Table S4. Cost calculation for SC Network2

Production Cost
w / Site producing product w / Product w / mw (kg) / PCw (USD/kg) / Production cost of product w (USD)
1 / API-FR-01 / A / 100 / 7,500.00 / 750,000
2 / API-FR-01 / R / 300 / 7,300.00 / 2,190,000
3 / DP-CN-01 / DP / 1200 / 400.00 / 480,000
4 / PKG-ES-01 / DInt / 1500 / 0.30 / 450
5 / PKG-ES-01 / DF / 3000 / 0.50 / 1,500
6 / DC-FR-01 / DF / 3000 / 0.05 / 150
Total Production Cost / 3,422,100
Transportation Cost
x / Transportation route x / Mode of transport / dx (km) / mx (kg) / TCx (x 10-5 USD/kg-km) / Transportation cost of route x (USD)
1 / SUP-BE-01 to API-FR-01 / Truck / 500 / 950 / 10.28 / 49
2 / SUP-DK-01 to API-FR-01 / Rail / 1200 / 800 / 2.52 / 24
3 / SUP-IT-01 to API-FR-01 / Truck / 1000 / 1250 / 10.28 / 128
4 / API-FR-01 to DP-CN-01 / Air Cargo / 8000 / 300 / 85.10 / 2,042
5 / SUP-CN-03 to DP-CN-01 / Truck / 2600 / 450 / 10.28 / 120
6 / SUP-KR-02 to DP-CN-01 / Ship / 1600 / 450 / 1.14 / 8
7 / DP-CN-01 to PKG-ES-01 / Air Cargo / 8800 / 1200 / 85.10 / 8,986
8 / SUP-GR-01 to PKG-ES-01 / Rail / 2200 / 1500 / 2.52 / 83
9 / SUP-PT-01 to PKG-ES-01 / Truck / 400 / 300 / 10.28 / 12
10 / PKG-ES-01 to DC-FR-01 / Truck / 800 / 3000 / 10.28 / 247
11 / DC-FR-01 to WS-FR-01 / Truck / 600 / 1500 / 10.28 / 92
12 / DC-FR-01 to WS-DE-01 / Truck / 800 / 1500 / 10.28 / 123
Total Transportation Cost / 11,917
Material Cost
y / Site supplying product y / Material y / my (kg) / MCy (USD/kg) / Material cost of material y (USD)
1 / SUP-BE-01 / B / 600 / 30.00 / 18,000
2 / SUP-IT-01 / C / 500 / 40.00 / 20,000
3 / SUP-DK-01 / D / 300 / 5,500.00 / 1,650,000
4 / SUP-DK-01 / M / 300 / 500.00 / 150,000
5 / SUP-DK-01 / E / 200 / 350.00 / 70,000
6 / SUP-BE-01 / G / 100 / 250.00 / 25,000
7 / SUP-BE-01 / I / 250 / 35.00 / 8,750
8 / SUP-IT-01 / P / 100 / 1,200.00 / 120,000
9 / SUP-IT-01 / S / 400 / 750.00 / 300,000
10 / SUP-IT-01 / T / 250 / 1,800.00 / 450,000
11 / SUP-CN-03 / Excipient1 / 450 / 35.00 / 15,750
12 / SUP-KR-02 / Excipient2 / 450 / 7.50 / 3,375
13 / SUP-PT-01 / Int-Packaging1 / 200 / 2.50 / 500
14 / SUP-PT-01 / Int-Packaging2 / 100 / 2.50 / 250
15 / SUP-GR-01 / Ext-Packaging1 / 750 / 1.75 / 1,313
16 / SUP-GR-01 / Ext-Packaging2 / 750 / 1.00 / 750
Total Material Cost / 2,833,688
Sum of production, transportation and material costs / 6,267,704

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