Impact of promoter SNPs (MAF>2%) on predicted transcription factor binding sites
Variant / Software1 / Factor / Detailed Family Information / Score WT2 / Score SNP2
c.-1779C/T / MI / POU5F1-3* / Octamer binding protein / ND / 0,81
MI / AIRE / Autoimmune regulatory element binding factor / ND / 0,86
TESS / EcR / Present / ND
TESS / NF-1* / ND / Present
c.-1171T/C / MI / HSF2 / Heat shock factors / 0,95 / ND
MI / MEF2 / MEF2, myocyte-specific enhancer binding factor / 0,84 / ND
MI / ZNF217* / Zinc finger transcriptional repressor / 0,9 / ND
MI / SOX9 / SOX/SRY-sex/testis determinig and related HMG box factors / ND / 0,77
MI / CART-1 / Cart-1 (cartilage homeoprotein 1) / ND / 0,86
TESS / Delta factor / ND / Present
TESS / GATA-1* / ND / Present
TESS / NF-E / ND / Present
c.-922T/C / TESS / GR* / Present / ND
TESS / GKLF / Present / ND
TESS / MalT / ND / Present
c.-874G/A / MI / E-box MYC-MAX / E-box binding factors / 0,91 / ND
MI / TFIIB* / RNA polymerase II transcription factor II B / 0,97 / ND
TESS / GCF / Present / ND
TESS / ZF5 / Present / ND
TESS / c-Myc* / ND / Present
TESS / Myogenin / ND / Present
c.-873C/T / MI / E-box, ATF6* / E-box binding factors / ND / 0,93
MI / E-box, MYC-MAX* / E-box binding factors / 0,91 / ND
MI / TFIIB* / RNA polymerase II transcription factor II B / 0,97 / ND
MI / ZFP628 / GT box / ND / 0,7
TESS / GCF / Present / ND
TESS / ZF5 / Present / ND
c.-201C/G / MI / NRSF* / Neuron-restrictive silencer factor / ND / 0,69
MI / AP1R / MAF and AP1 related factors / ND / 0,82
TESS / LBP-1 / Present / ND
c.-85C/G / MI / MYBL / Cellular and viral myb-like transcriptional regulators / ND / 0,9
TESS / Sp1* / Sp1 / Present / ND
1 MI: MatInspector and TESS: Transcription Element Search Software
2 ND: Not detected
*: Expressed in the MCF-7 cell line.