09/14/2004 Page 1 of 3
PATHOPHYSIOLOGY I
Immunology Section - 2004-2005 Schedule
Note: All lectures are in HHSC 401
Required Textbooks: Abbas and Lichtman, Cellular and Molecular Immunology, 5th ed.
or Janeway et al., Immunobiology 6th ed.
Primer on the Rheumatic Diseases, ed. 12 (PRD)
WR = Web Resource
SC = Supplementary Case
Date / time / Faculty / Topic / Reading /Start / End
Week 1 / Abbas / Janeway
Wed.
9/1 / 9:00 / 9:50 / Greenberg / 1. Introduction to the Immune System I / 1, 2
WR 1, 2 / 1
WR 1, 2
Fri.
9/3 / 9:00 / 9:50 / Calame / 2. Chemistry, Genetics, and Structure of Antigen Receptors I / 3, 7
WR 2 / 3:103-115
WR 2
10:00 / 10:50 / Calame / 3. Chemistry, Genetics, and Structure of Antigen Receptors II / 3, 7 / 4
Week 2 / Abbas / Janeway
Tue.
9/7 / 11:00 / 11:50 / Calame / 4. Regulation of B Cell Development and the Humoral Response / 7:129-155; 9 / 7:241-253; 258-266; 276-280; 293-303; 9:367-387; 6:213-221
Thu.
9/9 / 9:00 / 9:50 / Winchester / 5. Antigen Presentation / 5 / 5:169-182; 8:319-347
10:00 / 10:50 / Winchester / 6. MHC Class I: Structure and Genetics / 4
WR 3, 4 / 1:29-31; 3:115-131; 5:183-198;
WR 3, 4
1:00 / 1:50 / Braunstein / 7. Ontogeny of T Cells / 7:151-162
SC 1 / 7:251-258
SC 1
Fri.
9/10 / 2:00 / 2:50 / Braunstein / 8. T Cell Effector Mechanisms I: Help and DTH / 6; 13:307-308; 310-313; 8 / 6: 212-215; 218-221; 7:267-275; 8:357-361; 12:544-547
Week 3 / Abbas / Janeway
Wed.
9/15 / 10:00 / 10:50 / Winchester / 9. MHC Class II: Structure and Genetics / 4
WR 3, 4 / 5:183-198
Wr 3, 4
11:00 / 11:50 / Preceptors / I : Lymphocyte development; Immunoglobulins I (Cases 1-4) / 7
20:453-458 / 7
Fri.
9/17 / 9:00 / 9:50 / Schindler / 10. Signal Transduction in the Immune System / 8; 11
WR 5 / 6:203-212; 228-237; 8:347-351; Appendix III; Appendix IV
WR 5
Week 4 / Abbas / Janeway
Tue.
9/21 / 10:00 / 10:50 / Greenberg / 11. T Cell Effector Mechanisms III: Cytotoxicity; Innate Immunity I / 13:314-317
WR 6 / 8:351-356
WR 6
Fri.
9/24 / 9:00 / 9:50 / Schindler / 12. T Cell Effector Mechanisms II: T Cell Polarization / 13:303-308
SC 2 / 8:346-351; Appendix III
SC 2
Week 5 / Abbas / Janeway
Tue.
9/28 / 9:00 / 9:50 / McConnell / 13. Innate Immunity II: Complement / 14:326-342
WR 7, 8 / 2:55-75; 9:395-397
WR 7, 8
11:00 / 11:50 / Greenberg / 14. Phagocytic Leukocytes and Fcg Receptors / 14:318-325 / 2,:42-48;
6:226-227
9:398-406
Thu.
9/30 / 9:00 / 9:50 / Greenberg / 15. Innate Immunity III: Receptors of the Innate Immune System / 12:275-292
WR 9, 10 / 2:37-55; 84-87
WR 9, 10
11:00 / 12:50 / Preceptors / II. Immunoglobulins II; Bacterial immunity I (Cases 5-7) / 20:453-458 / 5:193-194
Date / time / Faculty / Topic / Reading
Start / End
Week 6 / Abbas / Janeway
Mon.
10/4 / 9:00 / 9:50 / Winchester / 16. Introduction to Autoimmunity / 16
WR 3, 4 / 13:557-566
WR 3, 4
Tue.
10/5 / 9:00 / 9:50 / Cairo / 17. Transplantation / 2:33-34;
14:342-343
WR 11 / 13:596-607
WR 11
Wed.
10/6 / 9:00 / 9:50 / Pernis / 18. Mucosal Immunity / 20:453-463
WR 12 / 11:432-445
WR 12
11:00 / 12:50 / Preceptors / III. Bacterial immunity II; Transplantation
(Cases 8-10) / 16
WR 11 / 13:596-607
WR 11
Fri.
10/8 / 9:00 / 9:50 / Winchester / 19. Viruses that Infect Lymphocytes I: HIV / 20:464-476
WR 13 / 11:491-509
WR 13
Week 7 / Abbas / Janeway
Mon.
10/11 / 9:00 / 9:50 / Chess / 20. Viruses that Infect Lymphocytes II: EBV and HTLV / WR 14, 15 / WR 14, 15
10:00 / 10:50 / McConnell / 21. Hypersensitivity and IgE-Mediated Syndromes / 19
WR 16, 17 / 12:517-542
WR 16, 17
11:00 / 12:50 / Greenberg/
Canfield / Immunology Review Group I
Tue.
10/12 / 10:00 / 10:50 / Zou / 22. Tolerance and Immunoregulation / 10
WR 18 / 13:566-577
WR 18
Wed. 10/13 / 9:00 / 9:50 / Clynes / 23. Tumor Immunology / 17
WR 19 / 14:630-642
WR 19
11:00 / 12:50 / Preceptors / IV. Immunity to Intracellular Pathogens
(Cases 11-13) / 20:464-476
WR 13, 14, 15 / 11:491-509
WR 13, 14, 15
Thu.
10/14 / 9:00 / 9:50 / OPEN
2:00 / 4:00 / Greenberg/
Canfield / Immunology Review Group II
Week 8 / Abbas / Janeway
Tue.
10/19 / 9:00 / 9:50 / Chess / 24. Systemic Lupus Erythematosis and Vasculitis / 18:411-418
PRD 17, 21
WR 20 / 13:564-566; 593-594
PRD 17, 21
WR 20
11:00 / 12:50 / Preceptors / V. Hypersensitivity
(Cases 14-16) / 19
WR 16, 17 / 12:517-542
WR 16, 17
Wed.
10/20 / 9:00 / 9:50 / Chess / 25. Rheumatoid Arthritis / PRD 9
WR 21 / PRD 9
WR 21
Thurs.
10/21 / 10:00 / 10:50 / Chess / 26. Th1-driven Diseases: MS and Diabetes mellitus; Scleroderma / 18:421
PRD 18
WR 22, 23, 24 / PRD 18
WR 22, 23, 24
11:00 / 12:50 / Preceptors / VI. Autoimmunity I: SLE and Vasculitis
(Cases 17-19) / 18:411-418
PRD 17, 21
WR 20 / 12:542-544; 13:564-566; 593-594
PRD 17, 21
WR 20
Week 9 / Abbas / Janeway
Mon.
10/25 / 10:00 / 10:50 / Winchester / 27. MHC Class I-associated Diseases: Spondyloarthritis and Reactive Arthritis / PRD 11 / PRD 11
11:00 / 12:50 / Preceptors / VII. Autoimmunity II: Arthritis; MHC Class I-associated diseases
(Cases 20-22) / PRD 11
WR 21 / PRD 11
WR 21
Fri.
10/29 / 10:00 / 10:50 / Nickerson / 28. Approach to the Patient with Rheumatic Disease
11:00 / 12:50 / Preceptors / VIII: Autoimmunity III: Th1-driven diseases; Scleroderma (Cases 23-25) / WR 22, 23, 24 / WR 22, 23, 24
Week 10
Mon.
11/1 / 9:30 / 12:30 / Immunology Exam (HHSC 401 (Medical); HHSC 301 (Dental)
WR 1: A Concise History of Immunology
WR 2: The Immune System: First of Two Parts
WR 3: The HLA System: First of Two Parts
WR 4: The HLA System: Second of Two Parts
WR 5: Primary Immunodeficiency Diseases Due To Defects In Lymphocytes
WR 6: Lymphocyte-Mediated Cytolysis and Disease
WR 7: Complement: First of Two Parts
WR 8: Complement: Second of Two Parts
WR 9: Innate Immunity
WR 10: Mechanisms of Disease: Acute-phase Proteins and Other Systemic Responses to Inflammation
WR 11: Long-term Care after Hematopoietic-cell Transplantation in Adults
WR 12: The Role of Th1/Th2 Polarization in Mucosal Immunity
WR 13: Novel Therapies Based on Mechanisms of HIV-1 Cell Entry
WR 14: Epstein–Barr Virus Infection
WR 15: Viruses and Lymphomas
WR 16: Allergy And Allergic Diseases - First Of Two Parts
WR 17: Allergy And Allergic Diseases - Second Of Two Parts
WR18: Tolerance and Autoimmunity
WR 19: Progress on New Vaccine Strategies for the Immunotherapy and Prevention of Cancer
WR 20: Medium- and Large-vessel Vasculitis
WR 21: Evolving Concepts of Rheumatoid Arthritis
WR 22: Multiple Sclerosis
WR 23: Insulin-Dependent Diabetes Mellitus
WR 24: Raynaud’s Phenomenon
SC 1: Supplementary Case 1: An inherited defect in TCR signaling
SC 2: Supplementary Case 2: An inherited defect in cytokine signaling
PRECEPTOR GROUP ASSIGNMENTS
Group/ Preceptor Email Tel. Office
Room
1. HHSC 304 Dr. Steven Greenberg 5-1586 BB 914
2. HHSC 306 Dr. Raphael Clynes 5-5289 P&S 8-510
3. HHSC 308 Dr. Stephen Canfield 5-6086 P&S 8-430B
4. HHSC 310 Dr. Alessandra Pernis 5-3763 P&S 9-435
5. HHSC 316 Dr. Robert Winchester 5-7226 PH 4-405
Dr. David McConnell 845 651 4555 c/o PH 8E-101
6. HHSC 320 Dr. Katherine Nickerson 5-9388 PH 8 East 105
Dr. Kevan Herold 304-5492 NBDC 2
Key: BB = Black Building
HHSC = Hammer Health Sciences Center
IP = Irving Pavillion
NBDC = Naomi Berrie Diabetes Center
P&S = Physicians & Surgeons
PH = Presbyterian Hospital