Evidence Table 69. KQ1—Continuous data—Ischemic heart disease (coronary artery disease)

Author Year
Study Design / Definition of outcome / CHD Risk Category / CVD drug (dose mg/d) / Supplement/ Control / N / Post treatment Mean/
(Median)
SD/SE
Lower limit (IQR, 95% CI)
Upper Limit (IQR, 95% CI) / Mean change / % change from baseline /
SD /
P Value / Between group differences in Means/ medians
SD /
P Value / Additional comments / Overall Risk of Bias (ROB) Assessment /
Unstable angina (see also Dich. data)
Miyamoto 200448
Parallel / Number of anginal attacks recorded after before and after 1 month / High / Diltiazem (100-200) / Vitamin E (0.4) / 20 / Mean: 0.4
SE: 0.1 / P: <0.01 / P: NS / -
Placebo / 20 / Mean: 0.6
SE: 0.1 / P: <0.01
Motoyama 199850
Parallel / Number of anginal attacks recorded after 1 month / High / Diltiazem (200) / Vitamin E (0.3) / 30 / Mean: 0.2
SD: 0.5 / Mean:
-6.7 / Meandiff: 0.7 / -
Placebo / 30 / Mean: 0.9
SD: 1.1 / Mean:
-5.9
Evidence Table 69. KQ1—Continuous data—Ischemic heart disease (coronary artery disease) (continued) /
Author Year
Study Design / Definition of outcome / CHD Risk Category / CVD drug (dose mg/d) / Supplement/ Control / N / Post treatment Mean/
(Median)
SD/SE
Lower limit (IQR, 95% CI)
Upper Limit (IQR, 95% CI) / Mean change/ % change from baseline/
SD /
P Value / Between group differences in Means/ medians
SD /
P Value / Additional comments / Overall Risk of Bias (ROB) Assessment /
(Re)stenosis – see also Dich. data)
Yamamoto 199569
Parallel / Coronary artery diameter- nonspastic segments: angiographically normal site where acetylcholine injection did not provoke coronary vasospasm (diameter [mm], expressed as a % after admin of ISDN was reduced by < 50% after intracoronary admin of acetylcholine) – 4 months follow-up / High / Diltiazem (90-120) / Omega-3 (EPA, DHA, or both) (3.6) / 12 / Mean: 3.0
SE: 0.1 / - / - / - / -
No treatment / 10 / Mean: 2.9
SE: 0.2 / -
Yamamoto 199569
Parallel / coronary artery diameter- spastic segments: spastic site = site of the most severe narrowing in the coronary vasospasm artery after injection of acetylcholine (mm) – 4 months follow-up / High / Diltiazem (90-120) / Omega-3 (EPA, DHA, or both) (3.6) / 12 / Mean: 2.9
SE: 0.1 / - / - / - / -
No treatment / 10 / Mean: 3.0
SE: 0.3 / -
Dehmer 198817
Parallel / Luminal narrowing (%) after angioplasty – 3-4 months follow-up / High / ASA (325) + dipyridamole (225) + calcium channel blockers (NR) / Omega-3 (EPA, DHA, or both) (3.2) / 43 / Mean: 25
SD: 15.1 / - / - / - / -
No treatment / 39 / Mean: 29
SD: 14 / -