems

·  Gathered fair understanding in ensuring that the activities are performed in a timely / accurate manner and according to the policies and procedures

·  An effective communicator with skills in troubleshooting, team building, problem solving & abilities to work under pressure

CORE COMPETENCIES

·  Organizing day-to-day research activities and resolving procedural problems as appropriate to the timely completion of research objectives

·  Setting-up, calibrating, operating and maintaining a variety of laboratory and/or field research equipment as specified by the requirements of the research study

·  Planning project activities and implementing project plans within preset budgets and deadlines

·  Ensuring that appropriate procedures and standards for the collection & preservation of analytical samples are adhered to

·  Investigating failure in the process and reverting with suggestions to higher authorities

·  Serving as Core Committee Member of ISO 9001 2000 for getting certification to GVK BIO

·  Carrying out troubleshooting of all technical problems

·  Performing various tests & inspections to ensure that products developed were in compliance with pre-set quality specifications

·  Maintaining quality standards and ensuring stringent adherence to the same

·  Assessing gaps & adopting corrective action to cover the same

ACADEMIC CREDENTIALS

·  PhD (2003): Heterocyclic Chemistry; Kurukshetra University Kurukshetra, Haryana, India; Advisors: Dr. S N Dhawan and Dr. Pawan K Sharma.

·  CSIR-UGC NET: Qualified in Dec. 1999.

·  MSc (1997): Organic Chemistry; Kurukshetra University Kurukshetra, Haryana, India.

·  BSc (1995): Botany, Zoology, Chemistry; RKSD College Kaithal (Affiliated to Kurukshetra University Kurukshetra) Haryana.

EMPLOYMENT HISTORY

·  Associate Professor (April 2014 – present)

Department of Chemistry, Akal College of Basic Sciences, Eternal University

·  Teaching below Courses at Graduate and Post Graduate Level:

CHEM-101 (Basic Organic Chemistry)

CHEM-103 (Lab Work)

CHEM-202 (Stereochemistry and Reaction Mechanism)

CHEM-302 (Organic Chemistry)

CHEM-505 (Lab Work)

CHEM-551 (Organic Spectroscopy)

CHEM-556 (Lab Work)

·  Submitted one proposal to CSIR for research grant

·  One more proposal is ready for submission to DST for research grant

Extra Responsibilities:

·  Coordinator for Time table committee and INSPIRE program, DST Govt of India

·  Associate Principal Scientist, April 2011 to March 2014

Senior Scientist, October 2007 to March 2011

Scientist, November 2006 to September 2007

GVK Biosciences Pvt. Ltd., Hyderabad, India, Chemistry Service Division,

Worked for ~7.5 years in Chemistry service division and managed several US and European Clients & serve their chemistry needs.

Major areas of focus were:

Synthetic Chemistry

Custom Synthesis

Library Design and Synthesis (Parallel Chemistry)

Impurity Synthesis

Building Blocks and Scaffold Synthesis

Reference Compounds

Discovery Chemistry

To speed up Drug Discovery research programs of international clients in identifying pre-clinical candidates, worked on the focused arrays of 20-100 compounds in 10-50 mg scale with chemical purities of ≥95% (by LC-MS and NMR) to get the Hits Compound followed by structural modification of hits compound to improve potency and selectivity to get Hit to Lead.

Custom synthesis of novel organic compounds in milligrams to multi-gram quantities for the areas of medical research, chemical / pharmaceutical development, lead compound / pro-drug development, flavors, fragrances and agro chemicals were executed.

Worked in the below Collaboration Models

·  Full time equivalent (FTE)

·  Fee for service (FFS) per library

·  Single price per compound

Synthesized lot of Building blocks and scaffolds which were either very costly or no vendor was available.

Besides this, gain extensive experience in impurity synthesis, reference compounds and various techniques used in the synthetic chemistry.

Job responsibilities during stay at GVK BIO:

·  Interaction with the clients periodically for project requirements, clarifications and updates.

·  Synthesis of molecules as per the defined route or define the route to synthesize the molecules.

·  Building strong customer relations both internally and externally.

·  In charge for Projects & manage a group of 25 chemists (1 Senior Scientist and 1 Associate Scientist).

·  Project Management: Designing, planning & execution of projects in a cost effective manner.

·  Giving guidance to the associated group in terms of scientific & technical skills.

·  Doing literature collection & identifying suitable reaction conditions.

·  Analyzing the spectral data & taking decisions accordingly with respect to projects requirement.

·  Allotment of work to the associated group & making changes as per the need.

·  Preparing and presenting weekly, monthly reports and final project reports.

Research Scientist I, July 2006 to October 2006

Research Associate II, May 2004 to June 2006

Lupin Ltd. (Research Park), Pune, India, Medicinal Chemistry, Anti-diabetes Division

Achievements during stay at Lupin Ltd:

Worked in the New Chemical Entity Department for ~2.5 years and gain below achievements:

·  Optimization, Synthesis, Purification and Characterization of novel anti-diabetic molecules as PPARγ activator on the basis of their SAR. The effort was devoted towards synthesis of analogues, thereby increasing solubility and enhancing the bioavailability of the compounds that have shown promising activity

·  Carried out the synthesis of over 72 NCE’s

·  Scale up of 6 anti-diabetic molecules involving multiple steps in gram scale for in vivo testing.

·  Dexter Chemicals India Pvt. Ltd. Kurukshetra, India

Research Scientist, December 2003 to April 2004

Worked on the synthesis, purification and characterization of ~20 disaccharide molecules on mg scale

·  B. S. Anangpuria Institute of Technology and Management, Faridabad, Haryana

Lecturer in Chemistry, October 2001 to December 2003

Taught basic chemistry to B. Tech 1st year students

·  Chemistry Department, Kurukshetra University, Kurukshetra, Haryana, India.

Research Assistant in Collaborative Research Project between Ranbaxy Research Laboratory Gurgaon and K.U. Kurukshetra, July 1998 to September 2001

Prepared ~72 Compounds (2,4-disubstituted thiazole molecules) and shipped to Ranbaxy Research Laboratory Gurgaon

·  Sri Krishna Institute of Engineering and Technology, Kurukshetra, Haryana

Lecturer in Chemistry, December 1997 to July 1998

Taught basic chemistry to B. Tech 1st year students

SKILLS ACQUIRED

v  Spectroscopic Techniques: Well versed with spectroscopic techniques like NMR, IR, HPLC, LCMS and MS.

v  Computers: Applications of computers like

·  Chemical Structure Drawing in Chemdraw, ISIS Draw, Chemword

·  Word Processing using MS Word, Power Point etc

·  Literature Search by using MDL Bilstein, Scifinder, Reaxys etc

AWARD AND RECOGNITION HIGHLIGHTS

·  Recipient of GVK BIO Value Star Award for Customer Focus from GVK Biosciences in 2007

·  Attained Certificate of Vendor Appreciation from a big pharmaceutical company for problem solving, execution of projects, team management and good communication skills

·  Recipient of Team Award Certificate from GVK Biosciences in 2013

PROFESSIONAL ENHANCEMENT

·  Workshops Attended

o  Good Laboratory Practices at ConnectIT Solutions, Hyderabad in 2011

o  E-Mail Writing Skills at GVK Biosciences 2013

o  Business Communication Skills at Lupin Limited 2005

o  Relationship Management at GVK Biosciences 2008

·  Training Attended

o  Accent Neutralization at GVK Biosciences 2010

FELLOWSHIP

Junior Research Fellowship (July 1998 to Sep. 2001)

(From Collaborative Research Project between Ranbaxy Research Laboratory Gurgaon and K.U. Kurukshetra)

LIST OF PUBLICATIONS

v  Synthesis and characterization of some novel 4-formyl pyrazolylthiazoles of potential medicinal interest using Vilsmeier-Haack reaction. Pawan K Sharma, Karan Singh, S N Dhawan & S P Singh. Indian J Chem, 41A (2002) 2071-2075.

v  Vilsmeier-Haack reaction on hydrazones: a convenient synthesis of 4-formylpyrazoles. Karan Singh, Suman Ralhan, Pawan K Sharma & S N Dhawan. J Chem Res, (2005) 316-318.

v  Synthesis and characterization of some novel indeno[1,2-c]pyrazoles. Karan Singh, Pawan K Sharma, S N Dhawan & S P Singh. J Chem Res, (2005) 526-529.

v  Synthesis and anti-inflammatory evaluation of some pyrazolo[3,4-b]pyridines. PawanK.Sharma, KaranSingh, SurenderKumar, PawanKumar, S.N.Dhawan, SukhbirLal, HolgerUlbrichand GerdDannhardt. Medicinal Chemistry Research. (2011) 20 (2), 239-244

v  Synthesis, characterization and antimicrobial study of some benzenesulfonamide based bipyrazoles. Karan Singh and Pawan K Sharma. International Journal of Pharmacy and Pharmaceutical Sciences (2014) 6 (10), 345-351

v  Synthesis, characterization and antimicrobial study of some novel fluorine based 2-aminothiazoles. Karan Singh and Pawan K Sharma. International Journal of Pharmacy and Pharmaceutical Sciences (2014) 6 (10), 429-433

v  Application of indan-1,3-dione in heterocyclic synthesis. Karan Singh. Curr. Org. Syn. (Accepted)

PERSONAL INFORMATION

Birth Date: 08-07-1975

Place: Kaul, Kaithal, Haryana

Nationality: Indian

Wife: Mrs. Sony (M.Sc. Food and Nutrition)

Children: Nehal and Vertika

Languages known: English, Hindi

CV/Dr. Karan Singh