Page 1 Thomas J. Grayden, M.D.
CURRICULUM VITAE
A.PERSONAL INFORMATION
NameThomas J. Grayden, M.D.
Business AddressU.C.IrvineCollege of Medicine
U.C.IrvineMedicalCenter
Neuropsychiatric Center
101 City Drive South
Orange, CA92868
Mailing AddressFANCOC
20768 La Paz Road Suite 731
Aliso Viejo, Ca 92656
Phone: (949) 207-3457
Fax: (949) 680-4147
Place of BirthMinneapolis, Minnesota
Citizenship U.S.A
Tax I.D.20-5026455
- EDUCATION
CollegeArizonaStateUniversity, B.S.,
Sept 1973 to June 1977
1001 S Mill Ave
Tempe, Arizona85281
(480) 965-4154
MedicalSchoolUniversity of Minnesota, M.D.,
Sept 1978 to June 1982
3 Morrill Hall
Minneapolis, MN55455
(612) 625-5000
InternshipUniversity of California, Davis
July 1982 to June 1983, Rotating Intern
DavisOne Shields AvenueDavis, CA95616
(530) 752-1011
ResidenciesUniversity of California, Irvine
July 1983 to June 1986
101 The City Drive South • Orange, CA92868
714.456.7890
FellowshipsUSC Institute of Psychiatry and Law
July 1986 to June 1987, Forensic Psychiatry
1975 Zonal Avenue
KAM 500
Los Angeles, CA 90089-9034
American Psychiatry Association, May 1996
LicensureCalifornia, 1983 (Certificate G-50401)
Board Certification Diplomate, American Board of Psychiatry and
Neurology, 1998, General Psychiatry
Diplomate, American Board of Psychiatry and
Neurology, 1999, Forensic Psychiatry
Diplomate, American Board of Forensic
Medicine, 1999
C.PROFESSIONAL BACKROUND
Academic Appointments
Clinical Instructor of Psychiatry
UC Irvine College of Medicine, 1986-1987
Clinical Instructor of Psychiatry
University of Southern California School of Medicine, 1986-1987
Assistant Clinical Professor of Psychiatry
UC Irvine College of Medicine, 1987-1996
Associate Clinical Professor
UC Irvine College of Medicine, 1996-2000
Clinical Professor
UC Irvine College of Medicine, 2001-current
Administrative Responsibilities
Chief Resident
Brea Neuropsychiatric Hospital, 1985-1986
Chief of Forensic Services, Department of Psychiatry
UC Irvine College of Medicine, 1987-Present
Attending Unit Director, Adult Inpatient Psychiatric Unit
UC Irvine College of Medicine, 1987-1988
Adult Unit Medical Director, CharterHospital Mission Viejo, 1990-1992
Secretary, Medical Executive Committee, CharterHospitalMission Viejo 1991
Medical Director, Partial Hospitalization Program, CPCLaguna HillsHospital 1992-1994
Chief of Staff, CPCLaguna HillsHospital, 1993
Medical Director, U.C.IrvineCollege of Medicine Outpatient Psychiatry Services, 1994-2006
Unit Attending Physician, Royale Therapeutic Residential Center, 1998- Present
Appointments
Expert Witness, Los Angeles County Superior Court Department 95, 1986-1987
Expert Witness, Orange County Superior Court, 1987-Present
Orange CountySuperior Court Expert Witness Panel, 1989-Present
California Medical Board Consulting Psychiatrist, 1989-1992
Teaching Responsibilities
Lecture on anxiety disorders to junior and senior medical students, 1989-2006
Lectures on forensic psychiatry as core curriculum to both psychiatry and interns and residents, 1988- Present
Elective psychiatry resident seminar on forensic psychiatry, 1988-Present
Supervision of interns and residents in Psychiatry Department, UC Irvine College of Medicine 1989- Present
Monthly staff in-service lectures on general psychiatry, Charter Hospital Mission Viejo, 1990-1992
Monthly staff in-service lectures on general and forensic psychiatry, CPC Laguna Hills Hospital, 1993-1994
D.RESEARCH PROTOCOLS PRINCIPLE INVESTIGATOR
1.A5361022 A 52 Week Open Label Safety Study Of Pd 0332334 In Subjects With Generalized Anxiety Disorder.
2.A1281158 A Six Week Double Blind Multicenter Palcebo Controlled Study Evaluating The Efficacy And Safety Of Flexible Doses Of Oral Ziprasidone As Add-On, Adjunctive Therapy With Lithium Valproate Or Lamotrigine In Bipolar Depression.
3.A5361018 A Phase 3 Randomized Double Blind Parallel Group 8 10 Week Placebo Controlled Fixed Dose Study Of Pd 0332334 And Paroxetine Evaluating The Efficacy And Safety Of Pd 0332334 For The Treatment Of Generalized Anxiety Disorder.
E.RESEARCH PROTOCOLS CO-INVESTIGATOR
1. Randomized, Parallel-Group Pilot Study to Evaluate the Brain Effects and Efficacy of Exelon Compared to Aricept in Patients with Alzheimer's Disease with a 12 month adjunctive Namenda® extension.
2. A Double-Blind, Phase II, Safety and Efficacy Evaluation of ONO-2506PO in Patients with Mild to Moderate Alzheimer's disease.
3. Alzheimer's Disease Neuroimaging Protocol (ADNI)
4. rA Six-Week, Randomized, Double-Blind, Multi-center, Fixed-Flexible Dose, Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral Ziprasidone in Outpatients with Bipolar 1 Depression .
5. A Multicenter, Double-Blind, Flexible-Dose, 6 Month Trial Comparing the Efficacy and Safety of Asenapine With Olanzapine in Stable Subjects With Predominant, Persistent Negative Symptoms of Schizophrenia.
6. A Randomized, Double-Blind, Placebo-Controlled, Sequential Panel Study of the Safety and Tolerability of Progressively Decreasing Titration Schedules of Bifeprunox in Subjects with Either Schizophrenia or Bipolar Disorder with an Optional Open-Label 26-Week Extension.
7. A Multicenter, Randomized, Double-Blind, Fixed-Dose, Efficacy and Safety Trial of Farampator (Org 24448) (250 and 500 mg b.i.d.) vs. Placebo as Augmentation Therapy in Schizophrenic Subjects Currently Receiving Risperidone .
8. A double blind, placebo controlled, randomized, and single and multiple dose phase I study to explore the functional neuronal activity of farampator (Org 24448) by means of FDG PET, fMRI and pEEG in healthy subjects.
9. A Multicenter, Double-Blind, Flexible-Dose, 6 Month Extension Trial Comparing the Safety and Efficacy of Asenapine With Olanzapine in Subjects Who Completed Protocol A7501013.
10. A Double-Blind, 40-Week Continuation Study Evaluating the Safety of Asenapine and Olanzapine in the Treatment of Subjects with Acute Mania
11. A Randomized, Double-Blind, Parallel Group, Active-Controlled Tolerability and Safety Study of MK-3756 (SM 13496/Lurasidone) in Clinically Stable Schizophrenic Outpatients.
12. A Phase II, Double Blind, Randomized, Placebo-Controlled, Parallel-Group, Dose-Ranging Study Assessing the Efficacy and Safety of AC-3933 Tablets Twice Daily in Adults with Mild to Moderate Alzheimer’s Disease.
13. A Multicenter, Randomized, Double-Blind, Parallel-Group Fixed-Dose Study of the Effect on Weight of Bifeprunox versus Olanzapine in the Treatment of Outpatients with Schizophrenia.
14. A Multicenter, Randomized, Double-blind, Placebo-controlled, 16-Week Study of Aripiprazole Used as Dual Therapy in the Treatment of Patients with Chronic Stable Schizophrenia or Schizoaffective Disorder Demonstrating an Inadequate Response to Quetiapine or Risperidone Monotherapy.
15. A Multicenter, Randomized, Blinded, Controlled, Parallel Group Trial to Demonstrate the Efficacy of Reg Guided Pharmacotherapy Of Subjects With Treatment-Resistant Depression.
16. A Clinical Trial to Determine Striatal and Extrastriatal Dopamine D3D2-Receptor Occupancy after Multiple Oral Doses of RGH-188 in Schizophrenic Patients Using Positron Emission Tomography with the D3D2-Receptor Ligand 18F-Fallypride.
17. Self perceptions of risk study of violence UCI, Irvine This study is designed to develop a highly efficient method for assessing patients' risk of violence and self harm in the community. Although "risk assessment tools" are available, they are rarely used because they are time consuming and do not inform risk management well. This study will develop a clinically feasible and useful method for predicting your patients' self harm and violence. We will compare clinicians' judgment (i.e., current practice) with a brief computerized assessment (the COVR) and a completely novel approach that focuses on patients' self-perceptions of risk.
Principal Investigator: J.L. Skeem, Ph.D.
F.SOCIETY MEMBERSHIPS
Local
Orange CountyPsychiatry Society, 1985-Present
American Academy of Psychiatry and the Law, Southern California Chapter, 1987- Present
National
American Medical Association, 1981- Present
American Psychiatric Association, 1983- Present
American Academy of Psychiatry and the Law, 1986- Present
American Society of Clinical Psychopharmacology, 1993- Present
AmericanCollege of Forensic Examiners, 1999- Present
G.COMMITTEE MEMBERSHIPS
Bipolar Advisory Committee Eli Lilly 2004 to current
MedicalSchool Admission Interview Committee, College of Medicine, University of California, Irvine, 1988-2004
Membership and Credentials Committee, OrangeCounty Psychiatric Society, 1988-1992
Medical Executive Committee, CharterHospital Mission Viejo, 1990-1992
Bylaws Committee, CPCLaguna HillsHospital 1992
Medical Executive Committee, CPC Laguna Hills Hospital, 1993-1994
Pharmacy and Therapeutics Committee, CPC Laguna Hills Hospital, 1993-1994
Quality Management Committee Chairman, Department of Psychiatry Outpatient Services, U.C. Irvine, 1997- 2006
Credentials Committee, PacifiCare Behavioral Health, 1996- 2004
California Psychiatric Association Committee on Judicial Action, 2000-Present
Acting Head, Ad Hoe Residency Training director Committee, Department of Psychiatry, UC Irvine, 1999
Investigational Review Board, UC Irvine Medical Center, 1998-2006
H.CONSULTANTSHIPS
United States Department of Justice Federal Bureau of Prisons, 1986-1987
Los AngelesCounty Superior Court, 1986-1987
Los Angeles County Juvenile Court, 1986-1987
Los AngelesCounty Superior Court, Mental Health Division, 1986-1987
Los AngelesCounty Family Law Division, 1986-1987
Los AngelesCounty Municipal Court, 1986-1987
Los Angeles County District Attorney’s Office, 1986-1987
Los Angeles County Public defenders Office, 1986-1987
Los Angeles County Probation Department, 1986-1987
Los Angeles County Sheriff’s Department, 1986-1987
Los Angeles County Department of Mental Health, 1986-1987
Los Angeles County Department of Health Services, 1986-1987
California State Department of Parole, 1986-1987
CaliforniaStateUniversity, Fullerton, 1987-1988
Mental Health Court, Orange CountySuperior Court, 1987-Present
Royale Therapeutic Residential Center, 1988-Present
California Board of Medical Quality Assurance, 1989-1993
SaddlebackCollegeMission Viejo, Ca Student Health Clinic, 1989-1990
Community Psychiatric Centers at CPC Laguna Hills, BreaCanyon, and Santa Ana Hospitals, 1991-1994
Vertex Neuromedical Consultants, 1992
Brain Imagining Center, CaliforniaCollege of Medicine, University of California, Irvine, 1992-1998
Liver Transplant Team, UC Irvine Medical Center, 1994-2002
Central Nervous System Advisory Forum, Janssen Pharmaceutical Research
Foundation, 1999
I.AWARDS
Fellowship Award, American Psychiatric Association, 1996
Teacher of the Year award, Department of Psychiatry, UC Irvine, July 1, 1997, to June 30, 1998
Certificate of Recognition, UCI Institutional Review Board, June 2000
J.SPECIAL PRESENTATIONS
Use of positron emission tomography in Traumatic brain injury, Grayden, T.J., Lottenburg, S., Poster Session, PET and SPECT Brain Imagining Symposium, Johns Hopkins University School of Medicine, March 11, 1993.
Traumatic Brain Injury, T.J. Grayden, Grand Rounds, University of California, Irvine, MedicalCenter, August 16,1984.
K.BIBLIOGRAPHY
1.Grayden, T.J., “Medicine in the Courtroom: Issues of the Psychiatrist.” University Service News Vol. 3 2-3.1989.
2.Wolf, M.J., Grayden, T.J., Carreon, D., et al. “Efficacy of Time Limited Psychotherapy and Buspirone and Borderline Patients.” 1989 Western Psychological Association Program of Abstracts, April 1989.
3.Yin, Y., Carreon, D., Wolf, M., Grayden, T.J., Rice, R., Isenhart, R., Sandman, C., Potkin, S. “Increased Photic-Driving EEG Alpha in Depressed Patients.” 1990 Western Psychological Association Program of Abstracts, April 1990.
4.Wolf, M.J., Carreon, D., et al “Psychotherapy and Busiprone in Borderline Patients.” 143rd A.P.A New Research Program and Abstracts, May 1990.
5.Wolf, M.J., Grayden, T.J., Carreon, D., et al. “Treatment of Borderline Personality Disorder with a Serotonin 1a Agonist.” 114th A.P.A New Research Program and Abstracts, May 1991.
6.Yang, J., Grayden, T., “Patient Confidentially Even after the Patient Dies,” 2000 AmericanCollege of Forensic Examiners Annual Meeting, Program of Abstracts, October 2000.
7.Lavid, N.E., Grayden, T.J., Gottschalk, L.A., Bechtel, R.J., “Computerized analysis of Refusal Of Treatment: A Preliminary Study of the Influence Of Neuropsychiatric Traits on Judicial Decisions.” American Journal of Forensic Psychiatry, Volume 23, Issue 3, 2002.