A genome-wide association study of cognitive function in Chinese adulttwins

Biogerontology

Chunsheng Xu1,2,3, Dongfeng Zhang1, Yili Wu1,Xiaocao Tian2,3,Zengchang Pang1,2,3, Shuxia Li4, Qihua Tan4,5

1Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University,Qingdao, Shandong, China

2Qingdao MunicipalCenter for Disease Control and Prevention, Qingdao, Shandong, China

3Qingdao Institute of Preventive Medicine, Qingdao, Shandong, China

4Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark

5Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark

Address correspondence to:

Prof. Dongfeng Zhang, Tel.: +86 532 82991712, e-mail:

Supplementary Table 2 pathways discovered in GSEA

Gene Set Name [# Genes (K)] / Description / # Genes in Overlap (k) / k/K / p-value / FDR q-value
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPO
IPOPROTEINS [478] / Genes involved in Metabolism of lipids and lipoproteins / 24 / 2.39 e-7 / 2.06 e-4
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SM
_SMALL_MOLECULES [413] / Genes involved in Transmembrane transport of small molecules / 21 / 1.1 e-6 / 4.5 e-4
KEGG_VIBRIO_CHOLERAE_INFECTION [56] / Vibrio cholerae infection / 8 / 1.57 e-6 / 4.5 e-4
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY [352] / Genes involved in Generic Transcription Pathway / 18 / 5.85 e-6 / 1.23 e-3
REACTOME_HEMOSTASIS [466] / Genes involved in Hemostasis / 21 / 7.16 e-6 / 1.23 e-3
REACTOME_INTEGRIN_CELL_SURFACE_INTERAC
RACTIONS [79] / Genes involved in Integrin cell surface interactions / 8 / 2.15 e-5 / 3.07 e-3
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM [85] / Hypertrophic cardiomyopathy (HCM) / 8 / 3.66 e-5 / 4.5 e-3
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TR
_TRANSPORT [241] / Genes involved in SLC-mediated transmembrane transport / 13 / 6.58 e-5 / 6.31 e-3
KEGG_CALCIUM_SIGNALING_PATHWAY [178] / Calcium signaling pathway / 11 / 7.11 e-5 / 6.31 e-3
REACTOME_INTEGRATION_OF_ENERGY_METABOL
BOLISM [120] / Genes involved in Integration of energy metabolism / 9 / 7.34 e-5 / 6.31 e-3
REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOS
EOSIDES_AND_RELATED_MOLECULES [31] / Genes involved in Transport of vitamins, nucleosides, and related molecules / 5 / 8.28 e-5 / 6.48 e-3
KEGG_OXIDATIVE_PHOSPHORYLATION [135] / Oxidative phosphorylation / 9 / 1.81 e-4 / 1.3 e-2
KEGG_ALZHEIMERS_DISEASE [169] / Alzheimer's disease / 10 / 2.14 e-4 / 1.41 e-2
REACTOME_DNA_REPAIR [112] / Genes involved in DNA Repair / 8 / 2.56 e-4 / 1.57 e-2
KEGG_GLIOMA [65] / Glioma / 6 / 3.86 e-4 / 2.06 e-2
REACTOME_CELL_SURFACE_INTERACTIONS_AT_
AT_THE_VASCULAR_WALL [91] / Genes involved in Cell surface interactions at the vascular wall / 7 / 3.95 e-4 / 2.06 e-2
KEGG_WNT_SIGNALING_PATHWAY [151] / Wnt signaling pathway / 9 / 4.15 e-4 / 2.06 e-2
REACTOME_REGULATION_OF_INSULIN_SECRETI
ETION [93] / Genes involved in Regulation of Insulin Secretion / 7 / 4.51 e-4 / 2.06 e-2
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_
AL_SYNAPSES [186] / Genes involved in Transmission across Chemical Synapses / 10 / 4.59 e-4 / 2.06 e-2
KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELI
ELICOBACTER_PYLORI_INFECTION [68] / Epithelial cell signaling in Helicobacter pylori infection / 6 / 4.93 e-4 / 2.06 e-2
KEGG_N_GLYCAN_BIOSYNTHESIS [46] / N-Glycan biosynthesis / 5 / 5.58 e-4 / 2.06 e-2
REACTOME_CELL_CYCLE [421] / Genes involved in Cell Cycle / 16 / 5.73 e-4 / 2.06 e-2
KEGG_LONG_TERM_POTENTIATION [70] / Long-term potentiation / 6 / 5.76 e-4 / 2.06 e-2
KEGG_PANCREATIC_CANCER [70] / Pancreatic cancer / 6 / 5.76 e-4 / 2.06 e-2
KEGG_TYPE_II_DIABETES_MELLITUS [47] / Type II diabetes mellitus / 5 / 6.17 e-4 / 2.12 e-2
KEGG_FOCAL_ADHESION [201] / Focal adhesion / 10 / 8.36 e-4 / 2.64 e-2
KEGG_CELL_ADHESION_MOLECULES_CAMS [134] / Cell adhesion molecules (CAMs) / 8 / 8.49 e-4 / 2.64 e-2
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SY
_SYSTEM [76] / Phosphatidylinositol signaling system / 6 / 8.92 e-4 / 2.64 e-2
REACTOME_BASIGIN_INTERACTIONS [30] / Genes involved in Basigin interactions / 4 / 9.28 e-4 / 2.64 e-2
REACTOME_NEURONAL_SYSTEM [279] / Genes involved in Neuronal System / 12 / 9.53 e-4 / 2.64 e-2
REACTOME_GASTRIN_CREB_SIGNALLING_PATHW
THWAY_VIA_PKC_AND_MAPK [205] / Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK / 10 / 9.71 e-4 / 2.64 e-2
KEGG_INSULIN_SIGNALING_PATHWAY [137] / Insulin signaling pathway / 8 / 9.81 e-4 / 2.64 e-2
REACTOME_OPIOID_SIGNALLING [78] / Genes involved in Opioid Signalling / 6 / 1.02 e-3 / 2.66 e-2
REACTOME_CELL_CYCLE_MITOTIC [325] / Genes involved in Cell Cycle, Mitotic / 13 / 1.15 e-3 / 2.92 e-2
KEGG_PATHWAYS_IN_CANCER [328] / Pathways in cancer / 13 / 1.25 e-3 / 3.08 e-2
REACTOME_LATENT_INFECTION_OF_HOMO_SAPI
APIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS [33] / Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis / 4 / 1.34 e-3 / 3.2 e-2
KEGG_PANTOTHENATE_AND_COA_BIOSYNTHESIS [16] / Pantothenate and CoA biosynthesis / 3 / 1.53 e-3 / 3.5 e-2
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTIO
TION [115] / Vascular smooth muscle contraction / 7 / 1.58 e-3 / 3.5 e-2
REACTOME_IMMUNE_SYSTEM [933] / Genes involved in Immune System / 26 / 1.59 e-3 / 3.5 e-2
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS [184] / Genes involved in G alpha (q) signalling events / 9 / 1.68 e-3 / 3.62 e-2
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRAT
RATION [118] / Leukocyte transendothelial migration / 7 / 1.83 e-3 / 3.85 e-2
REACTOME_POST_TRANSLATIONAL_PROTEIN_MO
_MODIFICATION [188] / Genes involved in Post-translational protein modification / 9 / 1.95 e-3 / 3.99 e-2
KEGG_MAPK_SIGNALING_PATHWAY [267] / MAPK signaling pathway / 11 / 2.14 e-3 / 4.29 e-2
KEGG_DILATED_CARDIOMYOPATHY [92] / Dilated cardiomyopathy / 6 / 2.39 e-3 / 4.59 e-2
REACTOME_DEVELOPMENTAL_BIOLOGY [396] / Genes involved in Developmental Biology / 14 / 2.4 e-3 / 4.59 e-2
REACTOME_ACTIVATED_AMPK_STIMULATES_FAT
FATTY_ACID_OXIDATION_IN_MUSCLE [19] / Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle / 3 / 2.55 e-3 / 4.78 e-2