Table e-2: Standardized coefficients of structural equation models evaluating the mediation of the effects of acetazolamide on quality of life at 6 months via idiopathic-intracranial-hypertension-related symptoms and signs. Coefficients with p < 0.05 are in bold.

Treatment
Status Variable / Variable
NEI-VFQ-25 / Variable
Neuro-oph Supplement / Variable
SF-36 PCS / Variable
SF-36 MCS
Variable / Est. / p / Est. / p / Est. / p / Est. / p / Est. / p
PMD, best eye / 0.14 / 0.12 / 0.29 / 0.003 / 0.25 / 0.003 / 0.21 / 0.003 / 0.09 / 0.003
Visual acuity, worst eye / -0.04 / 0.68 / 0.05 / 0.69 / 0.11 / 0.69 / 0.12 / 0.69 / -0.02 / 0.69
HIT-6 / -0.09 / 0.33 / -0.17 / 0.23 / -0.18 / 0.23 / -0.19 / 0.23 / -0.11 / 0.23
Back pain / -0.01 / 0.93 / 0.13 / 0.33 / 0.07 / 0.33 / 0.03 / 0.33 / 0.09 / 0.33
Neck pain / 0.19 / 0.08 / 0.22 / 0.09 / 0.16 / 0.09 / 0.20 / 0.09 / 0.07 / 0.09
Transient visual obscuration / 0.08 / 0.40 / 0.25 / 0.04 / 0.19 / 0.04 / 0.19 / 0.04 / 0.05 / 0.04
Binocular diplopia / 0.11 / 0.41 / 0.14 / 0.27 / 0.25 / 0.27 / 0.24 / 0.27 / 0.06 / 0.27
Dizziness/ vertigo / 0.32 / 0.002 / 0.05 / 0.71 / 0.06 / 0.71 / 0.09 / 0.71 / 0.09 / 0.71
Cognitive dysfunction / -0.07 / 0.54 / 0.21 / 0.14 / 0.14 / 0.14 / 0.05 / 0.14 / 0.04 / 0.14
Body mass index / -0.16 / 0.15 / -0.04 / 0.82 / -0.06 / 0.82 / -0.06 / 0.82 / -0.03 / 0.82
Photophobia / 0.12 / 0.25 / 0.08 / 0.49 / 0.13 / 0.49 / -0.04 / 0.49 / 0.10 / 0.49
Radicular pain / 0.01 / 0.91 / -0.07 / 0.60 / -0.02 / 0.60 / 0.04 / 0.60 / -0.10 / 0.60
Pulsatile tinnitus / 0.22 / 0.03 / 0.10 / 0.43 / 0.12 / 0.43 / 0.15 / 0.43 / 0.04 / 0.43
Non-pulsatile tinnitus / 0.07 / 0.60 / 0.06 / 0.65 / 0.01 / 0.65 / 0.29 / 0.65 / 0.12 / 0.65
Treatment (direct effect) / NA / NA / -0.04 / 0.77 / -0.03 / 0.77 / -0.10 / 0.77 / 0.00 / 0.77

PMD = perimetric mean deviation; HIT-6 = 6-item Headache Impact Test