Supplemental Table e-1.Brain regions showing significant differences in gray matter volumes (GMV) on MRI across family history groups

Cluster extent / x* / y / z / Z† / Anatomical region / Brodmann area
Reduced GMV in FHmp vs. FH-
2659 / 53 / -31 / 8 / 4.13 / Superior temporal gyrus / 41
437 / -11 / 11 / 8 / 3.66 / Caudate body
354 / 11 / 11 / 8 / 3.37 / Caudate body
1570 / -55 / -30 / 13 / 3.13 / Superior temporal gyrus / 42
Reduced GMV in FHmp vs. FHp
2059 / 53 / -31 / 8 / 3.69 / Superior temporal gyrus / 41
51 / -34 / -2 / 3.22 / Middle temporal gyrus / 41
150 / -29 / -71 / 33 / 3.42 / Precuneus / 19
1714 / -36 / 34 / 19 / 3.26 / Middle frontal gyrus / 10
-50 / 29 / 20 / 2.97 / Middle frontal gyrus / 46
Reduced GMV in FHmp vs. FHm
3661 / 54 / -28 / 7 / 4.43 / Superior temporal gyrus / 22
56 / -34 / 0 / 4.15 / Middle temporal gyrus / 22
302 / 48 / -39 / 39 / 3.53 / Inferior parietal lobule / 40
538 / -33 / 44 / 4 / 3.3 / Middle frontal gyrus / 10
104 / -27 / -20 / 4 / 3.02 / Putamen
Reduced GMV in FHm vs. FH-
822 / -39 / -71 / 44 / 3.22 / Superior parietal lobule / 7
38 / -65 / 48 / 3.19 / Superior parietal lobule / 7
-42 / -72 / 41 / 3.01 / Precuneus / 19
Reduced GMV in FHm vs. FHp
285 / -29 / -71 / 33 / 3.79 / Precuneus / 19
Reduced GMV in FHp vs. FH-
450 / 14 / -65 / 42 / 3.37 / Precuneus / 7

*Coordinates (x, y, z) from Talairach and Tournoux. †Z values at the peak of maximum significance at p<0.001, uncorrected. Only contrasts yielding significant results are reported.

Abbreviations: FH = family history of LOAD, FH- = negative FH, FHm = maternal FH, FHmp = maternal and paternal FH, FHp = paternal FH