Aacute Physiology and Chronic Health Evaluation

Table E1. Comparison of baseline characteristics in patients with and without severe sepsis at baseline (Data available for 6677 patients - consent to use data withheld for 57 patients, data missing for 263 [3.8%] patients)

Characteristic / With severe sepsis at baseline
(n=1218) / Without severe sepsis at baseline
(n=5459) / P value
Age (mean ±SD in years)
Gender- male (no., %)
Admission- surgical (no., %)
Trauma (no., %)
Adult respiratory distress syndrome (no., %)
APACHE IIa score (mean ±SD)
Urine output (mean ±SD, mL/h)
Mean arterial pressure (mean ±SD, mmHg)
Renal replacement therapy (no., %)
Mechanical ventilation (no., %)
Angiotensin-converting enzyme inhibitor (no., %)
SOFA Scoreb (mean, median, IQR)
Cardiovascular
Respiratory
Renal
Liver
Coagulation / 60.7±17.2
711, 58.4
265, 21.8
17 (1.4)
81 (6.7)
21.7±7.7
80.9±159.1
73.6±15.8
40, 3.3
707, 58.1
181, 14.9
1.84, 1 (1-3)
2.30, 2 (2-3)
1.10, 1 (0-2)
0.73, 0 (0-1)
0.63, 0 (0-1) / 58.0±19.3
3300, 60.5
2628, 48.1
1191 (21.8)
38 (0.7)
18.2±7.9
95.1±146.4
78.7±16.2
43, 0.8
3609, 66.1
770, 14.1
1.10, 1 (0-1)
1.68, 2 (1-3)
0.51, 0 (0-1)
0.35, 0 (0-1)
0.39, 0 (0-1) / <0.001
0.19
<0.001
<0.001
<0.001
<0.001
0.01
<0.001
<0.001
<0.001
0.76
<0.001
<0.001
<0.001
<0.001
<0.001

aAcute Physiology and Chronic Health Evaluation

bSequential Organ Failure Assessment Score

Electronic supplementary material: Kaplan Meier Estimates for probability of survival for patients with severe sepsis assigned albumin or saline, for allpatients (P-value=0.09)

Electronic supplementary material: Kaplan Meier Estimates for probability of survival for patients with severe sepsis assigned albumin or saline, for patients with a baseline serum albumin (BSA) ≤25 g/L. (P-value=0.16)

Kaplan Meier Estimates for probability of survival for patients with severe sepsis assigned albumin or saline, for patients with a baseline serum albumin (BSA) >25 g/L. (P-value=0.13)

Kaplan Meier Estimates for probability of survival for patients with severe sepsis assigned albumin or saline, for patients with a baseline serum albumin (BSA) ≤25 g/ L or >25g/L.