Research outputs
Listing of Research outputs
Definitive zygosity scores in the peas in the pod questionnaire is a sensitive and accurate assessment of the zygosity of adult twins
Jarrar, Z. A., Ward, K. J., Mangino, M., Cherkas, L. F., Gill, R., Gillham-Nasenya, I., Yarand, D., Hart, D., Hammond, C. J. & Spector, T. D. Apr 2018 In : TWIN RESEARCH AND HUMAN GENETICS. 21, 2, p. 146-154
Research output: Contribution to journal › Article
Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand
Hollander, W. D. , Boer, C. G. , Hart, D. J. , Yau, M. S. , Ramos, Y. F. M. , Metrustry, S. , Broer, L. , Deelen, J. , Cupples, L. A. , Rivadeneira, F. , Kloppenburg, M. , Peters, M. , Spector, T. D. , Hofman, A. , Slagboom, P. E. , Nelissen, R. G. H. H. , Uitterlinden, A. G. , Felson, D. T. , Valdes, A. M. , Meulenbelt, I. & 1 others van Meurs, J. J. B. 30 Aug 2017 In : Annals of the rheumatic diseases. 76, 12, p. 2046-2053
Research output: Contribution to journal › Article
Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene
Warner, S. C., Walsh, D. A., Laslett, L. L., Maciewicz, R. A., Soni, A., Hart, D. J., Zhang, W., Muir, K. R., Dennison, E. M., Leaverton, P., Rampersaud, E., Cooper, C., Spector, T. D., Cicuttini, F. M., Arden, N. K., Jones, G., Doherty, M. & Valdes, A. M. Aug 2017 In : European journal of pain (London, England). p. 1277-1284
Research output: Contribution to journal › Article
Serum Lipid Levels and Risk of Hand Osteoarthritis: The Chingford Prospective Cohort Study
Garcia-Gil, M., Reyes, C., Ramos, R., Sanchez-Santos, M. T., Prieto-Alhambra, D., Spector, T. D., Hart, D. J. & Arden, N. K. 9 Jun 2017 In : Scientific Reports. 7, 1, 3147
Research output: Contribution to journal › Article
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis
Castaño-Betancourt, M. C. , Evans, D. S. , Ramos, Y. F. M. , Boer, C. G. , Metrustry, S. , Liu, Y. , den Hollander, W. , van Rooij, J. , Kraus, V. B. , Yau, M. S. , Mitchell, B. D. , Muir, K. , Hofman, A. , Doherty, M. , Doherty, S. , Zhang, W. , Kraaij, R. , Rivadeneira, F. , Barrett-Connor, E. , Maciewicz, R. A. & 17 others Arden, N., Nelissen, R. G. H. H., Kloppenburg, M., Jordan, J. M., Nevitt, M. C., Slagboom, E. P., Hart, D. J., Lafeber, F., Styrkarsdottir, U., Zeggini, E., Evangelou, E., Spector, T. D., Uitterlinden, A. G., Lane, N. E., Meulenbelt, I., Valdes, A. M. & van Meurs, J. B. J. 4 Oct 2016 In : PL o S Genetics. 12, 10, e1006260
Research output: Contribution to journal › Article
Aging Trajectories in Different Body Systems Share Common Environmental Etiology: The Healthy Aging Twin Study (HATS)
Moayyeri, A., Hart, D. J., Snieder, H., Hammond, C. J., Spector, T. D. & Steves, C. J. Feb 2016 In : TWIN RESEARCH AND HUMAN GENETICS. 19, 1, p. 27-34 8 p.
Research output: Contribution to journal › Article
A comparison of radiographic anatomic axis knee alignment measurements and cross-sectional associations with knee osteoarthritis
Goulston, L. M., Sanchez-Santos, M. T., D'Angelo, S., Leyland, K. M., Hart, D. J., Spector, T. D., Cooper, C., Dennison, E. M., Hunter, D. & Arden, N. K. 14 Dec 2015 In : Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 24, 4, p. 612-622
Research output: Contribution to journal › Article
Individuals with high bone mass have an increased prevalence of radiographic knee osteoarthritis
Hardcastle, S. A., Dieppe, P., Gregson, C. L., Arden, N. K., Spector, T. D., Hart, D. J., Edwards, M. H., Dennison, E. M., Cooper, C., Sayers, A., Williams, M., Davey Smith, G. & Tobias, J. H. 1 Feb 2015 In : Bone. 71, p. 171-179 9 p.
Research output: Contribution to journal › Article
Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women
Kluzek, S., Bay-Jensen, A. C., Judge, A., Karsdal, M. A., Shorthose, M., Spector, T., Hart, D., Newton, J. L. & Arden, N. K. 2015 In : BIOMARKERS. 20, 8, p. 557-564 8 p.
Research output: Contribution to journal › Article
Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors
Kerkhof, H. J. M., Bierma-Zeinstra, S. M. A., Arden, N. K., Metrustry, S., Castano-Betancourt, M., Hart, D. J., Hofman, A., Rivadeneira, F., Oei, E. H. G., Spector, T. D., Uitterlinden, A. G., Janssens, A. C. J. W., Valdes, A. M. & van Meurs, J. B. J. Dec 2014 In : Annals of the Rheumatic Diseases. 73, 12, p. 2116-2121
Research output: Contribution to journal › Article
Association of interleukin-6 gene polymorphisms with hand osteoarthritis and hand osteoporosis
Blumenfeld, O., Williams, F. M. K., Valdes, A., Hart, D. J., Malkin, I., Spector, T. D. & Livshits, G. Sep 2014 In : Cytokine. 69, 1, p. 94-101 8 p.
Research output: Contribution to journal › Article
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance
Ramos, Y. F. M. , Metrustry, S. , Arden, N. , Bay-Jensen, A. C. , Beekman, M. , de Craen, A. J. M. , Cupples, L. A. , Esko, T. , Evangelou, E. , Felson, D. T. , Hart, D. J. , Ioannidis, J. P. A. , Karsdal, M. , Kloppenburg, M. , Lafeber, F. , Metspalu, A. , Panoutsopoulou, K. , Slagboom, P. E. , Spector, T. D. , van Spil, E. W. E. & 6 others Uitterlinden, A. G., Zhu, Y., Valdes, A. M., van Meurs, J. B. J., Meulenbelt, I. & arcOGEN consortium Sep 2014 In : Journal of Medical Genetics. 51, 9, p. 596-604 9 p.
Research output: Contribution to journal › Article
Osteophytes, enthesophytes and High Bone Mass: A bone-forming triad with relevance for osteoarthritis?
Hardcastle, S. A., Dieppe, P., Gregson, C. L., Arden, N. K., Spector, T. D., Hart, D. J., Edwards, M. H., Dennison, E. M., Cooper, C., Williams, M., Davey-Smith, G. & Tobias, J. H. Sep 2014 In : Arthritis and Rheumatology. 66, 9, p. 2429-2439 11 p.
Research output: Contribution to journal › Article
Prevalence of radiographic hip osteoarthritis is increased in high bone mass
Hardcastle, S. A., Dieppe, P., Gregson, C. L., Hunter, D., Thomas, G. E. R., Arden, N. K., Spector, T. D., Hart, D. J., Laugharne, M. J., Clague, G. A., Edwards, M. H., Dennison, E. M., Cooper, C., Williams, M., Davey Smith, G. & Tobias, J. H. Aug 2014 In : Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 22, 8, p. 1120-8 9 p.
Research output: Contribution to journal › Article
SMAD3 Is Associated with the Total Burden of Radiographic Osteoarthritis: The Chingford Study
Aref-Eshghi, E., Zhang, Y., Hart, D., Valdes, A. M., Furey, A., Martin, G., Sun, G., Rahman, P., Arden, N., Spector, T. D. & Zhai, G. 22 May 2014 In : PL o S One . 9, 5, 7 p., e97786
Research output: Contribution to journal › Article
Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31
Styrkarsdottir, U. , Thorleifsson, G. , Helgadottir, H. T. , Bomer, N. , Metrustry, S. , Bierma-Zeinstra, S. , Strijbosch, A. M. , Evangelou, E. , Hart, D. , Beekman, M. , Jonasdottir, A. , Sigurdsson, A. , Eiriksson, F. F. , Thorsteinsdottir, M. , Frigge, M. L. , Kong, A. , Gudjonsson, S. A. , Magnusson, O. T. , Masson, G. , Hofman, A. & 17 others Arden, N. K., Ingvarsson, T., Lohmander, S., Kloppenburg, M., Rivadeneira, F., Nelissen, R. G. H. H., Spector, T., Uitterlinden, A., Slagboom, P. E., Thorsteinsdottir, U., Jonsdottir, I., Valdes, A. M., Meulenbelt, I., van Meurs, J., Jonsson, H., Stefansson, K. & The TREAT-OA Consortium May 2014 In : Nature Genetics. 46, 5, p. 498-502 5 p.
Research output: Contribution to journal › Article
Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis
Neogi, T., Soni, A., Doherty, S. A., Laslett, L. L., Maciewicz, R. A., Hart, D. J., Zhang, W., Muir, K. R., Wheeler, M., Cooper, C., Spector, T. D., Cicuttini, F., Jones, G., Nevitt, M., Liu, Y., Arden, N. K., Doherty, M. & Valdes, A. M. Jan 2014 In : Annals of the Rheumatic Diseases. 73, 1, p. 315-317 3 p., N/A
Research output: Contribution to journal › Letter
The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study
Panoutsopoulou, K., Metrustry, S., Doherty, S. A., Laslett, L. L., Maciewicz, R. A., Hart, D. J., Zhang, W., Muir, K. R., Wheeler, M., Cooper, C., Spector, T. D., Cicuttini, F. M., Jones, G., Arden, N. K., Doherty, M., Zeggini, E., Valdes, A. M. & arcOGEN Consortium 2014 In : Annals of the Rheumatic Diseases. 73, 12, p. 2082-2086 5 p., N/A
Research output: Contribution to journal › Article
Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study
Blumenfeld, O., Williams, F. M. K., Hart, D. J., Spector, T. D., Arden, N. & Livshits, G. Jul 2013 In : Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 21, 7, p. 923-929 7 p., N/A
Research output: Contribution to journal › Article
Neuropathic Features of Joint Pain: A Community-Based Study
Soni, A., Batra, R. N., Gwilym, S. E., Spector, T. D., Hart, D. J., Arden, N. K., Cooper, C., Tracey, I. & Javaid, M. K. Jul 2013 In : Arthritis & Rheumatism. 65, 7, p. 1942-1949 8 p., N/A
Research output: Contribution to journal › Article
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region
Peters, M. J. , Broer, L. , Willemen, H. L. D. M. , Eiriksdottir, G. , Hocking, L. J. , Holliday, K. L. , Horan, M. A. , Meulenbelt, I. , Neogi, T. , Popham, M. , Schmidt, C. O. , Soni, A. , Valdes, A. M. , Amin, N. , Dennison, E. M. , Eijkelkamp, N. , Harris, T. B. , Hart, D. J. , Hofman, A. , Huygen, F. J. P. M. & 32 others Jameson, K. A., Jones, G. T., Launer, L. J., Kerkhof, H. J. M., de Kruijf, M., McBeth, J., Kloppenburg, M., Ollier, W. E., Oostra, B., Payton, A., Rivadeneira, F., Smith, B. H., Smith, A. V., Stolk, L., Teumer, A., Thomson, W., Uitterlinden, A. G., Wang, K., van Wingerden, S. H., Arden, N. K., Cooper, C., Felson, D., Gudnason, V., Macfarlane, G. J., Pendleton, N., Slagboom, P. E., Spector, T. D., Voelzke, H., Kavelaars, A., van Duijn, C. M., Williams, F. M. K. & van Meurs, J. B. J. Mar 2013 In : Annals of the Rheumatic Diseases. 72, 3, p. 427-436 10 p., N/A
Research output: Contribution to journal › Article
The UK Adult Twin Registry (TwinsUK Resource)
Moayyeri, A., Hammond, C. J., Hart, D. J. & Spector, T. D. Feb 2013 In : TWIN RESEARCH AND HUMAN GENETICS. 16, 1, p. 144-149 6 p., N/A
Research output: Contribution to journal › Article
Lower limbs composition and radiographic knee osteoarthritis (RKOA) in Chingford sample: A longitudinal study
Blumenfeld, O., Williams, F. M. K., Hart, D. J., Arden, N. K., Spector, T. D. & Livshits, G. Jan 2013 In : ARCHIVES OF GERONTOLOGY AND GERIATRICS. 56, 1, p. 148-154 7 p., N/A
Research output: Contribution to journal › Article
Effects of age on genetic influence on bone loss over 17 years in women: the Healthy Ageing Twin Study (HATS)
Moayyeri, A., Hammond, C. J., Hart, D. J. & Spector, T. D. Oct 2012 In : Journal of Bone and Mineral Research. 27, 10, p. 2170-2178 9 p.
Research output: Contribution to journal › Article
Longitudinal study of variation in body mass index in middle-aged UK females
Livshits, G., Malkin, I., Williams, F. M. K., Hart, D. J., Hakim, A. & Spector, T. D. Oct 2012 In : AGE. 34, 5, p. 1285-1294 10 p.
Research output: Contribution to journal › Article
Change in body mass index during middle age affects risk of total knee arthoplasty due to osteoarthritis: A 19-year prospective study of 1003 women
Nicholls, A. S., Kiran, A., Javaid, M. K., Hart, D. J., Spector, T. D., Carr, A. J. & Arden, N. K. Aug 2012 In : KNEE. 19, 4, p. 316-319 4 p.
Research output: Contribution to journal › Article
The natural history of radiographic knee osteoarthritis: A fourteen-year population-based cohort study
Leyland, K. M., Hart, D. J., Javaid, M. K., Judge, A., Kiran, A., Soni, A., Goulston, L. M., Cooper, C., Spector, T. D. & Arden, N. K. Jul 2012 In : Arthritis & Rheumatism. 64, 7, p. 2243-2251 9 p., N/A
Research output: Contribution to journal › Article
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype
Malfait, A-M. , Seymour, A. B. , Gao, F. , Tortorella, M. D. , Le Graverand-Gastineau, M-P. H. , Wood, L. S. , Doherty, M. , Doherty, S. , Zhang, W. , Arden, N. K. , Vaughn, F. L. , Leaverton, P. E. , Spector, T. D. , Hart, D. J. , Maciewicz, R. A. , Muir, K. R. , Das, R. , Sorge, R. E. , Sotocinal, S. G. , Schorscher-Petcu, A. & 2 others Valdes, A. M. & Mogil, J. S. Jun 2012 In : Annals of the Rheumatic Diseases. 71, 6, p. 1042-1048 7 p., N/A
Research output: Contribution to journal › Article
Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
Betancourt, M. C. C. , Cailotto, F. , Kerkhof, H. J. , Cornelis, F. M. F. , Doherty, S. A. , Hart, D. J. , Hofman, A. , Luyten, F. P. , Maciewicz, R. A. , Mangino, M. , Metrustry, S. , Muir, K. , Peters, M. J. , Rivadeneira, F. , Wheeler, M. , Zhang, W. , Arden, N. , Spector, T. D. , Uitterlinden, A. G. , Doherty, M. & 3 others Lories, R. J. U., Valdes, A. M. & van Meurs, J. B. J. 22 May 2012 In : Proceedings of the National Academy of Sciences of the United States of America. 109, 21, p. 8218-8223 6 p.