I. (A) Name: Simeon Idowu Babalola, CADMUS

CURRICULUM VITAE

I. (a) Name: Simeon Idowu Babalola, CADMUS

(b) Date of Birth: 5 January, 1969

Health and Preventive Medicine

(d) Faculty: Veterinary Medicine

II. (a) First Academic Appointment: Lecturer II (9 April, 1997)

(b) Present post (with date): Professor (1 August, 2012)

III. University Education (with dates)

a) University of Ibadan, Ibadan (1986 - 1992)

b) University of Ibadan, Ibadan (1995 - 1997)

c) University of Ibadan, Ibadan (1997- 2007)

IV. Academic Qualifications (with dates and granting bodies)

(a) Doctor of Veterinary Medicine, University of Ibadan (October, 1992)

(b) Master of Veterinary Public Health, University of Ibadan (April, 1997)

V. Professional Qualifications and Diploma (with date)

(a) Registered Veterinary Surgeon (VCN Reg. No. 2223) - 1992.

(b) Certificate in Advanced Immunology- Molecular and Cellular Basis of the

Normal Immune Response (February 1998, Ibadan, Nigeria).

(c) Certificate in Molecular Typing of Mycobacterium bovis and Processing of Bovine Tissues for TB Diagnosis, Veterinary Laboratories Agency, United Kingdom (February, 2004).

(d) Diploma in Molecular Tools and Epidemiology of Tuberculosis, Institut Pasteur, Paris (April, 2006).

VI. Scholarships, Fellowships and Prizes (with dates) in respect of

Undergraduate and Postgraduate work only):

(a) John D. and Catherine T. MacArthur Foundation/University of Ibadan Foreign Training Grant - 2004 (i) Short-term training in studies on drug susceptibility in multi-drug resistance strains of TB, Johns Hopkins School of Public Health, Baltimore, USA (Dr. Ying Zhang Laboratory) and

(ii) Short-term training in biochemical dynamics of M. tuberculosis, University of Pennsylvania, Department of Infectious Disease (Prof. Rubin Harvey’s Laboratory).

(b) Veterinary Laboratories Agency (VLA), United Kingdom-Training support (Short-term training in processing of bovine tissues for TB diagnosis, molecular diagnosis of M. tuberculosis complex, and techniques of ruminant immunology relevant to the assessment of immune responses in cattle infected with bovine tuberculosis).

(c) International Development Research Centre (IDRC) and International Livestock Research Institute (ILRI) Research Grant (Improving benefits of urban and peri-urban production through management of associated human and environmental health risks in Nigeria (with emphasis on Tuberculosis). IDRC/ILRI (2004-2006).

(d) John D. and Catherine T. MacArthur Foundation Grant to the University of Ibadan 2006 (Grant 800/406/54/2006/REG/2).

(e) John D. and Catherine T. MacArthur Foundation, USA under the Higher Education Initiative in Africa (Grant No. 97944-0-800/406/99) for the establishment of a Center of Excellence that supports this Consortium of Universities (Co-Principal Investigator).

(f) World Bank STEP-B award of Centre of Excellence in Infectious and Zoonotic Diseases to the University of Ibadan (FME/stepb/R3/5) (Co-Investigator).

VII. Honours, Distinctions and Membership of Learned Societies

Honours:

(a) Travel award by International Union Against Tuberculosis and Lung Disease for the 46th Union World Conference on Lung Health, Cape Town, South Africa, 2-6 December, 2015.

(b) Travel award by Keystone Symposia on Host response in tuberculosis, January 22nd-27th, 2015. Santa Fe, New Mexico, USA.

(b) Northwestern University AIDS International Training & Research Programme, 2012 Fogarty Training Fellowship (Short term training specifically directed at writing NIH focused grant proposals, Northwestern University, Chicago, USA, April, 2012).

(d) Animal Health Board, New Zealand Travel Grant to attend the 5th International M. bovis Conference in New Zealand, 2009.

(e) Northwestern University AIDS International Training & Research Programme, 2009 Fogarty Training Research Grant (A prevalence study of MDR-TB in Ibadan, Nigeria: exploring two rapid diagnostic assays).

(f) Northwestern University AIDS International Training & Research Programme, 2008 Fogarty Training Fellowship (Short term training in a BSL3 TB Laboratory in the area of TB bacteriology (culture, microscopy and drug susceptibility) and molecular diagnostics of Human TB in a National Institute of Health (NIH), USA funded Laboratory (SEREFO Project) in University of Bamako Mali.

(g) Immunodiagnostic Travel Grant to attend 2008 TB Immunodiagnostic Conference, Virginia

Beach, USA.

(h) CTA Travel Grant to attend the 2008 Brucellosis Conference in London.

(i) University of Ibadan Multi-Disciplinary Senate Research Grant 2007 (Co- Investigator) (Anti-tuberculosis evaluation of 20 medicinal plants identified from the Southwestern Nigerian Ethnomedicine).

Membership of learned societies:

(a) Member, Nigerian Veterinary Medical Association (NVMA)

(b) Member, American Society of Microbiology (ASM)

(d) Member, International Epidemiological Association

(e) American Thoracic Society (ATS)

VIII. Details of Teaching Experience at University Level

I was employed on 9 April, 1997 as a Lecturer Grade II in the Department of

Veterinary Public Health & Preventive Medicine where I have been teaching till

date. This represents a teaching experience of 18 years at the University level. Over this period, I have thought the following courses:

(a) Undergraduate (1997 to date).

S/N / Courses / Course Title / Unit / Semester
1 / Veterinary Biostatistics / VPH 411 / 2 / 1st
2 / Veterinary Zoonoses and Environmental Health / VPH 525 / 2 / 2nd
3 / Food (Meat and Milk) Hygiene / VPH 513 / 2 / 1st
4 / Public Health and Preventive Medicine Clinics I / VPH 531 / 3 / 1st and 2nd
5 / Public Health and Preventive Medicine Clinics II / VPH 632 / 6 / 1st and 2nd
6 / Field Practice III (Public Health and Epidemiology) / VPH 422 / 6 / Vacation

(b) Postgraduate (2007 to date)

S/N / Courses / Course Title / Unit / Semester
1 / Advanced Meat and Milk Hygiene / VPH 710 / 3 / 1st
2 / Control of Major and Emerging Zoonoses / VPH 713 / 2 / 1st
3 / Abattoir Design and Management / VPH 721 / 2 / 2nd
4 / Veterinary Environmental Health / VPH 722 / 2 / 2nd
5 / Seminar Presentation / VPH 730 / 2 / 3rd
6 / Project / VPH 731 / 6 / 3rd

Undergraduate Supervision

I have supervised 15 undergraduate students’ projects to date.

Postgraduate Supervision

I have supported and supervised 12 Masters students in the area of Veterinary Public Health (MVPH), 2 PhD students and currently doing the same for 4 students on their PhD Theses.

(e) Administrative Experience

I have had the privilege of serving the University at various levels since 1997 as:

i. Departmental Representative, Faculty Field Trip 2003-2005

ii. Member, Departmental Finance Committee 2003-2005

iii. Sub-Dean (Clinics), Faculty of Veterinary Medicine 2005-2007

iv. Faculty Rep in Faculty Board of Agric. & Forestry 2009-2010

v. Departmental Clinical Co-ordinator 2008-date

vi. Head of Veterinary Public Health Unit 2010 to date

vii Member of Senate, University of Ibadan 2011 to date

viii Congregation Representative (Board of Health) 2011 to 2013

ix Congregation Representative (Development Committee) 2015 to date

IX. Research

(a) Completed:

(i) Molecular characterization of human and bovine tubercle bacilli in Ibadan,

and evidence of zoonotic transmission (2001-2007). The early part of this

research work established for the first time, the molecular epidemiological baseline

of strains of the Mycobacterium tuberculosis complex causing tuberculosis in

humans and cattle in Nigeria. Using spoligotyping, variable-number tandem-repeat

analysis and deletion typing techniques, we were able to confirm that majority of

tuberculosis disease in humans in Ibadan is caused by a single, closely related

group of Mycobacterium tuberculosis strains. The study also showed that

approximately 13% of the disease in humans is caused by strains of

Mycobacterium africanum and M. bovis. This work resulted in several publications

(papers 12, 15, 17, 20) and the training of a postgraduate student who is now a

Lecturer 1 in the Department. Furthermore, through grants received from

IDRC/ILRI Funded Project (2004-2006) and the John D. and Catherine T.

MacArthur / University of Ibadan Re-entry Grant 2006, I was able to provide

more insight into the epidemiology of bovine tuberculosis and the zoonotic

transmission of BTB in Nigeria. This project culminated in the training of three

postgraduate students (in the University of Ibadan, Othman Dan Fodiyo University,

Sokoto and University of Pretoria, South Africa). The project also led to some

publications (papers 22, 32, 36, 48 and 55). Overall, the results generated from

these series of projects have significant implications for public health.

(ii) Exploring the use of faecal samples in the diagnosis of tuberculosis in pediatric

patients in Ibadan (2005-2007).

Tuberculosis is a major cause of childhood morbidity and mortality in

Nigeria. Diagnosis of childhood tuberculosis is a global challenge making early

treatment a mirage. In this study, we investigated the stools of some children for

the presence of Mycobacteria. Approximately 5% (9/192) of apparently well

children had evidence of potentially serious tuberculosis infection. The results have

been published (paper 30).

(iii) Insight into the prevalence of tuberculosis in dental patients in Ibadan (2006-

2007).

Acquisition of TB in healthcare facilities is a well-recognized hazard for healthcare workers and patients. To determine the prevalence of Mycobacterium tuberculosis infection among dental patients and to assess dentists’ risk for exposure, we conducted a study among dental patients at a large tertiary hospital in Nigeria, a country where tuberculosis is endemic. Ten (13%) of 78 sputum samples obtained were positive for M. tuberculosis. The work has been published in the Journal of Emerging Infectious Diseases (EID) (Cadmus, S.I.B., Okoje VN, Taiwo BO, van Soolingen D. (2010). Mycobacterium tuberculosis exposure for dentists, Ibadan, Nigeria. Journal of Emerging Infectious Diseases Vol. 16. No. 9, 1479-1481).

(b) In Progress:

(i) Antituberculosis evaluation of 20 medical plants identified from the Southwestern Nigerian Ethnomedicine (University of Ibadan Multidisciplinary Senate Research Grant 2007).

One the major objectives of my involvement in this study, is to explore the knowledge that I have acquired over the years in the area of TB and Mycobacteriology with other colleagues (from the Faculty of Pharmacy) in the University to find a cure for tuberculosis through the exploration of ethnomedicine. This is an ongoing project, and initial results indicate possibility of local medicinal plants that could serve as lead candidates for anti-tuberculosis. This project is also facilitating the training of 3 postgraduate students in the University.

(ii) Diagnostic methods for the confirmation of tuberculous lymphadenitis in

patients with extrapulmonary tuberculosis in patients attending the Fine

Needle Aspiration Cytology (FNAC) Clinic in the Department of Pathology,

University College Hospital, Ibadan.

This is an ongoing project to strengthen the diagnostic algorithm of patients with

extra-pulmonary TB in conjunction with colleagues in the Department of

Pathology, College of Medicine, University College Hospital, Ibadan. One of the

goals of this project is to apply my research skills towards better patient care in

human hospitals given the concept of “One Health”. Two major

scientific papers have been published from this ongoing project (papers 15, 17).

(iii) Prevalence study of MDR-TB in a local setting in Nigeria using the Nitrate

Reductase Assay (NRA) and Microscopic Observation Drug Susceptibility

(MODS) Assay (Collaborative study with the Northwestern University AIDS

International Training & Research Programme, 2008 Fogarty Training Grant

No. D43TW007995).

This project sets out to show some of my active research interests in the area of TB Diagnostics. It is expected that the proper evaluation of these rapid diagnostic TB assays in local laboratories, will provide further scientific evidence for their ease of use or otherwise in settings like Nigeria. In carrying out this project, I also collaborated with a senior colleague in Department of Microbiology and this has resulted and helped in the training of a PhD student who is rounding up his Thesis. Through this research initiative, in 2010, the PhD candidate training on this project (Falodun, I.O.) was awarded a $10,000 grant from the African Doctoral Dissertation Research Fellowship (ADDRF). Furthermore, preliminary findings from this project have been presented at several international conferences including the Keystone Conference held in July, 2012 in Kampala, Uganda (Pattern of drug resistance in HIV-negative tuberculosis patients in Ibadan, Nigeria---Falodun, I., Ogunlade, O., Fagade, O., Adewole, I., Taiwo, B., Murphy, R., Cadmus, S). Another abstract (Pattern of drug resistance among tuberculosis patients with and without HIV infection in Ibadan, Nigeria--- Cadmus S, Falodun O, Ogunlade O, Fagade O, Adewole IF, van Soolingen, Dick., Taiwo BO, Murphy RL) from this project was also accepted for presentation at the 43rd Union World Conference on Lung Health (a prestigious International Conference for Tuberculosis and Lung Disease) to be held in November, 2012 in Kuala Lumpur, Malaysia.

(iv) Epidemiology of brucellosis in different species of animals Nigeria

(Collaborative study with the Brucellosis Unit of the Veterinary Laboratories

Agency, UK).

This project is actually a major attempt at re-awakening brucellosis (a disease of great economic and zoonotic importance) research in Nigeria after a lull in active work on the disease especially in the University of Ibadan. The approach involves active collaboration with the Brucellosis Unit of the Veterinary Laboratories Agency (UK), an OIE Center of Excellence in Brucellosis Research and other researchers from different Universities and institutions in Nigeria. To date, 6 postgraduate students (2 PhD, 4 Masters) have benefited or are still benefiting from this project in different Universities in Nigeria (University of Ibadan, Ahmadu Bello University, University of Agriculture, Abeokuta). In addition, 4 DVM students have also benefited from this project by carrying out their final year projects through facilities and reagents provided. Finally, I also provided community service through the University of Ibadan Veterinary Teaching Hospital by offering free brucellosis diagnosis to animals where such need arose.

(i) Cadmus, S.I.B. Molecular characterization of human and bovine tubercle bacilli

in Ibadan. Ph.D Thesis 2006. University of Ibadan.

X. Publications

(a) Books already published:

(1) Adeyemi, I.G., Alonge, D.O, Agbede, S.A, Ogundipe, G.A.T., Ishola,

O.O., Babalobi, O.O., Ijagbone I.F., Cadmus, S.I.B., Adedeji, O.B.,

Adeyemo, O.K., Olugasa B.O., Adetunji V.O., Olatoye I.O., Awosanya,

A.E.J., Ojomo, B, and Agboola, B.B. (2008): Clinical and Laboratory

Manual Veterinary Public Health, Preventive Medicine, Wildlife and

Fishery Diseases. First Edition, Kehny prints, ISBN 978-978-839-1 Ibadan