Leah C. Jimmerson, PhD.
University of Colorado Denver, Skaggs School of Pharmacy Department of Pharmaceutical Sciences 12850 E Montview Blvd, V20-C238 Aurora, CO 80045|970-980-9566|
HIGHLIGHTED SKILLS
·Analytical method development and validation expertise-published 3 peer reviewed methods for measurement of nucleos(t)ides in various human sample types
·Troubleshooting of HPLC/mass spectrometry instruments –fixing of leaks, solving high pressure issues, tuning and instrument calibration
·Preparation of SOP and AVR documents according to FDA guidelines
·Pharmacokinetic data analysis of large datasets (150+ samples with 10-20 covariates) using Microsoft Excel, SAS® and/or GraphPad Prism®
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highlighted phd accomplishments:
·Published method on measurement of endogenous purines in human cells—showed accuracy, precision and selectivity for LC-MS/MS quantification, proved conditional stability, and only method to test dried blood spot (DBS) stability
·Published method for measuring intracellular ribavirin with LC-MS/MS—first method to do this in multiple cell types, showed long term and conditional stability, correlated with R^2=0.95 to paired RBC lysate data, validated usefulness for measurement in DBS from venous or capillary blood
·Published novel method of measuring parent ribavirin in dried blood spots—only DBS method validated for this molecule, showed long term and conditional stability of samples, correlated to plasma measurements with R^2=0.98 suggesting DBS as suitable replacement matrix
·Completed three workshopson PheonixWinNonlin(including intermediate level training), two NONMEM workshops, and one SAAM II modeling software workshop
WORK EXPERIENCE
Research Assistant|University of Colorado, boulder|Oct 2007-aug 2011
·Supervisor: Dr. Natalie G. Ahn
·Created Excel database to keep track of hundreds of supplies and location of hundreds of samples
·Prepared all necessary buffers/solutions, growth plates and autoclaved supplies for lab projects
·In charge of waste management and monitoring of radiation levels
·Expert in DNA purification for 10+ research projects
·Created a computer based cellular model (IMOD software) for understanding migration of melanoma cells—used in 2013 publication
·Performed basic PCR, tissue culture, SDS page, protein ligations for several projects
Student laboratory assistant|colorado state university|oct 2004-feb 2006
·Supervisor: Dr. C. Michael Elliott
·Maintained inventory for chemicals and supplies of an organic chemistry lab—included using ChemDraw for newly synthesized chemical inventory
·Performed organic synthesis for 2-3 simple compounds for research use—utilized several purification and identification techniques such as crystallization, thin layer and column chromatography
·Organized and maintained dishes, equipment and other supplies for 3 laboratory rooms
professional Activity
·Teaching assistant for PharmD students Aug 2011-May 2012. Courses: Professional Skills Development 2 and Principles of Drug Action
·Graduate student mentor—provided guidance to first year grad student; i.e. time management, professional development, finding a research lab that fits
·Chair of University of Colorado Student Chapter of the American Association of Pharmaceutical Scientists Oct 2014-Oct 2015; Organized professional speakers, provided industry tours and aided in regional conference preparation(member since 2013)
·Young Investigators Scholarship 2014 and 2015 for the Conference on Retroviruses and Opportunistic Infections—awarded full travel (up to $700) and free registration ($750 value)
COMMUNICATION AND NETWORKING
·Conference on Retroviruses and Opportunistic Infections (CROI)—international well known conference (5000+ attendees) for past 25 years through International Antiviral Society-USA
·3 presentations: 2013 abstract 34 (second author); 2014 poster 637; 2015 poster 518
·International Workshop on Clinical Pharmacology of HIV/HCV Therapy—established for 17 years through Virology Education
·2 presentations: 2013 oral 19 and poster 03; 2014 poster 35; 2016 oral 17
·Annual Meeting of the American Association for the Study of Liver Diseases; Most highly attended liver meeting at 9,500 attendees from all over the world
·2 presentations: 2014 poster 991; 2014 poster 967 (second author)
EDUCATION
Phd|aug 2011-Present|University of Colorado anschutz medical campus
·Major: Pharmaceutical Sciences
·Related coursework (30 hours completed): Fundamentals of pharmaceutical sciences, medicinal chemistry, membrane dynamics, molecular interactions, applications of pharmacokinetics, clinical pharmacology, biostatistics
·Passed final exam and dissertation defense for PhD August 22, 2016: Title “Clinical Pharmacology of Ribavirin: Effect on Endogenous Nucleotides and Resulting Clinical Outcomes”
bACHELOR OF THE ARTS|AUG 2007-DEC 2010|UNIVERSITY OF COLORADO BOULDER
·Major: Chemistry and Biochemistry
AUG 2006-MAY 2007 |UNIVERSITY OF NEW MEXICO
·Major: Chemistry
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