Mary Vore
Revised 1/13/2013
CURRICULUM VITAE
MARY VORE
Date of Birth: June 27, 1947
Place of Birth: Guatemala, Central America
Marital Status: Married (Edgar T. Iwamoto, Ph.D.)
Children: Kenneth Edgar; Daniel Vore
Home Address: 1229 Summit Drive
Lexington, Kentucky 40502
(859) 2664556 (home)
(859) 257-3760 (office)
Citizenship: U.S.A.
Education: 1968; B.A. (cum laude), Asbury College, Wilmore, KY
Major: BiologyPre Med.
1972; Ph.D. Pharmacology, Vanderbilt School of
Medicine, Nashville, Tennessee 37232
Research and Professional Experience
2010 – 2011 Associate Dean for Faculty Advancement
1998 – 2002 Director of Graduate Studies, Graduate Center for Toxicology
1994 - Present: Director, Graduate Center for Toxicology
306 HSRB Chandler Medical Center
Lexington, Kentucky 40536-0305
July 1990 March 1991: Acting Chair, Department of Pharmacology
University of Kentucky
1986 1998 Professor, Department of Pharmacology
University of Kentucky College of Medicine
1983 1990: Vice-Chairman, Department of Pharmacology
University of Kentucky College of Medicine
1981 1986: Associate Professor, Department of Pharmacology
University of Kentucky College of Medicine
1979 - Present: Graduate Faculty, Graduate Center for Toxicology
University of Kentucky
1978 1981: Assistant Professor, Department of Pharmacology
University of Kentucky
1974 1978: Assistant Professor of Toxicology & Pharmacology
Department of Pharmacology
University of California San Francisco
1972 1974: Postdoctoral Fellow
Department of Biochemistry and Drug Metabolism
HoffmannLaRoche, Inc. with Dr. Antony YH Lu
Nutley, New Jersey 07110
1968 1972: Predoctoral Student
Department of Pharmacology
Vanderbilt School of Medicine
Vanderbilt University
Nashville, Tennessee 37232
Memberships: American Society for Pharmacology and Experimental Therapeutics
Society of Toxicology
American Association for the Study of Liver Disease
American Association for Cancer Research
Awards: Dean’s Distinguished Lecture – 2009
Sturgill Award - Graduate Education, 1998
Research Champion, College of Medicine, 1997
College of Medicine Faculty Research Award, 1993
PublicationsRefereed Journals
1. Vore M, B Sweetman and MT Bush: The metabolism 1nbutyl5,5diethylbarbituric acid (Nnbutylbarbital) in the rat. J Pharmacol Exp Ther 190:384394, 1974.
2. Vore M, JG Hamilton and AYH Lu: Organic solvent extraction of liver microsomal lipid. 1. The requirement of lipid for 3,4benzypyrene hydroxylase. Biochem Biophys Res Commun 56:10381044, 1974.
3. Lu, AYH, SG West, M Vore, D Ryan and WJ Levin: Liver microsomal electron transport system. 1. Role of cytochrome b5 in hydroxylation by reconstituted cytochrome P450 containing system. J Biol Chem 249:67016709, 1974.
4. West SB, W Levin, D Ryan, M. Vore and AYH Lu: Liver microsomal electron transport systems. The involvement of cytochrome b5 in the NADHdependent hydroxylation of 3,4benzypyrene by a reconstituted cytochrome P448 containing system. Biochem Biophys Res Commun 58:516522, 1974.
5. Vore M, AYH Lu, R Kuntzman and AH Conney: Organic solvent extraction of liver microsomal lipid. II. Effect on the metabolism of substrates and binding spectra of cytochrome P450. Mol Pharmacol 10:863974, 1974.
6. Goodman DR, PJ Hakkinen, JH Nemenzo and M Vore: Mutagenic evaluation of nitrofuran derivatives in Salmonella typhimurium, by the micronucleus test, and by in vitro cytogenetics. Mutation Res 48:295306, 1977.
7. Aufrere MB, B Hoener and ME Vore: A highperformance liquid chromatographic assay for nitrofurantoin in plasma and urine. Clin Chem 23:22072212, 1977.
8. Marietta, MP, M Vore, WL Way and AJ Trevor: Characterization of liver microsomal enzyme induction by ketamine. Biochem Pharmacol 26:24512453, 1977.
9. Vore M, J Bauer and V Pascucci: The effect of pregnancy on the metabolism of 14Cphenytoin in the isolated perfused rat liver. J Pharmacol Exp Ther 206:439447, 1978.
10. Aufrere MB, B Hoener and M Vore: Reductive metabolism of nitrofurantoin in the rat. Drug Met Dispos 6:403411, 1978.
11. Vore M, E Soliven and M Blunden: The effect of pregnancy on the biliary excretion of 14Cphenytoin in the rat. J Pharmacol Exp Ther 208:257262, 1979.
12. Vore M and E Soliven: Organic solvent extraction of liver microsomal lipid. II. Effect on the kinetic parameters of benzo(a)pyrene hydroxylase and benzphetamineNdemethylase activities. Biochem Pharmacol 28:36593665, 1979.
13. Vore M and E Soliven: Hepatic estrone and estradiol glucuronyl transferase activity in pregnancy: Induction by pretreatment with 3methylcholanthrene and phenobarbital. Drug Met Dispos 7:247251, 1979.
14. Vore M and MT Bush: The metabolism of lnbutyl5,5diethyl-barbituric acid (Nnbutylbarbital) in the rat. II. Distribution of the drug and its metabolites in various tissues in vivo and in the isolated perfused liver system. J Pharmacol Exp Ther 212:103108, 1980.
15. Meyers M, W Slikker, G Pascoe and M Vore: Characterization of cholestasis induced by estradiol17βDglucuronide in the rat. J Pharmacol Exp Ther 214:8793, 1980.
16. Vore M and C Montgomery: The effect of estradiol17β treatment on the metabolism and biliary excretion of phenytoin in the isolated perfused rat liver and in vivo. J Pharmacol Exp Ther 215:7176, 1980.
17. Montgomery C and M Vore: The effect of diethylstilbestrol treatment on the metabolism and biliary excretion of [14C]phenytoin in the isolated perfused rat liver. Toxicol Appl Pharmacol 58:510519, 1981.
18. Meyers M, W Slikker and M Vore: Steroid Dring glucuronide: characterization of a new class of cholestatic agents in the rat. J Pharmacol Exp Ther 218:6373, 1981.
19. Brock WJ and M Vore: Hepatic morphine and estrone glucuronyltransferase activity and morphine biliary excretion in the isolated perfused rat liver. Effect of pregnancy and estradiol17b treatment. Drug Metab Dispos 10:336343, 1982.
PublicationsRefereed JournalsContinued
20. Auansakul AC and M Vore: The effect of pregnancy and estradiol17β treatment on the biliary transport maximum of dibromosulfophthalein, and the glucuronide conjugates of [14C]5phenyl5parahydroxyphenylhydantoin and [14C]morphine in the isolated perfused rat liver. Drug Metab Dispos 10:344349, 1982.
21. Slikker W, Jr, M Vore, JR Bailey, M Meyers and C Montgomery: Hepatotoxic effects of estradiol17βDglucuronide in the rat and monkey. J Pharmacol Exp Ther 225:138143, 1983.
22. Vore M, H Hadd and W Slikker, Jr: Ethynylestradiol17βDring glucuronide conjugates are potent cholestatic agents in the rat. Life Sci 32:29892993, 1983.
23. Brock W and M Vore: Characterization of uptake of steroid glucuronides into isolated male and female rat hepatocytes. J Pharmacol Exp Ther 229:175181, 1984.
24. Brock W, S Durham and M Vore: Characterization of the interaction between estrogen metabolites and taurocholate for uptake into isolated hepatocytes. Lack of correlation between cholestasis and inhibition of taurocholate uptake. J Steroid Biochem 20:11811185, 1984.
25. Brock WJ and M Vore: The effect of pregnancy and treatment with estradiol17β on the transport of organic anions into isolated rat hepatocytes. Drug Metab Dispos 12:712716, 1984.
26. Potts Brian D, CA Martin and M Vore: Gas chromatographic quantitation of methylphenidate in plasma using solidphase extraction and nitrogen sensitive detection. Clin Chemistry, 30:13741377, 1984.
27. Hamann SR, TG Tan, KE Kaltenborn, KLR Brouwer, RA Blouin, SL Chang, M Vore and RG McAllister, Jr: Effects of phenobarbital and SKF525A on in vitro hepatic metabolism of verapamil and nifedipine. Pharmacology, 30:121128, 1985.
28. Hamann SR, KE Kaltenborn, M Vore, TG Tan and RG McAllister: Cardiovascular and pharmacokinetic consequences of combined administration of verapamil and propranolol in dogs. Am J Cardiol 56:147156, 1985.
29. Durham S, R Mack, III and M Vore: Effects of taurocholate infusion on biliary excretion in isolated perfused rat liver: Decreased biliary excretion of dibromosulfophthalein in pregnancy. Drug Metab Dispos 13:695699, 1985.
30. Brouwer KLR and M Vore: The effect of hypoxia and pregnancy on antipyrine metabolism in isolated perfused rat liver. J Pharmacol Exp Ther 234:584589, 1985.
31. Durham S and M Vore: Taurocholate and steroid glucuronides. Mutual protection against cholestasis in the isolated perfused rat liver. J Pharmacol Exp Ther 237:490495, 1986.
32. Hughes MF, WJ Brock, LJ Marion and M Vore: Characterization of covalent binding of Nnitrosonornicotine in rat liver microsomes. Carcinogenesis 7:38, 1986.
33. Takacs A, A Auansakul, S Durham and M Vore: High and low affinity binding of [3H] cholate to rat liver plasma membranes. Biochem Pharmacol 36:25472555, l987.
34. Takacs A and M Vore: Binding of 3Hestradiol17β(βDglucuronide), a cholestatic organic anion, to rat liver plasma membranes. Evidence consonant with identification of organic anion carriers. Mol Pharmacol 32:511518, l987.
35. Brouwer KLR, S Durham and M Vore: Multiple carriers for uptake of 3Hestradiol17β(βDglucuronide) in isolated rat hepatocytes. Mol Pharmacol 32: 519523, l987.
36. Connors S and M Vore: Coregulation of C3OH vs C17OH glucuronidation of 17βestradiol in pregnancy and following treatment with phenobarbital or ethinylestradiol. J Pharmacol Exp Ther 246:5459, 1988.
37. Vore M, C Montgomery, S Durham, D Schlarman and WH Elliott: Structureactivity relationship of the cholestatic activity of dihydrotestosterone glucuronide, allo bile acids and lithocholate. Life Sci 44:20332040, 1989.
38. Martin CA, M Vore, BD Potts, RJ Kryscio, JC Norton, JM Madigan, RJ Welsh, WM Heffron and JP Liu. Methylphenidate plasma concentrations in chronically and acutely treated latencyage children. Pharmacology, 39:4649, 1989.
39. Ott MT, Vore M, Barker DE, Strodel WE and McClain CJ: Monokine Depression of Bile Flow in the Isolated Perfused Rat Liver. J Surgical Res 47:248250, 1989.
Publications Refereed Journals Continued
40. Little K Y, Gay T L and Vore M: Predictors of Response to High Dose Antipsychotics in Chronic Schizophrenics. Psychiatry Research 30:19, 1989.
41. Teo S and M Vore: Mirexinduced inhibition of uptake of taurocholate and estradioll7β(βDglucuronide) in isolated hepatocytes. Toxicol Appl Pharmacol, 104:411420, 1990.
42. Changchit A, S Durham and M Vore: Characterization of 3Hestradiol17β(βDglucuronide) binding sites in basolateral and canalicular liver plasma membranes. Biochem Pharmacol, 40:12191225, 1990.
43. Vore M, S Durham, S Yeh and T Ganguly: Hepatic clearance and biliary secretory rate maximum of taurocholate in the recirculating and single pass isolated perfused rat liver: Effects of the cholestatic agent, estradiol 17β(βDglucuronide). Biochem Pharmacol, 4l(3):43l437, 1991.
44. Teo S and M Vore. Mirex inhibits bile acid secretory function in vivo and in the isolated perfused rat liver. Toxicol Appl Pharmacol 109:161-170, 1991.
45. Zimniak P, SA Ziller III, I Panfil, A Radominska, H Wolters, F Kuipers, R Sharman, M Saxena, M Moslen, M Vore, R Vonk, Y Awasthi and R Lester. Identification of an anion-transport ATPase that catalyzes glutathione conjugate-dependent ATP hydrolysis in canalicular plasma membranes from normal rats and rats with conjugated hyperbilirubinemia (GY mutant)1. Arch Biochem Biophys 292(2):534-538, 1992.
46. Liu Y and M Vore. Prolactin stimulates maternal bile secretory function postpartum. J Pharmacol Exp Therap 261: 560-566, 1992.
47. Vore M. Canalicular Transport: Discovery of ATP-Dependent Mechanisms. Toxicol. Appl. Pharmacol. 118(1):2-7, 1993.
48. Bluhm RE, MG Frazer, M Vore, CW Pinson and KF Badr: Endothelins 1 and 3: Potent cholestatic agents secreted and excreted by the liver that interact with cyclosporine. Hepatology 18(4):961-968, 1993.
49. Ganguly T, JF Hyde and M Vore: Prolactin increases Na+/taurocholate cotransport in isolated hepatocytes from postpartum rats and ovariectomized rats. J Pharmacol Exp Therap 267(1):82-87, 1993.
50. Gosland M, C Tsuboi, T Hoffman, S Goodin and M Vore: Estradiol-17β glucuronide: An inducer of cholestasis and a physiological substrate for the multidrug resistance transporter. Cancer Res. 53:5382-5385, 1993.
51. Vore M, and T Hoffman: Carrier-mediated electrogenic transport of 3H-estradiol-17β (β-D-glucuronide) in rat liver basolateral membrane vesicles. Am. J. Physiol., G546-G551, 1994.
52. Ganguly, TC, Y Liu, J F Hyde, B Hagenbuch, PJ Meier and M Vore: Prolactin increases hepatic Na+/taurocholate cotransport activity and messenger RNA postpartum. Biochem J, 303:33-36, 1994. PMC1137552
53. Liu Y, T Ganguly, JF Hyde and M Vore: Prolactin increases mRNA encoding Na+/taurocholate (TC) cotransport polypeptide and hepatic Na+/TC cotransport. Am J Physiol, 268:G11-G17, 1995.
54. Albers KM, F Davis, T Perrone, E Lee, Y Liu and M Vore: Ectopic expression of a keratin intermediate filament protein in liver of transgenic mice causes alterations in structure and function. J Cell Biol, 128:157-169, 1995. PMC2120333
55. Vore M, T Hoffman and M Gosland: ATP-dependent transport of estradiol-17β-(β -D-glucuronide) in rat canalicular membrane vesicles. Am J Physiol, 271:G791-G798, 1996.
56. Kanai N, R Lu, Y Bao, AW Wolkoff, M Vore and VL Schuster: Estradiol 17-β-D-glucuronide is a high affinity substrate for the organic anion transporter "Oatp". Am J Physiol 270:F326-F331, 1996.
57. Liu, Y, L Huang, T Hoffman, M Gosland and M Vore: MDR1 substrate-modulators protect against estradiol l7 β-(β-D-glucuronide) cholestasis in the rat liver. Cancer Res. 56:4992-4997, 1996.
58. Liu Y, F Suchy, J Silverman and M Vore: Prolactin increases ATP-dependent taurocholate transport in canalicular plasma membranes from rat liver. Am J Physiol., 272:G46-G53, 1997.
PublicationsRefereed JournalsContinued
59. Ganguly TC, ML O’Brien, SJ Karpen, JF Hyde, FJ Suchy and M Vore. Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by STAT5. J Clin Invest 99:2906-2914, 1997. PMC508142
60. Martin CA, AG Mainous III, RO Mainous, MJ Oler, T Curry and M Vore. Progesterone and adolescent suicidality. Biol Psychiatry 42:956-958, 1997.
61. Huang L, T Hoffman and M Vore. ATP-dependent transport of estradiol-17b-(b-D-glucuronide) in membrane vesicles by MDR1 expressed in insect cells. Hepatology 28:1371-1377, 1998.
62. Luquita MG, VA Catania, EJ Sanchez-Pozzi, M Vore and AD Mottino. Prolactin increases the hepatic content of Yb subunits of glutathione S-transferase in the rat. Drug Metab Dispos 27:122-124, 1999.
63. Kline RM, Fennewald, Vore ME, Bertolone SJ, Hente ML. Oral contraceptives: A cause of hyperbilirubinemia in stem cell transplant patients. J Pediatric Hematology/Oncology 21: 436-440, 1999.
64. Luquita MG, Catania VA, Sanchez-Pozzi EJ, Vore M, Veggi LM, Pellegrino JM and Mottino AD. Induction of phase II biotransformation reactions in rat jejunum during lactation. Possible involvement of prolactin. Biochim Biophys Acta 1472:82-92, 1999.
65. Mottino AD, Hoffman T, Jennes L and Vore M. Expression and localization of the multidrug resistant protein mrp2 in rat small intestine. J Pharmacol Exp Therap 293:717-723, 2000.
66. Huang L and Vore M. Mrp2 is essential for estradiol-17b(b-D-glucuronide) induced cholestasis in rat. Hepatology 32:66-72, 2000.
67. Cao J, Huang L, Liu Y, Hoffman T, Stieger B, Meier PJ and Vore M. Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin. Hepatology 33: 140-147, 2001.
68. Gowri PM, Ganguly TC, Cao J, Devalaraja MN, Groner B and Vore M. Conversion of Threonine-757 to Valine enhances Stat5 transactivation potential J Biol Chem 276:10485-10491, 2001.
69. Mottino AD, Hoffman T, Jennes L, Cao J and Vore M. Expression of multidrug resistance-associated protein 2 in small intestine from pregnant and postpartum rats. Amer J Physiol 280: G1261-G1273, 2001.