Sabine Hazan- Steinberg M.D.

Professional Name: Sabine Hazan MD

1746 South Victoria #220,230 Ventura Ca 93003

Tel: 8053390549

Fax: 8056421540

PERSONAL:

Languages: French, English, Spanish, Hebrew.

Marital Status: Married Dr. A. Steinberg (Cardiologist)

Citizenship: Canadian and American

Hobbies: Photography, painting, scuba diving, fishing, skiing, travel and writing

EXPERTISE IN GI:

Esophageal and Anal Motility, Diagnostic and Therapeutic Gastroscopy, Diagnostic and Therapeutic Colonoscopy, Diagnostic ERCP, Endocinch, Liver biopsies and Capsule Endoscopy

CURRENT LICENSURES:

California license - Oct 2003 to present: C51399

NY license - 1999 to present: 215073-1

Florida license – 1994 to 2005: ME66973

GCP: 2/18/2012

American Board Certified in Gastroenterology: Nov 2001

American Board Certified in Internal Medicine: August 1998

DEA Licensure: 3H41 69062.

EDUCATIONAL BACKGROUND:

1987 - 1992 DALHOUSIE UNIVERSITY, Nova Scotia, Canada

MEDICAL DIPLOMA (M.D) Awarded May 1992

1984 - 1987 CONCORDIA UNIVERSITY, Montreal, Canada

Bachelor of Sciences (BSc.) Biology Major, Physical Therapy and Minor Nutrition

1982 - 1984 CEGEP BREBEUF, Montreal, Canada

D.E.C. Specialty in Health, Pure & Applied Sciences

WORK EXPERIENCE:

01/08 – present Ventura Clinical Trials

Principal Investigator

1746 South Victoria Blvd., Suite 220

Ventura, CA 93003

01/08 – present Private Gastroenterology practice

Malibu, Ventura

11/09 - 12/09 Medical Director of Procare Hospice

01/08 to 12/08 Chief of Medicine at Community Memorial Hospital

Ventura, Ca

01/05 – 2008 Sub-investigator / PI for IMPACT CLINICAL TRIALS

Los Angeles, California.

01/05 - 1/08 Covington Menz Lyche Lin Hazan GI practice

Ventura, California.

09/99 - 9/2004 HS Medical P.C. Inc, Plattsburgh, New York.

Owner and President

07/97 - 09/99 HS Medical P.C. Inc, Jacksonville, Florida

Owner and President

09/99 - 11/99 OAK Terrace Nursing Home

Medical director

07/97 - 09/99 FLORIDA CHRISTIAN NURSING HOME, Jacksonville, Florida.

Private practitioner

07/95 - 07/97 FLORIDA CHRISTIAN NURSING HOME, Jacksonville, Florida.

Nursing Home Medical Director

09/94 - 07/95 JACKSON VILLE MEMORIAL HOSPITAL, Miami, Florida.

Urgent Care Center, General Practitioner

09/94 - 07/95 CAC RAMSAY, Miami, FLorida.

General Practitioner

09/91 - 12/91 TANTALOON HIGH SCHOOL, Nova Scotia, Canada.

Health Peer Advisor

03 /91 - 12/91 CHESTER CLINIC, Nova Scotia, Canada.

Physician Assistant to Dr. B. Swales

RESEARCH EXPERIENCE:

01/05 - present Principal investigator and subinvestigator for various clinical trials

IMPACT CLINICAL TRIALS, Los Angeles, California.

09/96 - 07/98 Principal investigator for various clinical trials

University of Florida, Jacksonville.

07/98 - 12/96 Hand-versus-Computer Operated Esophageal Balloon Distention in

Patients with Unexplained Chest Pain. Supervised by Dr. S. Achem

07/95 - 7/98 Coordinated numerous clinical trials.

Supervised by Dr. S. Achem, UNIVERSITY OF FLORIDA, Gastroenterology Division, Jacksonville, Florida

07/96 – 12/96 Long-term Reproducibility of Intraesophageal Balloon Distention Studies in Patients with Unexplained Chest Pain. Supervised by Dr. S. Achem

UNIVERSITY OF FLORIDA, Gastroenterology Division, Jacksonville, Florida

7/95 – 6/97 Lower Esophageal Sphincter Relaxation time: normal values and

prevalence of abnormal values in Patients with Noncardiac Chest pain

and/or Dysphagia. Supervised by Dr. S. Achem. UNIVERSITY OF FLORIDA, Gastroenterology Division, Jacksonville, Florida

7/95 - 7/97 Octreotide improves Sensory and Pain Thresholds in Patients with

Noncardiac Chest Pain. Supervised by Dr. S. Achem, UNIVERSITY OF FLORIDA, Gastroenterology Division, Jacksonville, Florida

1/93 - 5/93 Strongylodiasis in Patients with Systemic Lupus Erythematosus,

Supervised by Dr. Hoffman JACKSON MEMORIAL HOSPITAL, Infectious Disease Division, Miami, Florida

4/92 - 5/92 Incidence of Lactase Deficiency in Patients Status Post Cystoplasty

Supervised by Dr. Adwad. VICTORA GENERAL HOSPITAL, Urology Department, Nova Scotia, Canada

5/91 - 6/91 Effects of Water Diet on Patients in Supervised hospital setting

Supervised by Dr. Cookie, CAMPHILL HOSPITAL, Internal Medicine Department, NS, Canada.

1/91 - 2/91 Predisposing factors for Toxic Megacolon

Assisted by R.J. Sidorov, ROYAL VICTORIA HOSPITAL, Division, Nova Scotia, Canada

12/88 - 6/89 Complications of Liposuction.

Supervised by Dr. Tweed, VICTORIA GENERAL HOSPITAL, Plastic Surgery Department, Nova Scotia, Canada

12/87- 6/89 Best Exercise Program to Benefit Patient’s Status Post MI.

Supervised by Dr. Beresford.

PUBLICATIONS:

1) Be R, Hazan S, Gretz J, Buckley E, Kolts BE, McGee JB, Castell DO and SR Achem. Lower Esophageal Sphincter Relaxation time: Normal values and prevalence of abnormal values in Patients with Noncardiac Chest pain and /or dysphagia. Journal of Duval County Medical Association. - 47;7;296. June 1996.

2) Hazan S, Buckley F, Castell DO and Achem SR. Octreotide Improves Sensory and Pain

Thresholds in Patients with Noncardiac Chest Pain. Journal of the Duval County Medical Association. 47;7;291. June 1996.

3) Be R, Hazan S, Gretz J, Buckley E, Kolts BE, McGee JB, CasteLl DO an SR Achem. Lower

Esophageal Sphincter Relaxation time: normal values and prevalence of abnormal values in Patients with Noncardiac Chest pain and/or Dysphagia. Gastroenterology. April 1996;110:A6

4) Hazan S, Buckley E, Castell DO and Achem SR. Octreotide improves Sensory and Pain

Thresholds in Patients with Noncardiac Chest Pain. Gastroenterology. ApriL 1996; 110:4 132

5) Hazan S, Steinberg A, Morris N, Affronti JA, Achem SR. Long-term Reproducibility of

Intraesopheal. Balloon Distention Studies in Patients with Unexplained Chest Pain. Journal of Duval County Medical Association. 48;6:253 June 1997.

6) Hazan S, Morris N, Affronti JA, Achem SR. Hand - vs- Computer Operated Esophageal

Balloon Distention in Patients with Unexplained Chest Pain. Journal of Duval Courty Medical Association. 48;6:244. June 1997.

7) Hazan S, Steinberg A, Morris N, Affronti JA, Achem SR. Long-term Reproducibility of

lntraesophageat Balloon Distention Studies in Patients with Unexplained Chest Pain. Gastroenterologv. ApriL 1997; 112:A145.

8) Hazan S, Morris N, Affronti JA, Achem SR. Hand - vs- Computer Operated Esophageal

Balloon Distention in Patients with Unecptained Chest Pain. Gastroenterotogy. ApilI 1991; ii 2:4145.

9) Hazan Steinberg S, Colorectal Cancer, information is power.Synergy.Issue. May, 2007

MANUSCRIPTS IN PREPARATIONS:

1) Hazan, S, Achem SR. The effects of Octreotide in Patients with Unexplained Chest Pain.

2) Hazan S, Steinberg A, Morris N, Aifronti JA, Achem SR. Long-termReproducibility of IntraesophageaL Balloon Distention Studies in Patients with Unexplained Chest Pain.

3) Hazan S, Morris N, Aifronti JA, Achem SR. Hand - vs - Computer Operated Esophageal Balloon Distention in Patients with Unexplained Chest Pain.

4) Hazan S, Achem SR. Clinical Review on Balloon Distention.

5) Hazan S, and Achem SR. Intraesophageal Balloon Distention in the Evaluation of Patients with Noncardiac Chest Pain.

ORAL PRESENTATIONS:

1. Octreotide improves Sensory and Pain Threshold in Patients with Noncardiac Chest Pain.

Young Investigator’s Conference on Digestive Diseases Meeting sponsored by American Society for Gastrointestinal Endoscopy and Astra Merk Inc. Idaho, Coeur D’ Alene, ApriL 1996.

2. Long-term Reproducibility of Intraesophageal Balloon Distention Studies in Patients with Unexplained Chest Pain.

Young Investigator’s Conference on Digestive Diseases Meeting sponsored by American Society for Gastrointestinal Endoscopy and Astra Merk Enc. San Antonio, Texas. April 1997. University of Florida, Jacksonville Research Day, Jacksonville, Florida. June 1997.

3. Gastrointestinal Effects of Analgesics.

Anthony’s Restaurant

4. Non Cardiac Chest pain

Champlain Valley Hospital , Plattsburgh, NY, January 1, 2007

5. Reflux Esophagitis

Mountain Lake PBS, Health Show,Plattsburgh, NY, July 18th, 2001

6. Hepatitis C

Physician’s assistant annual conference, Lake Placid, NY, Feb7, 2002

8. Capsule Endoscopy.

Champlain Valley Physicians Hospital, Grand rounds, Plattsburgh, NY, March 7, 2003.

9. Capsule Endoscopy/Pillcam.

Community Memorial. Hospital, Grand rounds, Ventura, CA, September 13th, 2005

10. Gastrointestinal problems

Malibu Performing Arts Center, November 14th, 2006

Jewish Center, Feb 2007

11. C.Diff

CMH, Feb 2011, March2012, Oct 2014,

12. Reflux

CMH Sept 2015

13.Hepatitis

CMH July 2015

POSTER PRESENTATIONS:

A. Octreotide improves Sensory and Pain Threshold in Patients with NonCardiac Chest Pain.

National meeting of the American Gastroenterological Association, San Francisco, California. May 1996.

University of Florida, Jacksonville Research Day, Jacksonville, Florida. June 1996. Florida Gastroenterologic Society, Boca Raton Resort and Club, Boca Raton, Florida. September 1996.

Meeting of the Florida Chapter of American College of Physicians, Lago Mar Resort and Club, Fort Lauderdale, Florida. September 1996.

B. Hand - vs - Computer Operated Esophageal Balloon Distention in Patents With Unexplained Chest Pain.

National Meeting of the American Gastroenterological Association, Washington, DC. May 1991.

University of Florida, Jacksonville Research Day, Jacksonville, Florida. June 1997.

C. Long-term Reproducibility of lntraesophageal Balloon Distention Studies in Patients with Unexplained Chest Pain.

National Meeting of the American Gastroenterological Association, Washington, DC. May 1997.

University of Florida, Jacksonville Research Day, Florida. June 1997.

Florida Gastroenterologic Society, Lake Buena Vista Palace and Resort. Orlando, Florida. September 1997.

Meeting of the Florida Chapter of the American College of Physicians, Colony Beach and Tennis Resort, Long Boat Key, Florida. September 1997.

QUOTED:

I) Gazette Newspaper: December 20, 1999.

2) MacLain’s Magazine: April 3, 2000.

3) Press-Republican Newspaper: July 2001.

4) Time Magazine: February 2000.

5) Press-Republican Newspaper: March 4, 2003.

6) Malibu Times: 2008 various monthly issues

7) LA yoga magazine 2008

8) Articles in Ventura Star, 2008,2009,2010,2011,2012

9) Yale Law Journal May 7th, 2012

10) American J of Gastroenterology Feb 2005

HONORS & AWARDS:

1) Best Fellow Scientific Presentation-awarded by University of Florida Florida. May 30, 1996

2) Outstanding Poster Presentation-awarded By Florida Chapter American College of Physicians

September 28th, 1996

3) Outstanding Poster Presentation-awarded By Florida Chapter American College of physicians

29th Scientific meeting, September 27, 1997

4) Dean’s Research Award : University of Florida,May 12th, 1997

5) Certificate of merit for case presentation by a resident. Florida chapter of American College of physician, Miami, Florida. April 1993.

POST GRADUATE EDUCATION:

November 2004 EUS : British Berlin Institute

November 2003 Pillcarm sponsored by Given Imaging

Affiliated with Cornell University

New York, New York

September 2003 Capsule Endoscopy

Sponsored by Given imaging

September 2001 Endoluminal Gastroplication for the Treatment of Symptomatic Gastroesophageal Reflux Disease. (Endocinch)

Bard Endoscopic Technologies

Affiliated with Brigham and Women’s Hospital

July 1996 - July 1998 UNIVERSITY OF FLORIDA HEALTH SCIENCE CENTER

Division of Gastroenterology, Jacksonville, Florida

Clinical Gastroenterology fellow

Program Director: Dr. S. Achem

January 1997 GRADUATE HOSPITAL. Division of Gastroenterology

Philadelphia, PA: Gl preceptorship in Motility and Clinical Esophagology, Sponsored by Astra Merk.

Program Director: Dr. DO Castell

Ju1y 1995- July 1996 UNIVERSITY OF FLORIDA HEALTH SCIENCE CENTER

Division of Gastroenterology; Clinical Motility Research Fellow Program Director: Dr. Sami Achem

July 1992 - July 1995 JACKSON MEMORIAL HOSPITAL,

UNIVERSITY OF MIAMI, Miami, Florida: Internal Medicine Residency, PGY-1-3; Director: Dr. Marc Gelbard

EXTRACURRICULAR AWARDS AND CERTIFICATIONS:

June 1982 Classical and Jazz Ballet Instructor’s License.

August 1980 Crews Award for Sailing.

August 1979 Swimming Instructor’s License.

August 1978 Bronze Medal in Swimming.

December 1978 Silver Medal for Speed Ice Skating at Quebec Games.

PAST CERTIFICATIONS:

GCP ICH Certified, 2008, 2012

Medical, Council of Canada: Qualifying Exam, Part I, May 1992.

Medical Council of Canada: Qualifying Exam, Part II, May 1993.

FLEX Exam, June 1992.

A.C.L.S. Certification, May 2008

B.C.L.S Certification, May 1990

MEMBERSHIP:

2012 A.P.C.R ( Association of Clinical Research)

2012 GCP

2008 Chief of Medicine at Community Memorial Hospital

2005 to present Seaview IPA

2005 to present Buenaventura WA, Ojai IPA

2002 to 2003 Clinton County Medical Association - President Elect.

2001 to 2003 Clinton County Medical Association - Treasurer.

2001 to present American College of Gastroenterology.

2000 to 2004 Northern New York Physicians Individual Practice Association.

2000 to 2004 Northern New York Medical Alliance Management, Inc.

1997 to 1999 Duval County Medical Society.

1995 to present American Gastroenterological Association.

1995 to present American Society for Gastrointestinal Endoscopy.

1994 to 1995 Southern Medical Association.

1994 to 1995 American Society of Internal Medicine.

(voted Treasurer of ASIM, March 1994)

1992 to present American College of Physicians.

1992 to present American Medical Association.

1988 to 1999 Canadian Medical Association.

CLINICAL TRIALS:

RESEARCH EXPERIENCE:

Over 50 studies for last 17 years: Most Recent in last 8 years.

1.  Pozen; PPI / Aspirin study phase 4.

2.  Boehringer- Ingelheim; Hepatitis C phase 4.

3.  Salix; IBS drug phase 3.

4.  Takeda; IBD drug phase 4.

5.  Merk; Peptic ulcer disease phase 3

6.  Glaxo; Peptic ulcer disease phase 4

7.  TAP; PPI phase 4.

8.  GlaxoSmith Kline; Hepatitis C phase 2.

9.  Daiichi Sankyo; Coronary heart disease phase 3.

10.  Novartis; Hepatitis C phase 3.

11.  GSK; Herpes Labialis phase 3.

12.  Centocor : psoriasis phase 4

13.  Salix, Gastroparesis phase 3

14.  BI. A.fib.

15.  Roche Aleprevent.

16.  Amgen 138, 356, 348.

17.  GSK, Asthma

18.  Merck, C.diff

19.  Sanofi Pasteur, C.diff vaccine

20.  Merck, Peds DM

21.  Theravance, Gastroparesis phase 2.

22.  Tranzyme, Gastroparesis phase 2.

23.  Premier , Gastroparesis phase 2.

24.  GSK, COPD phase 3.

25.  Merck, Hepatitis c.

26.  Furiex 3001, IBSD phase 3.

27.  Furiex 3002, IBSD phase 3.

28.  Merck, Psoriasis phase 3.

29.  Astellas, Spec study.

30.  Paragon, Ulcer phase 3.

31.  Roche, Alecardio.

32.  Roche, Aleprevent

33.  Promethius, UC.

34.  Targacept, Gastroparesis

35.  Genentech ,Crohn’s

36.  Genntech ,Ulcerative colitis

37.  Acerta 003, Pancreatic Cancer

38.  Alcresta, Chronic Pancreatitis

39.  Summit, C.diff

40.  Chiltern, Constipation

41.  Abblynx, RA

42.  Pfizer, RA

43.  Rhythm, Gastroparesis

44.  Salix, Liver Failure

45.  Pfizer, Hyperlipidemia 1045,1022,1038

46.  Forrest LIND62, LIND63, Constipation

47.  Ironwood, Gastroparesis

48.  Perrigo, NY14-008, HSV1

49.  PSI, UC

50.  Hutchinson Pharma, UC

51.  Legacy, crohn’s

52.  Synterac, Chronic Pancreatitis

53.  Acerta 004, Pancreatic Cancer

DETAILS OF TRIALS BELOW:

Ironwood Gastroparesis ICP-112-202

A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Phase 2a Study of Oral IW-9179 Administered Once and Twice Daily for 4 Weeks to Patients With Diabetic Gastroparesis.

C.DiffVaccine H-030-014

Efficacy, Immunogenicity, and Safety Study of Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection